A patch-type thrombus monitoring and NO release closed-loop system for treating venous thrombosis

Through the multimodal monitoring and NO release control of the patch closed-loop system, the problems of real-time monitoring and accurate release in venous thrombosis treatment are solved, and efficient and safe thrombosis management is achieved, suitable for long-term wear and home treatment.

CN120114023BActive Publication Date: 2025-08-15BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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Patent Information

Application Number
CN202510592772.7
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-05-09
Publication Date
2025-08-15
Estimated Expiration
2045-05-09

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Abstract

The present invention provides a patch-type thrombus monitoring and NO release closed-loop system for treating venous thrombosis. The system comprises: a flexible patch substrate integrated with: a sensor module comprising a blood flow velocity sensor, a bioimpedance sensor, an acceleration sensor, and a temperature sensor, each for acquiring blood flow velocity v at the target vein, parameters related to vascular resistance R, limb motion status, and skin temperature in the patch area; an NO release module for releasing NO to act on the venous thrombosis site; a control module comprising a signal processing unit and a control unit, which receives signals output by the sensor module and runs a closed-loop control algorithm to generate NO release control instructions; and a power supply module for providing power to the sensor module, the control module, and the NO release module. This system integrates multimodal thrombus monitoring, decision-making, assisted NO release, and adaptive switching of treatment modes.
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