A traditional Chinese medicine composition for treating inflammatory dermatosis and a preparation method thereof

Abstract

The application discloses a traditional Chinese medicine composition for treating inflammatory dermatosis and a preparation method thereof, which is mainly prepared from the following Chinese herbal medicine raw materials in parts by weight: 10-15 parts of honeysuckle, 9-14 parts of forsythia, 10-20 parts of radix rehmanniae, 10-22 parts of cortex moutan, 10-20 parts of red peony root, 18-25 parts of kuh-seng, 15-25 parts of licorice, 12-18 parts of ophiopogon, 6-14 parts of radix codonopsis, 10-18 parts of hawthorn, 10-20 parts of radix scrophulariae, 8-18 parts of phellodendron, 30-45 parts of rhizoma coptidis, 8-15 parts of spina date seed, 8-14 parts of Uncaria, and 10-16 parts of borneol; the application can promote the generation of SCFAs, maintain the balance of intestinal microbial community, meanwhile, the SCFAs are also helpful to maintain the integrity and function of intestinal epithelial cells, thereby enhancing the intestinal barrier function, reducing the harmful substances and pathogens into blood, reducing the systemic inflammatory response, so that the skin inflammation can be directly inhibited, the skin recovery can be promoted, and the body obesity of patients with high-sugar diet can be effectively inhibited.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medicinal material preparation, and particularly relates to a traditional Chinese medicine composition for treating inflammatory skin disorders and a preparation method thereof. BACKGROUND

[0002] Inflammatory skin disorders (ISDs) are the most common stubborn diseases in clinical practice. These diseases are mostly inflammatory reactions of the skin epithelial barrier to allergens and pathogens. Inflammation refers to the defensive response of living tissues with vascular systems to injury factors. Vascular response is the center of the inflammatory process and is often manifested as redness, swelling, heat, pain, and dysfunction. Inflammatory skin disorders, represented by psoriasis, are a type of disease with high incidence and great harm in dermatology. They have many immunological changes similar to infection immunity, tumor immunity, transplantation immunity, autoimmunity, and allergic reactions. Common inflammatory skin disorders mainly include psoriasis, systemic lupus erythematosus, lichen planus, atopic dermatitis, acute contact dermatitis, seborrheic dermatitis, acne, and rhinophyma.

[0003] The causes of inflammatory skin disorders are not completely the same, and the treatment methods are also different. People with high-sugar diets can cause an increase in insulin levels in the body, promote excessive secretion of oil by sebaceous glands, cause blockage of hair follicle orifices, form comedones and acne, and further aggravate the inflammatory degree of acne. There are many drugs and treatment methods for treating this disease at present. Most of them are intended to disinfect and promote blood circulation at the acne site and inhibit the secretion of sebaceous glands, but the treatment effect is not ideal, the disease is prone to recurrence, and it is difficult to achieve a radical cure. One important reason is that the existing treatment does not fully address the imbalance of intestinal microorganisms. Intestinal microbial imbalance can affect the body's absorption and metabolism of nutrients, and further adversely affect skin health.

[0004] Therefore, it is necessary to design a traditional Chinese medicine composition for treating inflammatory skin disorders and a preparation method thereof to solve the above problems. SUMMARY

[0005] The present application overcomes the shortcomings of the prior art and provides a traditional Chinese medicine composition for treating inflammatory skin disorders and a preparation method thereof.

[0006] To achieve the above-mentioned purpose, the technical scheme adopted by the present application is as follows: a traditional Chinese medicine composition for treating inflammatory skin disorders, which is prepared from the following herbal medicine raw materials in parts by weight:

[0007] Honeysuckle 10-15 parts, 9-14 parts, 10-20 parts, 10-22 parts, 10-20 parts, 18-25 parts, 15-25 parts, 12-18 parts, 6-14 parts, 10-18 parts, 10-20 parts, 8-18 parts, 30-45 parts, 8-15 parts, 8-14 parts, 10-16 parts.

[0008] In a preferred embodiment of the present application, the traditional Chinese medicine composition for treating inflammatory skin diseases is prepared from the following herbal raw materials by weight:

[0009] Honeysuckle 11-14 parts, 10-13 parts, 12-18 parts, 12-19 parts, 11-17 parts, 20-24 parts, 16-23 parts, 15-18 parts, 10-14 parts, 12-17 parts, 11-17 parts, 10-16 parts, 32-42 parts, 10-14 parts, 9-13 parts, 12-16 parts.

[0010] In a preferred embodiment of the present application, the traditional Chinese medicine composition for treating inflammatory skin diseases is prepared from the following herbal raw materials by weight:

[0011] Honeysuckle 11-14 parts, 10-13 parts, 12-18 parts, 12-19 parts, 11-17 parts, 20-24 parts, 16-23 parts, 10-14 parts, 9-13 parts, 10-16 parts.

[0012] In a preferred embodiment of the present application, the traditional Chinese medicine composition for treating inflammatory skin diseases is prepared from the following herbal raw materials by weight:

[0013] Honeysuckle 12 parts, 11 parts, 14 parts, 17 parts, 16 parts, 21 parts, 20 parts, 14 parts, 8 parts, 13 parts, 12 parts, 10 parts, 32 parts, 10 parts, 11 parts, 13 parts.

[0014] A preparation method of a traditional Chinese medicine composition for treating inflammatory skin diseases, using the traditional Chinese medicine composition for treating inflammatory skin diseases according to any one of the preceding claims, comprising the following steps:

[0015] S1, wash and dry honeysuckle, forsythia, radix rehmanniae, cortex moutan, red peony root, kuh-seng, licorice, ophiopogon, codonopsis, phellodendron, hawthorn, scutellaria, and skullcap, and cut them into appropriate size pieces according to the requirements of the medicinal materials, mix and soak in water;

[0016] S2, filter out the soaked and mixed medicinal materials, and mix with clean water, first boil with strong fire, then simmer with small fire, filter to obtain medicinal liquid and medicinal residue, evaporate and concentrate the filtered medicinal liquid, and adjust the concentration of the medicinal liquid;

[0017] S3, add appropriate amount of excipient, humectant and adhesive to the concentrated medicinal liquid, and stir and mix to obtain mixed concentrated medicinal liquid, so as to improve the texture and use performance of the patch;

[0018] S4, add ice to the mixed concentrated medicinal liquid and mix uniformly, and cool to room temperature to obtain the traditional Chinese medicine preparation.

[0019] In one preferred embodiment of the present application, in the S1, the extraction process is as follows:

[0020] Place the cleaned medicinal materials in clean water, and the water level is higher than the medicinal materials, maintain the water temperature at 23-25℃, soak for 2-4h, ensure that the medicinal materials are fully absorbed and expanded, and the tissues are softened, and ensure that the effective components of the medicinal materials are dissolved out.

[0021] In one preferred embodiment of the present application, in the S2, the specific process of mixing the soaked medicinal materials with clean water and decocting is as follows:

[0022] Put the soaked medicinal materials into 5-8 times the weight of clean water, heat to boiling state with strong fire, maintain the temperature for 3-6min, then change to small fire and keep the state of slight boiling for 30-60min, and then filter the medicinal liquid.

[0023] In one preferred embodiment of the present application, in the S2, the specific process of evaporating and concentrating the medicinal liquid is as follows:

[0024] Add the filtered medicinal liquid into a suitable concentration pot, so that the medicinal liquid fills 4 / 5 of the volume of the concentration pot, heat the concentration pot at a temperature of 55-75℃ for 25-40min, then maintain the temperature at 75-90℃ for 40-80min, until the medicinal liquid is concentrated to 1 / 3-1 / 2 of the original volume.

[0025] In one preferred embodiment of the present application, the traditional Chinese medicine preparation is a powder, a capsule, a tablet, a pill or a granule.

[0026] The present application solves the defects in the background art, and has the following beneficial effects:

[0027] (1) The present application provides a traditional Chinese medicine composition for treating inflammatory skin diseases and a preparation method thereof. Honeysuckle has the effects of clearing heat and detoxifying and cooling blood, and forsythia can help honeysuckle enhance the ability of clearing heat and detoxifying, and has obvious improvement effect on symptoms such as redness and heat pain in inflammatory skin diseases. Rehmannia glutinosa, peony root and red root of paeonia can clear heat and cool blood, and red root of paeonia and peony root can clear heat and cool blood, promote blood circulation and remove blood stasis, and the three drugs used together can cool blood and promote blood circulation, and have significant effect on improving symptoms such as blood stasis and redness in skin diseases. Sophora flavescens has the effects of clearing heat and drying dampness, killing insects and stopping itching, and can improve the itching symptoms of patients with skin diseases. Ophiopogon japonicus, radix codonopsis, hawthorn and radix scrophulariae have synergistic effect on regulating and improving intestinal tract, can increase the moisture and nutrient substances in intestinal tract, promote intestinal peristalsis and digestive excretion function, improve intestinal environment and microbial community balance, and can also clear heat and toxins in intestinal tract, enhance intestinal barrier function and improve intestinal health. The traditional Chinese medicine with anti-inflammatory, disinfecting and antipyretic effects is combined with the traditional Chinese medicine that can improve intestinal health and promote intestinal flora balance to treat inflammatory skin diseases.

[0028] (2) The traditional Chinese medicine prepared by the present application can promote the generation of SCFAs by using radix codonopsis, cortex phellodendri, rhizoma coptidis, hawthorn, radix scrophulariae and ophiopogon japonicus, maintain the balance of intestinal microbial community, and SCFAs also help maintain the integrity and function of intestinal epithelial cells, thereby enhancing intestinal barrier function, reducing the entry of harmful substances and pathogens into blood, reducing systemic inflammatory response, and directly inhibiting skin inflammation and promoting the recovery of skin.

[0029] (3) The traditional Chinese medicine prepared by the present application can selectively increase the relative abundance of specific intestinal flora producing SCFAs by adding rhizoma coptidis and cortex phellodendri containing berberine, and the generated SCFAs can effectively inhibit the production and release of inflammatory mediators and reduce inflammatory response, thereby improving the symptoms of skin inflammation. Meanwhile, berberine has the property of anti-obesity and can effectively inhibit the obesity of patients with high-sugar diet. DETAILED DESCRIPTION

[0030] The technical solutions in the embodiments of the present application will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the present application.

[0031] In the following description, many specific details are set forth in order to provide a thorough understanding of the present application, but the present application can also be implemented in other ways different from those described herein, therefore, the protection scope of the present application is not limited by the specific embodiments disclosed below.

[0032] A traditional Chinese medicine composition for treating inflammatory skin diseases is prepared from the following herbal raw materials in parts by weight:

[0033] Jinyinhua 10-15 parts, Lianqiao 9-14 parts, Shengdihuang 10-20 parts, Danningpi 10-22 parts, Chishao 10-20 parts, Kuqian 18-25 parts, Gancao 15-25 parts, Maidong 12-18 parts, Dangshen 6-14 parts, Shanzha 10-18 parts, Huangqi 10-20 parts, Huangbai 8-18 parts, Huanglian 30-45 parts, Suanzaoren 8-15 parts, Gouteng 8-14 parts, Bingpian 10-16 parts.

[0034] In the present application, the traditional Chinese medicine composition for treating inflammatory skin diseases is prepared from the following herbal raw materials in parts by weight:

[0035] Jinyinhua 11-14 parts, Lianqiao 10-13 parts, Shengdihuang 12-18 parts, Danningpi 12-19 parts, Chishao 11-17 parts, Kuqian 20-24 parts, Gancao 16-23 parts, Maidong 15-18 parts, Dangshen 10-14 parts, Shanzha 12-17 parts, Huangqi 11-17 parts, Huangbai 10-16 parts, Huanglian 32-42 parts, Suanzaoren 10-14 parts, Gouteng 9-13 parts, Bingpian 12-16 parts.

[0036] In the present application, the traditional Chinese medicine composition for treating inflammatory skin diseases is prepared from the following herbal raw materials in parts by weight:

[0037] Jinyinhua 11-14 parts, Lianqiao 10-13 parts, Shengdihuang 12-18 parts, Danningpi 12-19 parts, Chishao 11-17 parts, Kuqian 20-24 parts, Gancao 16-23 parts, Suanzaoren 10-14 parts, Gouteng 9-13 parts, Bingpian 10-16 parts.

[0038] In the present application, the traditional Chinese medicine composition for treating inflammatory skin diseases is prepared from the following herbal raw materials in parts by weight:

[0039] Jinyinhua 12 parts, Lianqiao 11 parts, Shengdihuang 14 parts, Danningpi 17 parts, Chishao 16 parts, Kuqian 21 parts, Gancao 20 parts, Maidong 14 parts, Dangshen 8 parts, Shanzha 13 parts, Huangqi 12 parts, Huangbai 10 parts, Huanglian 32 parts, Suanzaoren 10 parts, Gouteng 11 parts, Bingpian 13 parts.

[0040] The traditional Chinese medicine of the present application has the following effects:

[0041] Jinyinhua: has the effects of clearing heat and resolving toxins, and dispelling wind-heat, and is suitable for skin diseases caused by heat and toxins.

[0042] Lianqiao: It has the effects of clearing heat and resolving toxins, and can help Jinyinhua to enhance the ability of clearing heat and resolving toxins. It has obvious improvement effect on symptoms such as redness and heat pain in inflammatory skin diseases.

[0043] Rehmannia: It has the effects of nourishing yin and kidney, and clearing heat and cooling blood, which is beneficial for skin inflammation caused by yin deficiency and excessive heat.

[0044] Danpi: It has the effects of clearing heat and cooling blood, and promoting blood circulation to remove blood stasis, which can be used to treat symptoms such as fever with skin rash, hematemesis and metrorrhagia, and may help improve blood circulation in the intestines.

[0045] Chishao: It has the effects of promoting blood circulation to remove blood stasis, and cooling blood and detoxifying, which helps to improve skin blood circulation and reduce inflammation.

[0046] Rehmannia, Danpi and Chishao, when used together, can both cool blood and promote blood circulation, and have significant effect on improving symptoms such as blood stasis and redness in skin diseases.

[0047] Kuhseng: It has the effects of clearing heat and drying dampness, killing insects and stopping itching, which can improve the symptoms of itching in patients with skin diseases. It contains alkaloids such as matrine, which has the effects of antibacterial and antiviral, and can regulate the intestinal microbial community, thereby helping to maintain intestinal health.

[0048] Gancao: It has the effects of tonifying spleen and qi, clearing heat and resolving toxins, relieving cough and phlegm, relieving pain and regulating various drugs, which has a certain protective effect on intestinal inflammation or ulcer, and can also relieve pain caused by intestinal spasm.

[0049] Shanzha: It can promote intestinal peristalsis and improve the intestinal environment, thereby facilitating the production of SCFAs.

[0050] Huangqi: It has the effects of clearing heat and drying dampness, and purging fire and detoxifying, which can inhibit the growth of various bacteria and viruses, and has therapeutic effect on skin diseases caused by heat and toxicity.

[0051] Huangbai and Huanglian: They contain berberine, which can selectively increase the relative abundance of specific intestinal flora that produces SCFAs, indirectly increasing the concentration of SCFAs in the intestine, and also has the effects of anti-obesity and anti-inflammatory.

[0052] Suanzaoren: It can regulate the central nervous system and relieve tension, thereby helping to reduce skin inflammatory reactions, and also improve sleep quality and help restore intestinal function.

[0053] Gouteng: It has the effects of clearing heat and calming the liver, and calming wind and relieving convulsions, which can reduce the excitability of the nervous system and relieve skin allergic reactions.

[0054] A preparation method of a traditional Chinese medicine composition for treating inflammatory skin diseases, using the traditional Chinese medicine composition for treating inflammatory skin diseases according to any one of the preceding claims, comprises the following steps:

[0055] S1, honeysuckle, forsythia, radix rehmanniae, danpi, red shao, kuh-seng, liquorice, ophiopogon, dangshen, huangbai, hawthorn, huangqin, huanglian, jujube kernel and uncaria are washed, dried and cut into appropriate size pieces according to the requirement of medicinal materials, and the washed medicinal materials are placed in clean water, the medicinal materials are immersed in clean water, the water temperature is maintained at 23-25 DEG C, and the medicinal materials are soaked for 2-4 hours to ensure that the medicinal materials are fully absorbed and expanded, the tissue is softened, and the effective components of the medicinal materials are dissolved out;

[0056] S2, the soaked medicinal materials are placed in 5-8 times of clean water of the total weight of the medicinal materials, heated to boiling state with strong fire, the temperature is maintained for 3-6 min, and then the fire is turned to small fire to keep the state of micro-boiling for 30-60 min, then the medicinal liquid and medicinal residue are filtered, the filtered medicinal liquid is added to a suitable concentration kettle, the medicinal liquid fills 4 / 5 of the volume of the concentration kettle, the concentration kettle is heated at a temperature of 55-75 DEG C for 25-40 min, and then the temperature is maintained at 75-90 DEG C for 40-80 min, until the medicinal liquid is concentrated to 1 / 3-1 / 2 of the original volume, and the filtered medicinal liquid is evaporated and concentrated to increase the concentration of the medicinal liquid;

[0057] The "strong fire" mentioned in the application refers to 80-120 DEG C fire, which is a term in traditional Chinese medicine, and refers to large and rapid fire during decoction; the "small fire" mentioned in the application refers to 40-60 DEG C fire, which is a term in traditional Chinese medicine, and refers to small and slow fire during decoction.

[0058] S3, a suitable amount of excipient, humectant and adhesive is added to the concentrated medicinal liquid, and stirred and mixed to obtain a mixed concentrated medicinal liquid, so as to improve the texture and use performance of the patch;

[0059] S4, the mixed concentrated medicinal liquid is mixed with ice and cooled to room temperature to obtain a traditional Chinese medicine preparation.

[0060] In the application, the traditional Chinese medicine preparation is a powder, a capsule, a tablet, a pill or a granule.

[0061] Experimental example one:

[0062] I. Preparation of different kinds of traditional Chinese medicine preparations

[0063] Example one:

[0064] (I) selection of traditional Chinese medicine raw materials (by weight: g)

[0065] Jinyinhua 12g, Lianqiao 11g, Shengdihuang 14g, Dangpi 17g, Chishao 16g, Kushen 21g, Gancao 20g, Maidong 14g, Dangshen 8g, Shanzha 13g, Huangqi 12g, Huangbai 10g, Huanglian 32g, Suanzaoren 10g, Gouteng 11g, Bingpian 13g.

[0066] (ii) Preparation steps of the traditional Chinese medicine preparation

[0067] The traditional Chinese medicine materials (except Bingpian) in the above are cleaned, and the cleaned medicine materials are placed in clean water so that the water covers the medicine materials. The water temperature is maintained at 23°C, and the medicine materials are soaked for 2.5h to ensure that the medicine materials are fully water-absorbed, swelled, and softened. The soaked medicine materials are placed in 6.5 times the weight of the medicine materials of clean water, and heated to boiling state with strong fire. The temperature is maintained for 4min, and then the heating is switched to weak fire to maintain a state of slight boiling for 40min. Then the medicine liquid is filtered to obtain the medicine liquid and medicine residue. The filtered medicine liquid is added to a suitable concentration kettle so that the medicine liquid fills 4 / 5 of the volume of the concentration kettle. The concentration kettle is heated at a temperature of 60°C for 30min, and then the temperature is maintained at 80-85°C for 40-80min until the medicine liquid is concentrated to 1 / 3 of the original volume. The filtered medicine liquid is evaporated and concentrated to increase the consistency of the medicine liquid. An appropriate amount of excipient, humectant and adhesive are added to the concentrated medicine liquid, and stirred and mixed to obtain a mixed concentrated medicine liquid. The ice Bingpian is added to the mixed concentrated medicine liquid, and cooled to room temperature to obtain a traditional Chinese medicine preparation. The traditional Chinese medicine preparation is dried at 70°C, and pulverized into fine powder. 20% sucrose is used to prepare granules with 80% ethanol as a wetting agent. The granules are dried at 60°C, sieved once through a 12-mesh sieve, and the fine powder is separated with a 60-mesh sieve to obtain granules.

[0068] Example 2

[0069] The preparation steps are substantially the same as in Example 1, except that the medicine materials of Maidong, Dangshen, Shanzha and Huangqi are removed.

[0070] Jinyinhua 12g, Lianqiao 11g, Shengdihuang 14g, Dangpi 17g, Chishao 16g, Kushen 21g, Gancao 20g, Huangbai 10g, Huanglian 32g, Suanzaoren 10g, Gouteng 11g, Bingpian 13g are selected.

[0071] The traditional Chinese medicine medicinal materials (except for borneol) are cleaned, the cleaned medicinal materials are placed in clean water, the medicinal materials are immersed in the clean water, the water temperature is maintained at 23°C, the medicinal materials are soaked for 2 hours to ensure that the medicinal materials are fully absorbed and swollen, the soaked medicinal materials are placed in 6 times the weight of the medicinal materials of clean water, the medicinal materials are heated to boiling state with strong fire, the temperature is maintained for 3.5 minutes, the heating is switched to weak fire, the medicinal materials are kept in a state of slight boiling for 40 minutes, then the medicinal liquid is filtered, the medicinal liquid and medicinal residue are obtained, the filtered medicinal liquid is added into a suitable concentration pot, the medicinal liquid fills 4 / 5 of the volume of the concentration pot, the concentration pot is heated at a temperature of 60°C for 28 minutes, then the temperature is maintained at 80-85°C, the medicinal liquid is heated for 40-65 minutes until the medicinal liquid is concentrated to 1 / 3 of the original volume, the filtered medicinal liquid is evaporated and concentrated, the concentration of the medicinal liquid is adjusted, a suitable amount of excipient, humectant and adhesive are added into the concentrated medicinal liquid, and the mixture is stirred and mixed, the mixed concentrated medicinal liquid is obtained, borneol is added into the mixed concentrated medicinal liquid, and the mixture is cooled to room temperature, the traditional Chinese medicine medicinal is obtained, the traditional Chinese medicine medicinal is dried at 70°C, and is pulverized into fine powder, 20% sucrose is taken, 80% ethanol is used as a wetting agent to prepare granules, the granules are dried at 60°C, the granules are screened once through a 12-mesh sieve, and the fine powder is separated through a 60-mesh sieve, and the granules are obtained.

[0072] Example Three

[0073] The example one is basically the same, except that the medicinal materials of cortex phellodendri and rhizoma coptidis are removed.

[0074] Jinyinhua 12g, Lianqiao 11g, Shengdihuang 14g, Dangpi 17g, Chishao 16g, Kuxin 21g, Gancao 20g, Maidong 14g, Dangshen 8g, Shanzha 13g, Huangqi 12g, Suanzhaoren 10g, Gouteng 11g, and Borneol 13g are selected.

[0075] The traditional Chinese medicine medicinal materials (except for borneol) are cleaned, the cleaned medicinal materials are placed in clean water, the medicinal materials are immersed in the clean water, the water temperature is maintained at 23°C, the medicinal materials are soaked for 2 hours to ensure that the medicinal materials are fully absorbed and swollen, the soaked medicinal materials are placed in 6 times the weight of the medicinal materials of clean water, the medicinal materials are heated with a strong fire until boiling, the temperature is maintained for 3.5 minutes, the heating is switched to a weak fire, the medicinal materials are kept in a state of slight boiling for 40 minutes, the medicinal liquid is filtered, the medicinal liquid and the medicinal residue are obtained, the filtered medicinal liquid is added into a suitable concentration pot, the medicinal liquid fills 4 / 5 of the volume of the concentration pot, the concentration pot is heated at a temperature of 60°C for 28 minutes, the temperature is maintained at 80-85°C, and the medicinal liquid is heated for 40-65 minutes until the medicinal liquid is concentrated to 1 / 3 of the original volume, the filtered medicinal liquid is evaporated and concentrated, the concentration of the medicinal liquid is adjusted, a suitable amount of excipient, humectant and adhesive are added into the concentrated medicinal liquid, and the mixture is stirred and mixed to obtain a mixed concentrated medicinal liquid, borneol is added into the mixed concentrated medicinal liquid, and the mixture is cooled to room temperature to obtain a traditional Chinese medicine medicinal agent, the traditional Chinese medicine medicinal agent is dried at 70°C, and is pulverized into fine powder, 20% sucrose is taken, 80% ethanol is used as a wetting agent to prepare granules, the granules are dried at 60°C, the granules are screened once through a 12-mesh sieve, and the fine powder is separated through a 60-mesh sieve, and a granule is obtained.

[0076] Comparative Example 1

[0077] Jinyinhua 12g, Lianqiao 11g, Shengdihuang 14g, Dangpi 17g, Chishao 16g, Kushen 21g, Gancao 20g, Maidong 17g, Dangshen 12g, Shanzha 16g, Huangqi 16g, Huangbai 10g, Huanglian 32g, Suanzaoren 10g, Gouteng 11g, and Borneol 13g are selected.

[0078] The traditional Chinese medicine medicinal materials (except for borneol) are cleaned, the cleaned medicinal materials are placed in clean water, the medicinal materials are immersed in the clean water, the water temperature is maintained at 23°C, the medicinal materials are soaked for 2.5 hours, the medicinal materials are fully soaked and expanded, the tissues are softened, the soaked medicinal materials are placed in 7 times the weight of the medicinal materials of clean water, the water is heated to boiling state by strong fire, the temperature is maintained for 5 minutes, the water is heated by weak fire, the water is kept in a state of slight boiling for 45 minutes, the medicinal liquid and the medicinal residue are obtained by filtering the medicinal liquid, the filtered medicinal liquid is added into a suitable concentration pot, the medicinal liquid fills 4 / 5 of the volume of the concentration pot, the concentration pot is heated at a temperature of 65°C for 35 minutes, the temperature is maintained at 80-85°C, the medicinal liquid is heated for 40-80 minutes until the medicinal liquid is concentrated to 1 / 3 of the original volume, the filtered medicinal liquid is evaporated and concentrated, the concentration of the medicinal liquid is adjusted, a suitable amount of excipient, humectant and adhesive are added into the concentrated medicinal liquid, and the mixture is stirred and mixed, the mixed concentrated medicinal liquid is obtained, borneol is added into the mixed concentrated medicinal liquid, and the mixture is cooled to room temperature, the traditional Chinese medicine medicinal agent is obtained, the traditional Chinese medicine medicinal agent is dried at 70°C, and is pulverized into fine powder, 20% sucrose is taken, 80% ethanol is used as a wetting agent to prepare granules, the granules are dried at 60°C, the granules are sieved once through a 12-mesh sieve, and the fine powder is separated by using a 60-mesh sieve, and the granules are obtained.

[0079] Comparative Example 2

[0080] Jinyinhua 12g, Lianqiao 11g, Shengdihuang 14g, Dangpi 17g, Chishao 16g, Kushen 21g, Gancao 20g, Maidong 17g, Dangshen 12g, Shanzha 16g, Huangqi 16g, Huangbai 12g, Huanglian 35g, Suanzaoren 10g, Gouteng 11g, and Borneol 13g are selected.

[0081] The traditional Chinese medicine materials (except for borneol) are cleaned, the cleaned traditional Chinese medicine materials are placed in clean water, the water level is higher than the traditional Chinese medicine materials, the water temperature is maintained at 23℃, the traditional Chinese medicine materials are soaked for 2.5 hours to ensure that the traditional Chinese medicine materials are fully soaked and expanded, the softened tissues are maintained, the soaked traditional Chinese medicine materials are placed in 7 times of the weight of the traditional Chinese medicine materials of clean water, a wu fire is used to heat the traditional Chinese medicine materials to a boiling state, the temperature is maintained for 5 minutes, a wen fire is used to heat the traditional Chinese medicine materials, the temperature is maintained at a slight boiling state for 45 minutes, then the traditional Chinese medicine liquid is filtered, the traditional Chinese medicine liquid and the traditional Chinese medicine residue are obtained, the filtered traditional Chinese medicine liquid is added into a suitable concentration pot, the concentration pot is filled with the traditional Chinese medicine liquid to 4 / 5 of the volume, the concentration pot is heated at a temperature of 65℃ for 35 minutes, then the temperature is maintained at 80-85℃, the traditional Chinese medicine liquid is heated for 40-80 minutes until the traditional Chinese medicine liquid is concentrated to 1 / 3 of the original volume, the filtered traditional Chinese medicine liquid is evaporated and concentrated, the concentration of the traditional Chinese medicine liquid is increased, a suitable amount of excipient, humectant and adhesive are added into the concentrated traditional Chinese medicine liquid, and the traditional Chinese medicine liquid is stirred and mixed to obtain a mixed concentrated traditional Chinese medicine liquid, the mixed concentrated traditional Chinese medicine liquid is added with borneol, and the mixed concentrated traditional Chinese medicine liquid is cooled to room temperature to obtain a traditional Chinese medicine preparation, the traditional Chinese medicine preparation is dried at 70℃, and is pulverized into fine powder, 20% of sucrose is taken, 80% of ethanol is used as a wetting agent to prepare granules, the granules are dried at 60℃, the granules are sieved once through a 12 mesh sieve, and the fine powder is separated through a 60 mesh sieve, and the granules are obtained.

[0082] Comparative Example Three

[0083] Jinyinhua 12g, Lianqiao 11g, Shengdihuang 14g, Dangpi 17g, Chishao 16g, Kushen 21g, Gancao 20g, Maidong 17g, Dangshen 12g, Shanzha 16g, Huangqi 16g, Huangbai 14g, Huanglian 38g, Suanzaoren 10g, Gouteng 11g, Borneol 13g are selected.

[0084] The above traditional Chinese medicine materials are prepared by the preparation method of Comparative Example One to obtain traditional Chinese medicine granules.

[0085] Comparative Example Four

[0086] Jinyinhua 12g, Lianqiao 11g, Shengdihuang 14g, Dangpi 17g, Chishao 16g, Kushen 21g, Gancao 20g, Maidong 17g, Dangshen 12g, Shanzha 16g, Huangqi 16g, Huangbai 16g, Huanglian 40g, Suanzaoren 10g, Gouteng 11g, Borneol 13g are selected.

[0087] The above traditional Chinese medicine materials are prepared by the preparation method of Comparative Example One to obtain traditional Chinese medicine granules.

[0088] II. The traditional Chinese medicine preparations prepared in Example One to Example Three and Comparative Example One to Comparative Example Four are applied to patients with skin acne, and the effects are evaluated.

[0089] (I) The source of the selected subject cases

[0090] The group selects 238 cases of facial acne patients, all of which are patients of Suzhou City Hospital of Traditional Chinese Medicine, meet the diagnostic criteria of "China Acne Treatment Guidelines", and take eight weeks as a course of treatment;

[0091] The 238 cases of facial acne patients are randomly divided into seven groups according to clinical manifestations, and the number of people in each group is the same.

[0092] (ii) Treatment method

[0093] The traditional Chinese medicine granules prepared by Examples 1 to 3 and Comparative Examples 1 to 4 are used to treat the seven groups of patients in a one-to-one manner.

[0094] The specific operation of treating each group of patients: take an appropriate amount of traditional Chinese medicine granules, add an appropriate amount of warm water to the traditional Chinese medicine granules, mix and dissolve, and make the patient take it, 1 course of treatment is eight weeks, and the medicine is taken 2-5 times a day, and the traditional Chinese medicine granules used each time is 4-8g, and the treatment course, the number of medication and the dosage of medication are adjusted according to the actual needs of the patients. According to the results of observing one course of treatment, the total effective rate of the above treatment is counted.

[0095] (III) Treatment evaluation

[0096] Cure: All red papules have subsided, only pigmentation and scarring are left.

[0097] Marked effect: Red papules subsided more than 70%, or severity reduced by more than 2 degrees.

[0098] Effective: 70%> red papules subsided> 30%, or severity reduced by more than 1 degree, and new skin lesions still appeared.

[0099] Ineffective: Red papules subsided less than 30%, or aggravated.

[0100] Total effective rate = [(cure + marked effect + effective) / total number of cases] * 100%

[0101] (1) The traditional Chinese medicine granules prepared by the above Examples 1, 2 and 3 are used to treat three groups of patients (34 people in each group) in a one-to-one manner, 1 course of treatment is eight weeks, and the medicine is taken 2-5 times a day, and the traditional Chinese medicine granules used each time is 4-8g, and the treatment course, the number of medication and the dosage of medication are adjusted according to the actual needs of the patients. According to the results of observing one course of treatment, the total effective rate of the above treatment is counted, and the total effective rate of the traditional Chinese medicine granules prepared by Examples 1, 2 and 3 is about 88.2%, 73.5% and 79.4%, respectively.

[0102] Select the above (1) in the 6 effective cured patients, visit the use of traditional Chinese medicine granules (due to space relationship is not in this one by one), the use of days is the use of days of patients with symptoms improved significantly, as shown in Table 1

[0103]

[0104] As can be seen from the above, the traditional Chinese medicine granules prepared by the present application have the effects of clearing heat and resolving toxins, and cooling blood, and can obviously improve the symptoms of redness, heat and pain in inflammatory skin diseases. When Ophiopogon japonicus, Codonopsis pilosula, Crataegus pinnatifida, Scrophularia ningpoensis, Phellodendron amurense and Coptis chinensis are present at the same time, the best effect can be achieved. When some of them are missing, the treatment effect on patients will be poor. Mainly because Ophiopogon japonicus, Codonopsis pilosula, Crataegus pinnatifida and Scrophularia ningpoensis have a synergistic effect in regulating and improving the intestinal tract, can increase the moisture and nutrients in the intestinal tract, promote intestinal peristalsis and digestive excretion function, also can promote the generation of SCFAs, improve the intestinal environment and microbial community balance, at the same time, can also remove the dampness-heat and toxins in the intestinal tract, enhance the intestinal barrier function, improve the intestinal health, reduce harmful substances and pathogens into the blood, reduce systemic inflammatory response, so as to achieve the purpose of inhibiting skin inflammation and promoting skin recovery.

[0105] Phellodendron amurense and Coptis chinensis contain berberine, which can change the pH value or oxidation-reduction state in the intestinal tract, create a more favorable environment for the growth of specific intestinal flora, and berberine can directly act as a growth factor for some intestinal flora, such as Bifidobacterium and Clostridium, promote their growth and reproduction, so as to selectively increase the relative abundance of specific intestinal flora producing SCFAs, and the generated SCFAs can effectively inhibit the production and release of inflammatory mediators, reduce inflammation, and thus improve the symptoms of skin inflammation.

[0106] (2) The traditional Chinese medicine granules prepared by the above comparative examples one, two, three and four were administered to four groups of patients (34 people in each group) one by one, 1 course of treatment for eight weeks, 2-5 times of medication per day, and 4-8g of traditional Chinese medicine granules were used each time, and the treatment course, medication frequency and dosage were adjusted according to the actual needs of patients. According to the results of observing the treatment of one course, the total effective rate of the above treatment was counted, and the total effective rate of the traditional Chinese medicine granules prepared by the above comparative examples one, two, three and four was counted, as shown in Table 2.

[0107] Table 2:

[0108]

[0109]

[0110] It can be concluded from Table 2 that the therapeutic effect of the traditional Chinese medicine granules on inflammatory skin diseases will be improved by increasing the proportion of such medicinal materials as Cortex Phellodendri and Coptis chinensis in the traditional Chinese medicine granules. However, when the proportion of these medicinal materials in the traditional Chinese medicine granules reaches a certain proportion, such as the comparative example three, the traditional Chinese medicine granules reach a maximum, and when the proportion of these medicinal materials continues to increase, the efficacy of the obtained traditional Chinese medicine granules will decrease. The main reason is that the proportion of such medicinal materials is too high, thereby excessively increasing the production of SCFAs, affecting the acid-base balance of the intestinal tract, causing excessive activation or inhibition of the immune response, and thus producing adverse effects on inflammatory skin diseases. At the same time, excessive increase of SCFAs will change the composition and metabolic activity of intestinal microorganisms, leading to a decrease in beneficial bacteria and an increase in harmful bacteria, causing microbial imbalance and exacerbating skin inflammation. Therefore, the comparative example three is the optimal solution of the present application.

[0111] Experimental Example Two

[0112] The influence of different doses of Cortex Phellodendri and Coptis chinensis combination on the relative abundance of specific SCFAs-producing flora in the intestinal tract of patients was explored, and the effect of this change on the control of obesity in patients was evaluated.

[0113] I. Source of selected subject cases

[0114] 50 patients with obesity caused by high-sugar diet and acne were selected, and 20 patients were randomly divided into five groups according to clinical manifestations, and the number of people in each group was the same.

[0115] II. Treatment method

[0116] Example three, comparative example one, comparative example two, comparative example three, comparative example four prepared traditional Chinese medicine granules, in a one-to-one manner, to treat five groups of patients;

[0117] The specific operation of treating each group of patients: take an appropriate amount of traditional Chinese medicine granules, add an appropriate amount of warm water to the traditional Chinese medicine granules, mix and dissolve, and make the patient take it, according to a 2-month treatment course, take the medicine 3 times a day, and use 6g of traditional Chinese medicine granules each time. According to the results observed after 2 months of treatment, the total effective rate of the above treatment was statistically analyzed.

[0118] 1. Body weight and body fat monitoring

[0119] Before the start of the experiment, during the experiment and at the end of the experiment, the body weight and body fat rate of the patients were measured using a body weight scale and a body fat scale, the changes in body weight and body fat were recorded, and the percentage of weight loss was calculated according to the formula: body weight percentage = (body weight before the start of the experiment - body weight after the end of the experiment) / body weight before the start of the experiment * 100%.

[0120] 2. Intestinal flora analysis

[0121] Fecal samples of the patients are collected before the experiment starts and at the end of the experiment; the intestinal flora composition in the fecal samples is analyzed using an intestinal flora analysis kit, with particular attention to the relative abundance of specific flora associated with the production of SCFAs.

[0122] 3. SCFAs detection

[0123] The concentrations of short-chain fatty acids such as acetic acid, propionic acid, and butyric acid in the fecal samples are determined using an SCFAs detection kit, and the differences in SCFAs concentrations between different dose groups and the control group are compared.

[0124] 4. Blood biochemical index detection

[0125] Blood samples of the patients are collected before the experiment starts and at the end of the experiment, and blood biochemical index detection kits are used to detect changes in biochemical indicators such as blood glucose and blood lipids, to evaluate the effectiveness of obesity control.

[0126] All the change rates in the table are (data before the experiment - data after the experiment) / data before the experiment * 100%

[0127] As shown in Table 3,

[0128] Table 3:

[0129]

[0130]

[0131] Considering that a high-sugar diet often leads to excess energy, which in turn triggers obesity, obesity not only affects appearance, but more importantly, is associated with a variety of health problems such as cardiovascular disease, diabetes, hypertension, fatty liver, etc.; and for patients who already have inflammatory skin diseases such as acne, continued obesity can cause excessive stretching of the skin, increasing the risk of skin inflammation and infection, thereby exacerbating the condition of skin diseases such as acne; therefore, in the traditional Chinese medicine preparation in this scheme, Huangbai and Huanglian are added to ensure that the berberine in the medicinal materials achieves the effect of inhibiting obesity in patients.

[0132] In summary, as shown in Tables 2 and 3, by increasing the proportion of Huangbai and Huanglian in the traditional Chinese medicine granules, not only can the therapeutic effect be improved, but also the obesity rate of patients can be inhibited and reduced, achieving the effect of anti-obesity;

[0133] Wherein, by increasing the proportion of Huangbai and Huanglian in the traditional Chinese medicine granules, the berberine contained in Huangbai and Huanglian will serve as a growth factor for Clostridium and Bifidobacterium, etc. so that these flora can ferment dietary fiber in the intestinal tract to produce more SCFAs, thereby reducing inflammation and improving skin inflammation symptoms; at the same time, the increase of Huangbai and Huanglian can inhibit and reduce the obesity rate of patients, achieving the effect of anti-obesity, mainly because the systemic inflammation and metabolic disorder caused by high-sugar diet are related to lipopolysaccharide (LPS), and berberine can reduce the LPS level in the body, thereby reducing inflammation and oxidative stress in the liver and visceral adipose tissue, improving obesity and metabolic disorder, and berberine can inhibit the activity of fatty acid synthase (FAS), reduce the synthesis of fatty acids and the accumulation of triglycerides, can prevent the proliferation and hypertrophy of adipocytes, and berberine can activate lipolysis enzymes (such as HSL), accelerate fat decomposition and the excretion of metabolic products, thereby inhibiting the obesity of patients with high-sugar diet, and at the same time, it can improve and treat acne caused by obesity of patients with high-sugar diet; based on this, the above comparative example three is the optimal solution of the present scheme.

[0134] The above is based on the ideal embodiment of the present application, through the above description, relevant personnel can make various changes and modifications without deviating from the technical idea of the present application. The technical scope of the present application is not limited to the content of the specification, and the technical scope must be determined according to the scope of the claims.

Claims

1. A traditional Chinese medicine composition for treating inflammatory skin diseases, characterized in that: The traditional Chinese medicine composition for treating inflammatory skin diseases is made of the following Chinese herbal medicine raw materials in weight parts: ​ Honeysuckle 10-15 parts, forsythia 9-14 parts, raw rehmannia 10-20 parts, danpi 10-22 parts, red peony root 10-20 parts, kuh-seng 18-25 parts, licorice 15-25 parts, ophiopogon 12-18 parts, dangshen 6-14 parts, hawthorn 10-18 parts, scutellaria 10-20 parts, phellodendron 8-18 parts, coptis 30-45 parts, jujube seed 8-15 parts, uncaria 8-14 parts, and borneol 10-16 parts.

2. The traditional Chinese medicine composition for treating inflammatory dermatosis according to claim 1, characterized in that: The traditional Chinese medicine composition for treating inflammatory skin diseases is made of the following Chinese herbal medicine raw materials in weight parts: Honeysuckle 10-15 parts, forsythia 9-14 parts, raw rehmannia 10-20 parts, danpi 10-22 parts, red peony root 10-20 parts, kuh-seng 18-25 parts, licorice 15-25 parts, ophiopogon 12-18 parts, dangshen 6-14 parts, hawthorn 10-18 parts, scutellaria 10-20 parts, phellodendron 8-18 parts, coptis 30-45 parts, jujube seed 8-15 parts, uncaria 8-14 parts, and borneol 10-16 parts.

3. The traditional Chinese medicine composition for treating inflammatory dermatosis according to claim 1, characterized in that: The traditional Chinese medicine composition for treating inflammatory skin diseases is made of the following Chinese herbal medicine raw materials in weight parts: Honeysuckle 10-15 parts, forsythia 9-14 parts, raw rehmannia 10-20 parts, danpi 10-22 parts, red peony root 10-20 parts, kuh-seng 18-25 parts, licorice 15-25 parts, ophiopogon 12-18 parts, dangshen 6-14 parts, hawthorn 10-18 parts, scutellaria 10-20 parts, phellodendron 8-18 parts, coptis 30-45 parts, jujube seed 8-15 parts, uncaria 8-14 parts, and borneol 10-16 parts.

4. The traditional Chinese medicine composition for treating inflammatory dermatosis according to claim 1, characterized in that: The traditional Chinese medicine composition for treating inflammatory skin diseases is made of the following Chinese herbal medicine raw materials in weight parts: Honeysuckle 10-15 parts, forsythia 9-14 parts, raw rehmannia 10-20 parts, danpi 10-22 parts, red peony root 10-20 parts, kuh-seng 18-25 parts, licorice 15-25 parts, ophiopogon 12-18 parts, dangshen 6-14 parts, hawthorn 10-18 parts, scutellaria 10-20 parts, phellodendron 8-18 parts, coptis 30-45 parts, jujube seed 8-15 parts, uncaria 8-14 parts, and borneol 10-16 parts.

5. A method for preparing a traditional Chinese medicine composition for treating inflammatory skin diseases, using the traditional Chinese medicine composition for treating inflammatory skin diseases according to any one of claims 1-4, characterized in that, The traditional Chinese medicine composition for treating inflammatory skin diseases is made of the following Chinese herbal medicine raw materials in weight parts: Honeysuckle 10-15 parts, forsythia 9-14 parts, raw rehmannia 10-20 parts, danpi 10-22 parts, red peony root 10-20 parts, kuh-seng 18-25 parts, licorice 15-25 parts, ophiopogon 12-18 parts, dangshen 6-14 parts, hawthorn 10-18 parts, scutellaria 10-20 parts, phellodendron 8-18 parts, coptis 30-45 parts, jujube seed 8-15 parts, uncaria 8-14 parts, and borneol 10-16 parts. The steps include: S1, wash and dry honeysuckle, forsythia, raw rehmannia, danpi, red peony root, kuh-seng, licorice, ophiopogon, dangshen, hawthorn, scutellaria, coptis, jujube seed, and uncaria, and cut them into appropriate size pieces according to the requirements of the medicinal materials, mix and soak in water; S2, filter out the soaked and mixed medicinal materials, mix with water, first boil with strong fire, then simmer with gentle fire, filter to obtain medicinal liquid and residue, evaporate and concentrate the filtered medicinal liquid to increase the concentration of the medicinal liquid; 6. The method of claim 5, wherein the method is characterized by the following steps: a) mixing the Chinese medicine composition; b) sterilizing the Chinese medicine composition; c) packaging the Chinese medicine composition; and d) storing the Chinese medicine composition. S3, add appropriate amount of excipient, humectant and adhesive to the concentrated medicinal liquid, stir and mix to obtain mixed concentrated medicinal liquid to improve the texture and performance of the patch; S4, add borneol to the mixed concentrated medicinal liquid, mix evenly, and cool to room temperature to obtain the traditional Chinese medicine preparation.

7. A method for preparing a traditional Chinese medicine composition for treating inflammatory skin diseases according to claim 5, characterized in that: In the S1, the extraction process is as follows: Place the washed medicinal materials in clean water, the water level should be higher than the medicinal materials, maintain the water temperature at 23-25℃, soak for 2-4h to ensure that the medicinal materials are fully absorbed, swollen, and softened to ensure the dissolution of the effective components. In the S2, the specific process of mixing the soaked medicinal materials with water and boiling is as follows: After soaking, the medicinal material is put into water with 5-8 times of the total weight of the medicinal material, heated to boiling state with strong fire, the temperature is maintained for 3-6 min, then changed to weak fire, kept in a state of micro-boiling for 30-60 min, then filtered the medicinal liquid.

8. A method for preparing a traditional Chinese medicine composition for treating inflammatory skin diseases according to claim 5, characterized in that: In the S2, the specific process of evaporation and concentration of the medicinal liquid is as follows: The filtered medicinal liquid is added into a suitable concentration pot, so that the medicinal liquid fills 4 / 5 of the volume of the concentration pot, the concentration pot is heated at a temperature of 55-75℃ for 25-40 min, then the temperature is maintained at 75-90℃, heated for 40-80 min, until the medicinal liquid is concentrated to 1 / 3-1 / 2 of the original volume.

9. A method for preparing a traditional Chinese medicine composition for treating inflammatory skin diseases according to claim 5, characterized in that: The traditional Chinese medicine preparation is a powder, a capsule, a tablet, a pill or a granule.

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