Animal-free lyophilization protectants for streptococcus pneumoniae
CN116121106BActive Publication Date: 2026-08-28CHENGDU INST OF BIOLOGICAL PROD
Patent Information
- Application Number
- CN202211214831.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2021-07-08
- Publication Date
- 2026-08-28
- Estimated Expiration
- 2041-07-08
AI Technical Summary
Technical Problem
但是，该保护剂含有较大比例的动物源成分，即脱脂奶粉和脱纤维羊血，其缺点是：一方面成本较高；另一方面容易混入动物源的病原体或致敏原，给疫苗产品带来了安全隐患
Benefits of technology
[0024]1.本发明的无动物源冻干保护剂中各组分相互配合，可在冻干过程中有效保护肺炎链球菌活性，效果与市售产品相当，但成本不到市售产品的1/10。
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN116121106B_ABST
Abstract
The application discloses a freeze-drying protective agent for Streptococcus pneumoniae without animal source, and belongs to the field of microorganism preservation. The freeze-drying protective agent is composed of the following components: 1-5% (weight / volume) soybean peptone, 1-5% (weight / volume) trehalose, 4-8% (weight / volume) mannitol and 0.3-1.5% (volume / volume) glycerol, and the rest is water. The freeze-drying protective agent can better maintain the activity of Streptococcus pneumoniae, and the effect is equivalent to that of a skimmed milk protective agent or a commercially available freeze-drying protective agent without animal source, but the freeze-drying protective agent does not contain animal source components and has low cost.
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Citation Information
Patent Citations
Streptococcus pneumoniae freeze-drying protective agent
CN111849781A
Cell cryopreservation solution and use thereof
WO2019172112A1