Process for the preparation of amino fullerene derivatives

By employing a nucleophilic substitution reaction between C60Cl6 and primary amine compounds in the presence of cumene hydroperoxide, the limitations in the preparation of amino-modified fullerene derivatives in existing technologies have been overcome. This approach enables the preparation of high-purity and high-efficiency amino-modified fullerene derivatives suitable for biomedical applications.

CN117447426BActive Publication Date: 2026-02-10BEIJING FUNAKANG BIOTECH CO LTD +1
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Patent Information

Application Number
CN202311341394.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-10-17
Publication Date
2026-02-10
Estimated Expiration
2043-10-17

AI Technical Summary

Technical Problem

In the existing technology, the preparation methods of amino-modified fullerene derivatives are limited by the types of amino compounds, cannot be applied to primary amine compounds, and have low reaction yields, making it difficult to achieve large-scale preparation and structural control.

Method used

Using C60Cl6 as a precursor, a nucleophilic substitution reaction was carried out with a primary amine compound in the presence of cumene hydroperoxide. The reaction was controlled by adding a secondary or tertiary amine to prepare aminofullerene derivatives with well-defined molecular structures, thus avoiding the use of acidic reagents.

Benefits of technology

The controlled synthesis of aminofullerene derivatives was achieved, shortening the reaction time, improving the preparation efficiency, and achieving a product purity of over 95%, ensuring the preparation of a defined number of aminofullerene derivatives.

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Abstract

The application provides a preparation method of an amino fullerene derivative, which comprises the following steps: adding an amine compound into a chlorinated fullerene solution, stirring the reaction at room temperature, and obtaining the amino fullerene derivative after the reaction is completed; the amine compound is a primary amine compound; no acidic reagent is added in the reaction process of the method; the fullerene is selected from at least one of hollow fullerenes, metal fullerenes, heterocyclic fullerenes and endohedral fullerenes. 60 The method realizes controllable amino modification of the fullerene by adding a secondary amine or a tertiary amine to regulate the nucleophilic substitution reaction of the primary amine compound on C 16, and obtains a series of novel structure tetraamino epoxy fullerene derivatives with clear molecular structures.
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