Application of paeonia suffruticosa stilbene compound extract in preparation of anti-porcine virus active component

By using stilbene compound extract (SEP) to inhibit the replication of porcine pseudorabies virus (PRV), the problem of limited effects of anti-PRV drugs in the prior art is solved, and better antiviral effects and lower doses are achieved.

CN120037282AActive Publication Date: 2025-05-27WUHAN ACADEMY OF AGRI SCI +1
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Patent Information

Application Number
CN202510335900.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-03-20
Publication Date
2025-05-27
Estimated Expiration
2045-03-20

AI Technical Summary

Technical Problem

There is a lack of effective anti-pig pseudorabies virus (PRV) drugs in the prior art, especially when facing domestic exponential variants, the effects of traditional drugs are limited.

Method used

Using stilbene compound extract (SEP) as the antiviral active ingredient, drug preparations, disinfectants and/or feed additives for the preparation of anti-pig rabies virus drugs are prepared.

Benefits of technology

SEP significantly reduces the death of viral-infected cells, has better antiviral effects and lower doses used, and SEP exhibits stronger antiviral ability in the inhibition of PRV compared to traditional resveratrol and leucidol.

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Abstract

The invention belongs to the field of biological medicines, and particularly relates to application of a peony stilbene compound extract (SEP) in preparation of an anti-porcine virus active component. According to the invention, SEP is extracted from peony seeds or pod shells, and can significantly inhibit the replication of porcine PRV virus in porcine kidney PK15 cells. The effective concentration is 0.0078-5 [mu] g / mL, the cell median lethal dose is 15.81 [mu] g / mL, and the anti-porcine PRV virus semi-inhibitor dose is 0.164 [mu] g / mL; and the cell survival rate reaches 84.7% and the virus inhibition rate reaches 90.4% due to 0.625 [mu] g / mL of SEP. Compared with resveratrol or piceatannol and a resveratrol and piceatannol mixture, the SEP has a better antiviral effect, a lower onset dose and a larger safe dose on porcine viruses, and has a very good application prospect in the fields of porcine virus-resistant feed development, veterinary drug, medicine development and the like.
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