Synergistic anti-wrinkle, firming and anti-inflammatory composition as well as preparation method and application thereof

Abstract

The invention discloses a synergistic anti-wrinkle, firming and anti-inflammatory composition as well as a preparation method and application thereof, and relates to the technical field of daily chemical products. The synergistic anti-wrinkle, firming and anti-inflammatory composition comprises the following components: a rambutan peel extract, a roxburgh rose fruit extract and a kangaroo claw extract. According to the synergistic anti-wrinkle, firming and anti-inflammatory composition and the preparation method and application thereof, the composition has a powerful anti-aging effect, after the rambutan peel extract, the kangaroo claw extract and the rosa roxburghii tratt fruit extract are compounded, the anti-aging and anti-inflammatory synergistic effect can be achieved, and the anti-wrinkle, firming and anti-inflammatory effects are achieved. And compared with any component independently used or a combination of two components, the composition has stronger anti-aging and anti-inflammatory effects.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemical products, and in particular to a synergistic anti-wrinkle, firming and anti-inflammatory composition, a preparation method and application thereof. Background Art

[0002] Collagen is the main structural protein of the skin, accounting for more than 70% of the skin. It supports the structure of the skin like a scaffold, keeping the skin elastic, firm and smooth. As we age, the synthesis of collagen in the body decreases year by year, about 1%-2% per year. After the age of 40, the loss of collagen accelerates, which causes the skin to lose its original firmness and elasticity, which is also an important factor leading to skin aging.

[0003] There are 29 types of collagen discovered so far, of which type I is the most abundant, accounting for about 80%-90% of the entire collagen. Type I collagen in the skin plays a role in shaping and supporting the skin and maintaining its thickness. By supplementing type I collagen to rebuild the collagen scaffold, fill the skin, promote collagen regeneration, restore skin elasticity, and effectively improve skin depression, looseness, and sagging.

[0004] As we age, the number, structure, and functional efficiency of mitochondria, the autonomous organelles that provide energy to cells, will be significantly reduced, damaged, or decreased, resulting in a serious lack of ATP production in cells, which in turn blocks normal physiological activities such as protein synthesis and DNA repair in cells, leading to cell aging and even death. Therefore, providing energy to cells to maintain their normal functions is also important for preventing skin aging.

[0005] Kangaroo paw extract improves the mechanical properties of the skin by promoting the production of tenascin-X, collagen and elastin in a multi-targeted manner. It is rich in fructose and fructose derivatives, which can promote the production of collagen precursor I, collagen XVII and tenascin-X.

[0006] Rosa roxburghii fruit extract is rich in vitamin C derivatives, polyphenols and other substances, and has excellent anti-inflammatory and antioxidant capabilities. Rosa roxburghii fruit extract can inhibit the release of damage-associated molecular patterns (DAMPs) induced by ultraviolet damage, prevent further activation of cells near damaged cells, and inhibit the production of inflammatory factor IL-8.

[0007] Rambutan peel extract contains polyphenols and carbohydrates, which can provide energy to keratinocytes, maintain the energy supply system, promote the synthesis of phospholipids and ceramides (including long-chain ceramides), optimize barrier function, enhance the skin's water-locking ability, and thus increase the skin's water content.

[0008] Many existing technologies achieve skin anti-aging by compounding multiple plant extracts. Chinese patent CN110123724A achieves the goal of delaying aging by combining multiple raw materials including sea buckthorn fruit extract to scavenge free radicals, but only evaluates the elasticity and wrinkle improvement effects through consumer questionnaires, and does not further study the anti-wrinkle and firming mechanism of the raw materials used. At the same time, it does not study the synergistic effect between the raw material combinations, nor does it provide a synergistic anti-wrinkle, firming and anti-inflammatory strong efficacy composition. Summary of the invention

[0009] In order to solve the above technical problems, the present invention provides a synergistic anti-wrinkle, firming and anti-inflammatory composition and a preparation method and application thereof.

[0010] The specific technical solutions include the following:

[0011] In a first aspect, a synergistic anti-wrinkle, firming and anti-inflammatory composition is provided, comprising the following components: rambutan (NEPHELIUM LAPPACEUM) peel extract, roxburghii (ROSA ROXBURGHII) fruit extract and kangaroo paw (ANIGOZANTHOS FLAVIDUS) extract.

[0012] The rambutan peel extract is from BASF's product Nephydrat. Rambutan is an evergreen tree of the Sapindaceae family. Rambutan peel extract is taken from the plant shell and is rich in 20-40% polyphenols and carbohydrates, including corilagin and geraniin.

[0013] The rosa roxburghii fruit extract is a product of IZAYOI produced by Ichimaru Co., Ltd. of Japan. The rosa roxburghii fruit is the fruit of the Rosa roxburghii flower, a specialty of the Yunnan-Guizhou Plateau of China.

[0014] The kangaroo paw (ANIGOZANTHOS FLAVIDUS) extract is a product of LUCAS MEYER, France, under the trade name SKINECTURA. Kangaroo paw flower is a perennial evergreen herbaceous plant under the genus ANIGOZANTHOS FLAVIDUS of the family Sanguiniaceae. It is a rare flower native to Western Australia. Its name comes from the fact that the shape of the flower is very similar to the curved front paw of a kangaroo. The kangaroo paw extract uses the flower and stem as the active ingredient extraction site.

[0015] Furthermore, the synergistic anti-wrinkle, firming and anti-inflammatory composition is composed of the following components in weight percentage: 0.01%-2% of rambutan peel extract, 0.02%-3% of roxburghii fruit extract, 0.05%-3% of kangaroo paw extract, and the balance is deionized water.

[0016] Furthermore, the synergistic anti-wrinkle, firming and anti-inflammatory composition is composed of the following components in weight percentage: 0.02%-1% rambutan peel extract, 0.05%-2.0% roxburghii fruit extract, 0.1%-2.0% kangaroo paw extract, and the balance is deionized water.

[0017] Furthermore, the rambutan peel extract accounts for 0.05%-0.5% by weight of the synergistic anti-wrinkle, firming and anti-inflammatory composition.

[0018] Furthermore, the weight percentage of the rosa roxburghii fruit extract in the synergistic anti-wrinkle, firming and anti-inflammatory composition is 0.1%-1%.

[0019] Furthermore, the kangaroo paw extract accounts for 0.5%-1% by weight of the synergistic anti-wrinkle, firming and anti-inflammatory composition.

[0020] In a second aspect, a method for preparing the synergistic anti-wrinkle, firming and anti-inflammatory composition as described in the first aspect is provided, comprising the following steps: sequentially adding rambutan peel extract, kangaroo paw extract and roxburghii fruit extract to deionized water, and stirring evenly to obtain the synergistic anti-wrinkle, firming and anti-inflammatory composition.

[0021] In a third aspect, there is provided use of the synergistic anti-wrinkle, firming and anti-inflammatory composition as described in the first aspect in the preparation of cosmetics or personal care products.

[0022] In a fourth aspect, a cosmetic is provided, comprising the synergistic anti-wrinkle, firming and anti-inflammatory composition as described in the first aspect and a pH regulator.

[0023] Preferably, the pH regulator accounts for 0.002%-0.2% by weight of the cosmetic.

[0024] Furthermore, the pH regulator is one or more of citric acid, sodium citrate, arginine, triethanolamine, sodium hydroxide, potassium hydroxide, hydrochloric acid, phosphate buffered saline, and hydroxyethylpiperazineethane sulfonic acid.

[0025] The cosmetics also include one or more of emollients, emulsifiers, moisturizers, skin conditioners, preservatives, and thickeners.

[0026] Among them, the emollient is selected from one or more of cetearyl alcohol, dimethicone, caprylic / capric triglyceride, avocado tree (BUTYROSPERMUM PARKII) fruit butter, isononyl isononanoate, jojoba (SIMMONDSIA CHINENSIS) seed oil, phytosteryl / octyldodecanol lauroyl glutamate, macadamia (MACADAMIA TERNIFOLIA) seed oil, squalane, diisostearyl malate, and phytosteryl macadamia oleate.

[0027] The emulsifier is selected from one or more of glyceryl stearate, PEG-100 stearate, cetearyl glucoside, coconut glucoside, hydrogenated lecithin, behenyl alcohol, polyglyceryl-10 stearate, potassium cetyl phosphate, sodium stearoyl glutamate, polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate, and batyl alcohol.

[0028] The moisturizer is selected from one or more of glycerin, butylene glycol, 1,3-propylene glycol, methylpropylene glycol, 1,2-hexanediol, caprylyl glycol, panthenol, ethylhexylglycerin, pentylene glycol, glyceryl polyether-26, dipropylene glycol, polyethylene glycol-32, polyethylene glycol-8, and PPG-10 methyl glucose ether.

[0029] The skin conditioning agent is selected from one or more of p-hydroxyacetophenone, sodium hyaluronate, β-glucan, polyglutamic acid, inositol, tremella polysaccharide, carbohydrate isomers, dipotassium glycyrrhizinate, bisabolol, allantoin, niacinamide, tranexamic acid, carnosine, decarboxylated carnosine hydrochloride, water-soluble proteoglycan, acetyl hexapeptide-8, trehalose, ascorbyl glucoside, ubiquinone, sodium DNA, tocopherol acetate, xylitol glucoside, and xylitol.

[0030] The preservative is selected from one or more of phenoxyethanol, methylparaben, and o-cymene-5-ol.

[0031] The thickener is selected from one or more of hydroxyethyl cellulose, cellulose, carbomer, xanthan gum, gum arabic, acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer, polyacrylate crosspolymer-6, sodium acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, and hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer.

[0032] In a fifth aspect, a method for preparing the cosmetics as described in the fourth aspect is provided, comprising the following steps: sequentially adding a synergistic anti-wrinkle, firming and anti-inflammatory composition and a pH adjuster, adjusting the pH to 4-7, and preparing the cosmetics.

[0033] Preferably, the pH is adjusted to 4-6.

[0034] More preferably, the pH is adjusted to 5-6.

[0035] Among them, the pH regulator in the cosmetics can improve the stability of the synergistic anti-wrinkle, firming and anti-inflammatory composition.

[0036] The beneficial effects of the present invention are:

[0037] The invention provides a synergistic anti-wrinkle, firming and anti-inflammatory composition and a preparation method and application thereof. The composition has a strong anti-aging effect. After rambutan (NEPHELIUM lappaceum) peel extract, kangaroo paw (ANIGOZANTHOS FLAVIDUS) extract and rosa roxburghii (ROSA roxburghii) fruit extract are compounded, anti-aging and anti-inflammatory synergistic effects can be obtained, and the anti-aging and anti-inflammatory effects are stronger than those of using any component alone or the components in combination of two. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying any creative work.

[0039] Figure 1 The anti-wrinkle and firming efficacy test results of Example 1 and Comparative Examples 1-4 of the present invention;

[0040] Figure 2 The anti-wrinkle and firming efficacy test results of Example 2 and Comparative Examples 5-9 of the present invention;

[0041] Figure 3 These are the anti-inflammatory efficacy test results of Example 3 and Comparative Examples 10-14 of the present invention. DETAILED DESCRIPTION

[0042] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0043] It should be understood that when used in this specification and the appended claims, the terms "include" and "comprises" indicate the presence of described features, integers, steps, operations, elements and / or components, but do not exclude the presence or addition of one or more other features, integers, steps, operations, elements, components and / or combinations thereof.

[0044] It should also be understood that the terms used in this specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. As used in the specification of the present invention and the appended claims, unless the context clearly indicates otherwise, the singular forms "a", "an" and "the" are intended to include plural forms.

[0045] It should be further understood that the term "and / or" used in the present description and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes these combinations.

[0046] In order to more fully understand the technical content of the present invention, the technical solution of the present invention is further introduced and illustrated in conjunction with specific embodiments below.

[0047] The rambutan (NEPHELIUM LAPPACEUM) peel extract in this embodiment and the comparative example is a product of BASF with the trade name of Nephydrat, the roxburghii (Rosa roxburghii) fruit extract is a product of IZAYOI (Ichimaru Co., Ltd., Japan), and the kangaroo paw (ANIGOZANTHOS FLAVIDUS) extract is a product of LUCAS MEYER Co., Ltd., France with the trade name of SKINECTURA.

[0048] Example 1

[0049] A synergistic anti-wrinkle, firming and anti-inflammatory composition is composed of the following components in percentage by weight: 0.1% of rambutan peel extract, 1% of roxburghii fruit extract, 1% of kangaroo paw extract, and the balance of deionized water.

[0050] The preparation method of the synergistic anti-wrinkle, firming and anti-inflammatory composition comprises the following steps: sequentially adding rambutan peel extract, kangaroo paw extract and roxburghii fruit extract into deionized water and stirring evenly to obtain the synergistic anti-wrinkle, firming and anti-inflammatory composition of Example 1.

[0051] Example 2

[0052] A synergistic anti-wrinkle, firming and anti-inflammatory composition is composed of the following components in percentage by weight: 0.2% of rambutan peel extract, 1% of roxburghii fruit extract, 2% of kangaroo paw extract, and the balance of deionized water.

[0053] Example 3

[0054] A synergistic anti-wrinkle, firming and anti-inflammatory composition is composed of the following components in percentage by weight: 0.05% of rambutan peel extract, 0.5% of roxburghii fruit extract, 0.5% of kangaroo paw extract, and the balance of deionized water.

[0055] Comparative Example 1

[0056] Compared with Example 1, the difference is that there is no roxburghii fruit extract, and the other conditions are the same.

[0057] Comparative Example 2

[0058] Compared with Example 1, the difference is that no rambutan peel extract is included, and other conditions are the same.

[0059] Comparative Example 3

[0060] Compared with Example 1, the difference lies in the use of the roxburghii fruit extract and the rambutan peel extract, and the other conditions are the same.

[0061] Comparative Example 4

[0062] Compared with Example 1, the difference is that there is no kangaroo paw extract and roxburghii fruit extract, and the other conditions are the same.

[0063] Comparative Example 5

[0064] Compared with Example 2, the difference lies in the weight percentage of the rambutan peel extract, and the other conditions are the same.

[0065] Comparative Example 6

[0066] Compared with Example 2, the difference lies in the weight percentage of the roxburghii fruit extract, and the other conditions are the same.

[0067] Comparative Example 7

[0068] Compared with Example 2, the difference lies in the weight percentage of the kangaroo paw extract, and the other conditions are the same.

[0069] Comparative Example 8

[0070] Compared with Example 2, the difference lies in the weight percentages of the kangaroo paw extract, the rambutan peel extract and the roxburghii fruit extract, and the other conditions are the same.

[0071] Comparative Example 9

[0072] Compared with Example 2, the difference is that 0.001% by weight of NAD is used instead of 2% by weight of kangaroo paw extract, and the other conditions are the same.

[0073] Comparative Example 10

[0074] Compared with Example 3, the difference is that there is no rambutan peel extract, and the other conditions are the same.

[0075] Comparative Example 11

[0076] Compared with Example 3, the difference is that there is no kangaroo paw extract, and the other conditions are the same.

[0077] Comparative Example 12

[0078] Compared with Example 3, the difference is that there is no kangaroo paw extract and rambutan peel extract, and the other conditions are the same.

[0079] Comparative Example 13

[0080] Compared with Example 3, the difference lies in the use of the roxburghii fruit extract and the rambutan peel extract, and the other conditions are the same.

[0081] Comparative Example 14

[0082] Compared with Example 3, the difference lies in the use of the roxburghii fruit extract and the kangaroo paw extract, and the other conditions are the same.

[0083] The preparation methods of the synergistic anti-wrinkle, firming and anti-inflammatory compositions of Examples 2-3 and Comparative Examples 1-14 are the same as that of Example 1.

[0084] Performance Testing

[0085] 1. Anti-wrinkle and firming efficacy test - Determination of promoting the production of type Ⅰ collagen

[0086] Experimental principle:

[0087] Specific anti-human type I collagen antibodies are pre-coated on high-affinity microplates. Specimens or standards and samples to be tested are added to the microplates in sequence. After incubation, the human type I collagen in the sample binds to the solid-phase antibody. After washing to remove unbound substances, biotinylated anti-ColⅠ antibodies are added for incubation and binding. After washing, enzyme conjugates (HRP-labeled avidin) are added for incubation and binding. After bottom washing, the color developing substrate TMB is added and color is developed in the dark. TMB is converted into blue under the catalysis of peroxidase and into the final yellow under the action of acid. The depth of color is proportional to the concentration of human type I collagen in the sample. Add the stop solution to terminate the reaction, measure the absorbance (OD value) at a wavelength of 450nm using an enzyme reader, and calculate the sample concentration.

[0088] Test method:

[0089] 1) After the cells were cultured for 24 hours, the sample to be tested (DMEM / F12 containing 10% FBS) was added and incubated with the cells for 48 hours.

[0090] 2) Separate the cell culture supernatant and use it in experiments immediately, or store it at -20℃ or -80℃ after packaging.

[0091] 3) Prepare washing working solution, antibody working solution and enzyme-labeled avidin working solution separately for later use.

[0092] 4) Treat the cell culture supernatant and measure the type I collagen concentration in each standard well and the sample well using an ELISA reader.

[0093] 2. Anti-inflammatory efficacy test

[0094] Experimental principle:

[0095] UVB (ultraviolet B) is the shorter wavelength part of ultraviolet light, which can penetrate the surface of the skin and induce inflammatory responses in skin cells. After UVB irradiation, skin cells (such as keratinocytes, fibroblasts, etc.) will release a variety of inflammatory factors, such as IL-6, which increases significantly, exacerbating the inflammatory response; the experiment uses a UVB-induced inflammation model of HaCaT cells to screen for composite objects with anti-inflammatory effects. RT-qPCR (real-time fluorescence quantitative PCR) is a technology used to quantitatively detect gene expression levels. Total RNA is extracted from cell or tissue samples, protein and DNA impurities are removed, and RNA is transcribed into cDNA using reverse transcriptase (such as SuperScript III). In the DNA amplification reaction, the total amount of product after each PCR cycle is measured by fluorescent chemicals. In the UVB-induced HaCaT cell model, the gene level of IL-6 can be detected by RT-qPCR technology, thereby evaluating the degree of inflammatory response and the anti-inflammatory effect of the test sample.

[0096] Test method:

[0097] 1) After HaCaT cells were cultured for 24 hours, UVB exposure was performed to establish the model

[0098] 2) After irradiation, add the sample to be tested (DMEM with 10% FBS) and incubate for 24 hours

[0099] 3) Collect cells for RNA extraction

[0100] 4) Reverse transcribe the extracted RNA into cDNA, and then perform qPCR to detect gene expression levels

[0101] The synergistic anti-wrinkle, firming and anti-inflammatory compositions of Examples 1-2 and Comparative Examples 1-9 were tested for their anti-wrinkle and firming efficacy. The test results are shown in Table 1:

[0102] Table 1 Anti-wrinkle and firming efficacy test results of Examples 1-2 and Comparative Examples 1-9

[0103]

[0104]

[0105] in, Figure 1 The anti-wrinkle and firming efficacy test results of Example 1 and Comparative Examples 1-4 of the present invention; Figure 2The anti-wrinkle and firming efficacy test results of Example 2 and Comparative Examples 5-9 of the present invention are shown in FIG. Figure 1 and Figure 2 The “*” in the table represents a significant difference compared with the blank control group, “*” represents 0.01≤P<0.05 (significance), “**” represents 0.001≤P<0.01 (extremely significant), “***” represents 0.0001≤P<0.001 (extremely significant), and “#” represents a significant difference compared with the comparative example.

[0106] from Figure 1-Figure 2 As can be seen from the test results of Table 1, the synergistic anti-wrinkle, firming and anti-inflammatory compositions (Comparative Examples 1-2) prepared by lacking one component and the synergistic anti-wrinkle, firming and anti-inflammatory compositions (Comparative Examples 3-4) prepared by lacking multiple components have poor effects. In addition, the synergistic anti-wrinkle, firming and anti-inflammatory compositions prepared by lacking multiple components have worse effects than the synergistic anti-wrinkle, firming and anti-inflammatory compositions prepared by lacking a single component. It can be seen that the present invention is to obtain anti-aging synergistic synergistic effects by compounding rambutan (NEPHELIUM LAPPACEUM) peel extract, kangaroo claw (ANIGOZANTHOS FLAVIDUS) extract, and rosa roxburghii (ROSA ROXBURGHII) fruit extract. In addition, the synergistic anti-wrinkle, firming and anti-inflammatory compositions (Comparative Examples 5-8) prepared by components not within the percentage content range specified in the present invention have poor effects. If other components are used to replace the components in the embodiments of the present invention to prepare a synergistic anti-wrinkle, firming and anti-inflammatory composition (Comparative Example 9), its effect is poor. It can be seen that the present invention also obtains a synergistic anti-aging effect by compounding the rambutan (NEPHELIUM lappaceum) peel extract, the kangaroo paw (ANIGOZANTHOS FLAVIDUS) extract, and the roxburghii (ROSA ROXBURGHII) fruit extract in a specific ratio.

[0107] The synergistic anti-wrinkle, firming and anti-inflammatory compositions of Example 3 and Comparative Examples 10-14 were tested for anti-inflammatory efficacy. The test results are shown in Table 2:

[0108] Table 2 Anti-inflammatory efficacy test results of Example 3 and Comparative Examples 10-14

[0109]

[0110] Figure 3 The anti-inflammatory efficacy test results of Example 3 and Comparative Examples 10-14 of the present invention are shown in FIG. Figure 3The “*” in the table represents a significant difference compared with the blank control group, “*” represents 0.01≤P<0.05 (significance), “**” represents 0.001≤P<0.01 (extremely significant), “***” represents 0.0001≤P<0.001 (extremely significant), and “#” represents a significant difference compared with the comparative example.

[0111] from Figure 3 As can be seen from the test results in Table 2, the synergistic anti-wrinkle, firming and anti-inflammatory compositions (Comparative Examples 10-14) prepared without one or more components have poor effects. It can be seen that the present invention can obtain a synergistic anti-inflammatory effect by compounding rambutan (NEPHELIUM LAPPACEUM) peel extract, kangaroo paw (ANIGOZANTHOS FLAVIDUS) extract and rosarox burghii (Rosa roxburghii) fruit extract.

[0112] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can easily think of various equivalent modifications or replacements within the technical scope disclosed by the present invention, and these modifications or replacements should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention shall be based on the protection scope of the claims.

Claims

1. A synergistic anti-wrinkle, firming and anti-inflammatory composition, characterized in that: Includes the following ingredients: Rambutan peel extract, Rosa roxburghii fruit extract and Kangaroo Paw extract.

2. The synergistic anti-wrinkle, firming and anti-inflammatory composition according to claim 1, characterized in that: The invention is composed of the following components in percentage by weight: 0.01-2% of rambutan peel extract, 0.02%-3% of roxburghii fruit extract, 0.05%-3% of kangaroo paw extract, and the balance is deionized water.

3. The synergistic anti-wrinkle, firming and anti-inflammatory composition according to claim 2, characterized in that: The invention is composed of the following components in percentage by weight: 0.02%-1% of rambutan peel extract, 0.05%-2.0% of roxburghii fruit extract, 0.1%-2.0% of kangaroo paw extract, and the balance of deionized water.

4. The synergistic anti-wrinkle, firming and anti-inflammatory composition according to claim 3, characterized in that: The weight percentage of the rambutan peel extract in the synergistic anti-wrinkle, firming and anti-inflammatory composition is 0.05%-0.5%.

5. The synergistic anti-wrinkle, firming and anti-inflammatory composition according to claim 3, characterized in that: The weight percentage of the roxburghii fruit extract in the synergistic anti-wrinkle, firming and anti-inflammatory composition is 0.1%-1%.

6. The synergistic anti-wrinkle, firming and anti-inflammatory composition according to claim 3, characterized in that: The weight percentage of the kangaroo paw extract in the synergistic anti-wrinkle, firming and anti-inflammatory composition is 0.5%-1%.

7. The method for preparing the synergistic anti-wrinkle, firming and anti-inflammatory composition according to any one of claims 1 to 6, characterized in that: The following steps are involved: Add rambutan peel extract, kangaroo paw extract and roxburghii fruit extract to deionized water in sequence and stir evenly to obtain a synergistic anti-wrinkle, firming and anti-inflammatory composition.

8. Use of the synergistic anti-wrinkle, firming and anti-inflammatory composition according to any one of claims 1 to 6 in the preparation of cosmetics or personal care products.

9. A cosmetic, characterized in that: The synergistic anti-wrinkle, firming and anti-inflammatory composition comprises the composition described in any one of claims 1 to 6 and a pH regulator.

10. The cosmetic according to claim 9, characterized in that The pH regulator is one or more of citric acid, sodium citrate, arginine, triethanolamine, sodium hydroxide, potassium hydroxide, hydrochloric acid, phosphate buffered saline solution, and hydroxyethylpiperazineethane sulfonic acid.

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