Modeling research management device for atorvastatin in atherosclerosis

Abstract

The invention discloses a modeling research management device for atorvastatin in atherosclerosis, and relates to the technical field of medical instruments, the device comprises a cage body, the top of the cage body is clamped with a cover plate, the top of the cover plate is fixedly connected with a storage tank, and the outer side wall of the cage body is provided with a display screen for recording data; the feeding mechanism comprises an electric telescopic rod fixedly connected to the bottom of the cover plate and a feeding disc fixedly connected to the output end of the electric telescopic rod; the feeding mechanism and the receiving mechanism comprise a heat insulation plate fixedly connected to the inner side wall of the storage tank, an isolation cylinder fixedly connected to the top of the heat insulation plate and used for dividing an upper half cavity of the storage tank into a storage bin and a water storage cavity, and a refrigeration piece penetrating through the heat insulation plate and used for refrigerating the water storage cavity. According to the modeling research management device for atorvastatin in atherosclerosis, the refrigeration sheet is started, so that the feed in the storage cavity is kept fresh.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a modeling research and management device for atorvastatin in atherosclerosis. Background Art

[0002] Atorvastatin is a commonly used drug, mainly used to treat hypercholesterolemia and prevent cardiovascular diseases. In modeling studies of atherosclerosis, atorvastatin is often used as an intervention drug to observe its effect on the progression of atherosclerosis.

[0003] A mouse model of atherosclerosis was established to study the effect of atorvastatin on mice. In this process, a blank group and a control group will be established. Several mice in different groups need to be raised and managed, and the use of atorvastatin and the records of indicators that need to be paid attention to between different groups need to be kept. Existing studies only have ordinary cages, which do not have the function of assisting atorvastatin in atherosclerosis research, and it is necessary to improve the tools for mouse breeding, such as cages. Summary of the invention

[0004] The main purpose of the present invention is to provide a management device for modeling research of atorvastatin in atherosclerosis. By setting up a feeding mechanism, a delivery mechanism and a guiding mechanism, the problem that only ordinary cages have no function of assisting atorvastatin in atherosclerosis research can be solved.

[0005] To achieve the above object, the present invention provides the following technical solutions: A management device for modeling research of atorvastatin in atherosclerosis, comprising: A cage body, a cover plate is clamped on the top of the cage body, a storage tank is fixedly connected to the top of the cover plate, and a display screen for recording data is installed on the outer wall of the cage body; A feeding mechanism, the feeding mechanism comprising an electric telescopic rod fixedly connected to the bottom of the cover plate, and a feeding plate fixedly connected to the output end of the electric telescopic rod; The feeding mechanism and the receiving mechanism include a heat insulation plate fixedly connected to the inner wall of the storage tank, an isolation cylinder fixedly connected to the top of the heat insulation plate to separate the upper chamber of the storage tank into a storage bin and a water storage chamber, and a refrigeration plate penetrating the heat insulation plate for cooling the water storage chamber; The guiding mechanism comprises a connecting spring fixedly connected to the bottom of the cover plate, and a guiding piece fixedly connected to the bottom end of the connecting spring.

[0006] Preferably, the feeding mechanism also includes a baffle fixedly connected to the lower half chamber of the storage tank to divide it into a heating zone and a placement zone, a delivery pump is fixedly installed inside the placement zone, the water inlet of the delivery pump is connected to the heating zone through a pipeline, the cooling end of the refrigeration plate extends to the inside of the water storage cavity, and the heat dissipation end of the refrigeration plate extends to the heating zone.

[0007] Preferably, the feeding mechanism further includes a feeding pipe penetrating the storage tank and communicating with the storage cavity, and a first electrically controlled valve fixedly mounted on the inner side wall of the feeding pipe.

[0008] Preferably, the feeding mechanism further comprises a water delivery pipe fixedly connected to the bottom of the storage tank and communicating with the placement area, and a second electrically controlled valve fixedly mounted on the inner side wall of the water delivery pipe.

[0009] Preferably, the feeding mechanism further comprises a partition fixedly connected to the inner wall of the feeding tray, the partition divides the chamber of the feeding tray into a feeding area and a water feeding area, the feeding area is located directly below the feed pipe, and the feeding area is located directly below the water feed pipe.

[0010] Preferably, the guide member comprises a connecting plate fixedly connected to the end surface of the connecting spring, and a first guide tube and a second guide tube fixedly connected to two ends of the connecting plate.

[0011] Preferably, the first guide tube is sleeved on the outer side wall of the feed tube, and the second guide tube is sleeved on the outer side wall of the water feed tube.

[0012] Compared with the prior art, the present invention has the following beneficial effects: 1. In the present invention, the electric telescopic rod is moved to drive the feeding tray to move downward until it contacts the bottom plate of the cage. At this time, the first guide tube and the second guide tube are suspended on the top of the feeding tray under the action of the connecting spring. Then, the first electric control valve and the second electric control valve are opened, and the amount of feed and clean water is quantitatively controlled by controlling the opening time of the electric control valve. When the feeding time is over, the electric telescopic rod is started to drive the feeding tray to move upward. During this process, the feeding tray will push the guide member to move upward and compress the connecting spring until the feeding tray is suspended inside the cage, so as to prevent the mice from transporting the bedding to the feeding tray during the movement, reduce the contamination of the feeding tray, and increase the movement area of ​​the mice.

[0013] 2. In the present invention, the water storage chamber is cooled by starting the refrigeration plate. In this process, not only the cooling efficiency inside the water storage chamber can be significantly improved, but also a more uniform temperature distribution can be ensured, thereby cooling the feed storage chamber to keep the feed inside the feed storage chamber fresh. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 After removing the cage body of the present invention Figure 1 Schematic diagram of the structure; Figure 3 For the present invention Figure 2 A schematic diagram of a top view structure; Figure 4 This is a schematic diagram of the internal structure of the storage tank of the present invention; Figure 5 For the present invention Figure 3 Schematic diagram of the back structure.

[0015] In the figure: 1. cage body; 2. cover plate; 3. storage tank; 401. electric telescopic rod; 402. feeding tray; 403. partition; 501. heat insulation board; 502. isolation tube; 503. refrigeration plate; 504. baffle; 505. delivery pump; 506. feeding pipe; 507. first electric control valve; 508. water supply pipe; 509. second electric control valve; 601. connecting spring; 602. guide member; 6021. connecting plate; 6022. first guide tube; 6023. second guide tube; 7. display screen. DETAILED DESCRIPTION

[0016] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0017] Embodiment 1: Figure 1-5 As shown, a device for administering atorvastatin in a modeling study of atherosclerosis comprises: A cage body 1, a cover plate 2 is engaged on the top of the cage body 1, a storage tank 3 is fixedly connected to the top of the cover plate 2, and a display screen 7 for recording data is installed on the outer wall of the cage body 1; The feeding mechanism includes an electric telescopic rod 401 fixedly connected to the bottom of the cover plate 2, and a feeding plate 402 fixedly connected to the output end of the electric telescopic rod 401; The feeding mechanism and the receiving mechanism include a heat insulation plate 501 fixedly connected to the inner wall of the storage tank 3, an isolation cylinder 502 fixedly connected to the top of the heat insulation plate 501 to separate the upper chamber of the storage tank 3 into a material storage bin and a water storage chamber, and a cooling plate 503 penetrating the heat insulation plate 501 for cooling the water storage chamber; The guiding mechanism includes a connecting spring 601 fixedly connected to the bottom of the cover plate 2 , and a guiding member 602 fixedly connected to the bottom end of the connecting spring 601 .

[0018] The feeding mechanism also includes a baffle 504 fixedly connected to the lower chamber of the storage tank 3, which is divided into a heating zone and a placement zone. A delivery pump 505 is fixedly installed inside the placement zone. The water inlet of the delivery pump 505 is connected to the heating zone through a pipeline. The cooling end of the refrigeration plate 503 extends to the inside of the water storage cavity, and the heat dissipation end of the refrigeration plate 503 extends to the heating zone. A sealing cover is provided on the top of the storage tank 3. By opening the sealing cover, clean water and feed are added to the inside of the water storage cavity and the feed storage cavity in turn. The water storage cavity and the heating zone are connected through a valve pipeline. By opening the valve, the clean water inside the water storage cavity flows to the heating zone.

[0019] The feeding mechanism also includes a feeding pipe 506 that passes through the storage tank 3 and is connected to the storage cavity, and a first electrically controlled valve 507 fixedly installed on the inner wall of the feeding pipe 506. The purpose of quantitative feed delivery is achieved by controlling the opening and closing time of the first electrically controlled valve 507.

[0020] The feeding mechanism also includes a water supply pipe 508 fixedly connected to the bottom of the storage tank 3 and connected to the placement area, and a second electrically controlled valve 509 fixedly installed on the inner wall of the water supply pipe 508. The purpose of quantitatively delivering clean water is achieved by controlling the opening and closing time of the second electrically controlled valve 509.

[0021] The feeding mechanism also includes a partition 403 fixedly connected to the inner wall of the feeding tray 402, and the partition 403 divides the chamber of the feeding tray 402 into a feeding area and a water feeding area. The feeding area is located directly below the feed pipe 506, and the feeding area is located directly below the water feed pipe 508.

[0022] The guide member 602 includes a connecting plate 6021 fixedly connected to the end surface of the connecting spring 601 , and a first guiding tube 6022 and a second guiding tube 6023 fixedly connected to both ends of the connecting plate 6021 .

[0023] The first guide tube 6022 is sleeved on the outer wall of the feeding tube 506 , and the second guide tube 6023 is sleeved on the outer wall of the water feeding tube 508 .

[0024] First, the sealing cover and the valve pipeline are opened, and the feed is transported to the storage chamber, and the clean water is transported to the water storage chamber and the heating area. Then, the sealing cover and the valve pipeline are closed. When feeding is needed, the electric telescopic rod 401 is started to drive the feeding plate 402 to move downward until it contacts the bottom plate of the cage body 1. At this time, the first guide tube 6022 and the second guide tube 6023 are suspended on the top of the feeding plate 402 under the action of the connecting spring 601. Then, the first electric control valve 507 and the second electric control valve 509 are opened, and the amount of feed and clean water is quantitatively controlled by controlling the opening time of the electric control valves. When the feeding time is over, the electric telescopic rod 401 is started to drive the feeding tray 402 to move upward. During this process, the feeding tray 402 will push the guide member 602 to move upward and compress the connecting spring 601 until the feeding tray 402 is suspended inside the cage 1, thereby preventing the mice from transferring the bedding to the feeding tray 402 during the movement, reducing the contamination of the feeding tray 402 and increasing the movement area of ​​the mice.

[0025] Embodiment 2: Figure 1-5 As shown, a device for administering atorvastatin in a modeling study of atherosclerosis comprises: A cage body 1, a cover plate 2 is engaged on the top of the cage body 1, a storage tank 3 is fixedly connected to the top of the cover plate 2, and a display screen 7 for recording data is installed on the outer wall of the cage body 1; The feeding mechanism includes an electric telescopic rod 401 fixedly connected to the bottom of the cover plate 2, and a feeding plate 402 fixedly connected to the output end of the electric telescopic rod 401; The feeding mechanism and the receiving mechanism include a heat insulation plate 501 fixedly connected to the inner wall of the storage tank 3, an isolation cylinder 502 fixedly connected to the top of the heat insulation plate 501 to separate the upper chamber of the storage tank 3 into a material storage bin and a water storage chamber, and a cooling plate 503 penetrating the heat insulation plate 501 for cooling the water storage chamber; The guiding mechanism includes a connecting spring 601 fixedly connected to the bottom of the cover plate 2 , and a guiding member 602 fixedly connected to the bottom end of the connecting spring 601 .

[0026] The feeding mechanism also includes a baffle 504 fixedly connected to the lower chamber of the storage tank 3, which is divided into a heating zone and a placement zone. A delivery pump 505 is fixedly installed inside the placement zone. The water inlet of the delivery pump 505 is connected to the heating zone through a pipeline. The cooling end of the refrigeration plate 503 extends to the inside of the water storage cavity, and the heat dissipation end of the refrigeration plate 503 extends to the heating zone. A sealing cover is provided on the top of the storage tank 3. By opening the sealing cover, clean water and feed are added to the inside of the water storage cavity and the feed storage cavity in turn. The water storage cavity and the heating zone are connected through a valve pipeline. By opening the valve, the clean water inside the water storage cavity flows to the heating zone.

[0027] By starting the refrigeration sheet 503, the water storage chamber is cooled. In this process, not only the cooling efficiency inside the water storage chamber can be significantly improved, but also the temperature distribution can be more uniform, thereby cooling the feed storage chamber to keep the feed inside the feed storage chamber fresh. In the process of cooling the water storage chamber, the other end of the refrigeration sheet 503 will start to heat the water inside the heating zone, and then the clean water inside the heating zone will be transported to the inside of the water delivery pipe 508 through the delivery pump 505 and cooled to prevent the clean water that the mice drink from being too cold. An appropriate number of mice are selected and randomly divided into a blank control group, a model group (usually fed with a high-fat diet), and different doses of atorvastatin treatment groups, and are placed in different cages 1 for feeding, and their feeding amount is displayed on the display screen 7.

[0028] The blank control group was given a normal diet or an equal amount of saline, while the model group was given a high-fat diet to induce the formation of atherosclerotic lesions; Mice in the atorvastatin treatment group were injected with atorvastatin at low doses (e.g., 2.5 mg / kg / d) and high doses (e.g., 5 mg / kg / d); The body weight, food intake, and behavioral changes of mice were monitored regularly to evaluate the effects of drug treatment on the mice; At the end of the experiment, the formation of atherosclerotic plaques, blood lipid levels, and the expression levels of related inflammatory factors and proteins were evaluated by appropriate methods (such as H&E staining, immunohistochemical staining, Western blot, etc.).

Claims

1. A management device for the study of atorvastatin in modeling of atherosclerosis, characterized in that: include: A cage body (1), a cover plate (2) being engaged with the top of the cage body (1), a storage tank (3) being fixedly connected to the top of the cover plate (2), and a display screen (7) for recording data being installed on the outer side wall of the cage body (1); A feeding mechanism, the feeding mechanism comprising an electric telescopic rod (401) fixedly connected to the bottom of the cover plate (2), and a feeding plate (402) fixedly connected to the output end of the electric telescopic rod (401); The material feeding mechanism and the material receiving mechanism comprise a heat insulation plate (501) fixedly connected to the inner wall of the storage tank (3), an isolation cylinder (502) fixedly connected to the top of the heat insulation plate (501) and separating the upper chamber of the storage tank (3) into a material storage bin and a water storage chamber, and a cooling plate (503) penetrating the heat insulation plate (501) and used for cooling the water storage chamber; The guiding mechanism comprises a connecting spring (601) fixedly connected to the bottom of the cover plate (2), and a guiding member (602) fixedly connected to the bottom end of the connecting spring (601).

2. The atorvastatin modeling research and management device according to claim 1, characterized in that: The feeding mechanism further comprises a baffle (504) fixedly connected to the lower chamber of the storage tank (3) and divided into a heating zone and a placement zone, a delivery pump (505) is fixedly installed inside the placement zone, a water inlet of the delivery pump (505) is connected to the heating zone through a pipeline, a cooling end of the cooling plate (503) extends to the inside of the water storage cavity, and a heat dissipation end of the cooling plate (503) extends to the heating zone.

3. The device for managing the modeling study of atorvastatin in atherosclerosis according to claim 2, characterized in that: The feeding mechanism further comprises a feeding pipe (506) which passes through the storage tank (3) and is connected to the storage chamber, and a first electrically controlled valve (507) fixedly mounted on the inner wall of the feeding pipe (506).

4. The atorvastatin modeling research and management device according to claim 3, characterized in that: The feeding mechanism further comprises a water delivery pipe (508) fixedly connected to the bottom of the storage tank (3) and communicating with the placement area, and a second electrically controlled valve (509) fixedly mounted on the inner side wall of the water delivery pipe (508).

5. The device for managing the modeling study of atorvastatin in atherosclerosis according to claim 4, characterized in that: The feeding mechanism further comprises a partition (403) fixedly connected to the inner wall of the feeding tray (402), wherein the partition (403) divides the chamber of the feeding tray (402) into a feeding area and a water feeding area, wherein the feeding area is located directly below the feed pipe (506) and the feeding area is located directly below the water feeding pipe (508).

6. The atorvastatin modeling research and management device according to claim 5, characterized in that: The guide member (602) comprises a connecting plate (6021) fixedly connected to the end surface of the connecting spring (601), and a first guide tube (6022) and a second guide tube (6023) fixedly connected to both ends of the connecting plate (6021).

7. The atorvastatin modeling research and management device according to claim 6, characterized in that: The first guide tube (6022) is sleeved on the outer wall of the feed tube (506), and the second guide tube (6023) is sleeved on the outer wall of the water feed tube (508).

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