A tropomyosin receptor kinase a inhibitor and preparation method and application thereof
By developing selective TrkA inhibitor compounds, the problem of significant side effects of existing analgesics in the treatment of chronic pain has been solved, achieving effective treatment for osteoarthritis, cancer pain, and other conditions, and possessing anti-cancer potential.
CN117362276BActive Publication Date: 2026-07-07FUDAN UNIVERSITY
Patent Information
- Application Number
- CN202210765888.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-06-30
- Publication Date
- 2026-07-07
- Estimated Expiration
- 2042-06-30
AI Technical Summary
Technical Problem
Existing analgesics have significant side effects when treating chronic pain and have limited efficacy, especially for osteoarthritis and cancer pain, and there is a lack of effective selective inhibitors.
Method used
A class of selective TrkA inhibitor compounds, including stereoisomers, prodrugs, solvates, hydrates or pharmaceutically acceptable salts thereof, have been developed to inhibit the TrkA signaling pathway through specific structural designs, providing analgesic and potential anticancer activities.
Benefits of technology
It achieves effective treatment for chronic pain such as osteoarthritis and cancer pain, while avoiding the side effect of increased appetite, and has potential anti-cancer activity.
✦ Generated by Eureka AI based on patent content.
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Figure CN117362276B_ABST
Abstract
The application belongs to the field of pharmaceutical chemistry, and particularly relates to a Tropomyosin Receptor Kinase A (TrkA) inhibitor and a preparation method and application thereof, a structural formula of which is shown as formula (I); the compound provided by the application has high inhibitory activity on TrkA and good subtype selectivity. The compound has potential application in analgesic treatment, including but not limited to chronic pain caused by osteoarthritis, cancer pain, back pain and the like; the compound also has potential anticancer activity.
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Citation Information
Patent Citations
Tropomyosin-related kinase inhibitors containing both a 1h-pyrazole and a pyrimidine moiety
WO2015159175A1