Pha combination microspheres and preparation method and application thereof

By preparing PHA composite microspheres with controlled molecular weight gradients, the problems of slow early degradation and inflammation caused by long-term degradation of PHA microspheres were solved, achieving rapid promotion of cell proliferation and collagen regeneration, as well as a lasting filling effect.

CN117085177BActive Publication Date: 2026-03-24BEIJING DATSING BIO TECH
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Patent Information

Application Number
CN202311085552.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-08-26
Publication Date
2026-03-24
Estimated Expiration
2043-08-26

AI Technical Summary

Technical Problem

Existing PHA microspheres have a very slow early degradation rate, making it difficult to rapidly promote cell proliferation and collagen regeneration, and long-term degradation may lead to acid accumulation and inflammation.

Method used

By mixing PHA microspheres of different molecular weights, PHA composite microspheres were prepared, and their degradation cycle was controlled to be around 21 weeks. By regulating the molecular weight distribution, a gradient degradation behavior was formed, which rapidly degraded in the early stage and continuously promoted cell proliferation and collagen regeneration in the long term.

Benefits of technology

This technology enables rapid degradation of PHA microspheres in the early stages, promoting cell proliferation and collagen regeneration, while avoiding acid accumulation and inflammation in the later stages of degradation, thus providing a long-lasting filling effect.

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Abstract

The application relates to the technical field of biomaterials, and particularly discloses a PHA combined microsphere as well as a preparation method and application thereof. The PHA combined microsphere provided by the application contains 10-40 wt% of PHA microspheres with a weight average molecular weight of less than 30000 Da and 1-40 wt% of PHA microspheres with a weight average molecular weight of more than 100000 Da, with the PHA being selected from one or more of poly-beta-hydroxybutyric acid, a copolymer of 3-hydroxybutyric acid ester and 3-hydroxyvaleric acid ester, a copolyester of 3-hydroxybutyric acid and 3-hydroxyhexanoic acid and poly(3-hydroxybutyric acid-co-4-hydroxybutyric acid). After the PHA combined microsphere is filled in the skin, on one hand, the PHA combined microsphere can be rapidly degraded in an early stage and promote the reproduction of fibroblasts and endothelial cells in a short time; on the other hand, the PHA combined microsphere can be continuously degraded within 21 weeks and cannot cause inflammation, so that the effect of persistent filling is achieved.
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