TGase-plant protein peptide nanogel delivery system loaded with fat-soluble active substances

The TGase-plant protein peptide nanogel delivery system utilizes the cross-linking effect of soybean peptides and TGase to solve the problem of low solubility of fat-soluble active substances in water, achieving high bioavailability and stable release, and exhibiting cholesterol-lowering effects.

CN118303635BActive Publication Date: 2026-06-26OIL CROPS RES INST CHINESE ACAD OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
OIL CROPS RES INST CHINESE ACAD OF AGRI SCI
Filing Date
2024-04-16
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Lipid-soluble active substances such as resveratrol and phytosterols have low solubility and low bioavailability in water. Existing plant protein delivery systems have poor water solubility and are not easily degraded, resulting in low bioavailability and release rate.

Method used

The TGase-plant protein peptide nanogel delivery system is used to form a cross-linked network structure by mixing plant protein peptides with TGase, which encapsulates fat-soluble active substances. The bioavailability and stability are improved by utilizing the water solubility of soybean peptides and the cross-linking effect of TGase.

Benefits of technology

It improves the bioavailability and release rate of fat-soluble active substances, enhances the stability and cholesterol-lowering ability of nanogels, and works synergistically to lower cholesterol.

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Abstract

The application discloses a TGase-plant protein peptide nanogel delivery system loaded with a fat-soluble active substance, and belongs to the technical field of nanogels. The TGase-plant protein peptide nanogel delivery system loaded with a fat-soluble active substance is prepared by reasonably utilizing plant protein peptides. In order to solve the problems of poor stability of soybean peptides and possible unsatisfactory embedding effect, TGase is added to the nanogel delivery system, so that the effective embedding of the fat-soluble active substance can be met, and the effective release of the fat-soluble active substance can also be met. Once the nanogel is ingested, the nanogel will be degraded in the gastrointestinal tract, so that the stable release of the active substance is ensured. Meanwhile, the peptides or amino acids generated after digestion also have biological activity, and can play a synergistic role with the bioactive compounds.
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Citation Information

Patent Citations

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