A tooth caries prevention paste and preparation method thereof

Abstract

This invention discloses a toothpaste for preventing tooth decay and its preparation method, relating to the field of oral care technology. The toothpaste comprises, by weight percentage: 10-35.2% abrasive, 1-3% surfactant, 0.8-2% thickener, 2-5% emollient, 0.5-1% preservative, 30-40% skin conditioning agent, 0.5-1.5% fragrance, and 30-40% water. This invention modifies titanium dioxide, coating it with a polysiloxane shell, and combines it with sorbitol and fluoride. This combination of multiple ingredients effectively prevents tooth decay and alleviates dental problems caused by cavities. The polysiloxane on the surface of titanium dioxide reacts with the enamel minerals in the microcracks and damaged areas of the teeth during friction, producing substances similar to tooth enamel minerals that repair the enamel, making teeth stronger. It achieves good anti-caries and antibacterial capabilities even at low fluoride concentrations and reduces tooth wear.

Description

Technical Field

[0001] This invention relates to the field of oral care technology, specifically to a dental anti-caries paste and its preparation method. Background Technology

[0002] The currently accepted theory of dental caries etiology is the four-factor theory, which mainly includes bacteria, oral environment, parasites (i.e., parasites including parasites, viruses, etc.), and time. Its basic points are: cariogenic food sugars (especially sucrose and refined carbohydrates) adhere tightly to the tooth surface on an acquired membrane formed by salivary proteins. This membrane, formed by the anatomical structure and biochemical and biophysical characteristics of the tooth surface, not only adheres firmly to the tooth surface but also, under suitable temperatures and with sufficient time, produces acid deep within the plaque, attacking the tooth, causing demineralization, and subsequently destroying organic matter, resulting in cavities. By weight, the proportion of organic matter in enamel is almost negligible. However, by volume, organic matter and water still occupy a considerable space in the enamel, making it a permeable solid. Small particles, including hydrogen ions and organic acids, can diffuse within it, thus determining the enamel's susceptibility to caries.

[0003] Previously, anti-caries toothpaste mainly added fluoride, such as sodium fluoride and sodium monofluorophosphate, to increase the concentration of fluoride ions in the product, thereby improving the teeth's resistance to tartar, cavities, and bacteria. It is worth noting that excessive fluoride can cause dental fluorosis and even skeletal fluorosis. High levels of fluoride in the body can affect health, and excessive use of fluoride-containing products may cause fluorosis, thereby damaging the nervous system and triggering osteoporosis.

[0004] Therefore, there is a need for a toothpaste that can achieve good anti-caries and antibacterial capabilities at low fluoride concentrations, effectively produce enamel-like minerals at damaged tooth sites, repair enamel to make teeth stronger, prevent demineralization of inorganic matter and decomposition of organic matter, and reduce tooth wear while ensuring cleaning ability. Summary of the Invention

[0005] To address the aforementioned technical problems and needs, this invention discloses a toothpaste that achieves good anti-caries and antibacterial capabilities at low fluoride concentrations, effectively produces enamel-like minerals at tooth damage sites, prevents demineralization of inorganic tooth matter and decomposition of organic tooth matter, and reduces tooth wear while maintaining cleaning power.

[0006] The present invention adopts the following technical solutions:

[0007] A toothpaste for preventing tooth decay, characterized in that it comprises, by weight percentage: 10-35.2% abrasive, 1-3% surfactant, 0.8-2% thickener, 2-5% emollient, 0.5-1% preservative, 30-40% skin conditioner, 0.5-1.5% fragrance, and 30-40% water.

[0008] Preferably, the dental anti-caries paste comprises, by weight percentage: 22.25% abrasive, 2% surfactant, 1.4% thickener, 3% emollient, 0.8% preservative, 36.25% skin conditioner, 1% fragrance, and 33.3% water.

[0009] Preferably, the abrasive agent comprises, by weight percentage: 97-99.8% silica and 0.2-3% titanium dioxide.

[0010] More preferably, the abrasive agent comprises, by weight percentage: 98.9% silica and 1.1% titanium dioxide.

[0011] Preferably, the titanium dioxide is a modified titanium dioxide nanomaterial, and the preparation method is as follows:

[0012] S1. Ultrasonically treat titanium dioxide powder in an ethanol solution of silver nitrate and impregnate it for 20-30 minutes, then filter it and dry the powder in a vacuum oven; the concentration of the ethanol solution of silver nitrate is 12-15 mol / L, the mass ratio of titanium dioxide powder to ethanol solution of silver nitrate is 1:5-10, the purity of silver nitrate is above 90%, and anhydrous ethanol is used.

[0013] S2. Add the titanium dioxide treated in step S1 to propylene glycol and stir to obtain solution A; the mass ratio of titanium dioxide to propylene glycol is 1:5~10.

[0014] S3. Mix water, propylene glycol, and sodium hydroxide in a mass ratio of water:propylene glycol:sodium hydroxide = 1~3:6~10:0.5~1.5 to obtain mixed solution B;

[0015] S4. At 35~45℃, add solution B to mixed solution A and stir for 1.5~3h to obtain titanium dioxide sol solution.

[0016] S5. Add polysiloxane to the titanium dioxide sol solution, stir and react at 50~65℃ for 4~6h, filter, and the modified titanium dioxide nanomaterial is obtained.

[0017] Preferably, the titanium dioxide powder is selected from anatase titanium dioxide powder, with a particle size of 200-300 nm. Anatase titanium dioxide is relatively abundant and has relatively stable properties.

[0018] The core of the modified titanium dioxide is anatase titanium dioxide, and the outer shell is polysiloxane. The inventors discovered that when titanium dioxide modified with polysiloxane is added, it can effectively adhere to the damaged areas of the teeth while cleaning them, producing a substance similar to the minerals in tooth enamel, which repairs the enamel and makes the teeth stronger.

[0019] Polysiloxane, a hydrophilic white rosin, can increase the viscosity and foaming properties of toothpaste, allowing it to adhere better to the tooth surface and aiding in the adhesion of titanium dioxide. Due to its excellent abrasive properties and extremely fine particles, polysiloxane can help remove dirt and plaque from the tooth surface, and when used in combination with titanium dioxide, it exhibits good antibacterial properties.

[0020] Preferably, the emollient is polyethylene glycol-400.

[0021] Preferably, the thickener comprises, by weight percentage: 57% carboxymethyl hydroxyethyl cellulose and 43% xanthan gum.

[0022] Preferably, the preservative comprises, by weight percentage: 37.5% sodium benzoate, 37.5% DMDM ​​hydantoin, and 25% tetrasodium pyrophosphate;

[0023] Preferably, the skin conditioning agent comprises, by weight percentage: 93.5-98.5% sorbitol, 0.5-1% sodium saccharin, and 1-5.5% sodium fluoride.

[0024] More preferably, the skin conditioning agent comprises, by weight percentage: 96.5% sorbitol, 0.7% sodium saccharin, and 2.8% sodium fluoride.

[0025] When sorbitol is used in combination with sodium fluoride and modified titanium dioxide, it can prevent the demineralization of inorganic tooth structure and the decomposition of organic tooth structure, inhibit the production of acid by acid-producing pathogenic plaque, and maximize the antibacterial properties of modified titanium dioxide.

[0026] The toothpaste of this invention provides a fluoride ion concentration of 400~700mg / kg.

[0027] The preparation method of the dental anti-caries paste of the present invention is as follows:

[0028] Deionized water was placed in a reaction vessel, the stirrer was turned on, and the stirring speed was set to 50 rpm. The skin conditioning agent was then added, and after it was completely dissolved, the stirring speed was increased to 80-100 rpm. The thickener was added to the reaction vessel, and stirring was maintained for 30 minutes for premixing and dispersion. The temperature was set to 70-80℃, and the abrasive was slowly added to the reaction vessel. After stirring for 1 hour, the temperature was maintained for 30 minutes. The temperature was then lowered to room temperature, and the stirring speed was reduced to 20-30 rpm. While stirring, the surfactant, emollient, and preservative were added in sequence. Then, a vacuum was drawn, and finally the fragrance was added. The mixture was stirred to homogenize and degassed to obtain the product.

[0029] The beneficial effects of this invention are:

[0030] This invention modifies titanium dioxide, coats it with a polysiloxane shell, and combines it with sorbitol and fluoride. This combination of multiple ingredients effectively prevents tooth decay and alleviates dental problems caused by cavities. During cleaning, it can effectively adhere to the damaged areas of teeth, producing substances similar to the minerals in tooth enamel, repairing tooth enamel and making teeth stronger. It can achieve good anti-caries and antibacterial capabilities even at low fluoride concentrations.

[0031] Titanium dioxide is a good abrasive with strong cleaning ability, but it can cause significant wear and tear on teeth. Modified titanium dioxide with polysiloxane can reduce the degree of wear on teeth. Detailed Implementation

[0032] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to specific examples. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0033] Example 1.

[0034] The dental anti-caries paste of this embodiment comprises, by weight: 10% abrasive, 3% surfactant, 2% thickener, 5% emollient, 1% preservative, 40% skin conditioner, 1.5% fragrance, and 37.5% water.

[0035] The abrasive in this embodiment comprises, by weight percentage: 97% silica and 3% titanium dioxide.

[0036] The titanium dioxide in this embodiment is a modified titanium dioxide nanomaterial, and the preparation method is as follows:

[0037] S1. Ultrasonically treat titanium dioxide powder in an ethanol solution of silver nitrate and impregnate for 20 minutes, then filter and dry the powder in a vacuum oven; the concentration of the ethanol solution of silver nitrate is 12 mol / L, the mass ratio of titanium dioxide powder to ethanol solution of silver nitrate is 1:5, the purity of silver nitrate is above 90%, and anhydrous ethanol is used.

[0038] S2. Add the titanium dioxide treated in step S1 to propylene glycol and stir to obtain solution A; the mass ratio of titanium dioxide to propylene glycol is 1:5.

[0039] S3. Mix water, propylene glycol, and sodium hydroxide in a mass ratio of water:propylene glycol:sodium hydroxide = 1:6:0.5 to obtain mixed solution B;

[0040] S4. At 35℃, solution B is added to mixed solution A and stirred for 1.5 hours to obtain titanium dioxide sol solution.

[0041] S5. Add polysiloxane to the titanium dioxide sol solution, stir and react at 50°C for 4-6 hours, filter, and the modified titanium dioxide nanomaterial is obtained.

[0042] The titanium dioxide powder in this embodiment is selected from anatase titanium dioxide powder, and the powder particle size is 200nm.

[0043] The emollient in this embodiment is polyethylene glycol-400.

[0044] The thickener in this embodiment comprises, by weight percentage: 57% carboxymethyl hydroxyethyl cellulose and 43% xanthan gum.

[0045] The preservatives in this embodiment, by weight percentage, include: sodium benzoate 37.5%, DMDM ​​hydantoin 37.5%, and tetrasodium pyrophosphate 25%;

[0046] The skin conditioning agent of this embodiment comprises, by weight percentage: 93% sorbitol, 0.1% sodium saccharin, and 5.5% sodium fluoride.

[0047] The dental caries prevention paste in this embodiment provides a fluoride ion concentration of 700 mg / kg.

[0048] The preparation method of the dental anti-caries paste in this embodiment is as follows:

[0049] Deionized water was placed in a reaction vessel, the stirrer was turned on, and the stirring speed was set to 50 rpm. The skin conditioning agent was then added, and after it was completely dissolved, the stirring speed was increased to 80 rpm. The thickener was added to the reaction vessel, and stirring was maintained for 30 minutes for premixing and dispersion. The temperature was set to 70℃, and the abrasive was slowly added to the reaction vessel. After stirring for 1 hour, the temperature was maintained for 30 minutes. The temperature was then lowered to room temperature, and the stirring speed was reduced to 20 rpm. While stirring, the surfactant, emollient, and preservative were added in sequence. Then, a vacuum was drawn, and finally the fragrance was added. The mixture was stirred to homogenize and degassed to obtain the product.

[0050] Example 2.

[0051] The toothpaste of this embodiment comprises, by weight percentage: 35.2% abrasive, 1% surfactant, 0.8% thickener, 2% emollient, 0.5% preservative, 30% skin conditioner, 0.5% fragrance, and 30% water.

[0052] The abrasive in this embodiment comprises, by weight percentage: 99.8% silica and 0.2% titanium dioxide.

[0053] The titanium dioxide in this embodiment is a modified titanium dioxide nanomaterial, and the preparation method is as follows:

[0054] S1. Ultrasonically treat titanium dioxide powder in an ethanol solution of silver nitrate for 30 minutes and then filter it. Dry the powder in a vacuum oven. The concentration of the ethanol solution of silver nitrate is 15 mol / L, the mass ratio of titanium dioxide powder to ethanol solution of silver nitrate is 1:10, the purity of silver nitrate is above 90%, and anhydrous ethanol is used.

[0055] S2. Add the titanium dioxide treated in step S1 to propylene glycol and stir to obtain solution A; the mass ratio of titanium dioxide to propylene glycol is 1:10.

[0056] S3. Mix water, propylene glycol, and sodium hydroxide in a mass ratio of water:propylene glycol:sodium hydroxide = 3:10:1.5 to obtain mixed solution B;

[0057] S4. At 45℃, solution B is added to mixed solution A and stirred for 3 hours to obtain titanium dioxide sol solution.

[0058] S5. Add polysiloxane to the titanium dioxide sol solution, stir and react at 65°C for 6 hours, filter, and the modified titanium dioxide nanomaterial is obtained.

[0059] The titanium dioxide powder in this embodiment is selected from anatase titanium dioxide powder, and the powder particle size is 300nm.

[0060] The emollient in this embodiment is polyethylene glycol-400.

[0061] The thickener in this embodiment comprises, by weight percentage: 57% carboxymethyl hydroxyethyl cellulose and 43% xanthan gum.

[0062] The preservatives in this embodiment, by weight percentage, include: sodium benzoate 37.5%, DMDM ​​hydantoin 37.5%, and tetrasodium pyrophosphate 25%;

[0063] The skin conditioning agent of this embodiment comprises, by weight percentage: 98.5% sorbitol, 0.5% sodium saccharin, and 1% sodium fluoride.

[0064] The dental caries prevention paste in this embodiment provides a fluoride ion concentration of 400 mg / kg.

[0065] The preparation method of the dental anti-caries paste in this embodiment is as follows:

[0066] Deionized water was placed in a reaction vessel, the stirrer was turned on, and the stirring speed was set to 50 rpm. The skin conditioning agent was then added, and after it was completely dissolved, the stirring speed was increased to 100 rpm. The thickener was added to the reaction vessel, and stirring was maintained for 30 minutes for premixing and dispersion. The temperature was set to 80℃, and the abrasive was slowly added to the reaction vessel. After stirring for 1 hour, the temperature was maintained for 30 minutes. The temperature was then lowered to room temperature, and the stirring speed was reduced to 30 rpm. While stirring, the surfactant, emollient, and preservative were added in sequence. Then, a vacuum was drawn, and finally the fragrance was added. The mixture was stirred to homogenize and degassed to obtain the product.

[0067] Example 3.

[0068] The toothpaste of this embodiment comprises, by weight percentage: 22.25% abrasive, 2% surfactant, 1.4% thickener, 3% emollient, 0.8% preservative, 36.25% skin conditioner, 1% fragrance, and 33.3% water.

[0069] The abrasive in this embodiment comprises, by weight percentage: 98.9% silica and 1.1% titanium dioxide.

[0070] The titanium dioxide in this embodiment is a modified titanium dioxide nanomaterial, and the preparation method is as follows:

[0071] S1. Ultrasonically treat titanium dioxide powder in an ethanol solution of silver nitrate and impregnate for 25 minutes, then filter and dry the powder in a vacuum oven; the concentration of the ethanol solution of silver nitrate is 13 mol / L, the mass ratio of titanium dioxide powder to ethanol solution of silver nitrate is 1:8, the purity of silver nitrate is above 90%, and anhydrous ethanol is used.

[0072] S2. Add the titanium dioxide treated in step S1 to propylene glycol and stir to obtain solution A; the mass ratio of titanium alkoxide to propylene glycol is 1:8.

[0073] S3. Mix water, propylene glycol, and sodium hydroxide in a mass ratio of water:propylene glycol:sodium hydroxide = 2:8:1 to obtain mixed solution B.

[0074] S4. At 40℃, solution B is added to mixed solution A and stirred for 2 hours to obtain titanium dioxide sol solution.

[0075] S5. Add polysiloxane to the titanium dioxide sol solution, stir and react at 60°C for 5 hours, filter, and the modified titanium dioxide nanomaterial is obtained.

[0076] The titanium dioxide powder in this embodiment is selected from anatase titanium dioxide powder, and the particle size is 250 nm.

[0077] The emollient in this embodiment is polyethylene glycol-400.

[0078] The thickener in this embodiment comprises, by weight percentage: 57% carboxymethyl hydroxyethyl cellulose and 43% xanthan gum.

[0079] The preservatives in this embodiment, by weight percentage, include: sodium benzoate 37.5%, DMDM ​​hydantoin 37.5%, and tetrasodium pyrophosphate 25%;

[0080] The skin conditioning agent in this embodiment comprises, by weight percentage: 96.5% sorbitol, 0.7% sodium saccharin, and 2.8% sodium fluoride.

[0081] The dental caries prevention paste in this embodiment provides a fluoride ion concentration of 550 mg / kg.

[0082] The preparation method of the dental anti-caries paste in this embodiment is as follows:

[0083] Deionized water was placed in a reaction vessel, the stirrer was turned on, and the stirring speed was set to 50 rpm. The skin conditioning agent was then added, and after it was completely dissolved, the stirring speed was increased to 90 rpm. The thickener was added to the reaction vessel, and stirring was maintained for 30 minutes for premixing and dispersion. The temperature was set to 75℃, and the abrasive was slowly added to the reaction vessel. After stirring for 1 hour, the temperature was maintained for 30 minutes. The temperature was then lowered to room temperature, and the stirring speed was reduced to 25 rpm. While stirring, the surfactant, emollient, and preservative were added in sequence. Then, a vacuum was drawn, and finally the fragrance was added. The mixture was stirred to homogenize and degassed to obtain the product.

[0084] Example 4.

[0085] The toothpaste of this embodiment comprises, by weight percentage: 22.25% abrasive, 2% surfactant, 1.4% thickener, 3% emollient, 0.8% preservative, 36.25% skin conditioner, 1% fragrance, and 33.3% water.

[0086] The abrasive in this embodiment comprises, by weight percentage: 98.9% silica and 1.1% titanium dioxide.

[0087] In this embodiment, the titanium dioxide is anatase titanium dioxide powder with a particle size of 250 nm.

[0088] The emollient in this embodiment is polyethylene glycol-400.

[0089] The thickener in this embodiment comprises, by weight percentage: 57% carboxymethyl hydroxyethyl cellulose and 43% xanthan gum.

[0090] The preservatives in this embodiment, by weight percentage, include: sodium benzoate 37.5%, DMDM ​​hydantoin 37.5%, and tetrasodium pyrophosphate 25%;

[0091] The skin conditioning agent in this embodiment comprises, by weight percentage: 96.5% sorbitol, 0.7% sodium saccharin, and 2.8% sodium fluoride.

[0092] The dental caries prevention paste in this embodiment provides a fluoride ion concentration of 550 mg / kg.

[0093] The preparation method of the dental anti-caries paste in this embodiment is as follows:

[0094] Deionized water was placed in a reaction vessel, the stirrer was turned on, and the stirring speed was set to 50 rpm. The skin conditioning agent was then added, and after it was completely dissolved, the stirring speed was increased to 90 rpm. The thickener was added to the reaction vessel, and stirring was maintained for 30 minutes for premixing and dispersion. The temperature was set to 75℃, and the abrasive was slowly added to the reaction vessel. After stirring for 1 hour, the temperature was maintained for 30 minutes. The temperature was then lowered to room temperature, and the stirring speed was reduced to 25 rpm. While stirring, the surfactant, emollient, and preservative were added in sequence. Then, a vacuum was drawn, and finally the fragrance was added. The mixture was stirred to homogenize and degassed to obtain the product.

[0095] Comparative Example 1.

[0096] The method for preparing the modified titanium dioxide differs from that in Example 3, and is as follows:

[0097] S1. Mix glacial acetic acid, sodium copper chlorophyllin, water and ethanol, and adjust the pH to 3-3.5 with hydrochloric acid to obtain solution A;

[0098] S2. Slowly add the ethanol solution of tetrabutyl titanate to solution A, stirring continuously during the addition process. Let it stand at room temperature for 24-36 hours, then freeze-dry under vacuum for 24 hours to obtain modified titanium dioxide.

[0099] Comparative Example 2.

[0100] The method for preparing the modified titanium dioxide differs from that in Example 3, and is as follows:

[0101] S1. Mix water and propylene glycol in a mass ratio of water:ethylene glycol = 1:6 to obtain solution A; add titanium dioxide powder to solution A and stir until homogeneous;

[0102] S2. At 35℃, solution B is added to mixed solution A and stirred for 1.5 hours to obtain titanium dioxide sol solution.

[0103] S3. Add polysiloxane to the titanium dioxide sol solution, stir and react at 50°C for 4-6 hours, filter, and the modified titanium dioxide nanomaterial is obtained.

[0104] Comparative Example 3.

[0105] The difference from Example 3 is that sodium fluoride is replaced with calcium fluoride.

[0106] Comparative Example 4.

[0107] Unlike implementation 3, sorbitol is replaced with glycerol.

[0108] 1. Antibacterial test

[0109] According to the antibacterial (inhibitory) test method in the "Disinfection Technical Specifications", the products described in Examples 1-3 and Comparative Examples 1-4 were tested for antibacterial activity against several common bacteria in the oral cavity.

[0110] Preparation of antibacterial tablets: Prepare round antibacterial agent tablets with a diameter of 5 mm and a thickness not exceeding 4 mm in a clean, sterile Petri dish, in sets of 4 tablets. Preparation of negative control images: Take sterile, dry filter paper discs, add sterile distilled water to each disc, and set aside.

[0111] Inoculation of test bacteria: Use a sterile cotton swab to collect a concentration of 5×10⁻⁶ bacteria. 5 cfu / ml ~5×10 6 The cfu / ml test bacterial suspension was evenly spread three times on the surface of a nutrient agar plate. After each spread, the plate should be rotated 60°. Finally, a cotton swab was used to spread the suspension around the edge of the plate. The plate was then covered and allowed to dry at room temperature for 5 minutes.

[0112] Placement of antibacterial agent samples: For each test, place one contaminated plate, with four sample patches from the same test group on each plate, plus one negative control photograph, for a total of five patches. Use sterile forceps to place the sample patches onto the plate surface. After placement, gently press the sample patches with sterile forceps to ensure they adhere tightly to the plate surface. Cover the plate and incubate for 20-24 hours, observing the results. Measure and record the length of the inhibition zone using calipers. Repeat the test three times.

[0113] 2. Relative tooth quality loss test

[0114] Resin sheets or hydroxyapatite were used as test pieces. After grinding and polishing, the roughness change before and after brushing was detected, and the friction value was calculated and converted into the dentin friction value RDA.

[0115] The experimental results are shown in Table 1:

[0116]

[0117] As can be seen from Examples 3-4 and Comparative Examples 1-2 above, titanium dioxide in the product of this invention is a good abrasive with strong cleaning ability and low wear on teeth. The modified titanium dioxide of this invention is coated with polysiloxane, which increases and reduces its surface friction while retaining the hardness of titanium dioxide, and can further reduce the wear on teeth.

[0118] As can be seen from Examples 3 and Comparative Examples 3-4 above, the titanium dioxide of the present invention, combined with sorbitol and fluoride, with multiple raw materials, effectively prevents tooth decay and alleviates dental problems caused by caries. During cleaning, it can effectively adhere to the damaged areas of the teeth and react with the polysiloxane on the surface of titanium dioxide during friction, producing substances similar to the minerals in tooth enamel at the micro-cracks and damaged areas of the teeth, repairing the tooth enamel and making the teeth stronger. It can achieve good anti-caries and antibacterial capabilities even at low fluoride concentrations.

[0119] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within the present invention.

[0120] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A dental anti-caries paste, characterized in that, By weight percentage: exfoliant 10-35.2%, surfactant 1-3%, thickener 0.8-2%, emollient 2-5%, preservative 0.5-1%, skin conditioning agent 30-40%, fragrance 0.5-1.5%, water 30-40%; The abrasive is composed of 97-99.8% silica and 0.2-3% titanium dioxide by weight. The emollient includes polyethylene glycol-400; The skin conditioning agent comprises, by weight percentage, at least: 93.5-98.5% sorbitol, 0.5-1% sodium saccharin, and 1-5.5% sodium fluoride; The titanium dioxide is a titanium dioxide nanomaterial, prepared by the following method: S1. Ultrasonically treat and impregnate titanium dioxide powder in an ethanol solution of silver nitrate for 20-30 minutes, then filter and dry the powder in a vacuum oven; the concentration of the ethanol solution of silver nitrate is 12-15 mol / L, the mass ratio of titanium dioxide powder to ethanol solution of silver nitrate is 1:5-10, the purity of silver nitrate is above 90%, and anhydrous ethanol is used; the particle size of the titanium dioxide powder is 200-300 nm. S2. Add the titanium dioxide treated in step S1 to propylene glycol and stir to obtain solution A; the mass ratio of titanium dioxide to propylene glycol is 1:5~10. S3. Mix water, propylene glycol, and sodium hydroxide in a mass ratio of water:propylene glycol:sodium hydroxide = 1~3:6~10:0.5~1.5 to obtain mixed solution B; S4. At 35~45℃, add solution B to mixed solution A and stir for 1.5~3h to obtain titanium dioxide sol solution. S5. Add polysiloxane to the titanium dioxide sol solution, stir and react at 50~65℃ for 4~6h, filter, and the modified titanium dioxide nanomaterial is obtained.

2. The dental anti-caries paste according to claim 1, characterized in that, By weight percentage, it includes: 22.25% exfoliant, 2% surfactant, 1.4% thickener, 3% emollient, 0.8% preservative, 36.25% skin conditioner, 1% fragrance, and 33.3% water.

3. The dental anti-caries paste according to claim 1, characterized in that, The thickener comprises, by weight percentage: 57% carboxymethyl hydroxyethyl cellulose and 43% xanthan gum.

4. The dental anti-caries paste according to claim 1, characterized in that, The preservatives, by weight percentage, comprise: 37.5% sodium benzoate, 37.5% DMDM ​​hydantoin, and 25% tetrasodium pyrophosphate; 5. A dental anti-caries paste according to claim 1, characterized in that, The preparation method is as follows: Deionized water was placed in a reaction vessel, the stirrer was turned on, and the stirring speed was set to 50 rpm. The skin conditioning agent was then added, and after it was completely dissolved, the stirring speed was increased to 80-100 rpm. The thickener was added to the reaction vessel, and stirring was maintained for 30 minutes for premixing and dispersion. The temperature was set to 70-80℃, and the abrasive was slowly added to the reaction vessel. After stirring for 1 hour, the temperature was maintained for 30 minutes. The temperature was then lowered to room temperature, and the stirring speed was reduced to 20-30 rpm. While stirring, the surfactant, emollient, and preservative were added in sequence. Then, a vacuum was drawn, and finally the fragrance was added. The mixture was stirred to homogenize and degassed to obtain the product.

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