Application of paeoniflorin in preparation of medicine for treating nodular sclerosis

By using paeoniae to inhibit the abnormal proliferation of tuberous sclerosis-related neural stem cells and promote the maturation of new neurons, the problem of lack of long-term effective treatment of tuberous sclerosis in the prior art has been solved, and the effect of significantly improving cognitive function and social behavior has been achieved.

CN119745904AInactive Publication Date: 2025-04-04UNIV OF MACAU
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Patent Information

Application Number
CN202411711718.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-27
Publication Date
2025-04-04
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The prior art lacks long-term effective methods for treating tuberous sclerosis, and most treatments are based on symptoms, with a lack of controlled experiments to prove their effectiveness.

Method used

Using peony glycoside or its pharmaceutically acceptable salts, the abnormal proliferation of adult neural stem cells is inhibited and the maturation of new neurons is promoted by the preparation of drugs to treat and/or prevent genetic intellectual and cognitive dysfunction diseases.

Benefits of technology

Paeoniae significantly inhibits the abnormal proliferation of adult neural stem cells in Tsc1 cKO mice, promotes the maturation of new neurons, corrects cognitive dysfunction, improves spatial memory ability and pattern separation cognitive function defects, and reduces social interaction disorders.

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Abstract

The invention belongs to the technical field of medicine application, discloses application of paeoniflorin in preparation of medicine for treating nodular sclerosis, and particularly discloses application of paeoniflorin or pharmaceutically acceptable salt thereof in preparation of medicine for treating and / or preventing hereditary intelligence and cognitive dysfunction diseases. The new medicinal value of the known compound paeoniflorin is explored, the paeoniflorin is used for treating the hereditary intellectual and cognitive impairment diseases (such as nodular sclerosis) and can be prepared into the medicine for treating the hereditary intellectual and cognitive impairment diseases, and a new application field is developed for application of radix paeoniae alba and radix paeoniae rubra medicinal materials.
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