Oral liquid for clearing heat and diminishing swelling and preparation method thereof

Abstract

The invention discloses oral liquid capable of clearing heat and diminishing swelling. The oral liquid is prepared from 150 parts of radix isatidis, 100 parts of rhizoma dioscoreae hypoglaucae, 150 parts of fructus forsythiae, 75 parts of pogostemon cablin, 150 parts of honeysuckle, 80 parts of wild chrysanthemum flowers, 150 parts of fingered citron, 50 parts of liquorice and 150 parts of rhizoma dryopteris crassirhizomae. The preparation method comprises the following steps: 1, decocting the honeysuckle until the honeysuckle is boiled, adding the honeysuckle for 1 hour, and taking liquid medicine; decocting for 40 minutes again, taking liquid medicine, and combining the liquid medicine with the liquid medicine in the step 1; concentrating to obtain clear paste with the relative density of 1.03-1.08, adding ethanol until the alcohol content is 65%, and standing for 48 hours; taking supernate, filtering, recovering ethanol from filtrate, concentrating to obtain extract with the relative density of about 1.04, adding 110g of cane sugar, stirring to dissolve, filtering, adding water to 1000ml, filling and sealing, and sterilizing. The traditional Chinese medicine has the advantages of clearing heat, eliminating dampness, cooling blood and detoxifying. The traditional Chinese medicine composition is used for treating wind-heat type common cold and viral infections such as upper respiratory infection, flu, parotitis and epidemic hemorrhagic conjunctivitis.

Description

Technical Field

[0001] The invention belongs to the field of preparations, and particularly relates to an oral liquid for clearing away heat and reducing swelling and a preparation method thereof. Background Art

[0002] Upper respiratory tract infections, influenza, and mumps are common illnesses that have different symptoms, but they also have some similarities. Here are the main symptoms of all three:

[0003] Symptoms of upper respiratory tract infection: 1. Sore throat: dry, painful or irritated throat. 2. Cough: dry cough or phlegm. 3. Congestion and runny nose: blocked nose, clear or yellow-green runny nose.

[0004] Symptoms of influenza: 1. Fever: high fever, usually above 38°C. 2. Chills: fever is accompanied by chills. 3. Cough: dry cough or sputum. 4. Sore throat: sore throat or burning sensation. 5. Nasal congestion and runny nose: blocked nose, runny nose. 6. Muscle and joint pain: sore muscles and joints all over the body.

[0005] Symptoms of mumps: 1. Parotid gland swelling: The parotid gland (below the ear) is swollen and tender. 2. Fever: May be accompanied by fever. 3. Headache: Headache. 4. Oral mucosal changes: Some patients may experience redness, swelling, and ulcers in the oral mucosa. 5. Gland pain: Gland pain worsens when chewing or swallowing.

[0006] Doctors usually prescribe drugs for clearing away heat and reducing swelling. The present invention provides an oral liquid for clearing away heat and reducing swelling and a preparation method thereof. Summary of the invention

[0007] The invention aims to provide an oral liquid for clearing away heat and reducing swelling and a preparation method thereof. The oral liquid for clearing away heat and reducing swelling comprises, by weight, 120-180 parts of isatis root, 80-120 parts of radix ophiopogonis, 120-180 parts of forsythia, 60-80 parts of patchouli, 120-180 parts of honeysuckle, 65-90 parts of wild chrysanthemum, 120-180 parts of citron, 30-80 parts of liquorice and 120-180 parts of cyperus rotundus.

[0008] Preferably, the Radix Isatidis is the main drug, and the weight ratio should be 12%-18%.

[0009] Preferably, the total weight ratio of the Forsythia suspensa, honeysuckle, wild chrysanthemum and Cyperus rotundus should account for 42%-48%.

[0010] Preferably, a heat-clearing and swelling-removing oral liquid comprises 150 parts of isatis root, 100 parts of ophiopogon, 150 parts of forsythia, 75 parts of patchouli, 150 parts of honeysuckle, 80 parts of wild chrysanthemum, 150 parts of bergamot, 50 parts of licorice, and 150 parts of cyrtomium wilfordii.

[0011] Isatis root: The Chinese herbal medicine Isatis root is a heat-clearing medicine. It is the dried root of the cruciferous plant Isatis indigotica. Isatis root has the effects of clearing away heat and detoxifying, cooling blood and relieving sore throat.

[0012] Dioscorea zingiberensis: It is the rhizome of Dioscorea zingiberensis, a plant of the Dioscoreaceae family. The rhizome is dug up in autumn and winter, the fibrous roots are removed, sliced ​​thinly, and dried in the sun. Its functions and indications are: removing dampness and turbidity, dispelling wind and removing numbness.

[0013] Forsythia suspensa: Forsythia suspensa has the effects of clearing away heat, detoxifying, reducing swelling and dispersing nodules. It is widely used in traditional Chinese medicine to treat symptoms such as wind-heat cold, initial stage of febrile disease, high fever and thirst. Modern pharmacological research has also shown that Forsythia suspensa has multiple pharmacological effects such as antipyretic, anti-inflammatory, antibacterial and antiviral. The methanol extract of Forsythia suspensa has obvious anti-inflammatory activity, among which arctigenin is the main active intermediary substance, which has significant anti-inflammatory and analgesic effects.

[0014] Patchouli: It is a dehumidifying medicine. It is the dried aerial part of the patchouli plant of the Lamiaceae family. It has the effects of aromatically clearing turbidity, stopping vomiting, and relieving heat.

[0015] Honeysuckle: Honeysuckle is famous for clearing away heat and detoxifying. It is mainly used to treat exogenous wind-heat, fever at the beginning of febrile disease, sore throat and other symptoms. Honeysuckle and its compound have significant antipyretic effect and significant anti-inflammatory effect. Honeysuckle has inhibitory effect on many pathogenic bacteria, and its antibacterial active ingredient is chlorogenic acid compounds.

[0016] Wild chrysanthemum: a perennial herb of the Asteraceae family, slightly cold in nature, with the effects of dispersing wind-heat, reducing swelling and detoxifying.

[0017] Buddha's hand: Qi-regulating medicine soothes the liver and regulates qi, harmonizes the stomach and relieves pain. It is used for liver and stomach qi stagnation, chest and flank pain, fullness in the stomach, loss of appetite and vomiting.

[0018] Licorice: It is a Qi-tonifying medicine. It is the dried root and rhizome of the legume plants Licorice, Glycyrrhiza uralensis or Glycyrrhiza glabra. It has the functions of invigorating Qi and tonifying the middle, removing phlegm and relieving cough, detoxifying, relieving acute pain and alleviating the properties of the medicine.

[0019] Mianma Guanzhong: It is a heat-clearing medicine, which is the dried rhizome and petiole residues of Dryopteris crassipes, a plant of the Dryopteris family. It has the effects of clearing heat, detoxifying and expelling parasites. It is mainly used for abdominal pain caused by parasites and sores.

[0020] A preparation method of an oral liquid for clearing heat and reducing swelling comprises the following steps: 1. immersing Radix Isatidis, Radix Dioscoreae, Fructus Forsythiae, Pogostemon Cablin, Flos Chrysanthemi Indici, Citron, Licorice, and Rhizoma Cynomorii in water to soften the medicinal materials, decocting until boiling, adding honeysuckle, and the decocting time is 1 hour, and taking the medicinal liquid;

[0021] 2. Boil again for 40 minutes, take the liquid medicine, and combine it with the liquid medicine in step 1;

[0022] 3. Concentrate to a clear paste with a relative density of 1.03-1.08, add ethanol to make the alcohol content reach 65%, and let it stand for 48 hours;

[0023] 4. Take the supernatant, filter, recover ethanol from the filtrate, concentrate to an extract with a relative density of about 1.04, add 110g sucrose, stir to dissolve, filter, add water to 1000ml, fill and sterilize.

[0024] Furthermore, the relative density is measured at 40°C.

[0025] Furthermore, the pH value of the product prepared according to the above method is 4-6.

[0026] The invention has the following beneficial effects: the prescription contains 9 Chinese medicines, namely, Radix Isatidis, Fructus Forsythiae, Flos Lonicerae, Flos Chrysanthemi Indici, Rhizoma Cynomorii, Fructus Cibotii, Patchouli, Rhizoma Dioscoreae, and Licorice. The main medicine is Radix Isatidis, and the other 8 Chinese medicines are all auxiliary medicines. In the prescription, Radix Isatidis clears away heat and detoxifies, cools blood and reduces swelling as the main medicine; Fructus Forsythiae penetrates evil and detoxifies, Flos Lonicerae dissipates heat and detoxifies, Fructus Chrysanthemi Indici and Rhizoma Cynomorii clear away heat and detoxifies as the auxiliary medicine; Fructus Cibotii and Patchouli are used to soothe the stomach and stop vomiting, Rhizoma Dioscoreae helps to relieve and relieve dampness and heat; Licorice is used as the messenger to harmonize the various medicines. It clears away heat and dampness, cools blood and detoxifies. It is used for viral infections such as wind-heat cold and upper respiratory tract infection, influenza, mumps, and epidemic hemorrhagic conjunctivitis. DETAILED DESCRIPTION

[0027] The present invention is further described in detail below in conjunction with the embodiments:

[0028] Example 1

[0029] Take 150g of Radix Isatidis, 100g of Herba Forsythiae, 150g of Herba Patchouli, 75g of Herba Lonicerae, 150g of Herba Chrysanthemi Indici, 80g of Herba Chrysanthemi Indici, 150g of Herba Cibotii, 50g of Herba Glycyrrhizae, and 150g of Herba Cynomorii, and start the preparation: 1. Add water to the Radix Isatidis, Herba Pyrophili, Herba Forsythiae, Herba Patchouli, Herba Chrysanthemi Indici, 150g of Herba Cynomorii, and soften the herbs. Boil until boiling and add Herba Lonicerae for 1 hour, and take the medicinal liquid; 2. Decoction again for 40 minutes, take the medicinal solution, and combine it with the medicinal solution in step 1; 3. Concentrate to a clear paste with a relative density of 1.03-1.08, add ethanol to make the alcohol content reach 65%, and let it stand for 48 hours; 4. Take the supernatant, filter, recover ethanol from the filtrate, concentrate to an extract with a relative density of about 1.04, add 110g of sucrose, stir to dissolve, filter, add water to 1000ml, fill, sterilize, and obtain this product.

[0030] In this oral liquid, Forsythia suspensa, Citron and Honeysuckle are important medicines. As quality control materials, the efficacy of these three substances in this oral liquid is identified.

[0031]

Identification

[0032] (2) Take 60 ml of this product, evaporate it on a water bath, add 5 ml of methanol to the residue to dissolve it, filter it, and use the filtrate as the test solution. Take another 1 g of honeysuckle control medicinal material, add 10 ml of methanol, ultrasonically treat it for 20 minutes, filter it, and concentrate the filtrate to 1 ml as the control medicinal material solution. Take the chlorogenic acid reference substance again, add methanol to make a solution containing 1 mg per 1 ml, as the reference substance solution. According to the thin layer chromatography method (General Rules 0502 of the 2015 edition of the Chinese Pharmacopoeia), take 10 μl of each of the above three solutions and spot them on the same silica gel g thin layer plate, use the upper layer solution of butyl acetate-formic acid-water (14:5:5) as the developing agent, develop it, take it out, dry it, and examine it under ultraviolet light (365 nm). In the chromatogram of the test product, fluorescent spots of the same color appear at the corresponding positions of the chromatogram of the control medicinal material and the chromatogram of the reference substance. Conclusion: This product contains the active ingredient of honeysuckle.

[0033] (3) Take 60 ml of this product, evaporate it on a water bath, add 10 ml of ethanol to the residue, treat it with ultrasound for 20 minutes, filter, evaporate the filtrate to dryness, and add 0.5 ml of ethanol to the residue to dissolve it, which is used as the test solution. Take another 1 g of the reference medicinal material of bergamot, and prepare the reference medicinal material solution in the same way starting from "add 10 ml of ethanol". According to the thin layer chromatography method (General Rules 0502 of the 2015 edition of the Chinese Pharmacopoeia), take 10 μl of each of the above solutions and spot them on the same silica gel g thin layer plate, use cyclohexane-ethyl acetate (3:1) as the developing solvent, develop, take out, dry, and examine under ultraviolet light (365 nm). In the chromatogram of the test product, at the corresponding position of the chromatogram of the reference medicinal material, a fluorescent spot of the same color appears. Conclusion: This product contains the active ingredient of bergamot.

[0034] At the same time, the pH value of this product is determined to be within the effective range of 4-6.

[0035] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. An oral liquid for clearing away heat and reducing swelling, characterized in that: The invention comprises 120-180 parts of isatis root, 80-120 parts of ophiopogon, 120-180 parts of forsythia, 60-80 parts of patchouli, 120-180 parts of honeysuckle, 65-90 parts of wild chrysanthemum, 120-180 parts of citron, 30-80 parts of liquorice and 120-180 parts of cyrtomium wilfordii.

2. The oral liquid for clearing heat and reducing swelling according to claim 1, characterized in that: The weight ratio of Radix Isatidis should be between 12% and 18%.

3. The oral liquid for clearing heat and reducing swelling according to claim 1, characterized in that: The total weight ratio of the forsythia, honeysuckle, wild chrysanthemum and Cyperus rotundus should account for 42%-48%.

4. The oral liquid for clearing heat and reducing swelling according to claim 1, characterized in that: The invention comprises 150 parts of Radix Isatidis, 100 parts of Rhizoma Dioscoreae, 150 parts of Fructus Forsythiae, 75 parts of Pogostemon Cablin, 150 parts of Flos Lonicerae, 80 parts of Flos Chrysanthemi Indici, 150 parts of Citron, 50 parts of Radix Glycyrrhizae, and 150 parts of Rhizoma Cyrthospermi.

5. A method for preparing a heat-clearing and swelling-removing oral liquid, characterized in that: The following steps are involved:

1. Add water to soften the Radix Isatidis, Fructus Forsythiae, Flos Chrysanthemi Indici, Rhizoma Cynomorii, Fructus Cibotii, Fructus Patchouli, Fructus Dioscoreae, and Radix Glycyrrhizae, boil until boiling, add Flos Lonicerae, and boil for 1 hour to obtain the medicinal liquid; 2. Boil again for 40 minutes, obtain the medicinal liquid, and combine it with the medicinal liquid in step 1; 3. Concentrate to a clear paste with a relative density of 1.03 to 1.08, add ethanol to make the alcohol content reach 65%, and let stand for 48 hours; 4. Take the supernatant, filter, recover ethanol from the filtrate, concentrate to an extract with a relative density of 1.04, add 110 parts of sucrose, stir to dissolve, filter, add water to 1000 ml, fill, and sterilize.

6. The method for preparing a heat-clearing and swelling-removing oral liquid according to claim 5, characterized in that: The relative density is measured at 40°C.

7. The method for preparing a heat-clearing and swelling-removing oral liquid according to claim 5, characterized in that: The pH value of this product is 4-6.