Traditional Chinese medicine composition with weight losing effect and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition with a weight-losing effect and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from, by weight, 5-10 parts of roselle, 5-10 parts of lotus leaves, 2-6 parts of semen cassiae, 2-6 parts of semen raphani, 2-6 parts of coix seeds, 2-6 parts of poria cocos, 1-2 parts of blood oranges, 1-3 parts of codonopsis pilosula, 1-2 parts of astragalus membranaceus, 1-2 parts of gordon euryale seeds, 1-3 parts of dendrobium officinale and 1-3 parts of radix ophiopogonis. , 1-3 parts of dogwood, and 1-3 parts of cistanche. The traditional Chinese medicine composition is unique and reasonable in compatibility, simple in preparation method, free of toxic and side effects, obvious in effect, low in recurrence rate and low in adverse reaction.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition with weight loss effect and application thereof. Background Art

[0002] Obesity is a metabolic disease caused by excess energy intake exceeding consumption, which results in the storage of excess energy in the form of fat, leading to an increase in the volume and excessive proliferation of fat cells. With the improvement of people's living standards and changes in lifestyle, the incidence of obesity is on the rise. Its pathogenesis and treatment have also become a hot topic in medical research. Studies have shown that genetic genes, environmental factors, living habits and dietary excess nutrition can all cause obesity. Obesity-induced metabolic abnormalities, type 2 diabetes, cardiovascular diseases and tumors have brought serious medical burdens. The weight loss products studied and applied at home and abroad are mainly Western weight loss medicines and dietary fiber products, including appetite suppressants, digestion and absorption blockers, hormones and drugs that increase energy consumption, which have large side effects. Traditional Chinese medicine has the characteristics of syndrome differentiation and treatment and few side effects. Therefore, the research and development of safe and effective Chinese medicines for weight loss and lipid reduction has become an international research hotspot with positive significance.

[0003] Some Chinese medicine compositions with weight loss effects are also disclosed in the prior art, such as the patent number "CN202410778175.9" discloses "A Chinese medicine composition with weight loss effect and its preparation method and application", in which the Chinese medicine composition is composed of the following raw materials by weight: 2-10 parts of lotus leaves, 5-15 parts of raw hawthorn, 5-10 parts of Poria cocos, 5-15 parts of Roselle, 5-10 parts of tangerine peel, 1-5 parts of Gynostemma pentaphyllum, 1-5 parts of pearl powder, and 2-10 parts of tea leaves; the green tea is any one of Longjing, Biluochun, Xianhao, Maofeng, Cuiya, and Huangjinya. Although the patent discloses several ingredients in the formula of this application, the preparation process of the patent application is complicated and the compatibility needs to be improved. Summary of the invention

[0004] In view of the deficiencies in the prior art, the purpose of the present invention is to develop a Chinese medicine composition with weight loss effect and its application. The Chinese medicine composition has a unique and reasonable compatibility, no toxic side effects, obvious effects, low adverse reactions and low recurrence rate, and a simple and reasonable preparation method.

[0005] The technical solution of the present invention is: A Chinese medicine composition with weight loss effect, the medicine formula and dosage by weight are: 5-10 parts of roselle, 5-10 parts of lotus leaf, 2-6 parts of cassia seed, 2-6 parts of radish seed, 2-6 parts of coix seed, 2-6 parts of tuckahoe, 1-2 parts of blood orange, 1-3 parts of codonopsis pilosula, 1-2 parts of astragalus, 1-2 parts of euryale, 1-3 parts of dendrobium officinale, 1-3 parts of ophiopogon japonicus, 1-3 parts of cornus officinalis and 1-3 parts of cistanche deserticola.

[0006] Alternatively, the drug formula and dosage by weight are: 5-10 parts of roselle, 5-10 parts of lotus leaf, 2-6 parts of cassia seed, 2-6 parts of radish seed, 2-6 parts of coix seed, 2-6 parts of poria, 1-2 parts of blood orange, 1-3 parts of codonopsis pilosula, 1-2 parts of astragalus, and 1-2 parts of euryale.

[0007] Preferably, the formula and weight dosage of the traditional Chinese medicine composition are: 7 parts of roselle, 7 parts of lotus leaf, 4 parts of cassia seed, 4 parts of radish seed, 4 parts of coix seed, 4 parts of poria, 1 part of blood orange, 2 parts of codonopsis pilosula, 1 part of astragalus, 1 part of Euryale ferox, 2 parts of dendrobium officinale, 2 parts of ophiopogon, 2 parts of cornus officinalis, and 2 parts of cistanche.

[0008] Alternatively, the drug formula and dosage by weight are: 7 parts of roselle, 7 parts of lotus leaf, 4 parts of cassia seed, 4 parts of radish seed, 4 parts of coix seed, 4 parts of poria, 1 part of blood orange, 2 parts of codonopsis pilosula, 1 part of astragalus, and 1 part of euryale.

[0009] The preferred preparation method is: the preparation method comprises selecting roselle, lotus leaf, cassia seed, radish seed, coix seed, Poria, blood orange, Codonopsis pilosula, Astragalus, Euryale ferox, Dendrobium officinale, Ophiopogon japonicus, Cornus officinalis and Cistanche deserticola in the above proportions, grinding them into fine powder, passing through a 60-80 mesh sieve to obtain a finished medicinal powder.

[0010] Furthermore, the finished drug powder is further made into one of tablets, granules, pills, capsules and oral liquids according to conventional techniques in the art.

[0011] The present invention also provides application of the traditional Chinese medicine composition in preparing medicine for treating obesity.

[0012] The prescription of the present invention is explained as follows: Junyao Roselle has the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, and beautifying and nourishing the skin. As the main medicine in this prescription, its main functions are clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, improving blood circulation, promoting metabolism, and helping to lose weight and beautify.

[0013] Lotus leaves can clear away heat and dampness, raise the clear and lower the turbid. Lotus leaves can clear away heat and relieve summer heat, promote diuresis and reduce swelling, have a good effect on relieving symptoms caused by damp heat, and help eliminate excess water and fat in the body.

[0014] 2. Minister medicine: Cassia seed clears the liver and improves eyesight, moistens the intestines and promotes bowel movements. Cassia seed can clear liver fire, lower blood lipids, and has a good effect on red and swollen eyes caused by liver fire. It also helps to promote bowel movements and reduce the accumulation of toxins in the body.

[0015] Radish seeds can help digestion, relieve stagnation, and reduce qi and resolve phlegm. Radish seeds can promote gastrointestinal motility, help digestion, reduce moisture and phlegm in the body, and help lose weight.

[0016] Coix seed can invigorate the spleen and eliminate dampness, clear away heat and discharge pus. Coix seed can invigorate the spleen and eliminate dampness, help to eliminate moisture in the body and reduce fat accumulation.

[0017] Poria can promote diuresis and eliminate dampness, strengthen the spleen and calm the mind. Poria can promote diuresis and eliminate dampness, help eliminate excess water in the body, strengthen the spleen and calm the mind, and improve sleep quality.

[0018] 3. Adjuvant Blood oranges are rich in vitamin C and antioxidants, which help improve immunity, promote metabolism and reduce fat accumulation.

[0019] Codonopsis pilosula can nourish the middle and replenish qi, strengthen the spleen and nourish the stomach. Codonopsis pilosula can strengthen the body, improve immunity, and at the same time help digestion and absorption, and reduce fatigue.

[0020] Astragalus can replenish qi, strengthen the exterior, and promote diuresis. Astragalus can enhance the body's immunity, improve disease resistance, and at the same time help promote diuresis and reduce edema.

[0021] Gorgon fruit can strengthen the spleen and stop diarrhea, strengthen the kidney and astringe the essence. Gorgon fruit can strengthen the spleen and stop diarrhea, help improve digestive function, and at the same time strengthen the kidney and astringe the essence and enhance physical fitness.

[0022] Dendrobium candidum nourishes yin and clears heat, promotes the production of body fluid and quenches thirst. Dendrobium can nourish yin fluid and clear heat and detoxify. Ophiopogon can nourish yin and moisten the lungs, clear the heart and relieve restlessness. The two herbs are used to prevent the loss of yin fluid caused by drugs such as clearing heat and detoxifying, promoting dampness and relieving constipation.

[0023] Cornus officinalis nourishes the liver and kidneys, and astringes and consolidates the body. Cornus officinalis nourishes the liver and kidneys, strengthens the body, and astringes and consolidates the body. Cistanche deserticola nourishes the kidney yang, benefits the essence and blood, moistens the intestines and promotes bowel movements, and helps expel toxins from the body. The two herbs work together to restrain the harsh nature of the main and auxiliary herbs.

[0024] Compared with the prior art, the advantages of the present invention are: 1. The pharmacodynamic research data of the present invention prove that the composition of the present invention can reduce the body weight of nutritionally obese rats to varying degrees and has a good improvement effect on abnormal lipid metabolism.

[0025] 2. The clinical use effect of the present invention proves that patients treated with the composition of the present invention can effectively reduce body weight, BMI, waist-to-hip ratio, triglycerides, and total cholesterol, and the results are close to those of the orlistat group, with significant effects, few adverse reactions, low recurrence rate, high safety, and suitable for long-term use.

[0026] 4. The preparation method of the Chinese medicine composition of the present invention is simple and the clinical experimental effect is highly effective.

[0027] 5. Compared with the formula of the comparative example, the synergistic effect between the drugs in the Chinese medicine composition of the present invention is stronger and the therapeutic effect is better.

[0028] The detailed structure of the present invention is further described below in conjunction with specific implementation methods. DETAILED DESCRIPTION

[0029] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0030] The parts by weight described in the embodiments of the present invention refer to mass, and the general unit is g or kg. Example 1

[0031] A Chinese medicine composition with weight loss effect, the medicine formula and dosage by weight are: 7 parts of roselle, 7 parts of lotus leaf, 4 parts of cassia seed, 4 parts of radish seed, 4 parts of coix seed, 4 parts of tuckahoe, 1 part of blood orange, 2 parts of codonopsis pilosula, 1 part of astragalus, 1 part of euryale, 2 parts of dendrobium officinale, 2 parts of ophiopogon, 2 parts of cornus and 2 parts of cistanche.

[0032] Preparation method: Grind the above fourteen herbs into fine powder, pass through a 60-mesh to 80-mesh sieve to obtain finished powder, and package them with polyester / aluminum / polyethylene composite films, with 2g in each bag. Comparative Example 1

[0033] A traditional Chinese medicine composition, the drug formula and dosage by weight are: 7 parts of roselle, 4 parts of cassia seed, 4 parts of radish seed, 1 part of blood orange, 2 parts of codonopsis pilosula, 1 part of astragalus, and 1 part of euryale.

[0034] The preparation method is the same as that of Example 1: the above seven herbs are crushed into fine powder, passed through a 60-mesh to 80-mesh sieve to obtain finished powder, and then packaged with a composite film such as polyester / aluminum / polyethylene, with 2 g in each bag. Example 2

[0035] A traditional Chinese medicine composition, the drug formula and dosage by weight are: 7 parts of roselle, 7 parts of lotus leaf, 4 parts of cassia seed, 4 parts of radish seed, 4 parts of coix seed, 4 parts of tuckahoe, 1 part of blood orange, 2 parts of codonopsis pilosula, 1 part of astragalus, and 1 part of euryale.

[0036] Preparation method: Grind the above ten herbs into fine powder, pass through a 60-mesh to 80-mesh sieve to obtain finished powder, and package them with polyester / aluminum / polyethylene composite films, with 2g in each bag. Example 3 Animal pharmacodynamics experimental data Experiment 1 Effects of the Chinese medicine composition of Example 1 and the Chinese medicine composition of the comparative example on the obese rat model 1. Purpose of the test:

[0037] This experiment replicated the obese rat model to examine the therapeutic effect of the composition of Example 1 on nutritionally obese rats, providing a pharmacological basis for the clinical application of the composition of Example 1.

[0038] 2. Test materials: Test substances (test products): the composition of Example 1 (Gu Yitang (Hunan) Health Technology Co., Ltd.), the composition of Comparative Example 1 (Gu Yitang (Hunan) Health Technology Co., Ltd.), the composition of Example 2 (Gu Yitang (Hunan) Health Technology Co., Ltd.), intended clinical route: oral, 2 g at a time, 3 times a day, intended clinical course of treatment: 3 months, positive control group, name: Sibutramine Hydrochloride Capsules, production unit: Hainan General Sanyo Pharmaceutical Co., Ltd.; experimental animals: SPF grade, 75 SD male rats, weight range: 180-220 g.

[0039] 3. Methods 3.1 Establishment of the nutritional obesity model in rats and animal treatment 75 SPF grade SD male rats were randomly divided into a normal group of 10 rats and other groups of 65 rats according to their body weight, and were fed with ordinary feed and nutritious feed respectively. The formula of nutritious feed is as follows: add 10g of milk powder, 10g of lard, 1 egg, 10 drops of concentrated cod liver oil (vitamin A17000U, vitamin D1700U), and 250g of fresh soybean sprouts to every 100g of ordinary feed, and increase 2g every week until the 6th week. The feed is supplied twice a day, and no more is added after eating. The weight of rats fed with nutritious feed exceeds 20% of the weight of rats fed with ordinary feed as the obesity standard, and 50 obese rats are screened out, and they are randomly divided into a model control group, a sibutramine group (positive control), a ratio 1, an embodiment 2, and an embodiment 1 according to their body weight, with 10 rats in each group. Sibutramine group (positive control), ratio 1, example 2, example 1 were given once a day by gavage in the morning, the dosage volume was 10 mL / kg; the model control group was given the same volume of 0.5% sodium carboxymethyl cellulose by gavage, and the dosage was continued for 4 weeks. Weigh the body weight once a week, and after the last administration and fasting for 24 hours, chloral hydrate anesthesia, blood was collected from the abdominal aorta, centrifuged at 3000 r / min for 10 minutes, serum was separated, and stored in a -70℃ refrigerator for standby use, and the fat around the kidneys and testicles was taken, and the wet weight was weighed, and a small piece of adipose tissue from the same part around the genitals was taken, fixed with 2.5% formaldehyde ethanol solution, and the number and diameter of fat cells in the whole field of view were counted under a 400x microscope. 2.2 Determination of serum triglyceride (TG) and total cholesterol (TC) content The above serum was taken and determined by an automatic biochemical analyzer.

[0040] 3.2 Dose setting The clinical dosage of the composition of Example 1, Comparative Example 1 and Example 2 is 6 g / day, which is converted into a rat clinical equivalent dosage based on body surface area = adult dosage × 0.018 × 5 = 0.54 g / kg. The dosage of sibutramine hydrochloride (positive control group) group is set at 0.008 g / kg.

[0041] 3.3 Result calculation and statistics SPSS21.0 software was used for data statistics. The experimental data were expressed as `x±S. Normality and homogeneity of variance were compared among multiple groups. When the variance was homogeneous and normal, one-way analysis of variance was used. When it was not normal, the Nonparametric T test was used. When it was normal but the variance was not homogeneous, the Tamhane's T2 test was used. If it was not normal, the Kruskal-Wallis test was used, and the Mann-Whitney test was used for pairwise comparison analysis. P<0.05 indicated statistical significance, and P<0.01 indicated that the difference tested was very significant.

[0042] 4 Test results 4.1 Effects on body weight and fat in the nutritional obesity rat model As shown in Table 1, compared with the blank control group, the body weight, wet weight of fat around the kidney and wet weight of fat around the testicles of the rats in the model control group were significantly increased (P<0.01); compared with the model control group, the body weight, wet weight of fat around the kidney and wet weight of fat around the testicles of the rats in Comparative Example 1, Example 2, Example 1 and the positive control group were significantly reduced (P<0.05 or P<0.01); compared with Comparative Example 1 and Example 2, the body weight, wet weight of fat around the kidney and wet weight of fat around the testicles of Example 1 were significantly reduced (P<0.05 or P<0.01), there was no statistically significant difference between Example 1 and the positive control group (P>0.05), and compared with Comparative Example 1, the body weight, wet weight of fat around the kidney and wet weight of fat around the testicles of the rats in Example 2 were significantly reduced (P<0.05). The results are shown in Table 1.

[0043]

[0044] As shown in Table 2, compared with the blank control group, the TG and TC levels of the rats in the model control group were significantly increased (P<0.01); compared with the model control group, the TG and TC levels of the rats in the comparative example 1, embodiment 2, embodiment 1, and the positive control group were significantly reduced (P<0.05 or P<0.01); compared with the comparative example 1 and embodiment 2, the TG and TC levels of embodiment 1 were significantly reduced (P<0.05 or P<0.01), there was no statistically significant difference in TG and TC between embodiment 1 and the positive control group (P>0.05), and TC was significantly reduced in embodiment 2 compared with the comparative example 1 (P<0.05). The results are shown in Table 2.

[0045]

[0046] As shown in Table 3, compared with the blank control group, the number of rat cells in the model control group was significantly reduced (P<0.01), and the cell diameter was significantly increased (P<0.01); compared with the model control group, the number of rat cells in Comparative Example 1, Example 2, Example 1, and the positive control group was significantly increased (P<0.05 or P<0.01), and the diameter of rat cells was significantly reduced (P<0.05 or P<0.01); compared with Comparative Example 1 and Example 2, the number of rat cells in Example 1 was significantly increased (P<0.05 or P<0.01), and the diameter of rat cells was significantly reduced (P<0.05 or P<0.01), and there was no statistically significant difference between Example 1 and the positive control group (P>0.05), and the number of rat cells in Example 2 was significantly increased compared with Comparative Example 1 (P<0.05), and the diameter of rat cells was significantly reduced (P<0.05). The results are shown in Table 3.

[0047]

[0048] 5. Conclusion: Under the conditions of this experiment, Comparative Example 1, Example 2, and the composition of Example 1 can increase the number of cells in nutritionally obese rats to varying degrees, significantly reduce the cell diameter of highly nutritionally obese rats, reduce TG and TC levels, and reduce body weight, wet weight of fat around the kidneys, and wet weight of fat around the testicles. Example 1 has better efficacy than Comparative Example 1 and Example 2; Example 1 has a significant synergistic effect compared with Comparative Example 1 and Example 2.

[0049] Example 4 Clinical analysis data of the Chinese medicine composition of Example 1 General data: 122 patients who met the diagnosis of pure obesity were selected according to the standard for observation and randomly divided into Example 1 and a control group. In Example 1, there were 35 males and 26 females, aged 20 to 60 years old, with an average age of (43.27±6.14) years old, and a course of 8 months to 6 years; in the control group, there were 33 males and 28 females, aged 20 to 60 years old, with an average age of (42.85±6.63) years old, and a course of 8 months to 7 years. There was no significant difference in the general conditions between the two groups (P>0.05), and they were comparable.

[0050] Inclusion criteria: patients who meet the Western medicine diagnostic criteria for simple obesity; obese patients who meet the phlegm-dampness constitution in traditional Chinese medicine; aged between 18 and 65 years old. All patients meet the obesity diagnostic criteria, with a weight exceeding the standard weight by 20%, or a BMI exceeding 24.

[0051] Exclusion criteria: pregnant or lactating women; those who are allergic to Chinese medicine ingredients; those with serious complications of heart, liver, kidney, brain, etc. or other serious primary diseases, and mental patients.

[0052] Treatment method: The control group was treated with orlistat (produced by Chongqing Huasen Pharmaceutical Co., Ltd., national medicine standard H20103180) during meals or within one hour after meals, 1 tablet / time, 3 times / day; the Example 1 group orally took the product of Example 1 of the present invention (provided by Gu Yitang (Hunan) Health Technology Co., Ltd., 2g / bag), 1 bag each time, 3 times a day, and both groups of patients were treated for 3 consecutive months. During the medication period, it is forbidden to eat fatty, sweet, thick, sticky, heavy and difficult to digest food, reduce the amount of staple food, increase the amount of vegetables and fruits, and appropriately increase the amount of exercise.

[0053] Criteria for judging efficacy: Cured: clinical symptoms completely disappeared and body weight returned to normal levels; markedly effective: most clinical symptoms disappeared and body weight decreased by more than 5kg; effective: clinical symptoms were alleviated and body weight decreased by more than 3kg; ineffective: clinical symptoms did not improve significantly and body weight decreased by less than 3kg.

[0054] Observation indicators: The changes in body weight, BMI, waist circumference, waist-to-hip ratio and blood lipids (triglycerides, total cholesterol) were observed before and after treatment. The occurrence of gastrointestinal reactions, fatty stools, abdominal pain, allergies and other adverse reactions during the treatment were observed. The patients were followed up for 1 year and the recurrence of obesity was recorded.

[0055] Statistical methods: SPSS16.0 statistical software was used for data collection and analysis. The t-test was used for comparison of quantitative data, and the x2 test was used for comparison of counting data. P<0.05 indicated statistical significance.

[0056]

[0057]

[0058]

[0059]

[0060] As shown in Tables 4-7, the weight, BMI, waist-hip ratio, triglycerides and total cholesterol of the two groups of patients before and after treatment were compared: before treatment, there was no significant difference in weight, BMI, waist-hip ratio, triglycerides and total cholesterol between the two groups (P>0.05); after treatment, the weight, BMI, waist-hip ratio, triglycerides and total cholesterol of the two groups were lower than those before treatment (P<0.05 or P<0.01); the weight, BMI, waist-hip ratio, triglycerides and total cholesterol of the control group after treatment were similar to those of the Example 1 group, and there was no significant difference (P>0.05); observation and comparison of adverse reactions: the incidence of adverse reactions in the Example 1 group after treatment was lower than that in the control group, and the difference was statistically significant (P<0.05); observation and comparison of recurrence rate: the incidence of adverse reactions in the Example 1 group after treatment was lower than that in the control group, and the difference was statistically significant (P<0.05).

[0061] The above is a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, can make equivalent replacements or changes according to the technical solutions and concepts of the present invention, which should be covered by the protection scope of the claims of the present invention.

Claims

1. A Chinese medicine composition having a weight loss effect, characterized in that: The drug formula and dosage by weight are as follows: 5-10 parts of roselle, 5-10 parts of lotus leaf, 2-6 parts of cassia seed, 2-6 parts of radish seed, 2-6 parts of coix seed, 2-6 parts of tuckahoe, 1-2 parts of blood orange, 1-3 parts of codonopsis pilosula, 1-2 parts of astragalus, 1-2 parts of Euryale ferox, 1-3 parts of dendrobium officinale, 1-3 parts of ophiopogon japonicus, 1-3 parts of cornus officinalis, and 1-3 parts of cistanche deserticola. Alternatively, the drug formula and dosage by weight are: 5-10 parts of roselle, 5-10 parts of lotus leaf, 2-6 parts of cassia seed, 2-6 parts of radish seed, 2-6 parts of coix seed, 2-6 parts of poria, 1-2 parts of blood orange, 1-3 parts of codonopsis pilosula, 1-2 parts of astragalus, and 1-2 parts of euryale.

2. A Chinese medicine composition with weight loss effect according to claim 1, characterized in that: The drug formula and dosage by weight are as follows: 7 parts of roselle, 7 parts of lotus leaf, 4 parts of cassia seed, 4 parts of radish seed, 4 parts of coix seed, 4 parts of tuckahoe, 1 part of blood orange, 2 parts of codonopsis pilosula, 1 part of astragalus, 1 part of Euryale ferox, 2 parts of dendrobium officinale, 2 parts of ophiopogon, 2 parts of cornus officinalis, and 2 parts of cistanche; Alternatively, the drug formula and dosage by weight are: 7 parts of roselle, 7 parts of lotus leaf, 4 parts of cassia seed, 4 parts of radish seed, 4 parts of coix seed, 4 parts of poria, 1 part of blood orange, 2 parts of codonopsis pilosula, 1 part of astragalus, and 1 part of euryale.

3. A method for preparing a Chinese medicine composition having a weight loss effect according to any one of claims 1 to 2, characterized in that: The preparation method comprises selecting roselle, lotus leaf, cassia seed, radish seed, coix seed, tuckahoe, blood orange, codonopsis, astragalus, euryale, dendrobium officinale, ophiopogon japonicus, cornus officinalis and cistanche deserticola according to the above proportion, crushing them into fine powder, and passing through a 60-80 mesh sieve to obtain finished medicinal powder.

4. A Chinese medicine composition with weight loss effect as described in claim 3, and its preparation method and use: the finished powder is further made into one of tablets, granules, pills, capsules and oral liquids according to conventional techniques in the art.

5. Use of the Chinese medicine composition according to any one of claims 1 to 2 in the preparation of a drug for treating obesity.

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