Decoction for treating diabetic foot ulcer by dredging channels and promoting healing

Abstract

The invention relates to a meridian-dredging and healing-promoting decoction for treating diabetic foot ulcer, and belongs to the technical field of traditional Chinese medicine preparation. The formula of the meridian-dredging and healing-promoting decoction comprises a monarch drug, a ministerial drug, an adjuvant drug and a conductant drug, the monarch drug comprises 20g of bombyx batryticatus used for dispelling wind, dredging collaterals, detoxifying and removing stasis; ministerial drugs: 10g of curcuma zedoary used for promoting blood circulation to remove blood stasis, and 15g of oyster used for softening hardness to dissipate stagnation; and adjuvant drugs: 3g of leech used for breaking blood and removing stasis, 10g of bighead atractylodes rhizome used for tonifying spleen and drying dampness, 10g of ligusticum wallichii used for promoting qi to activate blood, and 10g of achyranthes bidentata used for guiding the drugs to move downwards. The traditional Chinese medicine decoction is a clinical effective empirical prescription, accords with the theory of reducing phlegm, removing blood stasis, dredging collaterals and promoting healing in traditional Chinese medicine, improves the vascular function and promotes ulcer healing, the lower limb blood vessels of a patient treated by the decoction are smooth, and ulcer healing is obvious; a multi-target action mechanism can synchronously improve vasculopathy and repair wounds, and the limitation of traditional single-mechanism treatment is broken through; in addition, the traditional Chinese medicine composition is high in safety and especially suitable for long-term bedridden patients and complication patients.

Description

Technical Field

[0001] The invention relates to a meridian-promoting and healing decoction for treating diabetic foot ulcers, belonging to the technical field of traditional Chinese medicine pharmaceuticals. Background Art

[0002] Diabetic foot ulcer is one of the serious complications of diabetes. Its core pathological mechanism is hyperglycemia-induced vascular endothelial damage, microcirculation disorders and delayed wound repair.

[0003] At present, clinical treatment is mainly based on anti-infection, vascular intervention and debridement, but there are problems such as antibiotic resistance, bleeding risk of anticoagulants, limited effect of interventional treatment, decreased quality of life after amputation and high cost, with an annual medical burden of more than 20 billion yuan. Traditional Chinese medicine has the advantage of "multiple components and multiple targets" in the treatment of diabetic foot ulcers, but the existing compound prescriptions mostly focus on a single mechanism and lack systematic regulation of the pathogenesis of "phlegm and blood stasis blocking the collaterals" and the molecular pathways of vascular lesions. Based on this, the present invention provides a Tongmai Cuyu decoction for the treatment of diabetic foot ulcers. Summary of the invention

[0004] In view of this, the present invention provides a decoction for promoting blood circulation and promoting healing for treating diabetic foot ulcers. The present invention is a clinically effective empirical prescription, which conforms to the TCM theory of "resolving phlegm and removing blood stasis, promoting blood circulation and promoting healing", improves vascular function and promotes ulcer healing.

[0005] The invention provides a Tongmai Cuyu decoction for treating diabetic foot ulcers. The proposed technical scheme is as follows: the formula of the Tongmai Cuyu decoction comprises a monarch drug, a minister drug, an adjuvant drug and a guiding drug, wherein the monarch drug: 20g of Bombyx Batryticatus, used for dispelling wind and unblocking collaterals, detoxifying and dispersing nodules; the minister drug: 10g of Curcuma Atractylodes, used for promoting blood circulation and removing blood stasis, 15g of Oyster, used for softening and dispersing nodules; the adjuvant and guiding drugs: 3g of Leech, used for breaking blood circulation and removing blood stasis, 10g of Atractylodes macrocephala, used for invigorating the spleen and drying dampness, 10g of Ligusticum chuanxiong, used for promoting qi and activating blood circulation, and 10g of Achyranthes bidentata, used for guiding the drugs downward.

[0006] Furthermore, the Tongmai Cuyu Decoction is prepared by the following steps: S1: Cleaning: Wash the medicinal materials weighed according to the weight ratio in the above formula in turn; S2: Preparation: Put the washed medicinal materials into a decoction container, and add 10 times the amount of water to the decoction container; S3: Decoction: Decoction twice; S4: Residue removal: Filter out the medicinal residue to obtain the Tongmai Cuyu Decoction.

[0007] Furthermore, in step S2, the mixture is decocted twice, the first time it is boiled and then simmered for 1 hour, and the second time it is decocted for 40 minutes.

[0008] The silkworm is a Chinese herbal medicine for dissolving phlegm and dispersing knots, which can relieve body convulsions, muscle stiffness, dissolve phlegm, eliminate lumps, etc. It is often used to improve symptoms such as facial paralysis, headache, dizziness, sore throat and swollen lymph nodes;

[0009] Curcuma is a blood-activating and blood-dissolving medicine that has the functions of promoting the circulation of qi and blood, dissipating blood stasis and swelling, helping to dredge the circulation of qi and blood in the body, dissolving blood stasis, and at the same time improving abdominal distension caused by food accumulation and relieving pain.

[0010] Oysters are salty, astringent, and slightly cold in nature. They enter the liver and kidney meridians and have the effects of calming the liver and suppressing yang, softening and dispersing nodules, and astringing and consolidating.

[0011] Leeches are pungent, salty, bitter, neutral, slightly toxic, and enter the liver meridian. They have the effects of breaking up blood, removing blood stasis, and promoting menstruation and eliminating symptoms.

[0012] Atractylodes macrocephala is a traditional Chinese medicine that strengthens the spleen and eliminates dampness. It has the effects of strengthening the spleen and stomach, improving loss of appetite, and promoting digestion and absorption. It is often used to relieve problems such as abdominal distension and diarrhea, limb fatigue, edema, and abnormal sweating.

[0013] Chuanxiong is a blood-activating and qi-promoting medicine that has the effects of promoting blood circulation and relieving pain. It is often used to improve dysmenorrhea, swelling and pain caused by injuries, headaches, joint pain and other problems caused by poor blood circulation.

[0014] Achyranthes bidentata is a blood-activating and blood-stasis-removing medicine that has the functions of promoting blood circulation and nourishing the liver and kidneys. It is often used to relieve joint pain, soreness of the waist and knees, and swelling and pain caused by trauma.

[0015] The beneficial effects of the invention are as follows: the invention is a clinically effective empirical prescription, which conforms to the TCM theory of "resolving phlegm and removing blood stasis, unblocking meridians and promoting healing", improves vascular function and promotes ulcer healing. After the decoction treatment, the patient's lower limb blood vessels are unobstructed and the ulcer heals significantly; its multi-target mechanism of action can simultaneously improve vascular lesions and wound repair, breaking through the limitations of traditional single mechanism treatment; in addition, the Chinese medicine composition has high safety and is particularly suitable for patients who are bedridden for a long time and have complications. DETAILED DESCRIPTION

[0016] The preferred embodiments of the present invention will be described in detail below.

[0017] The invention provides a Tongmai Cuyu decoction for treating diabetic foot ulcers. The formula of the Tongmai Cuyu decoction comprises a monarch drug, a minister drug, an adjuvant drug and a guiding drug, wherein the monarch drug: 20g of Bombyx Batryticatus, which is used for dispelling wind and unblocking collaterals, detoxifying and dispersing nodules; the minister drug: 10g of Curcuma, which is used for promoting blood circulation and removing blood stasis, and 15g of Oyster, which is used for softening and dispersing nodules; the adjuvant and guiding drugs: 3g of Hirudo, which is used for breaking blood circulation and removing blood stasis, 10g of Atractylodes macrocephala, which is used for invigorating the spleen and drying dampness, 10g of Ligusticum chuanxiong, which is used for promoting qi and promoting blood circulation, and 10g of Achyranthes bidentata, which is used for guiding the drugs to move downward.

[0018] As an optional embodiment, the Tongmai Cuyu Decoction is prepared by the following steps: S1: Cleaning: Wash the medicinal materials weighed according to the weight ratio in the above formula in turn; S2: Preparation: Put the washed medicinal materials into a decoction container, and add 10 times the amount of water to the decoction container; S3: Decoction: Decoction twice, boil for the first time and then simmer for 1 hour, and decoct for the second time for 40 minutes; S4: Residue removal: Filter out the medicinal residue to obtain the Tongmai Cuyu Decoction.

[0019] As an optional embodiment, a typical case:

[0020] Liu XX, 72 years old.

[0021] Chief complaint: Foot skin ulcers and exudation for more than 2 months, aggravated for 20 days.

[0022] Past history: history of hypertension for more than 20 years. Currently taking amlodipine besylate tablets, blood pressure is well controlled.

[0023] The patient has a 3-year history of cerebral infarction and is currently taking atorvastatin calcium tablets and clopidogrel.

[0024] The patient has a 10-year history of diabetes and is currently taking chewable acarbose tablets, but his blood sugar control is poor.

[0025] Current medical history: Two months ago, the skin of the feet became red and swollen, with local ulceration and exudation. Erythromycin ointment was applied for treatment, but the effect was not good.

[0026] 20 days ago, due to improper care, the ulceration and necrosis of the skin and soft tissue of the affected area worsened, accompanied by obvious exudation.

[0027] The diagnosis through wound surface, tongue and pulse is: phlegm and blood stasis are intertwined, and the blood vessels are blocked.

[0028] Auxiliary examination: 10.9 local hospital medical records, color Doppler ultrasound showed: thrombosis of the right calf posterior tibial vein and intermuscular vein; thickening of the intima-media of the bilateral lower limb arteries and plaque formation.

[0029] Treatment: On 10.09, dalteparin sodium 5000 IU ih was used; on 10.17, clopidogrel 75 mg was taken orally qd; on 10.23, dalteparin sodium was stopped and replaced with rivaroxaban 20 mg was taken orally qd.

[0030] The traditional Chinese medicine prescription Tongmai Cuyu Decoction was used on 10.10, 10.18, 10.25, 11.01, 11.08, 11.13 and 11.20.

[0031] Efficacy: October 14, October 29, November 1: Color Doppler ultrasound showed thrombosis of the right calf posterior tibial vein and bilateral intermuscular veins; thickening of the intima-media of the bilateral lower limb arteries and plaque formation.

[0032] After taking Tongmai Cuyu Decoction for 3 weeks (November 1): the posterior tibial vein in the right calf was unobstructed.

[0033] November 7: Color Doppler ultrasound showed bilateral intermuscular vein thrombosis; thickening of the intima-media of the bilateral lower limb arteries and plaque formation.

[0034] After taking Tongmai Cuyu Decoction for 5 weeks (November 14): the deep vein artery thrombosis in the left lower limb disappeared.

[0035] November 14: Color Doppler ultrasound showed that the intima of the left lower limb artery was thickened and rough, and multiple atherosclerotic plaques were formed in the left lower limb artery; the flow velocity in the deep vein of the left lower limb was slow, and the deep and superficial veins of the left lower limb were temporarily unobstructed.

[0036] After taking Tongmai Cuyu Decoction for 6 weeks (November 27): the plaques in the deep and superficial veins of both lower limbs disappeared.

[0037] November 27: Arteriosclerosis of both lower limbs; deep and superficial veins of both lower limbs are patent.

[0038] The present invention is a clinically effective empirical prescription, which conforms to the TCM theory of "resolving phlegm and removing blood stasis, unblocking meridians and promoting healing", improves vascular function and promotes ulcer healing. After treatment with Tongmai Cuyu Decoction, the patient's lower limb blood vessels are unobstructed and the ulcer heals significantly; its multi-target mechanism of action can simultaneously improve vascular lesions (inhibit plaques, promote new blood vessels) and wound repair (anti-inflammation, promote granulation growth), breaking through the limitations of traditional single mechanism treatment. In addition, the Chinese medicine composition has high safety and is particularly suitable for patients who are bedridden for a long time and have complications.

[0039] The present invention and its implementation methods are described above, and such description is not restrictive, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and implementation method similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. A decoction for promoting blood circulation and promoting healing for treating diabetic foot ulcer, characterized in that: The formula of the Tongmai Cuyu Decoction includes monarch medicine, ministerial medicine, adjuvant medicine and guiding medicine, wherein the monarch medicine: Bombyx Batryticatus 20g, is used for dispelling wind, unblocking meridians, detoxifying and dispersing nodules; the ministerial medicine: Curcuma 10g, is used for promoting blood circulation and removing blood stasis, and Oyster 15g, is used for softening and dispersing nodules; the adjuvant and guiding medicine: Leech 3g, is used for breaking blood and removing blood stasis, Atractylodes 10g, is used for invigorating the spleen and drying dampness, Ligusticum chuanxiong 10g, is used for promoting qi and activating blood circulation, and Achyranthes bidentata 10g, is used for guiding the medicine downward.

2. The decoction for promoting blood circulation and promoting healing for treating diabetic foot ulcer according to claim 1, characterized in that: The Tongmai Cuyu Decoction is prepared by the following steps: S1: cleaning: washing the medicinal materials weighed according to the weight ratio in the above formula in turn; S2: preparation: putting the washed medicinal materials into a decoction container, and adding 10 times the amount of water to the decoction container; S3: decoction: decoct twice; S4: residue removal: filtering out the medicinal residue to obtain the Tongmai Cuyu Decoction.

3. The decoction for promoting blood circulation and promoting healing for treating diabetic foot ulcer according to claim 2, characterized in that: In step S2, the mixture is decocted twice, the first time it is boiled and then decocted over low heat for 1 hour, and the second time it is decocted for 40 minutes.