Sulfur-selenium doped carbon dot and Halicin synergistic antibacterial material and preparation method thereof

By preparing sulfur-selenium-doped carbon dots and Halicin synergistic antibacterial materials, the problem of poor antibacterial effects in the prior art is solved, and more efficient internal and external antibacterial effects are achieved.

CN119817597APending Publication Date: 2025-04-15ANHUI PROVINCIAL CHILDRENS HOSPITAL (ANHUI XINHUA HOSPITAL ANHUI INST OF PEDIATRIC MEDICINE FUDAN UNIV CHILDRENS HOSPITAL ANHUI HOSPITAL)
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Patent Information

Application Number
CN202411982895.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-31
Publication Date
2025-04-15

AI Technical Summary

Technical Problem

The existing sulfur-selenium-doped carbon quantum dots and Halicin are used separately with poor antibacterial effects, making it difficult to effectively solve the needs of medical antibacterial materials.

Method used

By preparing a sulfur-selenium-doped carbon dot and Halicin synergistic antibacterial material, combined with S, Se-CQDs solution and Halicin solution, reacted with EDC and NHS chemical reagents, and oscillated at a constant temperature of 25°C, and then added dropwise under dark stirring conditions to form S, Se-CQDs-Hal nanoparticles.

Benefits of technology

This material can synergistically enter Halicin into bacterial cells to destroy proton flow, improve internal sterilization effect, and prevent bacteria from adhesion by forming a hydration layer, enhancing external antibacterial effect.

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Abstract

On one hand, the invention relates to a sulfur-selenium doped carbon dot and Halicin synergistic antibacterial material which is prepared from an S, Se-CQDs solution and a Halicin solution in parts by weight as follows: 50-120 parts of the S, Se-CQDs solution, 0.1-0.3 parts of an EDC chemical reagent, 0.1-0.3 parts of an NHS chemical reagent, 125-300 parts of the Halicin solution and 12-35 parts of a NaOH solution, and on the other hand, the invention relates to a preparation method of the sulfur-selenium doped carbon dot and Halicin synergistic antibacterial material. The characteristics that the sulfur-selenium-doped carbon dots are uniform in size and easy to enter cells are utilized, the sulfur-selenium-doped carbon dots can cooperate with the Halicin to enter the cells to destroy the flow of protons on cell membranes, so that the sterilization and antibacterial effects are achieved, the sulfur-selenium-doped carbon dots and the Halicin synergistic antibacterial material can form a hydration layer on the surface of a wound by utilizing the oxidation resistance of the sulfur-selenium-doped carbon dots, and the antibacterial effect of the wound is improved. The adhesion of bacteria is prevented, so that the antibacterial effect is enhanced.
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