Extract with antipruritic effect, preparation method of extract and application of extract in preparation of skin care products

Abstract

The invention provides an extract with an antipruritic effect, a preparation method of the extract and application of the extract in preparation of skin care products. Comprising the following components in parts by mass: 12-16 parts of a chrysanthellum indicum extract, 10-14 parts of a pseudo-ginseng extract, 1-4 parts of a purslane extract, 3-8 parts of a tea leaf extract, 5-11 parts of a mint leaf extract, 1-5 parts of a bitter gourd extract, 4-10 parts of a gynura succulent extract, 1-3 parts of an actinidia chinensis extract, 3-7 parts of a panax japonicus extract and 4-9 parts of a soapberry extract. According to the extract prepared by the invention, a plurality of components are compounded and have a synergistic effect, so that the extract has an excellent itching relieving effect.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and in particular relates to an extract with antipruritic effect, a preparation method thereof and application of the extract in preparing skin care products. Background Art

[0002] There are many mosquito repellent products on the market, which provide great help for people to get rid of mosquito troubles. The active ingredients of traditional mosquito repellent sprays are mostly pesticide ingredients. Although pesticide ingredients can achieve the effect of mosquito repellent, they may have strong potential toxic side effects on the human body, especially children. In addition, many products will have some adverse reactions after use, such as rough skin, wound infection, pigmentation, etc., so the research and development of safe and antipruritic products is an urgent need in the current market. Summary of the invention

[0003] The purpose of the present invention is to provide an extract with antipruritic effect and a preparation method thereof and application in the preparation of skin care products.

[0004] In order to achieve the above object, the present invention provides the following technical solutions: An extract with an antipruritic effect comprises the following components in parts by mass: 12-16 parts of golden chamomile extract, 10-14 parts of Panax notoginseng extract, 1-4 parts of Portulaca oleracea extract, 3-8 parts of tea extract, 5-11 parts of mint leaf extract, 1-5 parts of bitter melon extract, 4-10 parts of red vegetable extract, 1-3 parts of Actinidia chinensis extract, 3-7 parts of Panax japonicus extract and 4-9 parts of Sapindus mukorossi extract.

[0005] Furthermore, the preparation method of the Panax notoginseng extract is: (1) Weigh Panax notoginseng, crush and sieve to obtain Panax notoginseng powder, mix 100 parts by mass of Panax notoginseng powder with 600-700 parts by mass of purified water, and sterilize to obtain a dispersion; (2) adding 1-2 parts by weight of Lactobacillus helveticus and the dispersion into a fermentation tank, mixing them evenly, adjusting the pH to 6.2-6.4, and performing anaerobically fermentation at 36-40° C. After the fermentation is completed, sterilizing the fermentation liquid to obtain a fermentation liquid A; (3) adding 1-2 parts by weight of Lactobacillus brevis to fermentation liquid A and mixing evenly, adjusting the pH to 6.2-6.4, performing anaerobically fermentation at 36-40° C., and sterilizing after the fermentation to obtain fermentation liquid B; (4) adding 1-2 parts by weight of Bifidobacterium lactis to the fermentation liquid B and mixing evenly, adjusting the pH to 6.2-6.4, and performing anaerobically fermentation at 36-40° C. After the fermentation is completed, sterilizing treatment is performed to obtain a fermentation liquid C; (5) The fermentation liquid C is centrifuged, the precipitate is discarded, the supernatant is collected, and the supernatant is spray-dried to obtain a Panax notoginseng extract.

[0006] Furthermore, the step (2) is carried out by anaerobic fermentation for 3-5 days.

[0007] Furthermore, the anaerobic fermentation in step (3) is carried out for 2-4 days.

[0008] Furthermore, the step (4) is anaerobic fermented for 1-2 days.

[0009] Furthermore, the preparation method of the golden chamomile extract is: (1) Drying the golden chamomile, crushing it and passing it through a 60-80 mesh sieve to obtain golden chamomile fine powder; (2) First, place the golden chamomile micropowder at a low temperature of -28°C for 2-3 minutes, then rapidly heat it to 25°C within 2 seconds, and repeat 3-4 times; then pressurize it to 14-16MPa, maintain it for 2-3 minutes, then release the pressure to normal pressure, and repeat 2-3 times to obtain the pretreated golden chamomile micropowder; (3) Mixing the pretreated golden chamomile powder and ethanol aqueous solution in a mass ratio of 1:10-12, heating and refluxing for extraction 2-3 times, each extraction for 100-120 minutes, filtering, and combining the filtrate to obtain a golden chamomile crude extract; (4) The crude extract of golden chamomile is subjected to ultrasonic extraction, vacuum filtration, concentration and drying to obtain the golden chamomile extract.

[0010] Furthermore, the power of ultrasonic extraction is 240W-300W; the temperature of ultrasonic extraction is 40-50°C Furthermore, the volume fraction of the ethanol aqueous solution is 60-70%.

[0011] Furthermore, the ultrasonic extraction time is 20-30 minutes.

[0012] The present invention provides a method for preparing the extract with antipruritic effect, comprising the following steps: weighing golden chamomile extract, Panax notoginseng extract, purslane extract, tea extract, mint leaf extract, bitter melon extract, red vegetable extract, Actinidia chinensis extract, Panax japonica extract and Sapindus mukorossi extract according to a proportion, mixing them evenly, and obtaining the extract with antipruritic effect.

[0013] The invention also provides use of the extract with antipruritic effect in preparing skin care products.

[0014] Compared with the prior art, the advantages and beneficial effects of the present invention are as follows: the Panax notoginseng extract prepared by triple bacterial fermentation and the golden chamomile extract prepared by pretreatment and then alcohol extraction are more abundant in active components, and are synergistically compounded with the remaining multiple components, so that the prepared extract has a good antipruritic effect. The Panax notoginseng and golden chamomile extracts prepared by a special process are applied to skin care products, which can bring a series of beneficial effects. Both Panax notoginseng and golden chamomile have soothing and anti-inflammatory effects, and can relieve skin itching caused by allergies, dryness or irritation. The active ingredients in these two extracts can reduce skin inflammation and help treat acne, eczema and other inflammatory skin diseases. Panax notoginseng contains rich notoginseng saponins, which help accelerate skin cell regeneration and repair damaged tissues. Golden chamomile is rich in antioxidants, such as flavonoids, which can help resist free radical damage and slow down the skin aging process. For sensitive skin, the mild nature of these two extracts can help reduce redness and discomfort and enhance the skin barrier function. Certain active ingredients can help the skin lock in moisture and provide a long-term moisturizing effect. When these extracts work synergistically with other active ingredients, their effects in skin care products may be further enhanced. DETAILED DESCRIPTION

[0015] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0016] The strains used in the present invention are: Lactobacillus brevis, with an activity of 10 billion CFU / g. Collection number: SHBCC D14346. Deposited in Shanghai Microbiological Collection Center.

[0017] Lactobacillus acidophilus, bacterial activity 20 billion CFU / g. Collection number: CCTCC AB 2010208. Deposited in China Center for Type Culture Collection.

[0018] Bifidobacterium lactis, with an activity of 10 billion CFU / g. Collection number: SHBCC D24675. Deposited in Shanghai Microbiological Collection Center.

[0019] Lactobacillus casei, with an activity of 10 billion CFU / g. Collection number: SHBCC D24737. Deposited in Shanghai Microbiological Collection Center.

[0020] Lactobacillus helveticus, with an activity of 20 billion CFU / g. Collection number: CCTCC AB 2010205; deposited in China Center for Type Culture Collection.

[0021] Example 1 The present embodiment provides an extract with an antipruritic effect, comprising the following components in parts by mass: 14 parts of golden chamomile extract, 12 parts of Panax notoginseng extract, 3 parts of Portulaca oleracea extract, 5 parts of tea extract, 8 parts of mint leaf extract, 2 parts of bitter melon extract, 7 parts of red vegetable extract, 2 parts of Actinidia chinensis extract, 5 parts of Panax japonica extract and 7 parts of Sapindus mukorossi extract.

[0022] The preparation method of the Panax notoginseng extract is as follows: (1) Weigh Panax notoginseng, crush and sieve to obtain Panax notoginseng powder, mix 100 parts by mass of Panax notoginseng powder with 600 parts by mass of purified water, and sterilize to obtain a dispersion; (2) adding 1 part by weight of Lactobacillus helveticus and the dispersion into a fermentation tank, mixing them evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing the fermentation liquid to obtain a fermentation liquid A; (3) adding 1 part by weight of Lactobacillus brevis to the fermentation liquid A and mixing evenly, adjusting the pH to 6.4, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation liquid B; (4) adding 1 part by weight of Bifidobacterium lactis to the fermentation liquid B and mixing evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation liquid C; (5) The fermentation liquid C is centrifuged, the precipitate is discarded, the supernatant is collected, and the supernatant is spray-dried to obtain a Panax notoginseng extract.

[0023] The step (2) is subjected to anaerobic fermentation for 3 days.

[0024] The step (3) is subjected to anaerobic fermentation for 2 days.

[0025] The step (4) is subjected to anaerobic fermentation for 1 day.

[0026] The preparation method of the golden chamomile extract is: (1) Drying the golden chamomile, crushing it and passing it through a 60-mesh sieve to obtain golden chamomile fine powder; (2) First, place the golden chamomile micropowder at a low temperature of -28°C for 2 minutes, then rapidly heat it to 25°C within 2 seconds, and repeat this process 3 times; then pressurize it to 14 MPa, maintain it for 2 minutes, and then release the pressure to normal pressure, and repeat this process 2 times to obtain the pretreated golden chamomile micropowder; (3) Mix the pretreated golden chamomile powder and ethanol aqueous solution in a mass ratio of 1:10, heat and reflux for extraction twice, each extraction time for 100 min, filter, and combine the filtrate to obtain a golden chamomile crude extract; (4) The crude extract of golden chamomile is subjected to ultrasonic extraction, vacuum filtration, concentration and drying to obtain the golden chamomile extract.

[0027] The power of ultrasonic extraction is 240W; the temperature of ultrasonic extraction is 40℃ The volume fraction of the ethanol aqueous solution is 60%.

[0028] The ultrasonic extraction time was 20 min.

[0029] The preparation method of the extract with antipruritic effect comprises the following steps: weighing golden chamomile extract, Panax notoginseng extract, purslane extract, tea extract, mint leaf extract, bitter melon extract, red vegetable extract, Actinidia chinensis extract, Panax japonica extract and Sapindus mukorossi extract according to a proportion, mixing them evenly, and obtaining the extract with antipruritic effect.

[0030] Example 2 The present embodiment provides an extract with an antipruritic effect, comprising the following components in parts by mass: 16 parts of golden chamomile extract, 14 parts of Panax notoginseng extract, 4 parts of Portulaca oleracea extract, 8 parts of tea extract, 11 parts of mint leaf extract, 5 parts of bitter melon extract, 10 parts of red vegetable extract, 3 parts of Actinidia chinensis extract, 7 parts of Panax japonicus extract and 9 parts of Sapindus mukorossi extract.

[0031] The preparation method of the Panax notoginseng extract is as follows: (1) Weigh Panax notoginseng, crush and sieve to obtain Panax notoginseng powder, mix 100 parts by mass of Panax notoginseng powder with 700 parts by mass of purified water, and sterilize to obtain a dispersion; (2) adding 2 parts by weight of Lactobacillus helveticus and the dispersion into a fermentation tank, mixing them evenly, adjusting the pH to 6.4, and performing anaerobically fermentation at 40° C. After the fermentation is completed, sterilizing the fermentation liquid to obtain a fermentation liquid A; (3) adding 2 parts by weight of Lactobacillus brevis to fermentation broth A and mixing evenly, adjusting the pH to 6.4, and performing anaerobically fermentation at 40° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation broth B; (4) adding 2 parts by weight of Bifidobacterium lactis to the fermentation liquid B and mixing evenly, adjusting the pH to 6.4, and performing anaerobically fermentation at 40° C. After the fermentation is completed, sterilizing treatment is performed to obtain a fermentation liquid C; (5) The fermentation liquid C is centrifuged, the precipitate is discarded, the supernatant is collected, and the supernatant is spray-dried to obtain a Panax notoginseng extract.

[0032] The step (2) is subjected to anaerobic fermentation for 5 days.

[0033] The step (3) is subjected to anaerobic fermentation for 4 days.

[0034] The step (4) is subjected to anaerobic fermentation for 2 days.

[0035] The preparation method of the golden chamomile extract is: (1) Drying the golden chamomile, crushing it and passing it through an 80-mesh sieve to obtain golden chamomile fine powder; (2) First, place the golden chamomile micropowder at a low temperature of -28°C for 3 minutes, then rapidly heat it to 25°C within 2 seconds, and repeat this process 4 times; then pressurize it to 16MPa, maintain it for 3 minutes, and then release the pressure to normal pressure, and repeat this process 3 times to obtain the pretreated golden chamomile micropowder; (3) Mixing the pretreated golden chamomile powder and ethanol aqueous solution in a mass ratio of 1:12, heating and refluxing for extraction for 3 times, each extraction for 120 min, filtering, and combining the filtrate to obtain a golden chamomile crude extract; (4) The crude extract of golden chamomile is subjected to ultrasonic extraction, vacuum filtration, concentration and drying to obtain the golden chamomile extract.

[0036] The power of ultrasonic extraction is 300W; the temperature of ultrasonic extraction is 50℃ The volume fraction of the ethanol aqueous solution is 70%.

[0037] The ultrasonic extraction time was 30 min.

[0038] The preparation method of the extract with antipruritic effect comprises the following steps: weighing golden chamomile extract, Panax notoginseng extract, purslane extract, tea extract, mint leaf extract, bitter melon extract, red vegetable extract, Actinidia chinensis extract, Panax japonica extract and Sapindus mukorossi extract according to a proportion, mixing them evenly, and obtaining the extract with antipruritic effect.

[0039] Comparative Example 1 The difference between this comparative example and Example 1 is that the amounts of golden chamomile extract and Panax notoginseng extract are different.

[0040] An extract with an antipruritic effect comprises the following components in parts by mass: 4 parts of golden chamomile extract, 22 parts of Panax notoginseng extract, 3 parts of Portulaca oleracea extract, 5 parts of tea extract, 8 parts of mint leaf extract, 2 parts of bitter melon extract, 7 parts of red vegetable extract, 2 parts of Actinidia chinensis extract, 5 parts of Panax japonica extract and 7 parts of Sapindus mukorossi extract.

[0041] The preparation method of the Panax notoginseng extract is as follows: (1) Weigh Panax notoginseng, crush and sieve to obtain Panax notoginseng powder, mix 100 parts by mass of Panax notoginseng powder with 600 parts by mass of purified water, and sterilize to obtain a dispersion; (2) adding 1 part by weight of Lactobacillus helveticus and the dispersion into a fermentation tank, mixing them evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing the fermentation liquid to obtain a fermentation liquid A; (3) adding 1 part by weight of Lactobacillus brevis to the fermentation liquid A and mixing evenly, adjusting the pH to 6.4, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation liquid B; (4) adding 1 part by weight of Bifidobacterium lactis to the fermentation liquid B and mixing evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation liquid C; (5) The fermentation liquid C is centrifuged, the precipitate is discarded, the supernatant is collected, and the supernatant is spray-dried to obtain a Panax notoginseng extract.

[0042] The step (2) is subjected to anaerobic fermentation for 3 days.

[0043] The step (3) is subjected to anaerobic fermentation for 2 days.

[0044] The step (4) is subjected to anaerobic fermentation for 1 day.

[0045] The preparation method of the golden chamomile extract is: (1) Drying the golden chamomile, crushing it and passing it through a 60-mesh sieve to obtain golden chamomile fine powder; (2) First, place the golden chamomile micropowder at a low temperature of -28°C for 2 minutes, then rapidly heat it to 25°C within 2 seconds, and repeat this process 3 times; then pressurize it to 14 MPa, maintain it for 2 minutes, and then release the pressure to normal pressure, and repeat this process 2 times to obtain the pretreated golden chamomile micropowder; (3) Mix the pretreated golden chamomile powder and ethanol aqueous solution in a mass ratio of 1:10, heat and reflux for extraction twice, each extraction time for 100 min, filter, and combine the filtrate to obtain a golden chamomile crude extract; (4) The crude extract of golden chamomile is subjected to ultrasonic extraction, vacuum filtration, concentration and drying to obtain the golden chamomile extract.

[0046] The power of ultrasonic extraction is 240W; the temperature of ultrasonic extraction is 40℃ The volume fraction of the ethanol aqueous solution is 60%.

[0047] The ultrasonic extraction time was 20 min.

[0048] The preparation method of the extract with antipruritic effect comprises the following steps: weighing golden chamomile extract, Panax notoginseng extract, purslane extract, tea extract, mint leaf extract, bitter melon extract, red vegetable extract, Actinidia chinensis extract, Panax japonica extract and Sapindus mukorossi extract according to a proportion, mixing them evenly, and obtaining the extract with antipruritic effect.

[0049] Comparative Example 2 The difference between this comparative example and Example 1 is that the amounts of golden chamomile extract and Panax notoginseng extract are different.

[0050] An extract with an antipruritic effect comprises the following components in parts by mass: 22 parts of golden chamomile extract, 4 parts of Panax notoginseng extract, 3 parts of Portulaca oleracea extract, 5 parts of tea extract, 8 parts of mint leaf extract, 2 parts of bitter melon extract, 7 parts of red vegetable extract, 2 parts of Actinidia chinensis extract, 5 parts of Panax japonica extract and 7 parts of Sapindus mukorossi extract.

[0051] The preparation method of the Panax notoginseng extract is as follows: (1) Weigh Panax notoginseng, crush and sieve to obtain Panax notoginseng powder, mix 100 parts by mass of Panax notoginseng powder with 600 parts by mass of purified water, and sterilize to obtain a dispersion; (2) adding 1 part by weight of Lactobacillus helveticus and the dispersion into a fermentation tank, mixing them evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing the fermentation liquid to obtain a fermentation liquid A; (3) adding 1 part by weight of Lactobacillus brevis to the fermentation liquid A and mixing evenly, adjusting the pH to 6.4, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation liquid B; (4) adding 1 part by weight of Bifidobacterium lactis to the fermentation liquid B and mixing evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation liquid C; (5) The fermentation liquid C is centrifuged, the precipitate is discarded, the supernatant is collected, and the supernatant is spray-dried to obtain a Panax notoginseng extract.

[0052] The step (2) is subjected to anaerobic fermentation for 3 days.

[0053] The step (3) is subjected to anaerobic fermentation for 2 days.

[0054] The step (4) is subjected to anaerobic fermentation for 1 day.

[0055] The preparation method of the golden chamomile extract is: (1) Drying the golden chamomile, crushing it and passing it through a 60-mesh sieve to obtain golden chamomile fine powder; (2) First, place the golden chamomile micropowder at a low temperature of -28°C for 2 minutes, then rapidly heat it to 25°C within 2 seconds, and repeat this process 3 times; then pressurize it to 14 MPa, maintain it for 2 minutes, and then release the pressure to normal pressure, and repeat this process 2 times to obtain the pretreated golden chamomile micropowder; (3) Mix the pretreated golden chamomile powder and ethanol aqueous solution in a mass ratio of 1:10, heat and reflux for extraction twice, each extraction time for 100 min, filter, and combine the filtrate to obtain a golden chamomile crude extract; (4) The crude extract of golden chamomile is subjected to ultrasonic extraction, vacuum filtration, concentration and drying to obtain the golden chamomile extract.

[0056] The power of ultrasonic extraction is 240W; the temperature of ultrasonic extraction is 40℃ The volume fraction of the ethanol aqueous solution is 60%.

[0057] The ultrasonic extraction time was 20 min.

[0058] The preparation method of the extract with antipruritic effect comprises the following steps: weighing golden chamomile extract, Panax notoginseng extract, purslane extract, tea extract, mint leaf extract, bitter melon extract, red vegetable extract, Actinidia chinensis extract, Panax japonica extract and Sapindus mukorossi extract according to a proportion, mixing them evenly, and obtaining the extract with antipruritic effect.

[0059] Comparative Example 3 The difference between this comparative example and Example 1 is that the amounts of purslane extract, tea extract, mint leaf extract, bitter melon extract, red vegetable extract, Actinidia chinensis extract, Panax japonica extract and Sapindus mukorossi extract are different.

[0060] An extract with an antipruritic effect comprises the following components in parts by mass: 14 parts of golden chamomile extract, 12 parts of Panax notoginseng extract, 7 parts of Portulaca oleracea extract, 1 part of tea extract, 2 parts of mint leaf extract, 8 parts of bitter melon extract, 2 parts of red vegetable extract, 7 parts of Actinidia chinensis extract, 10 parts of Panax japonica extract and 2 parts of Sapindus mukorossi extract.

[0061] The preparation method of the Panax notoginseng extract is as follows: (1) Weigh Panax notoginseng, crush and sieve to obtain Panax notoginseng powder, mix 100 parts by mass of Panax notoginseng powder with 600 parts by mass of purified water, and sterilize to obtain a dispersion; (2) adding 1 part by weight of Lactobacillus helveticus and the dispersion into a fermentation tank, mixing them evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing the fermentation liquid to obtain a fermentation liquid A; (3) adding 1 part by weight of Lactobacillus brevis to the fermentation liquid A and mixing evenly, adjusting the pH to 6.4, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation liquid B; (4) adding 1 part by weight of Bifidobacterium lactis to the fermentation liquid B and mixing evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation liquid C; (5) The fermentation liquid C is centrifuged, the precipitate is discarded, the supernatant is collected, and the supernatant is spray-dried to obtain a Panax notoginseng extract.

[0062] The step (2) is subjected to anaerobic fermentation for 3 days.

[0063] The step (3) is subjected to anaerobic fermentation for 2 days.

[0064] The step (4) is subjected to anaerobic fermentation for 1 day.

[0065] The preparation method of the golden chamomile extract is: (1) Drying the golden chamomile, crushing it and passing it through a 60-mesh sieve to obtain golden chamomile fine powder; (2) First, place the golden chamomile micropowder at a low temperature of -28°C for 2 minutes, then rapidly heat it to 25°C within 2 seconds, and repeat this process 3 times; then pressurize it to 14 MPa, maintain it for 2 minutes, and then release the pressure to normal pressure, and repeat this process 2 times to obtain the pretreated golden chamomile micropowder; (3) Mix the pretreated golden chamomile powder and ethanol aqueous solution in a mass ratio of 1:10, heat and reflux for extraction twice, each extraction time for 100 min, filter, and combine the filtrate to obtain a golden chamomile crude extract; (4) The crude extract of golden chamomile is subjected to ultrasonic extraction, vacuum filtration, concentration and drying to obtain the golden chamomile extract.

[0066] The power of ultrasonic extraction is 240W; the temperature of ultrasonic extraction is 40℃ The volume fraction of the ethanol aqueous solution is 60%.

[0067] The ultrasonic extraction time was 20 min.

[0068] The preparation method of the extract with antipruritic effect comprises the following steps: weighing golden chamomile extract, Panax notoginseng extract, purslane extract, tea extract, mint leaf extract, bitter melon extract, red vegetable extract, Actinidia chinensis extract, Panax japonica extract and Sapindus mukorossi extract according to a proportion, mixing them evenly, and obtaining the extract with antipruritic effect.

[0069] Comparative Example 4 The difference between this comparative example and Example 1 is that the preparation method of Panax notoginseng extract is different.

[0070] An extract with an antipruritic effect comprises the following components in parts by mass: 14 parts of golden chamomile extract, 12 parts of Panax notoginseng extract, 3 parts of Portulaca oleracea extract, 5 parts of tea extract, 8 parts of mint leaf extract, 2 parts of bitter melon extract, 7 parts of red vegetable extract, 2 parts of Actinidia chinensis extract, 5 parts of Panax japonica extract and 7 parts of Sapindus mukorossi extract.

[0071] The preparation method of the Panax notoginseng extract is as follows: (1) Weigh Panax notoginseng, crush and sieve to obtain Panax notoginseng powder, mix 100 parts by mass of Panax notoginseng powder with 600 parts by mass of purified water, and sterilize to obtain a dispersion; (2) adding 1 part by weight of Lactobacillus casei and the dispersion into a fermentation tank, mixing them evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing the fermentation liquid to obtain a fermentation liquid A; (3) adding 1 part by weight of Lactobacillus acidophilus to fermentation liquid A and mixing evenly, adjusting the pH to 6.4, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation liquid B; (4) adding 1 part by weight of Lactobacillus helveticus to the fermentation liquid B and mixing evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing is performed to obtain a fermentation liquid C; (5) The fermentation liquid C is centrifuged, the precipitate is discarded, the supernatant is collected, and the supernatant is spray-dried to obtain a Panax notoginseng extract.

[0072] The step (2) is subjected to anaerobic fermentation for 3 days.

[0073] The step (3) is subjected to anaerobic fermentation for 2 days.

[0074] The step (4) is subjected to anaerobic fermentation for 1 day.

[0075] The preparation method of the golden chamomile extract is: (1) Drying the golden chamomile, crushing it and passing it through a 60-mesh sieve to obtain golden chamomile fine powder; (2) First, place the golden chamomile micropowder at a low temperature of -28°C for 2 minutes, then rapidly heat it to 25°C within 2 seconds, and repeat this process 3 times; then pressurize it to 14 MPa, maintain it for 2 minutes, and then release the pressure to normal pressure, and repeat this process 2 times to obtain the pretreated golden chamomile micropowder; (3) Mix the pretreated golden chamomile powder and ethanol aqueous solution in a mass ratio of 1:10, heat and reflux for extraction twice, each extraction time for 100 min, filter, and combine the filtrate to obtain a golden chamomile crude extract; (4) The crude extract of golden chamomile is subjected to ultrasonic extraction, vacuum filtration, concentration and drying to obtain the golden chamomile extract.

[0076] The power of ultrasonic extraction is 240W; the temperature of ultrasonic extraction is 40℃ The volume fraction of the ethanol aqueous solution is 60%.

[0077] The ultrasonic extraction time was 20 min.

[0078] The preparation method of the extract with antipruritic effect comprises the following steps: weighing golden chamomile extract, Panax notoginseng extract, purslane extract, tea extract, mint leaf extract, bitter melon extract, red vegetable extract, Actinidia chinensis extract, Panax japonica extract and Sapindus mukorossi extract according to a proportion, mixing them evenly, and obtaining the extract with antipruritic effect.

[0079] Comparative Example 5 The difference between this comparative example and Example 1 is that the preparation method of the golden chamomile extract is different.

[0080] An extract with an antipruritic effect comprises the following components in parts by mass: 14 parts of golden chamomile extract, 12 parts of Panax notoginseng extract, 3 parts of Portulaca oleracea extract, 5 parts of tea extract, 8 parts of mint leaf extract, 2 parts of bitter melon extract, 7 parts of red vegetable extract, 2 parts of Actinidia chinensis extract, 5 parts of Panax japonica extract and 7 parts of Sapindus mukorossi extract.

[0081] The preparation method of the Panax notoginseng extract is as follows: (1) Weigh Panax notoginseng, crush and sieve to obtain Panax notoginseng powder, mix 100 parts by mass of Panax notoginseng powder with 600 parts by mass of purified water, and sterilize to obtain a dispersion; (2) adding 1 part by weight of Lactobacillus helveticus and the dispersion into a fermentation tank, mixing them evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing the fermentation liquid to obtain a fermentation liquid A; (3) adding 1 part by weight of Lactobacillus brevis to the fermentation liquid A and mixing evenly, adjusting the pH to 6.4, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation liquid B; (4) adding 1 part by weight of Bifidobacterium lactis to the fermentation liquid B and mixing evenly, adjusting the pH to 6.2, and performing anaerobically fermentation at 36° C. After the fermentation is completed, sterilizing treatment is performed to obtain fermentation liquid C; (5) The fermentation liquid C is centrifuged, the precipitate is discarded, the supernatant is collected, and the supernatant is spray-dried to obtain a Panax notoginseng extract.

[0082] The step (2) is subjected to anaerobic fermentation for 3 days.

[0083] The step (3) is subjected to anaerobic fermentation for 2 days.

[0084] The step (4) is subjected to anaerobic fermentation for 1 day.

[0085] The preparation method of the golden chamomile extract is: (1) Drying the golden chamomile, crushing it and passing it through a 60-mesh sieve to obtain golden chamomile fine powder; (2) Mix golden chamomile powder and ethanol aqueous solution in a mass ratio of 1:10, heat and reflux for extraction twice, each extraction time for 100 min, filter, and combine the filtrate to obtain a golden chamomile crude extract; (3) The crude extract of golden chamomile is subjected to ultrasonic extraction, vacuum filtration, concentration and drying to obtain the golden chamomile extract.

[0086] The power of ultrasonic extraction is 240W; the temperature of ultrasonic extraction is 40°C.

[0087] The volume fraction of the ethanol aqueous solution is 60%.

[0088] The ultrasonic extraction time was 20 min.

[0089] The preparation method of the extract with antipruritic effect comprises the following steps: weighing golden chamomile extract, Panax notoginseng extract, purslane extract, tea extract, mint leaf extract, bitter melon extract, red vegetable extract, Actinidia chinensis extract, Panax japonica extract and Sapindus mukorossi extract according to a proportion, mixing them evenly, and obtaining the extract with antipruritic effect.

[0090] Performance Testing Experimental method: Mice were randomly divided into multiple groups, half male and half female, with 10 mice in each group. In this experiment, physiological saline was used as the reagent of the control group, and the products prepared in Examples 1-2 and Comparative Examples 1-5 were administered.

[0091] On the first day, the hair on the dorsum of the right hind foot of the mouse was removed, and the shaved area on the dorsum of the foot was evenly scratched with coarse sandpaper for 1 cm. 2 . On the second day, the antipruritic composition of the experimental group was applied to the wound surface on the dorsum of the mouse's foot, with an application amount of 0.5 ml per mouse each time. Apply 7 times 3 times a day. 30 minutes after the last application, drip histamine phosphate saline solution onto the wound surface on the dorsum of the mouse's foot, and then increase the concentration of histamine phosphate saline solution every 3 minutes. The concentrations were 0.01%, 0.02%, 0.03%, and 0.04%, respectively, increasing in sequence, with the concentration increasing by 0.01% each time, and the amount of each drop was 0.05 ml, until the mouse turned back and licked its right hind foot. Calculate the total amount of histamine as the itching valve of the present invention; compare with the blank control group, and perform inter-group difference analysis. The results are shown in Table 1: Table 1 Performance test results

[0092] It can be seen from the above performance test results that the extracts of Examples 1-2 have the best antipruritic effect, especially the performance of Example 1 is the most outstanding. However, since the comparative examples do not adopt the necessary technical solutions, they are significantly worse than the examples in the corresponding performance tests. In comparative examples 1-5, the raw material ratio and extraction method of the extracts are changed, and it can be seen that the antipruritic effect is reduced, proving that the raw material ratio and extraction method of the extracts have an important influence on the antipruritic effect. The above experimental results further prove the importance of the technical solution defined in the present invention for its technical effect.

[0093] 2. 20 g of the extract of the present invention, 1 g of alkyl glycoside, 5 g of glycerol, 2 g of caprylic / capric triglyceride, 0.8 g of acrylate cross-linked polymer, 0.02 g of disodium ethylenediaminetetraacetate, and 6 g of isopropyl palmitate are mixed to prepare a skin care product.

[0094] 700 patients with dry and itchy skin aged 30 to 70 were selected and randomly divided into groups, with 100 patients in each group. The skin care products prepared in the embodiments and comparative examples were applied. During the experiment, each group tried to maintain an unrestricted diet and lifestyle, and could not apply other moisturizing and antipruritic skin care products. The results are shown in Table 2.

[0095] Table 2 Test results

[0096] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An extract having an antipruritic effect, characterized in that: The invention comprises the following components in parts by weight: 12-16 parts of golden chamomile extract, 10-14 parts of Panax notoginseng extract, 1-4 parts of purslane extract, 3-8 parts of tea extract, 5-11 parts of mint leaf extract, 1-5 parts of bitter melon extract, 4-10 parts of red vegetable extract, 1-3 parts of Chinese kiwi fruit extract, 3-7 parts of japonica ginseng extract and 4-9 parts of soapberry extract.

2. The extract with antipruritic effect according to claim 1, characterized in that The preparation method of the Panax notoginseng extract is: (1) Weigh Panax notoginseng, crush and sieve to obtain Panax notoginseng powder, mix 100 parts by mass of Panax notoginseng powder with 600-700 parts by mass of purified water, and sterilize to obtain a dispersion; (2) adding 1-2 parts by weight of Lactobacillus helveticus and the dispersion into a fermentation tank, mixing them evenly, adjusting the pH to 6.2-6.4, and performing anaerobically fermentation at 36-40° C. After the fermentation is completed, sterilizing the fermentation liquid to obtain a fermentation liquid A; (3) adding 1-2 parts by weight of Lactobacillus brevis to fermentation liquid A and mixing evenly, adjusting the pH to 6.2-6.4, performing anaerobically fermentation at 36-40° C., and sterilizing after the fermentation to obtain fermentation liquid B; (4) adding 1-2 parts by weight of Bifidobacterium lactis to the fermentation liquid B and mixing evenly, adjusting the pH to 6.2-6.4, and performing anaerobically fermentation at 36-40° C., and sterilizing after the fermentation is completed to obtain a fermentation liquid C; (5) The fermentation liquid C is centrifuged, the precipitate is discarded, the supernatant is collected, and the supernatant is spray-dried to obtain a Panax notoginseng extract.

3. The extract with antipruritic effect according to claim 2, characterized in that The step (2) is anaerobic fermentation for 3-5 days.

4. The extract with antipruritic effect according to claim 2, characterized in that The step (3) is anaerobic fermented for 2-4 days.

5. The extract with antipruritic effect according to claim 2, characterized in that The step (4) is anaerobic fermentation for 1-2 days.

6. The extract with antipruritic effect according to claim 1, characterized in that The preparation method of the golden chamomile extract is: (1) Drying the golden chamomile, crushing it and passing it through a 60-80 mesh sieve to obtain golden chamomile fine powder; (2) First, place the golden chamomile micropowder at a low temperature of -28°C for 2-3 minutes, then rapidly heat it to 25°C within 2 seconds, and repeat 3-4 times; then pressurize it to 14-16MPa, maintain it for 2-3 minutes, then release the pressure to normal pressure, and repeat 2-3 times to obtain the pretreated golden chamomile micropowder; (3) Mixing the pretreated golden chamomile powder and ethanol aqueous solution in a mass ratio of 1:10-12, heating and refluxing for extraction 2-3 times, each extraction for 100-120 minutes, filtering, and combining the filtrate to obtain a golden chamomile crude extract; (4) The crude extract of golden chamomile is subjected to ultrasonic extraction, vacuum filtration, concentration and drying to obtain the golden chamomile extract.

7. The extract with antipruritic effect according to claim 6, characterized in that The power of ultrasonic extraction is 240W-300W; the temperature of ultrasonic extraction is 40-50°C; and the time of ultrasonic extraction is 20-30min.

8. The extract with antipruritic effect according to claim 6, characterized in that The volume fraction of the ethanol aqueous solution is 60-70%.

9. A method for preparing the extract with antipruritic effect according to any one of claims 1 to 8, characterized in that: The method comprises the following steps: weighing golden chamomile extract, Panax notoginseng extract, purslane extract, tea extract, mint leaf extract, bitter melon extract, red vegetable extract, Actinidia chinensis extract, Panax japonica extract and Sapindus mukorossi extract according to a proportion, mixing them evenly, and obtaining an extract with an antipruritic effect.

10. Use of the extract with antipruritic effect according to any one of claims 1 to 8 in the preparation of skin care products.

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