Multiple cosmetic compositions for whitening skin, lightening and / or reducing pigmented spots and uses thereof

Abstract

The present invention relates to a variety of novel cosmetic compositions comprising an extract of sedum aizoon, an extract of dictyopteris ferruginea, an extract of iris burenrena and nicotinamide, useful for improving, in particular, skin, keratin and in particular for reducing and / or removing pigmented spots.

Description

Technical Field

[0001] The present invention relates to a variety of novel cosmetic compositions for improving (especially skin) keratin and in particular for reducing, fading and removing skin pigment spots and pigment marks. The present invention also relates to a skin care method for whitening skin, reducing and / or removing and / or fading pigment spots. Background Art

[0002] Melanin is a pigment that is responsible for the coloration of human skin and hair. Melanogenesis is the process by which melanin is produced by specialized dendritic cells called melanocytes, located beneath or between the basal cells of the epidermis. Melanin produced by melanocytes is then transferred to keratinocytes, the outermost layer of the skin.

[0003] While melanin plays a key role in protecting the skin from harmful UV rays, abnormally high levels of melanin production and accumulation in the skin can lead to hyperpigmentation. The more melanin the melanocytes produce, the darker the skin's pigmentation. This can result in undesirable brown pigmented spots such as age spots, freckles, liver spots, melasma, vitiligo, or post-inflammatory hyperpigmentation caused by abrasions, burns, wounds, or dermatitis.

[0004] Many factors can lead to increased melanin production, which causes skin pigmentation. These factors can be related to the natural aging process and genetic influences, or they can be related to environmental factors such as exposure to ultraviolet (UV) light from the sun, inflammation, acne, stress, hormonal changes or pollution.

[0005] Although generally harmless, pigmentation on the skin, especially on the face, is often considered unsightly.

[0006] It is understood that various skin whitening agents that inhibit melanin production can prevent skin pigmentation or lighten pigment spots.

[0007] These whitening agents are mainly hydroquinone and its derivatives (such as arbutin and deoxyarbutin), ascorbic acid, kojic acid, azelaic acid, polyphenols (such as resveratrol) and isoflavones (such as glabridin). However, some of these whitening agents (such as hydroquinone), although effective, are known to cause melanocyte cytotoxicity and increase skin pigmentation. In addition, kojic acid and its derivatives have the disadvantage of being somewhat toxic and cannot be used in high doses in consumer products. In addition, in some cases, the use of these whitening agents may not be effective for people with severe pigmentation, freckles or age spots. In addition, these active ingredients will only have an effect after several weeks of continuous use, and, for toxicological reasons, the use of products containing certain active ingredients for too long may sometimes be unacceptable.

[0008] There are also some whitening agents, such as soybean extract and niacinamide and its derivatives, which are believed to improve skin appearance and reduce pigmentation by regulating the process of melanocyte transfer of melanin to keratinocytes. However, the effectiveness of these whitening agents still needs to be improved.

[0009] Patent No. EP2522331 provides a cosmetic composition consisting of niacinamide and resveratrol.

[0010] Patent No. EP3791932 provides a cosmetic composition comprising sclareolide, kojic acid and ascorbyl glucoside.

[0011] Patent No. FR3056106 provides a composition containing extracts of Dictyopsis ferns. Patents FR2926220 and FR3070864 provide cosmetic compositions containing extracts of Narcissus sutchuenensis.

[0012] The prior art also provides a composition consisting of a sea daffodil extract and a fern-like tricholoma extract, or a combination of a sea daffodil extract, a fern-like tricholoma extract and niacinamide.

[0013] Although the prior art provides skin lightening agents and compositions, there remains a need for new compositions that are safer, better tolerated by the skin, and more effective for whitening and reducing pigmentation.

[0014] Furthermore, there is a need for new compositions that are non-toxic, relatively inexpensive, and preferably of natural origin.

[0015] Applicants have discovered that the combination of Dictyoptera extract, Iris florentina extract and niacinamide has a surprising effect on whitening and / or improving keratinization, especially of the skin, and reducing and / or eliminating pigmentation imperfections associated with the blotchy appearance of the skin.

[0016] The applicant has also developed a novel cosmetic composition, which comprises at least one whitening agent combination, which comprises a fern-like clematis extract, niacinamide, a sea daffodil extract and a Florentine iris extract. It is observed that these preparations act synergistically and have significant whitening, lightening and even skin tone effects, especially this combination is used for a short time and has significant effects.

[0017] The composition of the present invention is mainly composed of plant extracts, and thus has the advantages of being easy to industrialize, easy to formulate, and very stable. In addition, the various compounds used are also easily available and extracted from renewable resources, so the cosmetic composition can be produced according to the principle of sustainable development. Summary of the invention

[0018] The present invention relates to a cosmetic composition, which comprises at least:

[0019] • Sea daffodil extract,

[0020] • Dictyophora fern extract,

[0021] • Florentine iris extract,

[0022] • Niacinamide.

[0023] In addition, the present invention also relates to a non-therapeutic cosmetic use of a composition, wherein the composition comprises at least a Dictyophora fernoides extract, an Iris florentina extract and niacinamide in a cosmetically acceptable carrier, and is used for whitening and / or improving keratin, in particular for whitening and / or brightening the skin.

[0024] In a preferred embodiment for cosmetic use, the composition further comprises at least a sea daffodil extract.

[0025] In a preferred embodiment, the composition comprises 0.001 wt%-0.5 wt% of the Dictyoptera exigua extract based on the total weight of the composition.

[0026] In a preferred embodiment, the composition comprises 0.1 wt%-20 wt% of niacinamide based on the total weight of the composition.

[0027] In a preferred embodiment, the composition comprises 0.0001 wt%-0.5 wt% of the sea daffodil extract based on the total weight of the composition.

[0028] In a preferred embodiment, the composition comprises 0.001 wt%-2 wt% of the iris frondosa extract based on the total weight of the composition.

[0029] In a preferred embodiment, the composition is in the form of an emulsion, preferably an oil-in-water emulsion.

[0030] In a preferred embodiment, the weight ratio of Dictyoptera pteris extract to niacinamide is 0.0001:1 to 0.1:1.

[0031] In a preferred embodiment, the cosmetic use is as follows:

[0032] • Reduce and / or lighten and / or reduce pigmentation spots, and / or

[0033] • Reduce the size of pigmented spots, and / or

[0034] • Even out or brighten skin tone, and / or

[0035] • Improves skin texture and overall appearance.

[0036] In a preferred embodiment, the pigmented spots are age freckles, freckles, melasma or liver spots, or post-inflammatory pigmented spots. DETAILED DESCRIPTION

[0037] The first aspect of the present invention relates to a non-therapeutic cosmetic use of a composition comprising a Dictyophora extract, an Iris florentina extract and niacinamide in a cosmetically acceptable carrier for whitening and / or improving (especially skin) keratin, and reducing and / or removing and / or lightening skin pigmentation spots.

[0038] A second aspect of the present invention relates to a variety of cosmetic compositions for whitening and / or improving (especially skin) keratin, the composition comprising at least:

[0039] • Dictyophora fern extract,

[0040] • Niacinamide,

[0041] • Sea daffodil extract,

[0042] • Florentine iris extract,

[0043] The third aspect of the present invention relates to a method of beauty care, comprising topically applying the composition of the present invention.

[0044] Cosmetic use for whitening and / or improving keratin

[0045] The first aspect of the present invention relates to a cosmetic use of a composition, wherein the composition comprises at least a Dictyophora extract and niacinamide in a cosmetically acceptable carrier, and is used for whitening and / or improving keratin, and reducing and / or removing skin pigmentation spots.

[0046] Preferably, the composition comprises at least Dictyopteris fernifolia extract, Iris florentina extract and niacinamide in a cosmetically acceptable carrier.

[0047] "Keratin" refers primarily to skin, especially body or facial skin, or scalp, nails or hair. Preferably, in the present invention, keratin is skin.

[0048] In this article, the terms "whitening", "lightening" or "depigmentation" are used interchangeably to refer to the process of improving the keratin of the skin (especially the skin) to lighten the natural dark skin color and also to reduce and / or eliminate pigmentation and pigment spots or marks on the skin.

[0049] Pigmented spots are marks on the skin that have more pigment than the adjacent skin and may be the result of a disorder in the production of melanin. These pigmented spots may be age spots, such as senile freckles; they may also be post-inflammatory pigmentation caused by friction, burns, wounds or dermatitis; or they may be caused by ultraviolet radiation, stress, hormonal changes or pollution. Pigmented spots include, but are not limited to, freckles, melasma (also known as liver spots), age-related vitiligo and solar leukoplakia.

[0050] The composition for use according to the invention comprises an extract of Dictyoptera: pteridophyta (also known as membrane fern or sea fern).

[0051] "Dictyoptera fern-like" refers to a perennial brown algae of the family Dictyoptera. This algae grows on rocks in low light conditions in subcoastal and circumcoastal areas. In the Atlantic Ocean, it grows under the leaves of seaweed. This algae is also found in photophilic communities in the southern Mediterranean.

[0052] Preferably, the extract of Dictyoptera fernifolia is a water extract obtained by leaching using a process known to those skilled in the art.

[0053] Advantageously, the composition used according to the present invention comprises 0.001 wt%-0.5 wt% (by weight of active ingredient) of Dictyoptera extract, preferably 0.005 wt%-0.1 wt%, more preferably 0.01 wt%-0.05 wt%, based on the total weight of the composition.

[0054] In the present invention, unless otherwise expressly stated, the expression "between X and Y" includes limit values. Therefore, this expression means that the relevant range includes X, Y and all values ​​from X to Y.

[0055] The cosmetic composition for use according to the present invention also comprises niacinamide.

[0056] Nicotinamide belongs to the B vitamins, also known as vitamin B3 or 3-pyridinecarboxamide (CAS: 98-92-0). Nicotinamide is a biologically active form of niacin and is found in many vegetables, roots and yeast.

[0057] Advantageously, the composition used according to the invention comprises 0.1 wt% to 20 wt% of nicotinamide, preferably 0.2 wt% to 10 wt%, more preferably 1 wt% to 8 wt%, relative to the total weight of the composition.

[0058] Advantageously, in the composition used according to the invention, the weight ratio of the Dictyoptera pteridophyta extract to niacinamide is from 0.0001:1 to 0.1:1, preferably from 0.001:1 to 0.01:1.

[0059] In a preferred embodiment, the composition used according to the present invention further comprises at least one other compound selected from the group consisting of a sea daffodil (also known as sea lily or sand lily) extract, an iris florentina extract and a mixture thereof.

[0060] "Sea daffodil" refers to a perennial bulbous plant of the Amaryllis family. It grows in the warm sandy land along the Mediterranean coast and the coast of southwestern Europe.

[0061] Preferably, the sea daffodil extract is a water extract. The water extract of sea daffodil can be obtained by any extraction process known to those skilled in the art, for example, collecting the plant parts to be extracted, drying and / or freeze-drying, water extraction and filtering the extract.

[0062] Preferably, the sea daffodil extract is taken from the aerial parts of the plant, such as stems, leaves, flowers, fruits and / or seeds, preferably leaves and flowers.

[0063] "Iris florentinae" refers to a rhizome plant with white flowers in the family Iridaceae. Generally, an extract of Iris florentinae is extracted from the root of the plant using an extraction process known to those skilled in the art. Preferably, the extract of Iris florentinae is an aqueous extract.

[0064] In a preferred embodiment, the composition used according to the present invention comprises at least:

[0065] • Dictyophora fern extract,

[0066] • Niacinamide,

[0067] • Sea daffodil extract,

[0068] • Florentine iris extract,

[0069] Advantageously, the cosmetic composition of the present invention comprises 0.0001 wt%-0.5 wt% (by weight of active ingredient) of the sea daffodil extract, preferably 0.0005 wt%-0.05 wt%, more preferably 0.001 wt%-0.02 wt%, based on the total weight of the composition.

[0070] Advantageously, the cosmetic composition of the present invention comprises 0.001 wt%-2 wt% (by weight of active ingredients) of the Florentine Iris extract, preferably 0.005 wt%-1 wt%, more preferably 0.01 wt%-0.5 wt%, based on the total weight of the composition.

[0071] Applicants have found that the above cosmetic composition is particularly effective in the following aspects:

[0072] • Reduce and / or lighten and / or reduce pigmentation spots, especially age spots, age lentigo, freckles, melasma (or liver spots) or post-inflammatory hyperpigmentation spots,

[0073] • Reduce the size of pigmented spots,

[0074] • Whiten and / or brighten the skin,

[0075] • Evens out and brightens skin tone, and / or makes skin glow,

[0076] • Improve skin clarity,

[0077] • Improves the overall appearance of the skin and refines its texture,

[0078] • Reduce signs of skin reactions and / or reduce redness,

[0079] • Keeps skin moisturized for several hours, and / or

[0080] •Reduce and / or soften wrinkles and fine lines.

[0081] "Improving the overall appearance of the skin" means achieving one or more of the following benefits: reducing skin blemishes and / or color imperfections, including even pigmentation; improving the skin's ability to retain moisture and / or protect itself from environmental aggressors; increasing the skin's firmness and / or suppleness.

[0082] The cosmetic composition of the present invention

[0083] The applicant has also found that some of the above compositions for whitening skin are not known in the prior art. The present invention also relates to these novel cosmetic compositions.

[0084] According to a second aspect, the present invention aims to provide a cosmetic composition comprising at least:

[0085] • Dictyophora fern extract,

[0086] • Niacinamide,

[0087] • Sea daffodil extract,

[0088] • Florentine iris extract,

[0089] Advantageously, the cosmetic composition of the present invention comprises 0.001 wt%-0.5 wt% (by weight of active ingredient) of the Dictyoptera exigua extract, preferably 0.005 wt%-0.1 wt%, more preferably 0.01 wt%-0.05 wt%, based on the total weight of the composition.

[0090] Advantageously, the cosmetic composition of the present invention comprises 0.1 wt%-20 wt% of niacinamide, preferably 0.2 wt%-10 wt%, more preferably 1 wt%-8 wt%, based on the total weight of the composition.

[0091] Advantageously, the cosmetic composition of the present invention comprises 0.0001 wt%-0.5 wt% (by weight of active ingredient) of the sea daffodil extract, preferably 0.0005 wt%-0.05 wt%, more preferably 0.001 wt%-0.02 wt%, based on the total weight of the composition.

[0092] Advantageously, the cosmetic composition of the present invention comprises 0.001 wt%-2 wt% (by weight of active ingredients) of the Florentine Iris extract, preferably 0.005 wt%-1 wt%, more preferably 0.01 wt%-0.5 wt%, based on the total weight of the composition.

[0093] The composition for use according to the present invention or the composition according to the present invention may further comprise one or more compounds commonly used in cosmetic formulations, including antioxidants, sunscreens, moisturizers, and the like.

[0094] Advantageously, the composition for use according to the invention or the composition according to the invention further comprises at least one plant-derived compound chosen from witch hazel extract (also known as witch hazel floral water or witch hazel hydroalcohol), chamomile extract, corn cob derivatives (including water-locking magnetite) or mixtures thereof.

[0095] The composition for use according to the present invention or the composition according to the present invention may also include one or more other keratin softening agents known in the prior art, for example: hydroquinone, tretinoin, tranexamic acid, α-hydroxy acid, kojic acid, glutathione, azelaic acid, arbutin, N-acetylglycine, mandelic acid, retinol and combinations thereof.

[0096] In one embodiment, the cosmetic composition of the present invention mainly comprises:

[0097] • Dictyophora fern extract,

[0098] • Niacinamide,

[0099] • Sea daffodil extract,

[0100] • Florentine iris extract,

[0101] •And acceptable carriers for cosmetic products.

[0102] The expression "mainly comprising" followed by one or more characteristics means that the composition may selectively include one or more additional formulation additives, but does not include other cosmetic active substances having whitening effects.

[0103] Acceptable carriers for cosmetics

[0104] Preferably, the composition of the present invention and the composition used according to the present invention further comprises a cosmetically acceptable carrier, which can act as a diluent or dispersant for the above composition.

[0105] "Acceptable for cosmetics" means that it is safe for contact with human skin and preferably does not contain any ingredients that may cause irritation to the skin.

[0106] The acceptable carrier of the cosmetic product may include, but is not limited to, adjuvants commonly used in skin care products, such as solvents, liquid or solid emollients, vegetable oils, paraffin oils, silicone oils, emulsifiers, humectants, thickeners, powders and propellants, fragrances, hydrophilic or lipophilic gelling agents, antioxidants, opacifiers, preservatives, pigments and buffers. The amount of these adjuvants is the conventional amount used in the cosmetic product formulation, for example, 0.01wt%-50wt% of the total weight of the composition.

[0107] Advantageously, the amount of the cosmetically acceptable carrier is 5 wt% to 99.6 wt%, preferably 15 wt% to 98 wt%, more preferably 75 wt% to 95 wt%, based on the total weight of the composition.

[0108] Forms of the cosmetic composition of the present invention

[0109] The composition for use according to the present invention or the composition according to the present invention can be prepared according to methods well known to those skilled in the art of cosmetic formulation, generally including simple steps such as mixing the components and heating.

[0110] Advantageously, the composition for use according to the invention or the composition according to the invention is in the form of an emulsion.

[0111] The emulsion may be an oil-in-water emulsion, a water-in-oil emulsion, a water-in-oil-in-water emulsion, an oil-in-water-in-oil emulsion, or a water-in-silicone oil emulsion.

[0112] The oil phase may include silicone oil, non-silicone oil (such as paraffin), fatty alcohol, fatty acid, fatty acid ester, wax or vegetable oil, or a mixture thereof. The aqueous phase may include water or an aqueous solution of a hydrophilic substance, such as a polyol, α-hydroxy acid, amino acid, protein hydrolyzate, monosaccharide and polysaccharide. The emulsifier may be a surfactant well known to those skilled in the art of beauty care, including nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants.

[0113] In a preferred embodiment, the composition for use according to the present invention or the composition according to the present invention is an oil-in-water emulsion.

[0114] The composition for use according to the invention or the composition according to the invention may be a cream, lotion, foam, oil, serum, gel, micellar water, oil, two-phase composition, milk, encapsulation system or stick preparation.

[0115] In a preferred embodiment, the composition for use according to the present invention or the composition according to the present invention is in the form of a cream or a milk.

[0116] Beauty care process

[0117] Another aspect of the present invention is to provide a non-therapeutic cosmetic method for whitening skin, the method comprising at least one step, namely: topically applying a cosmetically effective amount of a composition to the keratin of a subject (especially the skin), the composition comprising at least a Dictyophora fernis extract and niacinamide.

[0118] Preferably, the cosmetic composition further comprises at least a compound selected from the group consisting of a sea daffodil extract and a Florentine iris extract. Preferably, the cosmetic composition comprises a sea daffodil extract and a Florentine iris extract.

[0119] "Effective amount of cosmetics" refers to the amount of the composition required to achieve the desired whitening effect. Those skilled in the art can determine the amount of the composition used each time according to the skin type of the subject to be treated and the number and intensity of uneven pigmentation to be corrected.

[0120] Preferably, the composition is applied to one or more areas of the skin having pigmentation or pigment spots, such as the face, neck, décolleté, hands, arms, back and / or legs.

[0121] The duration of care can be determined according to the type and intensity of the pigment spots to be reduced and / or removed. For example, the composition of the present invention can be used once, twice or more per day. Typically, care can last for several days (e.g., 5-10 days), several weeks (e.g., 1-6 weeks) or several months (e.g., 1-12 months).

[0122] Example

[0123] The present invention is illustrated by the following non-limiting examples. In the above examples, unless otherwise specified, each component and its percentage are expressed by weight (wt%).

[0124] 1. Active ingredients and cosmetic compositions:

[0125] Element:

[0126] - Sea daffodil extract: available from CODIF under the trade name Neurolight.61G. The product consists of a mixture of water, glycerol and 0.3 wt% active ingredient (based on the total weight of the product).

[0127] - Extract of Dictyopsis fernscens: available from CODIF under the trade name 3M3 Lighteris G. The product consists of a mixture of water, glycerol and 0.9 wt% active ingredient (based on the total weight of the product).

[0128] - Florentine iris extract: available from Silab under the trade name IRIS ISO 0P. The product consists of a mixture of water, butylene glycol and 2.8 wt% active ingredients (based on the total weight of the product),

[0129] - Niacinamide: (CASN° 98-92-0) available from DSM under the trade name Niacinamide PC.

[0130] Composition: Cream

[0131]

[0132] How to prepare facial cream

[0133]

[0134] 2. Evaluation of the Skin Whitening Effect of the Composition

[0135] 2-1-Scheme:

[0136] 18 women and 2 men (aged between 24 and 65 years old, skin phenotypes IV, V and VI) and 21 women (aged between 33 and 67 years old, skin phenotypes I, II and III) were selected to test the composition of the present invention.

[0137] During the test, the composition was applied to the face twice a day to measure the color of skin phenotypes I, II, III and IV, V, VI; the composition was applied to the forearm twice a day to measure its moisturizing effect. The subjects had normal to dry skin with pigmentation spots, fine lines and wrinkles. The subjects used the composition twice a day for 8 weeks. The measurements were taken at the first examination and the results were recorded as D0 results; the measurements were taken at the intermediate examination after 4 weeks and the results were recorded as D28 results for phenotypes I, II and III; the measurements were taken at the final examination after 8 weeks and the results were recorded as D56 results for phenotypes IV, V and VI.

[0138] 2-2- Evaluation of skin tolerance of the composition of the present invention:

[0139] Clinical examinations performed by dermatologists have shown that the compositions according to the invention have very good skin tolerance.

[0140] 2-3) Subjective evaluation of the efficacy of the composition of the present invention by the subjects through a self-assessment questionnaire:

[0141]

[0142] 2-4-Clinical scoring

[0143] The following parameters were scored clinically visually by dermatologists on a scale of 1–9:

[0144] - Skin tone evenness: 1 means uneven skin tone with spots and blemishes; 9 means even skin tone with no spots and blemishes.

[0145] - Skin gloss: 1 means the skin is dull and lackluster; 9 means the skin is radiant and glowing.

[0146] - Skin color transparency: 1 means dark skin with severe pigmentation; 9 means fair skin with light pigmentation. The values ​​measured at D56 were compared with the initial values ​​at D0 using the non-parametric Wilcoxon test (significance: P < 0.05). The results will be quantified and expressed as the mean of statistically significant differences.

[0147] - Spot color intensity: 1 means the spot is very dark and highly pigmented; 9 means the spot is very light and has low pigmentation.

[0148]

[0149] According to the above results, the use of the composition of the present invention for more than 4 weeks can significantly improve the uniformity and transparency of skin color and skin radiance; the effect is even better after 8 weeks of use. The composition of the present invention can also reduce the intensity and size of pigment spots.

[0150] 2-5- Chromaticity evaluation

[0151] The following parameters were evaluated using a CR-400® Colorimeter:

[0152] • Gloss, denoted as “L*”,

[0153] • Yellow-blue hue, denoted as “b*”,

[0154] •Intensity of skin pigmentation, recorded as “ITA°” (Individual Typological Angle).

[0155] The calculation formula of the parameters is as follows:

[0156]

[0157] The values ​​measured at D56 were compared with the initial values ​​at D0 using Student's t-test (significance: P < 0.05). The results will be quantified and expressed as the mean of statistically significant differences.

[0158]

[0159] (1) The average of three consecutive measurements at the same site.

[0160] Based on these results, we can see that after 4 weeks of using the composition, there are statistically significant differences in skin radiance (L*) and pigmentation (ITA°), and after 8 weeks of use, the differences are even greater. An increase in the L* parameter indicates brighter skin, while an increase in the ITA° parameter indicates a whiter complexion.

Claims

1. A cosmetic composition, comprising at least: - Sea daffodil extract, - Dictyophora fern extract, - Florentine Iris Extract, -Niacinamide.

2. The composition according to claim 1, comprising 0.001 wt% to 0.5 wt% of the Dictyoptera extract based on the total weight of the composition.

3. The composition according to claim 1 or 2, comprising 0.1 wt% to 20 wt% of nicotinamide based on the total weight of the composition.

4. A composition according to any one of the preceding claims, comprising 0.0001 wt% to 0.5 wt% of the sea daffodil extract based on the total weight of the composition.

5. A composition according to any one of the preceding claims, comprising 0.001 wt% to 2 wt% of the Iris florentina extract based on the total weight of the composition.

6. A composition according to any preceding claim in the form of an emulsion, preferably an oil-in-water emulsion.

7. A non-therapeutic cosmetic use of a composition, the composition comprising at least a Dictyophora ferns extract, an Iris florentina extract and niacinamide in a cosmetically acceptable carrier, for whitening and / or improving keratin, particularly for whitening and / or brightening the skin.

8. The use according to claim 7, wherein the weight ratio of Dictyoptera pteridophyta extract to niacinamide is 0.0001:1 to 0.1:

1.

9. The use according to claim 7 or 8, for: - Reduce and / or lighten and / or reduce pigmentation spots, and / or - Reduce the size of pigmented spots, and / or - Even out or brighten skin tone, and / or - Improves skin texture and overall appearance.

10. The use according to claim 9, wherein the pigmented spots are age freckles, freckles, chloasma or liver spots, or post-inflammatory pigmented spots.

11. The use according to any one of claims 7 to 10, wherein the composition further comprises a sea daffodil extract.

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