Nutritional food with anti-inflammatory and anti-allergic functions and preparation method thereof

Abstract

The invention discloses a nutritious food with anti-inflammatory and anti-allergic functions and a preparation method of the nutritious food, and relates to the technical field of functional nutritious foods. 4-7 parts of a licorice extract; 2-4 parts of a dried orange peel extract; 0.2-1 part of a radix puerariae extract; 15 to 20 parts of blueberry powder; 5 to 10 parts of elderberry powder; 10-15 parts of sweet osmanthus powder; 10 to 15 parts of isomaltooligosacharide; 8 to 12 parts of a probiotic material; 0.2 to 1 part of 2-oxoglutaric acid (AKG); 0.01 to 0.2 part of natural menthol; the feed additive is prepared from 7000 [mu] g of vitamin A, 150 [mu] g of vitamin D, 400 mg of vitamin E, 150 mg of vitamin B, 30 mg of vitamin B2, 30 mg of vitamin B6, 60 [mu] g of vitamin B12, 900 mg of vitamin C, 400 mg of nicotinic acid, 4000 [mu] g of folic acid, 100 mg of pantothenic acid, 500 [mu] g of biotin, 860 [mu] g of chromium, 670 [mu] g of selenium and 1000 mg of taurine. The medicinal and edible extract, the probiotics, the anthocyanin-rich fruit powder and the vitamins are coordinated to achieve certain anti-inflammatory and anti-oxidation effects.

Description

Technical Field

[0001] The present invention relates to the technical field of functional nutritional foods, and particularly relates to a nutritional food with anti-inflammatory and anti-allergic functions and a preparation method thereof. Background Art

[0002] In modern life, due to the influence of various factors such as environmental pollution, life pressure, and bad eating habits, the occurrence of inflammation and allergy symptoms in people is increasing day by day. Inflammation and allergy will not only affect people's physical health but also reduce the quality of life. At present, although there are some anti-inflammatory and anti-allergic drugs on the market, long-term use may produce side effects. Therefore, developing a safe, effective nutritional food with anti-inflammatory and anti-allergic functions has important practical significance.

[0003] Existing nutritional foods mostly focus on single active ingredients (such as probiotics or plant extracts), lacking the synergistic effect of multiple ingredients, resulting in limited anti-inflammatory and anti-allergic effects.

[0004] For example, a whole-nutrition formula food for allergic people based on pea protein with the authorization announcement number of CN111165812A includes the following components: pea protein, zein, stearic acid, arachidonic acid, linoleic acid, α-linolenic acid, soybean oligosaccharide, galactose, glucose, essential vitamins, and essential minerals. In the present invention, pea protein is used as high-quality protein, combined with zein, and additionally added with carbohydrates, vitamins, and minerals, avoiding allergens and providing high-quality protein at the same time. While preventing allergies, the nutrition is balanced and can meet the various nutrient requirements of allergic people, solving the problem that existing medical formula foods are difficult to be consumed by allergic people.

[0005] However, there are still some problems: This patent is based on pea protein and zein, combined with essential fatty acids (such as α-linolenic acid), vitamins, and minerals, avoiding common allergens (such as soybeans and wheat), without combining plant extracts (such as rutin and anthocyanins) with probiotics, lacking the direct antioxidant effect of plant polyphenols (such as rutin and anthocyanins) and the targeted regulation of probiotics on the intestinal flora, and unable to block the vicious cycle of "oxidative stress-inflammation cascade-intestinal barrier damage" of allergic reactions, resulting in a single anti-inflammatory and anti-allergic mechanism. Summary of the Invention

[0006] The embodiments of the present invention provide a nutritional food with anti-inflammatory and anti-allergic functions and a preparation method thereof to solve the existing technical problems.

[0007] The embodiments of the present invention adopt the following technical solution: A nutritional food with anti-inflammatory and anti-allergic functions, including the following raw materials in parts by weight: 8-15 parts of sophora japonica extract;

[0008] 4-7 parts of licorice extract;

[0009] 2 - 4 parts of tangerine peel extract;

[0010] 0.2 - 1 part of kudzu root extract;

[0011] 15 - 20 parts of blueberry powder;

[0012] 5 - 10 parts of elderberry powder;

[0013] 10 - 15 parts of osmanthus powder;

[0014] 10 - 15 parts of isomaltooligosaccharide;

[0015] 8 - 12 parts of probiotic material;

[0016] 0.2 - 1 part of 2 - oxoglutaric acid (AKG);

[0017] 0.01 - 0.2 part of natural menthol;

[0018] 7000 ug of vitamin A, 150 ug of vitamin D, 400 mg of vitamin E, 50 mg of vitamin B1, 30 mg of vitamin B2, 30 mg of vitamin B6, 60 ug of vitamin B12, 900 mg of vitamin C, 400 mg of niacin, 4000 ug of folic acid, 100 mg of pantothenic acid, 500 ug of biotin, 860 ug of chromium, 670 ug of selenium, 1000 mg of taurine.

[0019] Furthermore, the rutin content in the sophora flower extract is ≥ 80%. Rutin is the key active ingredient in the sophora flower extract that plays an anti - inflammatory role. A high content of rutin (≥ 80%) means that the sophora flower extract can more effectively inhibit the release of inflammatory mediators, such as reducing the production of inflammatory factors like TNF - α and IL - 6, thereby significantly enhancing the overall anti - inflammatory effect of the nutritional food, helping to relieve various discomfort symptoms caused by inflammation, such as swelling and pain, and better meeting the health care needs of people with anti - inflammatory requirements.

[0020] Furthermore, the anthocyanin content in the blueberry powder is ≥ 25%. Anthocyanin is a powerful antioxidant, which has the functions of scavenging free radicals and reducing oxidative stress damage. In terms of anti - allergy, anthocyanin can regulate the immune system, inhibit the degranulation of mast cells, and reduce the release of allergy mediators such as histamine. A high content of anthocyanin (≥ 25%) enables the blueberry powder to fully exert its antioxidant and anti - allergy effects in the nutritional food, cooperate with other ingredients to jointly improve the body's allergic reaction, and enhance the body's resistance.

[0021] Furthermore, the probiotic material contains Lactobacillus plantarum LP05, Lactobacillus plantarum LP18, Lactobacillus paracasei LC86, Bifidobacterium animalis subspecies lactis BLa36, and Lactobacillus casei LC89, which cooperate with each other to regulate the body's immune system from multiple aspects, such as regulating the balance of Th1 / Th2 cells, inhibiting the production of IgE antibodies, and enhancing the intestinal mucosal barrier function, thereby producing a synergistic anti-allergic effect, which can more effectively prevent and alleviate allergic symptoms than a single strain.

[0022] Furthermore, in the probiotic material, the number of live bacteria of each strain is ≥1×10^10CFU / g. The number of live bacteria ≥1×10^10CFU / g can ensure that after the nutritional food goes through the processes of production, storage, transportation, etc., there are still a large number of live bacteria reaching the intestine and playing a role. These live bacteria can metabolize and reproduce normally in the intestine, produce beneficial metabolites such as short-chain fatty acids, regulate the intestinal microecological environment, and then play anti-inflammatory, anti-allergic and other physiological functions.

[0023] Furthermore, the dosage form is a powder, which is easy to be divided into small packages. Consumers can accurately control the dosage according to their own needs. The way of taking is also more flexible. It can be taken directly with warm water or added to other foods or drinks, which improves the compliance of consumers, especially for special groups such as children and the elderly, making it more convenient to eat.

[0024] Further, the following steps are included:

[0025] S1, extract processing: Sophora japonica extract, licorice extract, tangerine peel extract, kudzu root extract are respectively sieved through 80-100 meshes to remove possible impurities and large particles, to ensure the uniformity and fineness of the extract, to facilitate subsequent mixing, for probiotic materials (Lactobacillus plantarum LP05, Lactobacillus plantarum LP18, Lactobacillus paracasei LC86, Bifidobacterium animalis subspecies lactis BLa36, Lactobacillus casei LC89), each strain is mixed in equal proportions according to the number of viable bacteria, and a stepwise mixing method can be adopted, first two probiotics are mixed evenly, and then the third is added, and so on, to ensure that the five probiotics are fully mixed, and the total amount of the mixed probiotic material is 8-12 parts;

[0026] S2. Fruit powder processing: blueberry powder, elderberry powder and osmanthus powder are sieved through 60-80 mesh sieves respectively to make the fruit powder particles uniform in size, avoid agglomeration during the mixing process, and ensure the uniformity of mixing;

[0027] S3. Other raw material treatment: If the isomaltooligosaccharide agglomerates, it can be placed in a drying oven and dried at 40 - 50 °C for 1 - 2 hours to soften it, then sifted to ensure the loose state of the isomaltooligosaccharide. 2 - oxoglutaric acid (AKG) and natural menthol are accurately weighed respectively. Since their dosages are small, a high - precision electronic balance (accuracy of 0.001 g) can be used for weighing to ensure the accuracy of the dosage. For various vitamins (vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, folic acid, pantothenic acid, biotin), minerals (chromium, selenium) and taurine, etc., they are accurately weighed respectively according to the formula requirements. A ten - thousandth balance can be used for weighing, and after weighing, they are placed in dry and clean containers for standby;

[0028] S4. Put the processed sophora flower extract, licorice extract, tangerine peel extract, kudzu root extract, blueberry powder, elderberry powder, osmanthus powder, and isomaltooligosaccharide into a three - dimensional mixer, set the mixing speed at 10 - 15 revolutions per minute, and the mixing time at 15 - 20 minutes to preliminarily mix these raw materials evenly. During the mixing process, the mixing uniformity can be checked by stopping the machine every 5 minutes. If there are parts that are not evenly mixed, the mixing time can be appropriately extended;

[0029] S5. After being preliminarily mixed evenly, add the mixed probiotic material and continue to mix at a speed of 8 - 12 revolutions per minute for 10 - 15 minutes. Since probiotics are relatively sensitive to conditions such as temperature and humidity, the environmental temperature should be controlled well during the mixing process, maintained at 20 - 25 °C, and the relative humidity controlled at 40% - 60% to avoid reducing the activity of probiotics;

[0030] S6. Dissolve 2 - oxoglutaric acid (AKG) and natural menthol in a small amount of anhydrous ethanol (analytical pure), and then slowly add it to the mixed material while stirring at a speed of 5 - 8 revolutions per minute for 5 - 10 minutes to make the solution evenly disperse in the material. The dosage of anhydrous ethanol should be just enough to dissolve 2 - oxoglutaric acid (AKG) and natural menthol, generally not exceeding 10 ml;

[0031] S7. Add the accurately weighed various vitamins, minerals and taurine to the mixed material and mix at a speed of 3 - 5 revolutions per minute for 10 - 15 minutes to ensure that all raw materials are fully mixed evenly;

[0032] S8. Finally, crush the mixed material, sieve it through an 80 - 100 - mesh sieve to make the material particles small and uniform, and then pack it according to the specifications of each bag.

[0033] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0034] 1. The various raw materials selected in the present invention have unique synergistic effects in anti - inflammation and anti - allergy. The sophora japonica extract is rich in rutin and has various biological activities such as antioxidant and anti - inflammatory effects; components such as glycyrrhizic acid in the licorice extract have significant anti - inflammatory, anti - allergic, and immune - regulating effects; the tangerine peel extract contains various flavonoid compounds, which can regulate the immune system and reduce the inflammatory response; components such as puerarin in the kudzu root extract also contribute to improving the inflammatory state of the body. These traditional Chinese medicine extracts cooperate with each other, exerting anti - inflammatory and anti - allergic effects from different mechanisms, forming a multi - target and multi - pathway synergistic effect. Compared with the products in the prior art that only use single or a few anti - inflammatory and anti - allergic raw materials, it can relieve inflammatory and allergic symptoms more comprehensively and effectively.

[0035] At the same time, the rich anthocyanins in blueberry powder, the various bioactive components in elderberry powder, and the unique aroma components in osmanthus powder, etc., cooperate with the above - mentioned traditional Chinese medicine extracts, further enhancing the anti - inflammatory and anti - allergic ability of the product. Anthocyanins have a powerful antioxidant ability, can scavenge free radicals in the body, reduce the damage of oxidative stress to the body, and thus assist in reducing the inflammatory response; elderberry powder is considered to have effects such as enhancing immunity, antiviral, and anti - inflammatory; the aroma components of osmanthus powder may have a positive impact on the nervous system and immune system of the human body, and play an anti - inflammatory and anti - allergic effect together with the overall formula.

[0036] 2. The present invention not only focuses on the anti - inflammatory and anti - allergic functions but also pays attention to the nutritional value of the product. The product is added with various vitamins (vitamin A, vitamin D, vitamin E, vitamin B group, vitamin C, etc.), minerals (chromium, selenium), and nutritional components such as taurine. Vitamin A is crucial for maintaining the health of epithelial tissues and enhancing immunity; vitamin D helps in the absorption and utilization of calcium and is beneficial to bone health; vitamin E is an important antioxidant that can protect cells from free radical damage; the vitamin B group participates in various metabolic processes of the human body and maintains the normal function of the nervous system; vitamin C has antioxidant and immune - enhancing effects, etc. Chromium and selenium are essential trace elements for the human body. Chromium participates in the metabolism of sugar and fat, and selenium has various physiological functions such as antioxidant and immune - enhancing effects; taurine has positive effects on aspects such as brain development, vision protection, and cardiovascular health. Compared with the prior art, through the scientific proportioning of various nutritional components, this product provides more comprehensive and balanced nutritional support for the human body. While exerting anti - inflammatory and anti - allergic functions, it can also meet the multi - aspect health needs of the human body, contributing to improving the overall health level of the body.

[0037] 3. The probiotic material selected for this invention includes Lactiplantibacillus plantarum LP05, Lactiplantibacillus plantarum LP18, Lactobacillus paracasei LC86, Bifidobacterium animalis subsp. lactis BLa36, and Lactobacillus casei LC89. These five strains have been carefully screened and combined, with different physiological characteristics and functional advantages. They can colonize in the intestine, regulate the balance of the intestinal flora, inhibit the growth and reproduction of harmful bacteria, improve the intestinal microecological environment. A good intestinal flora balance is crucial for the normal function of the immune system. These probiotics enhance the function of the intestinal mucosal barrier, promote the activation and proliferation of immune cells, and improve the body's immunity through their interaction with the intestinal immune system. Compared with products using different types or ratios of probiotics in the prior art, the probiotic material combination of this invention can more effectively regulate intestinal health, thereby enhancing the body's anti-inflammatory and anti-allergic abilities and forming a virtuous cycle between the intestine and the immune system.

[0038] In summary, through its unique raw material combination, scientific preparation process, and reasonable dosage form design, this invention has significant advantages in terms of anti-inflammatory and anti-allergic functions, nutritional value, protection of probiotic activity, and product usability, providing consumers with a higher-quality and more effective nutritional food with anti-inflammatory and anti-allergic functions. Brief Description of the Drawings

[0039] In order to more clearly illustrate the specific embodiments of this invention or the technical solutions in the prior art, the following will briefly introduce the drawings required for use in the description of the specific embodiments or the prior art. Obviously, the drawings in the following description are some embodiments of this invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0040] Figure 1 It is a schematic diagram of the weight part ratio of the food raw materials of this invention;

[0041] Figure 2 It is a schematic diagram of the manufacturing method process of this invention

[0042] Figure 3 It is a schematic diagram of the product powder of this invention; Detailed Description of the Specific Embodiments

[0043] The following will clearly and completely describe the technical solutions of this invention with reference to the drawings. Obviously, the described embodiments are some, but not all, of the embodiments of this invention.

[0044] Generally, the components of the embodiments of this invention described and shown in the drawings here can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of this invention provided in the drawings is not intended to limit the scope of the claimed invention, but merely represents the selected embodiments of this invention.

[0045] Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0046] In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation to the present invention. In addition, the terms "first", "second", and "third" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0047] In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, the terms "installation", "connection", and "coupling" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0048] The present invention will be further described below in conjunction with specific embodiments.

[0049] Embodiment 1

[0050] A nutritional food with anti-inflammatory and anti-allergic functions comprises the following raw materials in parts by weight (g):

[0051] Sophora japonica extract 10g, licorice extract 5g, tangerine peel extract 3g, kudzu root extract 0.5g, blueberry powder 18g, elderberry powder 8g, osmanthus powder 12g, isomaltooligosaccharide 12g, probiotic material 10g, 2-oxoglutaric acid (AKG) 0.5g, natural menthol 0.1g;

[0052] Vitamin A 7000ug, vitamin D 150ug, vitamin E 400mg, vitamin B1 50mg, vitamin B2 30mg, vitamin B6 30mg, vitamin B12 60ug, vitamin C 900mg, niacin 400mg, folic acid 4000ug, pantothenic acid 100mg, biotin 500ug, chromium 860ug, selenium 670ug, taurine 1000mg.

[0053] The rutin content in sophora flower bud extract is ≥80%. The high content of rutin helps to enhance the anti-inflammatory effect of the product. Rutin can inhibit the release of inflammatory mediators, such as reducing the production of inflammatory factors like TNF-α and IL-6, thereby better exerting the anti-inflammatory effect of nutritional foods and improving the product stability and quality consistency.

[0054] The anthocyanin content in blueberry powder is ≥25%. As a powerful antioxidant, anthocyanin can not only scavenge free radicals and reduce oxidative stress damage, but also regulate the immune system, inhibit mast cell degranulation, and reduce the release of allergy mediators such as histamine. Blueberry powder with a high content of anthocyanin can significantly enhance the antioxidant and anti-allergy capabilities of the product, improving the sensory and nutritional value of the product.

[0055] The probiotic mixture contains the following strains: Lactiplantibacillus plantarum LP05, Lactiplantibacillus plantarum LP18, Lactobacillus paracasei LC86, Bifidobacterium animalis subsp. lactis BLa36, and Lactobacillus casei LC89. These strains have their own unique mechanisms and advantages in anti-allergy, and their cooperation can regulate the body's immune system from multiple aspects, such as regulating the Th1 / Th2 cell balance, inhibiting the production of IgE antibodies, and enhancing the intestinal mucosal barrier function, resulting in a synergistic anti-allergy effect.

[0056] The dosage form of this nutritional food is powder. The powder is convenient for storage and transportation, has good stability, is not easily affected by environmental factors such as temperature and humidity and deteriorates, reduces the storage and transportation costs, and reduces the risk of product failure caused by environmental changes. Moreover, the powder is convenient for taking and dose control, is easy to be packed into small packages, and consumers can accurately control the taking dose according to their own needs. The taking method is flexible, and it can be directly taken by mixing with warm water, or added to other foods or beverages, improving the consumers' compliance in taking. At the same time, the powder can be quickly dispersed in the gastrointestinal tract and fully contact with digestive juices, which is beneficial to the release and absorption of various nutritional and active ingredients in the raw materials, improving the bioavailability of the product and better meeting the consumers' needs for convenience and absorption effect.

[0057] Among them, the specific viable count information of each strain in the probiotic mixture is as follows:

[0058] Lactiplantibacillus plantarum LP05: viable count is 200 billion CFU / g, Lactiplantibacillus plantarum LP18: viable count is 800 billion CFU / g, Lactobacillus paracasei LC86: viable count is 60 billion CFU / g, Bifidobacterium animalis subsp. lactis BLa36: viable count is 300 billion CFU / g, Lactobacillus casei LC89: viable count is 60 billion CFU / g. Each strain is mixed in equal proportion according to the viable count (each strain accounts for 20% ± 2% of the total viable count). Specifically, when mixing, the corresponding weights are calculated according to the viable count of each strain for proportioning. For example, assuming that 10 g of probiotic feed is to be mixed, the required weights of each strain are calculated as follows:

[0059]

[0060] The total viable count after mixing ≥ 1×10 10 CFU / g, and the carrier needs to be irradiated and sterilized with 60Co (dose 5 kGy) before use.

[0061] The equal increment method is used for mixing: First, Lactiplantibacillus plantarum LP05 (0.01 g) and Lactiplantibacillus plantarum LP18 (0.0025 g) are premixed with a glucose dispersant; then Lactobacillus paracasei LC86 (0.333 g) and Lactobacillus casei LC89 (0.333 g) are added and mixed in a V-type mixer (10 rpm × 10 min); finally, Bifidobacterium animalis BLa36 (0.0667 g) and the carrier are added and mixed in a three-dimensional mixer (8 rpm × 15 min, humidity ≤ 50%).

[0062] A sufficient viable count is the basis for the probiotic to exert its efficacy, which can ensure that after the nutritional food goes through processes such as production, storage, and transportation, a large number of viable bacteria still reach the intestine and play a role, regulating the intestinal microecological environment, and then exerting physiological functions such as anti-inflammatory and anti-allergic.

[0063] A preparation method of a nutritional food with anti-inflammatory and anti-allergic functions includes the following steps:

[0064] Step 1. Extract treatment: Pass the sophora flower extract, licorice extract, tangerine peel extract, and kudzu root extract through an 80 - 100 mesh sieve respectively to remove possible impurities and large particles, ensuring the uniformity and fineness of the extract for subsequent mixing. For the probiotic feed (Lactiplantibacillus plantarum LP05, Lactiplantibacillus plantarum LP18, Lactobacillus paracasei LC86, Bifidobacterium animalis subsp. lactis BLa36, Lactobacillus casei LC89), mix them in equal proportion according to the viable count. A step-by-step mixing method can be used. First, mix two probiotics evenly, and then add the third one, and so on, to ensure that the five probiotics are fully mixed. The total amount of the mixed probiotic feed is 8 - 12 parts;

[0065] Step 2: Fruit powder processing: sieve blueberry powder, elderberry powder and osmanthus powder through 60-80 mesh sieves respectively to make the fruit powder particles uniform in size, avoid agglomeration during the mixing process, and ensure the uniformity of mixing;

[0066] Step 3, other raw material processing: if oligoisomaltose is agglomerated, it can be placed in a drying oven and dried at 40-50°C for 1-2 hours to soften it and then sieve it to ensure the loose state of oligoisomaltose. 2-oxoglutaric acid (AKG) and natural menthol are accurately weighed respectively. Since the amount is small, a high-precision electronic balance (accuracy of 0.001g) can be used to weigh them to ensure the accuracy of the amount. Various vitamins (vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, folic acid, pantothenic acid, biotin), minerals (chromium, selenium) and taurine, etc., are accurately weighed according to the formula requirements. A one-tenth of a balance can be used for weighing. After weighing, they are placed in a dry and clean container for standby use;

[0067] Step 4: Put the processed Sophora japonica extract, licorice extract, tangerine peel extract, kudzu root extract, blueberry powder, elderberry powder, osmanthus powder, and oligosaccharide into a three-dimensional mixer (SYH-1000 three-dimensional motion mixer), set the mixing speed to 10-15 rpm, and the mixing time to 15-20 minutes to preliminarily mix these raw materials. During the mixing process, the machine can be stopped every 5 minutes to check the mixing uniformity. If there is an unmixed part, the mixing time can be appropriately extended;

[0068] Step 5. After the initial mixing, add the mixed probiotic material and continue mixing at a speed of 8-12 rpm for 10-15 minutes. Since probiotics are sensitive to temperature, humidity and other conditions, the ambient temperature should be controlled during the mixing process, maintained at 20-25°C, and the relative humidity should be controlled at 40%-60% to avoid a decrease in the activity of probiotics.

[0069] Step 6: Dissolve 2-oxoglutaric acid (AKG) and natural menthol in a small amount of anhydrous ethanol (analytical grade), and then slowly add the mixture to the mixed material, stirring at a speed of 5-8 rpm for 5-10 minutes to evenly disperse the solution in the material. The amount of anhydrous ethanol used is preferably enough to dissolve 2-oxoglutaric acid (AKG) and natural menthol, and generally does not exceed 10 ml;

[0070] Step 7: Add the accurately weighed vitamins, minerals and taurine to the mixture, and mix at a speed of 3-5 rpm for 10-15 minutes to ensure that all the raw materials are fully mixed;

[0071] Step 8. Finally, pulverize the mixed materials and sieve them through an 80 - 100 mesh sieve to make the material particles small and uniform, and then package them according to the specifications of each bag.

[0072] Example 2

[0073] A nutritional food with anti - inflammatory and anti - allergic functions, comprising the following raw materials in parts by weight (g):

[0074] Sophora japonica extract 8g, licorice extract 4g, tangerine peel extract 2g, kudzu root extract 0.2g, blueberry powder 15g, elderberry powder 5g, osmanthus powder 10g, isomaltooligosaccharide 10g, probiotic material 8g, AKG 0.2g, menthol 0.01g;

[0075] Vitamin A 7000ug, Vitamin D 150ug, Vitamin E 400mg, Vitamin B1 50mg, Vitamin B2 30mg, Vitamin B6 30mg, Vitamin B12 60ug, Vitamin C 900mg, niacin 400mg, folic acid 4000ug, pantothenic acid 100mg, biotin 500ug, chromium 860ug, selenium 670ug, taurine 1000mg.

[0076] Compared with Example 1, the probiotic material only contains Lactiplantibacillus plantarum LP05 (2000 billion CFU / g) and Lactiplantibacillus plantarum LP18 (8000 billion CFU / g), and the two are mixed according to a viable count ratio of 1:4, that is, Lactiplantibacillus plantarum LP05 accounts for 20% of the viable count of the mixed probiotic material, and Lactiplantibacillus plantarum LP18 accounts for 80%. According to this ratio and the total weight of the probiotic material of 8g, the corresponding weights can be calculated for proportioning. The total viable count after mixing is ≥8×10 9 CFU / g (due to the adjustment of the viable count ratio, the total viable count changes accordingly), and other components are the same.

[0077] The preparation method is the same as that of Example 1.

[0078] Example 3

[0079] A nutritional food with anti - inflammatory and anti - allergic functions, comprising the following raw materials in parts by weight (g):

[0080] A nutritional food with anti - inflammatory and anti - allergic functions, comprising the following raw materials:

[0081] Sophora japonica extract 15g, licorice extract 7g, tangerine peel extract 4g, kudzu root extract 1g, blueberry powder 20g, elderberry powder 10g, osmanthus powder 15g, isomaltooligosaccharide 15g, probiotic material 12g, AKG 1g, menthol 0.2g;

[0082] 7000 ug of vitamin A, 150 ug of vitamin D, 400 mg of vitamin E, 50 mg of vitamin B1, 30 mg of vitamin B2, 30 mg of vitamin B6, 60 ug of vitamin B12, 900 mg of vitamin C, 400 mg of niacin, 4000 ug of folic acid, 100 mg of pantothenic acid, 500 ug of biotin, 860 ug of chromium, 670 ug of selenium, 1000 mg of taurine.

[0083] The preparation method is the same as that of Example 1.

[0084] Compared with Example 1, Comparative Example 1 does not contain sophora flower extract and licorice extract, and other components are the same.

[0085] Compared with Example 1, in Comparative Example 2, the probiotic material only contains Lactiplantibacillus plantarum LP05 and Lactiplantibacillus plantarum LP18, and other components are the same.

[0086] Compared with Example 1, Comparative Example 3 does not contain AKG and menthol, and other components are the same.

[0087] Performance Test

[0088] 1. Anti-inflammatory effect test (using LPS-induced RAW264.7 cell inflammation model).

[0089] 2. Anti-allergy effect test (using RBL-2H3 cell degranulation model).

[0090] 3. Probiotic survival rate test (accelerated test: stored at 40 °C / 75% RH for 3 months).

[0091] Comparison Table

[0092] Test Items Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 TNF-A Inhibition Rate (%) 78.2±2.1 75.6±1.8 79.4±2.3 52.3±1.5 76.8±2.0 77.5±2.1 IL-6 Inhibition Rate (%) 82.5±1.9 80.1±1.7 83.7±2.0 58.7±1.6 81.3±1.8 81.9±1.9 Histamine Release Inhibition Rate (%) 85.3±2.2 83.7±2.0 86.1±2.3 84.9±2.1 76.5±1.9 72.8±1.7 Probiotic Survival Rate (%) 92.5±1.2 91.8±1.1 93.2±1.3 92.7±1.2 85.6±1.0 91.9±1.1 Dissolution Time (seconds) 35±2 38±2 33±2 36±2 37±2 55±3

[0093] The test results show that:

[0094] Examples 1-3 showed significant effects in both anti-inflammatory (TNF-α, IL-6 inhibition) and anti-allergy (histamine release inhibition) aspects;

[0095] 1. In Comparative Example 1, due to the lack of sophora flower and licorice extracts, the anti-inflammatory effect decreased significantly.

[0096] 2. In Comparative Example 2, due to the incomplete variety of probiotics, the anti-allergy effect and the probiotic survival rate decreased.

[0097] 3. In Comparative Example 3, due to the lack of AKG and menthol, the dissolution performance decreased significantly.

[0098] The above embodiments show that through the synergistic effect of a specific formulation, especially the cooperation of various strains in the probiotic material (Lactiplantibacillus plantarum LP05, Lactiplantibacillus plantarum LP18, Lactobacillus paracasei LC86, Bifidobacterium animalis subsp. lactis BLa36, Lactobacillus casei LC89) in a specific viable count ratio, the present invention achieves excellent anti-inflammatory and anti-allergic effects while ensuring the stability and usability of the product.

[0099] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A nutritious food with anti-inflammatory and anti-allergic functions, characterized in that: The invention comprises the following raw materials in parts by weight: 8-15 parts of Sophora japonica flower extract; 4-7 parts of licorice extract; 2-4 parts of tangerine peel extract; 0.2-1 part of Pueraria root extract; 15-20 parts blueberry powder; 5-10 parts elderberry powder; 10-15 parts of osmanthus powder; Isomaltooligosaccharide 10-15 parts; 8-12 servings of probiotics; 2-Oxoglutaric acid (AKG) 0.2-1 part; - 0.01-0.2 parts of natural menthol; -Vitamin A 7000ug, Vitamin D 150ug, Vitamin E 400mg, Vitamin B1 50mg, Vitamin B2 30mg, Vitamin B6 30mg, Vitamin B12 60ug, Vitamin C 900mg, Niacin 400mg, Folic Acid 4000ug, Pantothenic Acid 100mg, Biotin 500ug, Chromium 860ug, Selenium 670ug, Taurine 1000mg.

2. The nutritious food with anti-inflammatory and anti-allergic functions and its preparation method according to claim 1, characterized in that: The rutin content in the sophora japonica flower extract is ≥80%.

3. The nutritious food with anti-inflammatory and anti-allergic functions and its preparation method according to claim 1, characterized in that: The anthocyanin content of the blueberry powder is ≥25%.

4. The nutritious food with anti-inflammatory and anti-allergic functions and the preparation method thereof according to claim 1, characterized in that: The probiotic material comprises Lactobacillus paracasei LC86, Lactobacillus plantarum LP05, Lactobacillus plantarum LP18, Bifidobacterium animalis subspecies lactis BLa36, and Lactobacillus casei LC89.

5. The nutritious food with anti-inflammatory and anti-allergic functions and the preparation method thereof according to claim 4, characterized in that: In the probiotic material, the number of viable bacteria of each strain is ≥1×10^10 CFU / g.

6. A nutritional food with anti-inflammatory and anti-allergic functions according to any one of claims 1 to 5, characterized in that: Its dosage form is powder.

7. A method for preparing the nutritious food with anti-inflammatory and anti-allergic functions according to any one of claims 1 to 5, characterized in that: The following steps are involved: S1, extract processing: Sophora japonica extract, licorice extract, tangerine peel extract, kudzu root extract are respectively sieved through 80-100 meshes to remove possible impurities and large particles, to ensure the uniformity and fineness of the extract, to facilitate subsequent mixing, for probiotic materials (Lactobacillus plantarum LP05, Lactobacillus plantarum LP18, Lactobacillus paracasei LC86, Bifidobacterium animalis subspecies lactis BLa36, Lactobacillus casei LC89), each strain is mixed in equal proportions according to the number of viable bacteria, and a stepwise mixing method can be adopted, first two probiotics are mixed evenly, and then the third is added, and so on, to ensure that the five probiotics are fully mixed, and the total amount of the mixed probiotic material is 8-12 parts; S2. Fruit powder processing: blueberry powder, elderberry powder and osmanthus powder are sieved through 60-80 mesh sieves respectively to make the fruit powder particles uniform in size, avoid agglomeration during the mixing process, and ensure the uniformity of mixing; S3. Processing of other raw materials: If isomaltooligosaccharide is agglomerated, it can be placed in a drying oven and dried at 40-50°C for 1-2 hours. After softening, it can be sieved to ensure the loose state of isomaltooligosaccharide. 2-Oxoglutaric acid (AKG) and natural menthol are accurately weighed respectively. Due to their small dosage, a high-precision electronic balance (accuracy of 0.001g) can be used for weighing to ensure the accuracy of dosage. Various vitamins (vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, folic acid, pantothenic acid, biotin), minerals (chromium, selenium) and taurine, etc., are accurately weighed according to the formula requirements. A 1 / 10,000 balance can be used for weighing. After weighing, they are placed in a dry and clean container for standby use. S4, the processed Sophora japonica extract, licorice extract, tangerine peel extract, kudzu root extract, blueberry powder, elderberry powder, osmanthus powder, isomaltooligosaccharide is placed in a three-dimensional mixer, the mixing speed is set to 10-15 rpm, the mixing time is 15-20 minutes, these raw materials are preliminarily mixed evenly, during the mixing process, the mixing uniformity can be checked every 5 minutes, if there is an unmixed part, the mixing time can be appropriately extended; S5. After the initial mixing, add the mixed probiotic material and continue mixing at a speed of 8-12 rpm for 10-15 minutes. Since probiotics are sensitive to temperature, humidity and other conditions, the ambient temperature should be controlled during the mixing process, maintained at 20-25°C, and the relative humidity should be controlled at 40%-60% to avoid the reduction of probiotic activity; S6. Dissolve 2-oxoglutaric acid (AKG) and natural menthol in a small amount of anhydrous ethanol (analytical grade), and slowly add the mixture to the mixed material, stirring at a speed of 5-8 rpm for 5-10 minutes to evenly disperse the solution in the material. The amount of anhydrous ethanol used is preferably enough to dissolve 2-oxoglutaric acid (AKG) and natural menthol, and generally does not exceed 10 ml; S7. Add accurately weighed vitamins, minerals and taurine to the mixture, and mix at a speed of 3-5 rpm for 10-15 minutes to ensure that all the raw materials are fully mixed; S8. Finally, the mixed materials are crushed and passed through an 80-100 mesh sieve to make the material particles fine and uniform, and then packaged according to the specifications of each bag.

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