Application of CHAF1B in preparation of medicine for regulating and controlling autophagy activity of breast cancer cells

Abstract

The invention is applicable to the technical field of biological medicines, and provides application of targeted CHAF1B in preparation of a medicine for regulating and controlling autophagy activity of breast cancer cells. The invention reveals that targeted CHAF1B can activate autophagic death of breast cancer cells for the first time, provides a new strategy for molecular targeted therapy of breast cancer, and shows a good anti-tumor effect; the CHAF1B is proved to be remarkably and highly expressed in breast cancer tissues and is related to prognosis of patients, so that the CHAF1B can be used as a potential diagnosis, treatment and prognosis monitoring target of the breast cancer; the invention discusses that CHAF1B targeted MAPK signal channel induces autophagic death, provides theoretical support for application of CHAF1B as a new therapeutic target, enriches cognition of CHAF1B for regulating breast cancer cell proliferation molecular mechanism, provides a new thought and direction for searching for a new target for breast cancer treatment, and provides a new foundation for application of CHAF1B targeted MAPK signal channel induced autophagic death and application of CHAF1B targeted MAPK signal channel induced autophagic death. And a theoretical basis and an experimental basis are provided for clinically developing a new treatment target.