Traditional Chinese medicine granules for treating icteric hepatitis and preparation method thereof

Abstract

The present invention belongs to the technical field of traditional Chinese medicine preparations, and specifically relates to a traditional Chinese medicine granule for treating icteric hepatitis and a preparation method thereof. The traditional Chinese medicine granule comprises the following components: Artemisia capillaris, Herba Lysimachiae, stir-fried Gardenia jasminoides, Rhubarb, Radix Isatidis, Patchouli, Eupatorium fortunei, Artemisia annua, Paeonia lactiflora, Paeonia suffruticosa, Salvia miltiorrhiza, Crataegus pinnatifida, Semen Coicis, and Apricot Kernel. The present invention selects and scientifically compounds the traditional Chinese medicines, with the various drugs complementing each other to achieve a comprehensive therapeutic effect of clearing heat and dampness while also taking into account external symptoms, blood stasis, and fullness. Thus, the present invention provides a comprehensive treatment solution for Yang jaundice in traditional Chinese medicine theory, particularly for complex conditions accompanied by multiple mixed symptoms such as external symptoms, blood stasis, and fullness, with a wider scope of application and more pronounced expected therapeutic effects.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to traditional Chinese medicine granules for treating icteric hepatitis and a preparation method thereof. Background Art

[0002] Yang jaundice is a common type of jaundice in Traditional Chinese Medicine (TCM). It's what modern medicine calls acute / subacute icteric hepatitis. It manifests as a yellowish hue, like orange peel, accompanied by fever, thirst, and dark, scanty urine. Traditional Chinese Medicine believes that Yang jaundice is often caused by accumulation of damp-heat in the liver and gallbladder, leading to dysfunctional drainage. However, in clinical practice, patients often present not only with the basic underlying pathogenesis of internal damp-heat, but also with complex conditions such as unresolved external pathogens, blood stasis, and distension in the spleen and stomach, making treatment more challenging.

[0003] Currently, there are two traditional Chinese medicine formulas for yang jaundice on the market: Chidan Tuihuang Granules and Yinzhihuang Granules. The following is a detailed analysis of the characteristics and shortcomings of these two similar traditional Chinese medicine formulas:

[0004] ①Chidan Tuihuang Granules:

[0005] a. Ingredients and Efficacy: Chidan Tuihuang Granules are primarily composed of Chinese herbs such as red peony root, salvia miltiorrhiza, and kudzu root, known for their cooling blood, clearing the liver, and promoting blood circulation and relieving jaundice. These ingredients work together to help alleviate symptoms of jaundice associated with acute and chronic viral cholestatic hepatitis, such as yellowing of the body and eyes, frequent urination, dry stools, dull pain or discomfort in the flanks, itchy skin, and thirst.

[0006] b. Adverse Reactions: Some patients may experience mild bitter taste in the mouth, nausea, and mild to moderate diarrhea during use. In addition, abnormalities in blood routine, urine routine, and serum creatinine levels have occasionally been observed in clinical trials, but these cannot be confirmed to be directly related to the use of this product. Due to differences in patient constitution and condition, the efficacy of Chidan Tuihuang Granules may vary from patient to patient, and some patients may not achieve the expected therapeutic effect.

[0007] ②Yinzhihuang Granules:

[0008] Ingredients and Efficacy: Yinzhihuang Granules are primarily composed of Chinese herbs such as Artemisia capillaris, Gardenia jasminoides, and Rhubarb. They have the effects of dispelling dampness, relieving jaundice, and clearing away heat and detoxifying. They are primarily used to treat jaundice caused by damp-heat in the liver and gallbladder or poor bile stasis, as well as to lower alanine aminotransferase (ALT). They are suitable for the treatment of acute and chronic hepatitis, among other conditions.

[0009] b. Adverse reactions: All three drugs in Yinzhihuang Granules are cooling drugs that simply clear away heat and dampness, but cannot take into account other symptoms. Improper use may cause symptoms such as stomach pain, diarrhea, vomiting, or abdominal distension and indigestion. These adverse reactions may affect the patient's medication experience and treatment effect.

[0010] In summary, commonly used Chinese patent medicine formulas such as Chidan Tuihuang Granules and Yinzhihuang Granules each have their own unique characteristics in terms of ingredients and efficacy, but they also have certain disadvantages and adverse reactions. When developing new Chinese herbal formulas for jaundice, we can draw on the advantages of these products while addressing their shortcomings and implementing improvements and innovations to enhance their efficacy and safety. Summary of the Invention

[0011] The purpose of the present invention is to overcome the shortcomings and deficiencies of the existing technology and provide a traditional Chinese medicine granule for treating icteric hepatitis and a preparation method, so as to solve the complex situation of multiple common mixed symptoms in patients with icteric hepatitis, and achieve the goal of clearing away heat and dampness while taking into account the symptoms of the exterior, blood stasis and fullness.

[0012] To achieve the above objectives, the technical solutions adopted by the present invention include:

[0013] In a first aspect, the present invention provides a traditional Chinese medicine granule for treating icteric hepatitis, comprising the following components: Artemisia capillaris, Herba Lysimachiae, stir-fried Gardenia jasminoides, Rhubarb, Radix Isatidis, Patchouli, Cyperus rotundus, Artemisia annua, Paeonia lactiflora, Paeonia suffruticosa, Salvia miltiorrhiza, Crataegus pinnatifida, Coix seed and bitter almond.

[0014] The Chinese medicine granules of the present invention contain the following four groups of component drugs:

[0015] (1) Heat-clearing and dampness-removing group: Artemisia capillaris, Houttuynia cordata, stir-fried Gardenia jaundice, Rhubarb, and Isatis root; this group of drugs directly treats the core pathogenesis of yang jaundice through its effects of clearing heat and dampness, detoxifying and relieving jaundice.

[0016] (2) The group that takes into account the symptoms of the exterior: Patchouli, Cymbopogon citratus, and Artemisia annua. This group of medicines can dispel the exterior pathogens and help to relieve the symptoms of the exterior caused by wind-cold or wind-heat, and enhance the body's resistance.

[0017] (3) Blood stasis group: red peony root, moutan bark, and salvia miltiorrhiza; this group of drugs has the effect of promoting blood circulation and removing blood stasis, can improve the condition of blood stasis, promote blood circulation in the lesion area, and accelerate recovery.

[0018] (4) The group that takes into account the fullness and distension of the spleen and stomach: hawthorn, coix seed, and bitter almond; this group of medicines can strengthen the spleen and digestion, regulate qi and relieve fullness, treat the common symptoms of fullness and distension of the spleen and stomach in yang jaundice, and restore the normal function of the spleen and stomach.

[0019] "Qian Jin Fang" states: "Jaundice is characterized by yellow eyes and abdominal distension, difficulty urinating, yellow body and fever." "Treatise on Febrile Diseases" states: "In Yangming disease, patients with fever and sweating are suffering from excessive heat and cannot cause jaundice. However, patients with sweating on the head but not on the body, which stops at the neck, difficulty urinating, and thirst for water are suffering from internal blood stasis and heat, and the body will inevitably turn jaundice." Descriptions in ancient books indicate that Yang jaundice is often accompanied by symptoms of the exterior, blood stasis, and fullness, and is often the norm. The classic provisions are basically consistent with clinical observations. Currently commonly used Chinese patent medicine formulas cannot meet the complex conditions of multiple common mixed symptoms. The present invention uses the above-mentioned components of Chinese medicine for scientific compounding, and the various medicines complement each other to achieve a comprehensive therapeutic effect of clearing away heat and dampness while taking into account the exterior symptoms, blood stasis, and fullness. This provides a comprehensive treatment solution for Yang jaundice in traditional Chinese medicine theory, especially for complex conditions accompanied by multiple mixed symptoms such as exterior symptoms, blood stasis, and fullness, and has a wider scope of application and more obvious expected therapeutic effects.

[0020] Preferably, the following components are included in parts by weight: 30-60 parts of Artemisia capillaris, 20-30 parts of Lysimachia chinensis, 10-20 parts of stir-fried Gardenia jasminoides, 10-15 parts of Rhubarb, 15-20 parts of Isatis root, 10-20 parts of Patchouli, 10-20 parts of Cyperus rotundus, 15-20 parts of Artemisia annua, 20-30 parts of Red Peony Root, 10-20 parts of Paeonia suffruticosa, 15-20 parts of Salvia miltiorrhiza, 15-20 parts of Hawthorn, 15-20 parts of Coix seeds and 10-15 parts of bitter almonds.

[0021] Preferably, the following components are included in parts by weight: 45 parts of Artemisia capillaris, 25 parts of Lysimachia chinensis, 15 parts of stir-fried Gardenia jasminoides, 12 parts of Rhubarb, 15 parts of Isatis root, 15 parts of Patchouli, 15 parts of Cyperus rotundus, 15 parts of Artemisia annua, 25 parts of Paeonia lactiflora, 15 parts of Paeonia suffruticosa, 15 parts of Salvia miltiorrhiza, 15 parts of Crataegus pinnatifida, 15 parts of Coix seed and 12 parts of bitter almond.

[0022] After investigation, it was found that when the dosage of each component in the Chinese medicine granules of the present invention is the above-mentioned optimal value, the various medicines complement each other and are well compatible. The comprehensive therapeutic effect of clearing away heat and dampness and taking into account exterior symptoms, blood stasis, and fullness is the best. After treatment with the Chinese medicine granules, the transaminase (ALT, AST) in the body of patients with icteric hepatitis decreased significantly, the liver function was significantly improved, and the coagulation indicators also decreased significantly, and the coagulation function recovered faster.

[0023] In a second aspect, the present invention provides a method for preparing the Chinese medicine granules, comprising the following steps:

[0024] (1) soaking the raw material in water, boiling it, and filtering it to obtain a first extract; then adding water to the filtered medicinal residue and boiling it again, filtering it to obtain a second extract;

[0025] (2) combining the first extract and the second extract, concentrating to a relative density of 1.25-1.30, adding 75% ethanol solution to adjust the alcohol content of the extract to 55-65%, stirring evenly, allowing to settle, collecting the supernatant, concentrating to a thick paste, adding pharmaceutically acceptable excipients, stirring evenly, granulating, and drying;

[0026] (3) The remaining drug residue after filtration is crushed, and extracted by percolation with 55-65% ethanol solution. The percolation liquid is collected and concentrated under low pressure to a thick paste. Pharmaceutically acceptable excipients are added, stirred, granulated, and dried.

[0027] (4) The granules prepared in step (2) and step (3) are mixed uniformly to obtain the Chinese medicine granules.

[0028] The preparation method of the Chinese medicine granules of the present invention is simple and easy, ensuring that the effective ingredients of the medicine are retained and the best therapeutic effect is achieved. In addition, the amount of dressing that needs to be added in large quantities in the Chinese medicine granule preparation is greatly reduced, and the Chinese medicine granule preparation is suitable for large-scale industrial production, and has broad market prospects and application value.

[0029] Preferably, in step (1), water is added for 1-2 hours, with the amount of water added for the first time being 15 times the mass of the raw material, and the amount of water added for the second time being 10 times the mass of the raw material. The medicinal materials need to be soaked before extraction to make the active ingredients more easily dissolve, and the appropriate amount of water needs to be determined based on the water absorption of the medicinal materials and the content of the active ingredients. Generally speaking, the amount of water added should be sufficient to fully soak the medicinal materials, but not too much so as not to affect the extraction efficiency.

[0030] Preferably, in step (1), the first boiling time is 1.5-2 hours, and the second boiling time is 1-1.5 hours.

[0031] Preferably, in step (3), the amount of ethanol solution added is 3-5 times the mass of the medicinal residue.

[0032] In a third aspect, the present invention provides the use of the Chinese medicine granules in preparing a medicine for treating icteric hepatitis.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] (1) The present invention selects the aforementioned Chinese medicines for scientific compounding, and the various medicines complement each other to achieve a comprehensive therapeutic effect of clearing away heat and dampness while taking into account the symptoms of the exterior, blood stasis, and fullness. Thus, for Yang jaundice in traditional Chinese medicine theory, especially for the complex condition accompanied by multiple mixed symptoms such as the symptoms of the exterior, blood stasis, and fullness, a comprehensive treatment solution is provided, which has a wider scope of application and is expected to have more obvious therapeutic effects.

[0035] (2) The preparation method of the Chinese medicine granules of the present invention is simple and easy, ensuring that the effective ingredients of the medicine are retained and the best therapeutic effect is achieved. In addition, the amount of dressing that needs to be added in large quantities in the Chinese medicine granule preparation is greatly reduced, and the Chinese medicine granule preparation is suitable for large-scale industrial production, and has broad market prospects and application value. DETAILED DESCRIPTION

[0036] To better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments. Those skilled in the art should understand that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0037] Example 1

[0038] This embodiment provides a traditional Chinese medicine granule for treating icteric hepatitis, comprising the following components in parts by weight: 45 parts of Artemisia capillaris, 25 parts of Lysimachia chinensis, 15 parts of stir-fried Gardenia jasminoides, 12 parts of Rhubarb, 15 parts of Isatis root, 15 parts of Patchouli, 15 parts of Cyperus rotundus, 15 parts of Artemisia annua, 25 parts of Paeonia lactiflora, 15 parts of Paeonia suffruticosa suffruticosa, 15 parts of Salvia miltiorrhiza, 15 parts of Crataegus pinnatifida, 15 parts of Coix seed, and 12 parts of bitter almond.

[0039] The preparation method of the Chinese medicine granules comprises the following steps:

[0040] (1) Soak the raw material in water for 1.5 hours, adding 15 times the weight of the raw material for the first time, then boiling for 2 hours, filtering to obtain a first extract, then adding water to the filtered medicinal residue and boiling again for 1.5 hours, adding 10 times the weight of the raw material for the second time, filtering to obtain a second extract;

[0041] (2) combining the first extract and the second extract, concentrating to a relative density of 1.25-1.30, adding 75% ethanol solution to adjust the alcohol content of the extract to 55-65%, stirring evenly, allowing to settle, collecting the supernatant, concentrating to a thick paste, adding pharmaceutically acceptable excipients, stirring evenly, granulating, and drying;

[0042] (3) The remaining drug residue after filtration is crushed, passed through an 80-120 mesh sieve, and extracted by percolation with 4 times the amount of 60% ethanol solution. The percolation liquid is collected and concentrated under low pressure to a thick paste. Pharmaceutically acceptable excipients are added, stirred, granulated, and dried.

[0043] (4) The granules obtained in step (2) and step (3) are mixed uniformly to obtain the Chinese medicine granules. During the granulation process, the size and uniformity of the granules need to be controlled.

[0044] Example 2

[0045] This embodiment provides a traditional Chinese medicine granule for treating icteric hepatitis, comprising the following components in parts by weight: 30 parts of Artemisia capillaris, 20 parts of Lysimachia chinensis, 10 parts of stir-fried Gardenia jasminoides, 10 parts of Rhubarb, 15 parts of Isatis root, 10 parts of Patchouli, 10 parts of Cyperus rotundus, 15 parts of Artemisia annua, 20 parts of Paeonia lactiflora, 10 parts of Paeonia suffruticosa, 15 parts of Salvia miltiorrhiza, 15 parts of Crataegus pinnatifida, 15 parts of Coix seed, and 10 parts of Apricot kernel;

[0046] The preparation method of the Chinese medicine granules comprises the following steps:

[0047] (1) Soak the raw material in water for 1 hour, adding 15 times the weight of the raw material for the first time, then boiling for 1.5 hours, filtering to obtain the first extract, then adding water to the filtered medicinal residue and boiling again for 1 hour, adding 10 times the weight of the raw material for the second time, filtering to obtain the second extract;

[0048] (2) combining the first extract and the second extract, concentrating to a relative density of 1.25-1.30, adding 75% ethanol solution to adjust the alcohol content of the extract to 55-65%, stirring evenly, allowing to settle, collecting the supernatant, concentrating to a thick paste, adding pharmaceutically acceptable excipients, stirring evenly, granulating, and drying;

[0049] (3) The remaining drug residue after filtration is crushed, passed through an 80-120 mesh sieve, and extracted by percolation with 3 times the amount of 55% ethanol solution. The percolation liquid is collected and concentrated under low pressure to a thick paste. Pharmaceutically acceptable excipients are added, stirred, granulated, and dried.

[0050] (4) The granules obtained in step (2) and step (3) are mixed uniformly to obtain the Chinese medicine granules. During the granulation process, the size and uniformity of the granules need to be controlled.

[0051] Example 3

[0052] This embodiment provides a traditional Chinese medicine granule for treating icteric hepatitis, comprising the following components in parts by weight: 60 parts of Artemisia capillaris, 30 parts of Lysimachia chinensis, 20 parts of stir-fried Gardenia jasminoides, 15 parts of Rhubarb, 20 parts of Isatis indigotica, 20 parts of Patchouli, 20 parts of Cyperus rotundus, 20 parts of Artemisia annua, 30 parts of Paeonia lactiflora, 20 parts of Paeonia suffruticosa, 20 parts of Salvia miltiorrhiza, 20 parts of Crataegus pinnatifida, 20 parts of Coix seeds, and 15 parts of Apricot kernel;

[0053] The preparation method of the Chinese medicine granules comprises the following steps:

[0054] (1) Soak the raw material in water for 2 hours, adding 15 times the weight of the raw material for the first time, then boiling for 2 hours, filtering to obtain the first extract, then adding water to the filtered medicinal residue and boiling again for 1.5 hours, adding 11 times the weight of the raw material for the second time, filtering to obtain the second extract;

[0055] (2) combining the first extract and the second extract, concentrating to a relative density of 1.25-1.30, adding 75% ethanol solution to adjust the alcohol content of the extract to 55-65%, stirring evenly, allowing to settle, collecting the supernatant, concentrating to a thick paste, adding pharmaceutically acceptable excipients, stirring evenly, granulating, and drying;

[0056] (3) The remaining drug residue after filtration is crushed, passed through an 80-120 mesh sieve, and extracted by percolation with 5 times the amount of 65% ethanol solution. The percolation liquid is collected and concentrated under low pressure to a thick paste. Pharmaceutically acceptable excipients are added, stirred, granulated, and dried.

[0057] (4) The granules obtained in step (2) and step (3) are mixed uniformly to obtain the Chinese medicine granules. During the granulation process, the size and uniformity of the granules need to be controlled.

[0058] Comparative Example 1

[0059] This comparative example provides a Chinese medicine granule, which comprises only the following components in parts by weight: 40 parts of Artemisia capillaris, 25 parts of Lysimachia chinensis, 15 parts of stir-fried Gardenia jasminoides, 12 parts of Rhubarb, and 18 parts of Isatis root;

[0060] The preparation method of the Chinese medicine granules is the same as that in Example 1.

[0061] Effect Examples

[0062] In order to verify the efficacy of the Chinese herbal granules of the present invention in treating icteric hepatitis, the inventors conducted a clinical trial study on patients with icteric hepatitis with Yang jaundice syndrome.

[0063] (1) Clinical data

[0064] 1. Case selection: The 62 cases selected were all patients with icteric hepatitis with positive jaundice who came to our department for treatment from July 2022 to July 2024; all patients were randomly divided into an observation group and a control group, with 31 people in each group. There was no statistically significant difference in age, gender, and clinical symptoms before treatment between the two groups, and they were comparable.

[0065] 2. Diagnostic criteria: Refer to the Guiding Principles for Clinical Research of New Traditional Chinese Medicines.

[0066] 3. Treatment methods:

[0067] Observation group: took the Chinese medicine granules described in Example 1 of the present invention, twice a day, 10 g each time, taken with boiled water, 30 days as a course of treatment, and two courses of treatment were taken consecutively;

[0068] Control group: taking the Chinese medicine granules described in Comparative Example 1 of the present invention and conventional liver-protecting and enzyme-lowering drugs for tailored treatment, twice a day, 10 g each time, taken with boiled water, 30 days as a course of treatment, and two courses of treatment in a row.

[0069] Table 1 compares the baseline data and symptom distribution of the two groups of patients with icteric hepatitis before treatment.

[0070] Table 1

[0071]

[0072] (2) Changes in liver function and coagulation indicators before and after treatment

[0073] As shown in Table 2, a comparison of the magnitude of improvement before and after treatment revealed that the observation group had significantly greater reductions in transaminases (ALT and AST) than the control group (P < 0.01). The observation group also had significantly greater reductions in total and direct bilirubin (P < 0.05). Regarding coagulation function, the observation group had significantly greater reductions in prothrombin time and INR (independent normalized ratio) than the control group (P < 0.01), indicating a more rapid recovery of coagulation function. The control group had slightly greater improvements in GGT and ALP, but the comparison between the two groups was not statistically significant.

[0074] Table 2 Decline in liver function and coagulation indexes of patients after treatment

[0075]

[0076]

[0077] Note: ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, glutamyltransferase; ALP, alkaline phosphatase; TBIL, total bilirubin; DBIL, direct bilirubin; PT, prothrombin time; INR, international normalized ratio.

[0078] (3) Changes in TCM syndrome scores before and after treatment

[0079] The results revealed that the Chinese medicine granules prepared in the examples of the present invention had a better clinical effect on improving TCM symptoms. As shown in Table 3, all clinical symptoms in the observation group were improved before and after treatment. Compared with the control group after treatment, the observation group was better than the control group in terms of flank pain, aversion to oil, abdominal pain, and constipation (P < 0.05); and was significantly better than the control group in terms of symptoms such as bitter taste in the mouth, dry mouth, nausea, and hiccups (P < 0.01). No treatment-related adverse reactions were observed in patients in each group after treatment.

[0080] Table 3

[0081]

[0082]

[0083] Compared with the observation group before treatment, #P<0.01; compared with the control group, *P<0.05, **P<0.01

[0084] (3) Comparison of total effective rate and hospitalization days between the two groups

[0085] As shown in Table 4, the total effective rate of the observation group was 93.55%, which was significantly higher than the 74.19% of the control group (P < 0.01). In terms of the length of hospital stay, the observation group had an average of nearly 2.5 days less than the control group, and the difference in length of hospital stay between the two groups was statistically significant (P < 0.05).

[0086] Table 4

[0087] Group Number of cases Significantly effective efficient invalid Total efficiency Number of days in hospital Observation Group 31 15(48.39) 14(45.16) 2(6.45) 93.55 11.35±2.86 control group 31 11(35.48) 12(38.71) 8(25.81) 74.19 13.84±3.12 t / χ2 / 6.21 4.78 11.97 8.79 2.34 P / <0.05 <0.05 <0.01 <0.01 <0.05

[0088] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A Chinese medicine granule for treating icteric hepatitis, characterized in that: The invention is composed of the following raw materials in parts by weight: 30-60 parts of Artemisia capillaris, 20-30 parts of Lysimachia chinensis, 10-20 parts of stir-fried Gardenia jasminoides, 10-15 parts of Rhubarb, 15-20 parts of Isatis indigotica, 10-20 parts of Patchouli, 10-20 parts of Cyperus rotundus, 15-20 parts of Artemisia annua, 20-30 parts of Paeonia lactiflora, 10-20 parts of Paeonia suffruticosa, 15-20 parts of Salvia miltiorrhiza, 15-20 parts of Hawthorn, 15-20 parts of Coix seeds and 10-15 parts of bitter almonds.

2. The Chinese medicine granules according to claim 1, characterized in that The invention is composed of the following raw materials in parts by weight: 45 parts of Artemisia capillaris, 25 parts of Lysimachia chinensis, 15 parts of stir-fried Gardenia jasminoides, 12 parts of Rhubarb, 15 parts of Isatis root, 15 parts of Patchouli, 15 parts of Cyperus rotundus, 15 parts of Artemisia annua, 25 parts of Paeonia lactiflora, 15 parts of Paeonia suffruticosa, 15 parts of Salvia miltiorrhiza, 15 parts of Crataegus pinnatifida, 15 parts of Coix seeds and 12 parts of bitter almonds.

3. The method for preparing the Chinese medicine granules according to claim 1 or 2, characterized in that: The following steps are involved: (1) Soaking the above raw materials in water, boiling them for the first time, filtering them to obtain a first extract, then adding water to the filtered medicinal residues for a second boiling, filtering them to obtain a second extract; (2) Combine the first extract and the second extract, concentrate to a relative density of 1.25-1.30, add 75% ethanol solution to make the alcohol content of the extract 55-65%, stir evenly, let it settle, take the supernatant, concentrate to a thick paste, add pharmaceutically acceptable excipients, stir evenly, granulate, and dry; (3) Take the remaining drug residue after filtration, crush it, add 55-65% ethanol solution and extract it by percolation method, collect the percolation liquid, concentrate it under low pressure to a thick paste, add pharmaceutically acceptable excipients, stir well, granulate, and dry; (4) The granules obtained in step (2) and step (3) are mixed uniformly to obtain the Chinese medicine granules.

4. The preparation method according to claim 3, wherein In the step (1), water is added and soaked for 1-2 hours, the amount of water added for the first time is 15 times the mass of the raw material, and the amount of water added for the second time is 10 times the mass of the raw material.

5. The preparation method according to claim 3, wherein In the step (1), the first boiling time is 1.5-2 hours, and the second boiling time is 1-1.5 hours.

6. The preparation method according to claim 3, wherein In the step (3), the amount of the ethanol solution added is 3-5 times the mass of the medicinal residue.

7. Use of the Chinese medicinal granules according to claim 1 or 2 in the preparation of a medicament for treating icteric hepatitis.

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