Diabetes therapy for regulating glycolipid metabolism by using traditional Chinese medicine compound

Abstract

The invention provides a diabetes therapy using a traditional Chinese medicine compound to regulate glycolipid metabolism, and belongs to the technical field of medicine.The diabetes therapy using the traditional Chinese medicine compound to regulate glycolipid metabolism is characterized in that the traditional Chinese medicine compound is composed of radix astragali, ginseng, coptis chinensis and other medicinal materials, and the weight ratio of the medicinal materials is determined according to clinical trials; the medicinal materials are soaked, decocted, filtered and concentrated to prepare decoction, or can be processed into pills, powder, capsules and the like, the taking dosage is determined according to the illness state and the physical condition of a patient, the treatment period is 3-6 months, and the scheme is adjusted according to the change of indexes such as fasting blood glucose, postprandial 2-hour blood glucose, glycosylated hemoglobin and blood fat in the treatment period. The therapy can adjust glycolipid metabolism in a multi-target mode, personalized treatment is achieved, the side effect of the traditional Chinese medicine compound is small, different dosage forms meet various requirements, insulin resistance can be effectively improved, the risk of diabetic complications is reduced, and a safer and more effective treatment choice is provided for diabetic patients.

Description

Technical Field

[0001] The invention belongs to the field of medical technology, and specifically relates to a diabetes therapy for regulating sugar and lipid metabolism using a traditional Chinese medicine compound. Background Art

[0002] In the field of diabetes treatment, the current mainstream treatment methods face many difficulties. Although Western medicine can quickly lower blood sugar, long-term use has obvious side effects. Commonly used biguanides may cause gastrointestinal discomfort, lactic acidosis and other adverse reactions; sulfonylurea drugs are prone to cause hypoglycemia and may also increase the burden on pancreatic beta cells and accelerate their functional decline. Although insulin injections can effectively supplement the lack of insulin in the body, they are inconvenient to use. Patients need to master complex injection techniques, and frequent injections will cause pain to patients. At the same time, it is difficult to control the insulin dosage. Too large a dose can easily cause hypoglycemia, and too small a dose cannot effectively control blood sugar, and may also cause weight gain and other problems. Moreover, whether it is Western medicine or insulin, it can only simply control blood sugar, and it is difficult to fundamentally regulate sugar and lipid metabolism disorders, and the effect on preventing and improving diabetic complications is limited.

[0003] In view of the above-mentioned difficulties, it is urgent to develop a safe and effective new method for the treatment of diabetes. Chinese herbal compound, with its unique multi-target and overall regulatory advantages, has become a new direction for solving these problems. The various ingredients in the Chinese herbal compound work synergistically and can act on multiple links of glucose and lipid metabolism at the same time, which can not only regulate blood sugar, but also improve dyslipidemia, reduce blood viscosity, and reduce the risk of vascular lesions. For example, astragalus, ginseng, etc. can enhance the body's positive energy, improve immunity, and improve insulin resistance; coptis chinensis, mulberry leaves, etc. directly act on the blood sugar regulation mechanism and lower blood sugar levels; salvia miltiorrhiza, herba scutellariae, etc. can promote blood circulation and remove blood stasis, improve blood circulation, and reduce vascular damage. The present invention aims to utilize the characteristics of these Chinese medicines, through a scientific and reasonable formula and preparation process, to develop a diabetes therapy that uses Chinese herbal compound to regulate glucose and lipid metabolism, so as to provide diabetic patients with safer and more effective treatment options, to make up for the shortcomings of existing treatment methods, better control the disease, prevent complications, and improve the quality of life of patients. Summary of the invention

[0004] The purpose of the present invention is to provide a diabetes therapy that uses a Chinese medicine compound to regulate glucose and lipid metabolism, aiming to solve the problem that although the existing Chinese and Western medicines can reduce blood sugar quickly, they have serious side effects when used for a long time. For example, biguanides and sulfonylureas can cause a variety of adverse reactions. Insulin injection can supplement insulin, but it is inconvenient to use and difficult to control the dosage, and it can also cause weight gain. Moreover, neither Western medicine nor insulin can fundamentally regulate glucose and lipid metabolism disorders, and it is difficult to effectively prevent and improve diabetic complications.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A diabetes therapy for regulating glucose and lipid metabolism using a Chinese medicine compound, characterized by comprising the following steps:

[0007] Provided is a traditional Chinese medicine compound, which consists of 15-30g of astragalus, 5-15g of ginseng, 3-10g of coptis root, 10-20g of salvia miltiorrhiza, 10-15g of wolfberry, 10-20g of kudzu root, 10-15g of mulberry leaf and 10-15g of euphorbia pulex. The weight ratio of each medicinal material can be adjusted according to the optimal ratio determined by a large number of clinical trials.

[0008] Wash the above-mentioned Chinese medicinal materials, soak them in an appropriate amount of water for 30-60 minutes, boil them over high heat, then simmer them over low heat for 30-60 minutes, filter and take the juice; add an appropriate amount of water for a second decoction, boil them over high heat, then simmer them over low heat for 20-40 minutes, combine the two decoctions, concentrate them to an appropriate concentration, and make them into a Chinese medicinal decoction, or further dry and crush them to make other dosage forms such as pills, powders, and capsules.

[0009] The dosage is determined according to the patient's condition and physical condition. Generally, patients with mild diabetes take one dose per day, divided into two doses, once in the morning and once in the evening. Patients with moderate and severe diabetes can increase the dosage or frequency of administration appropriately. The treatment cycle is 3-6 months. During this period, the treatment plan should be appropriately adjusted under the guidance of a doctor according to changes in the patient's fasting blood sugar, 2-hour postprandial blood sugar, glycosylated hemoglobin, total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and other indicators.

[0010] As a preferred scheme of the present invention, the adjustment standard of the treatment scheme is: when the patient's fasting blood sugar is lower than 7.0mmol / L for three consecutive times, the blood sugar 2 hours after a meal is lower than 10.0mmol / L for three consecutive times, the glycosylated hemoglobin is reduced to below 7.0%, and the total cholesterol is reduced to below 5.2mmol / L, the triglyceride is reduced to below 1.7mmol / L, the low-density lipoprotein cholesterol is reduced to below 3.4mmol / L, and the high-density lipoprotein cholesterol is increased to 1.0mmol / L (male) or 1.3mmol / L (female) or above, the drug dosage or the number of times of administration can be appropriately reduced; conversely, if the above indicators do not achieve the expected improvement effect, the drug dosage or the number of times of administration needs to be appropriately increased.

[0011] As a preferred embodiment of the present invention, the Chinese medicine compound is used in the preparation of a drug for regulating glucose and lipid metabolism in diabetic patients, improving insulin resistance, and reducing the risk of diabetic complications. The dosage form of the drug includes but is not limited to decoctions, pills, powders, and capsules.

[0012] Compared with the prior art, the present invention has the following beneficial effects:

[0013] 1. In this plan, the Chinese medicine compound is composed of multiple medicinal materials such as astragalus, ginseng, and coptis chinensis. The medicinal materials work synergistically with each other and act on multiple links of glucose and lipid metabolism. Astragalus and ginseng can enhance the body's positive energy, improve immunity, improve insulin resistance, and promote the body's utilization of sugar; coptis chinensis, mulberry leaves, etc. directly act on the blood sugar regulation mechanism and lower blood sugar levels; salvia miltiorrhiza and herba astragali can promote blood circulation and remove blood stasis, improve blood circulation, regulate blood lipids, reduce blood viscosity, reduce the risk of vascular lesions, and fundamentally regulate glucose and lipid metabolism disorders.

[0014] 2. In this plan, the dosage and frequency of taking are determined according to the patient's condition and physical condition. Mild patients take one dose per day, divided into two doses. Moderate and severe patients can increase the dose appropriately. This reflects the principle of personalized treatment. During the 3-6 month treatment cycle, the treatment plan is adjusted under the guidance of a doctor based on changes in multiple indicators such as the patient's fasting blood sugar, 2-hour postprandial blood sugar, glycosylated hemoglobin, and blood lipids. When indicators improve well, the dosage is reduced to avoid overtreatment. When indicators are not ideal, the treatment is strengthened to ensure that the treatment effect is accurate and effective, and to better meet the treatment needs of different patients.

[0015] 3. In this plan, the Chinese herbal compound is derived from natural Chinese medicinal materials, with relatively small side effects, and patients are more likely to accept long-term treatment. Different dosage forms such as decoctions, pills, powders, and capsules meet the needs of different patients. Decoctions are absorbed quickly and are suitable for patients with initial diagnosis and severe conditions; pills are easy to carry and store, and are suitable for patients taking medication for a long time; powders are absorbed quickly and are simple to make, and are suitable for those with weak spleen and stomach function; capsules can cover up the smell of the drug, and are suitable for those who are sensitive to odors, thereby improving patients' treatment compliance. DETAILED DESCRIPTION

[0016] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0017] Example 1

[0018] The present invention provides the following technical solutions:

[0019] A diabetes therapy for regulating glucose and lipid metabolism using a Chinese medicine compound, characterized by comprising the following steps:

[0020] Provided is a traditional Chinese medicine compound, which consists of 15-30g of astragalus, 5-15g of ginseng, 3-10g of coptis root, 10-20g of salvia miltiorrhiza, 10-15g of wolfberry, 10-20g of kudzu root, 10-15g of mulberry leaf and 10-15g of euphorbia pulex. The weight ratio of each medicinal material can be adjusted according to the optimal ratio determined by a large number of clinical trials.

[0021] Wash the above-mentioned Chinese medicinal materials, soak them in an appropriate amount of water for 30-60 minutes, boil them over high heat, then simmer them over low heat for 30-60 minutes, filter and take the juice; add an appropriate amount of water for a second decoction, boil them over high heat, then simmer them over low heat for 20-40 minutes, combine the two decoctions, concentrate them to an appropriate concentration, and make them into a Chinese medicinal decoction, or further dry and crush them to make other dosage forms such as pills, powders, and capsules.

[0022] The dosage is determined according to the patient's condition and physical condition. Generally, patients with mild diabetes take one dose per day, divided into two doses, once in the morning and once in the evening. Patients with moderate and severe diabetes can increase the dosage or frequency of administration appropriately. The treatment cycle is 3-6 months. During this period, the treatment plan should be appropriately adjusted under the guidance of a doctor according to changes in the patient's fasting blood sugar, 2-hour postprandial blood sugar, glycosylated hemoglobin, total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and other indicators.

[0023] In a specific embodiment of the present invention, the Chinese medicine compound is composed of the following material selection basis: Astragalus membranaceus replenishes qi and strengthens the exterior. Modern research has found that it can promote the body's metabolism and resist fatigue. In the treatment of diabetes, it helps to improve the patient's immunity and enhance the body's utilization of sugar; ginseng greatly replenishes vital energy, can regulate the body's metabolism, improve insulin resistance, and thus assist in regulating blood sugar; Coptis chinensis contains ingredients such as berberine, which has a significant effect on lowering blood sugar; Salvia miltiorrhiza promotes blood circulation and removes blood stasis, can improve the hypercoagulable state of blood in diabetic patients, and reduce the risk of vascular complications; Lycium barbarum nourishes the liver and kidneys, and has an improving effect on the symptoms of liver and kidney yin deficiency caused by diabetes; Pueraria lobata relieves muscles and reduces fever, promotes fluid production and quenches thirst, and can increase insulin sensitivity; mulberry leaves dispel wind-heat, clear the lungs and moisturize dryness, and the alkaloids and other ingredients they contain can inhibit the increase of blood sugar; Phellodendron chinense breaks blood and dredges the menstruation, can regulate blood lipids, and improve blood circulation.

[0024] Flexibility in ratio: Although the approximate dosage range of each medicinal material is given, it is emphasized that the optimal ratio can be determined based on clinical trials. This is because different patients have different constitutions and severity of illness, and their sensitivity and needs for drugs are also different. For example, patients with weaker constitutions may be more suitable for the upper limit of ginseng dosage; while patients with more internal heat may appropriately increase the dosage of coptis chinensis.

[0025] Preparation method: Combination of tradition and science: Using the traditional Chinese medicine decoction method, soaking the herbs first can fully dissolve the active ingredients and improve the efficacy. Boiling with high heat can quickly activate the ingredients in the herbs, while slow decoction with low heat can fully release the active ingredients into the decoction. After two decoctions, the decoctions are combined to obtain the active ingredients in the herbs to the greatest extent. Different dosage forms are made, such as pills, which are easy to carry and take, and suitable for long-term treatment; powders are absorbed quickly; capsules can cover up the bad smell of the drug and improve patient compliance.

[0026] Key points for quality control: During the preparation process, the amount of water, decoction time and temperature control all have an impact on the efficacy of the medicine. For example, too little water may result in the herbs not being thoroughly decocted and the effective ingredients not being fully extracted; too much water may make the decoction too thin and reduce the efficacy. Too long a decoction time may destroy some of the effective ingredients, while too short a time may result in insufficient dissolution of the effective ingredients.

[0027] Treatment plan: Personalized treatment: The dosage and frequency of administration are determined according to the severity of the patient's condition, which reflects the principle of personalized treatment. Mild patients have relatively mild conditions, and conventional doses can effectively control the condition; moderate and severe patients have complex conditions, and increasing the dosage or frequency can help better regulate glucose and lipid metabolism.

[0028] Dynamic monitoring and adjustment: The treatment cycle is set at 3-6 months. During this period, blood sugar-related indicators such as fasting blood sugar, 2-hour postprandial blood sugar, glycosylated hemoglobin, and blood lipid indicators such as total cholesterol and triglycerides are monitored to fully understand the changes in the patient's condition. Doctors adjust the treatment plan based on these indicators. If the indicators improve well, the dosage can be appropriately reduced to avoid overtreatment; if the indicators are not ideal, the treatment will be strengthened to ensure the treatment effect. This makes the treatment process more scientific and accurate, can better meet the needs of patients, improve treatment effects, and reduce the risk of diabetic complications.

[0029] Specifically in this plan, the treatment plan adjustment standard is: when the patient's fasting blood sugar is lower than 7.0mmol / L for three consecutive times, the blood sugar 2 hours after a meal is lower than 10.0mmol / L for three consecutive times, the glycosylated hemoglobin is reduced to below 7.0%, and the total cholesterol is reduced to below 5.2mmol / L, the triglyceride is reduced to below 1.7mmol / L, the low-density lipoprotein cholesterol is reduced to below 3.4mmol / L, and the high-density lipoprotein cholesterol is increased to 1.0mmol / L (male) or 1.3mmol / L (female) or above, the drug dosage or the number of times taken can be appropriately reduced; conversely, if the above indicators do not achieve the expected improvement effect, the drug dosage or the number of times taken needs to be appropriately increased.

[0030] In this embodiment: During the actual treatment process, medical staff must strictly monitor the patient's various indicators in accordance with the standards. The time point of each test must be fixed, for example, fasting blood sugar is tested in the early morning before eating, and blood sugar 2 hours after a meal is measured from the first bite of food to ensure the accuracy and comparability of the test results.

[0031] When the patient reaches the improvement standard of indicators, the reduction of drug dosage should follow the principle of gradual progress. For example, the original daily dose of Chinese herbal decoction can be changed to a dose every two days. Observe the patient's physical reaction and indicator changes for 1-2 weeks. If it remains stable, further adjust the dosage or the number of doses. For the increase of drug dosage or the number of doses, it is also necessary to pay close attention to whether the patient has any adverse reactions, such as gastrointestinal discomfort, getting angry and other symptoms. If adverse reactions occur, adjust the treatment measures in time and treat the patient accordingly. At the same time, in the process of adjusting the treatment plan, it is necessary to strengthen the health education of patients, inform them of the changes in indicators and the reasons for adjusting the plan, and improve the compliance and self-management awareness of patients.

[0032] Specifically in this scheme, the Chinese medicine compound is used in the preparation of a drug for regulating glucose and lipid metabolism in diabetic patients, improving insulin resistance, and reducing the risk of diabetic complications. The dosage form of the drug includes but is not limited to decoctions, pills, powders, and capsules.

[0033] In this embodiment: Decoction: For patients who are newly diagnosed and have relatively severe conditions and need to control their conditions as soon as possible, decoction is preferred. Because decoctions are absorbed quickly and can quickly exert their medicinal effects. When preparing decoctions, strictly follow the prescribed decoction method to ensure that the effective ingredients of the medicinal materials are fully dissolved. At the same time, in order to improve the taste of the decoction, some flavoring agents, such as honey (suitable for patients with good blood sugar control), can be appropriately added without affecting the efficacy of the medicine to improve patient acceptance.

[0034] Pills: Suitable for patients with relatively stable conditions who need to take medicine for a long time. Pills are easy to carry and store, and patients can take them on time and in the right amount. When making pills, the size and weight of the pills must be strictly controlled to ensure that the drug content of each pill is consistent and the drug effect is stable. For patients with difficulty swallowing, the pills can be crushed and taken with warm water.

[0035] Powder: Powders are absorbed quickly and the production process is relatively simple. Powders can be used for patients with weak spleen and stomach functions who have difficulty digesting pills. When taking powders, mix them with an appropriate amount of warm water or rice soup before taking to avoid direct irritation of the mouth and throat.

[0036] Capsules: Capsules are a better choice for patients who are sensitive to the smell of drugs and have difficulty accepting the smell of decoctions and powders. When producing capsules, the quality and sealing of the capsules must be ensured to prevent the drugs from getting damp and deteriorating. At the same time, tell patients to take capsules with an appropriate amount of warm water to avoid the capsules sticking to the esophageal wall.

[0037] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A diabetes therapy using a Chinese herbal compound to regulate glucose and lipid metabolism, characterized in that: The following steps are involved: Provided is a traditional Chinese medicine compound, which consists of 15-30g of astragalus, 5-15g of ginseng, 3-10g of coptis root, 10-20g of salvia miltiorrhiza, 10-15g of wolfberry, 10-20g of kudzu root, 10-15g of mulberry leaf and 10-15g of euphorbia pulex. The weight ratio of each medicinal material can be adjusted according to the optimal ratio determined by a large number of clinical trials. Wash the above-mentioned Chinese medicinal materials, soak them in an appropriate amount of water for 30-60 minutes, boil them over high heat, then simmer them over low heat for 30-60 minutes, filter and take the juice; add an appropriate amount of water for a second decoction, boil them over high heat, then simmer them over low heat for 20-40 minutes, combine the two decoctions, concentrate them to an appropriate concentration, and make them into a Chinese medicinal decoction, or further dry and crush them to make other dosage forms such as pills, powders, and capsules. The dosage is determined according to the patient's condition and physical condition. Generally, patients with mild diabetes take one dose per day, divided into two doses, once in the morning and once in the evening. Patients with moderate and severe diabetes can increase the dosage or frequency of administration appropriately. The treatment cycle is 3-6 months. During this period, the treatment plan should be appropriately adjusted under the guidance of a doctor according to changes in the patient's fasting blood sugar, 2-hour postprandial blood sugar, glycosylated hemoglobin, total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and other indicators.

2. A diabetes therapy for regulating glucose and lipid metabolism using a Chinese herbal compound according to claim 1, characterized in that: The treatment plan adjustment standard is: when the patient's fasting blood sugar is lower than 7.0mmol / L for three consecutive times, the blood sugar 2 hours after a meal is lower than 10.0mmol / L for three consecutive times, the glycosylated hemoglobin is reduced to below 7.0%, and the total cholesterol is reduced to below 5.2mmol / L, the triglyceride is reduced to below 1.7mmol / L, the low-density lipoprotein cholesterol is reduced to below 3.4mmol / L, and the high-density lipoprotein cholesterol is increased to 1.0mmol / L (male) or 1.3mmol / L (female) or above, the drug dosage or the number of times taken can be appropriately reduced; conversely, if the above indicators do not achieve the expected improvement effect, the drug dosage or the number of times taken should be appropriately increased.

3. A diabetes therapy for regulating glucose and lipid metabolism using a Chinese herbal compound according to claim 2, characterized in that: The Chinese medicine compound is used in preparing a medicine for regulating glucose and lipid metabolism in diabetic patients, improving insulin resistance, and reducing the risk of diabetic complications. The dosage form of the medicine includes but is not limited to decoctions, pills, powders, and capsules.