Preparation process of nasal cavity traditional Chinese medicine pills

Abstract

The invention discloses a nasal cavity traditional Chinese medicine pill preparation technology, and relates to the technical field of traditional Chinese medicine. The nasal cavity traditional Chinese medicine pill is prepared from the following materials in parts by mass: 3 to 9 parts of radix aconiti carmichaeli, 2 to 5 parts of rhizoma seu radix notopterygii, 2 to 5 parts of radix scutellariae, 2 to 5 parts of ramulus cinnamomi, 3 to 6 parts of herba plantaginis, 2 to 5 parts of radix saposhnikoviae, 2 to 6 parts of rhizoma cyperi, 1 to 3 parts of cortex cinnamomi, 3 to 6 parts of ramulus mori, 2 to 8 parts of menthol and 1 to 3 parts of hydroxypropyl methyl cellulose. The pill prepared from the materials acts on the nasal cavity, the inconvenience of a traditional dressing is avoided, and treatment of a patient in daily life is facilitated. Meanwhile, different components are respectively mixed and then placed in a spray dryer to be prepared into spherical particles, so that the treatment efficiency and convenience are greatly improved, a patient can more quickly and comprehensively exert the medicine effect under the action of airflow in the breathing process, substantive treatment help is brought, the treatment period is shortened, the treatment efficiency is improved, and the treatment cost is reduced. Therefore, the problems of nerve paralysis and dyskinesia of facial expression muscles are better solved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and specifically to a preparation process of traditional Chinese medicine pills for the nasal cavity. Background Art

[0002] In the ancient Chinese medical classic "Huangdi Neijing", there is already a record that "the lungs open into the nose", believing that the nasal cavity is the channel for the lungs to communicate with the outside world and has the functions of absorbing the efficacy of medicine and regulating the whole body. Nasal administration in traditional Chinese medicine is called "nasal therapy" or "smelling medicine", and its history can be traced back to the Han Dynasty two thousand years ago.

[0003] Traditional Chinese medicine believes that the nasal cavity is connected to the Yangming meridians of the hand and foot and the Governor Vessel among the twelve meridians. Drugs can directly reach the brain orifices through the nasal cavity and have a unique curative effect on head and face diseases, especially facial paralysis. The surface area of the nasal mucosa reaches 150 cm 2 , with rich blood vessels. Drugs can bypass the first-pass effect of the liver, and the bioavailability is increased by 3 to 5 times compared with other methods.

[0004] In the Chinese invention patent application publication specification CN104138453A, a traditional Chinese medicine preparation for treating facial nerve paralysis is disclosed, which is made from the following raw medicinal materials: 25 - 40 grams of scorpio, 25 - 35 grams of lancea tibetica hook.f., 20 - 30 grams of slough, 15 - 25 grams of peristrophe roxburghiana (schult.) bremek., 5 - 10 grams of brucea javanica (l.) merr., 15 - 25 grams of pseudostellaria heterophylla (miq.) pax ex pax & hoffm., 15 - 25 grams of patrinia scabiosaefolia fish., 5 - 15 grams of barilla, 10 - 20 grams of oroxylum indicum (l.) kurz., 5 - 15 grams of glechoma longituba (nakai) kupr., and 5 - 10 grams of moschus. The preparation method is: take each raw medicinal material, mix, crush, and pass through a 100-mesh sieve to obtain the medicinal powder.

[0005] When treating with the above-mentioned traditional Chinese medicine preparation in the patent application publication specification, the medicinal powder needs to be adjusted into a paste with warm water and applied to the affected side. When using this medicinal application, it needs to be prepared and then applied to the surface of the affected side. Due to the skin absorption barrier, the treatment range for nerve paralysis and the movement disorder of facial expression muscles is relatively limited, thus reducing the absorption speed and efficiency of the drug. At the same time, using the external application method requires the patient to regularly change the dressing to ensure drug absorption and continuously keep the surface of the dressing clean, which will bring inconvenience to the patient in daily life. Summary of the Invention

[0006] (1) Technical Problems to be Solved

[0007] Aiming at the deficiencies of the prior art, the present invention provides a preparation process of traditional Chinese medicine pills for the nasal cavity. The pills are prepared from a variety of traditional Chinese medicine powders, solving the problems of limited treatment range for patients with nerve paralysis and movement disorder of facial expression muscles, and inconvenience during use.

[0008] (2) Technical Solutions

[0009] To achieve the above object, the present application provides a preparation process for nasal traditional Chinese medicine pills, adopting the following technical solution:

[0010] A preparation process for nasal traditional Chinese medicine pills includes 3-9 parts by mass of aconite root, 2-5 parts by mass of notopterygium root, 2-5 parts by mass of scutellaria root, 2-5 parts by mass of cassia twig, 3-6 parts by mass of plantain herb, 2-5 parts by mass of ledebouriella root, 2-6 parts by mass of nutgrass galingale rhizome, 1-3 parts by mass of cinnamon bark, 3-6 parts by mass of mulberry twig, 2-8 parts by mass of menthol, and 1-3 parts by mass of hydroxypropyl methylcellulose.

[0011] Preferably, the ratio of aconite root, scutellaria root, nutgrass galingale rhizome, and cinnamon bark is 3:2:2:1.

[0012] Preferably, the aconite root, scutellaria root, nutgrass galingale rhizome, and cinnamon bark need to be processed by stir-frying with bran. After cleaning the aconite root, it needs to be decocted in water for 5 hours. After cleaning the scutellaria root, it needs to be subjected to a boiling water bath for 30 minutes. After cleaning the nutgrass galingale rhizome, it is placed in the steam of a 15% vinegar solution for steaming and fumigating. After washing the cinnamon bark, it is placed in a low-temperature processing and drying machine and baked at a low temperature of 45°C.

[0013] Among them, it should be specifically noted that the aconite root, scutellaria root, nutgrass galingale rhizome, and cinnamon bark all need to be processed to remove the harmful components to the human body, so as to better exert the physical and chemical properties of each drug. In the combination ratio of 3:2:2:1, this ratio has unique advantages and application scopes in traditional Chinese medicine theory. Both aconite root and cinnamon bark are herbs with a very hot nature, which can warm yang and dispel cold, and promote the circulation of qi and blood. In traditional Chinese medicine theory, facial expression disorders such as facial nerve paralysis are often related to poor circulation of qi and blood and stagnation of cold qi. Therefore, these two drugs can improve the blood circulation of the face through their function of warming yang and dispelling cold, thus contributing to the recovery of the facial nerve.

[0014] Scutellaria root has the efficacy of clearing heat and drying dampness, and can reduce the inflammatory reaction in the nasal cavity and face. Facial expression disorders such as facial nerve paralysis are often accompanied by inflammatory reactions, and the use of scutellaria root can reduce this inflammation, thus contributing to the repair of the facial nerve. Nutgrass galingale rhizome can soothe the liver and relieve depression, and regulate qi and blood. In traditional Chinese medicine theory, the liver is in charge of dredging and regulating, and is closely related to the regulation of qi and blood. The occurrence of facial expression disorders such as facial nerve paralysis is related to factors such as disharmony of qi and blood and emotional discomfort.

[0015] Moreover, the nasal cavity, as an important acupoint in traditional Chinese medicine meridians, is closely connected to facial meridians such as the facial nerve. By administering drugs through the nasal cavity, the drugs can directly act on the facial meridians and reach the lesion site, thereby improving the treatment effect. This administration method reduces the loss and side effects of drugs during use.

[0016] To sum up, the aconite root, scutellaria root, nutgrass galingale rhizome, and cinnamon bark in the ratio of 3:2:2:1 have the advantages of warming yang and dispelling cold, clearing heat and drying dampness, soothing the liver and relieving depression, local drug administration, and comprehensive conditioning in the preparation of nasal traditional Chinese medicine for facial expression disorders such as nerve paralysis.

[0017] A preparation method for a nasal traditional Chinese medicine pill, comprising the following steps:

[0018] S1: Select aconite roots, notopterygium roots, skullcap roots, cassia twigs, plantain herbs, divaricate saposhnikovia roots, nutgrass galingale rhizomes, cinnamon twigs, and mulberry twigs that are bright in color, plump in shape, free of impurities, mildew, and insect damage. Place them in a container, rinse with water, and dry in the shade for later use.

[0019] S2: Take out the aconite roots, skullcap roots, nutgrass galingale rhizomes, and cinnamon twigs, respectively process them through roasting and drying in the shade, then place them in a pulverizer and sieve through 800 - 1000 meshes. The obtained powder is put into a spray dryer to form spherical particles, obtaining a particle mixture A.

[0020] S3: Place the notopterygium roots, cassia twigs, plantain herbs, divaricate saposhnikovia roots, and mulberry twigs in a pulverizer and sieve through 800 - 1000 meshes. The obtained powder is put into a spray dryer to form spherical particles, obtaining a particle mixture B.

[0021] S4: Place the two particle mixtures A and B together in a traditional Chinese medicine pill making machine. During the process, add menthol and hydroxypropyl methylcellulose, and spray supermolecular water to finally obtain the nasal traditional Chinese medicine pill.

[0022] Preferably, the mesh number for sieving the pulverized different drugs is in the range of 800 - 1000 meshes.

[0023] Among them, it should be specifically noted that the drugs are pulverized and sieved through 800 - 1000 meshes, so that the particle size of the drugs is controlled within the range of 5 - 18 μm, enabling the drugs to dissolve faster in nasal secretions, thereby improving the absorption rate and bioavailability of the drugs. At the same time, it avoids problems such as uneven drug content and instability caused by differences in particle size, and controls the quality of the preparation of the nasal traditional Chinese medicine pill.

[0024] Preferably, the aconite roots, skullcap roots, nutgrass galingale rhizomes, and cinnamon twigs need to be processed through roasting and then pulverized to form spherical particles before use.

[0025] Preferably, the aconite roots, skullcap roots, nutgrass galingale rhizomes, and cinnamon twigs are made into a particle mixture A, and then mixed with another particle mixture B made from notopterygium roots, cassia twigs, plantain herbs, divaricate saposhnikovia roots, and mulberry twigs to make pills.

[0026] Among them, it should be specifically noted that making the drugs that need to be processed into spherical particles for later use improves the stability and bioavailability of the drugs and can effectively reduce the side effects of the drugs.

[0027] (III) Beneficial effects

[0028] The present invention provides a preparation process for a nasal traditional Chinese medicine pill, having the following beneficial effects:

[0029] (1) The preparation process of the nasal traditional Chinese medicine pill is prepared from various traditional Chinese medicinal materials such as aconite root, notopterygium root, skullcap root, cassia twig, plantain herb, divaricate saposhnikovia root, nutgrass galingale rhizome, cinnamon bark, and mulberry twig. For the treatment of nerve palsy and facial expression muscle movement disorders, compared with traditional externally applied drugs that need to penetrate the skin, muscles, and bony barriers, with a bioavailability of less than 5%, the active ingredients in the nasal traditional Chinese medicine pill can be absorbed through the nasal mucosa and then diffuse along the olfactory nerve endings to the trigeminal ganglion, and reach the facial nerve canal area directly through axonal transport. At the same time, the surface area of the nasal mucosa reaches 150 cm 2 , with rich blood flow, and the drug enters the blood in 5 - 15 minutes. Its use method is more convenient and fast, greatly improving the convenience of treatment, reducing the psychological burden of patients, and bringing substantial therapeutic help.

[0030] (2) The preparation process of the nasal traditional Chinese medicine pill is carefully prepared by scientifically proportioning various traditional Chinese medicine powders. Compared with the traditional dressing method for treating facial nerve palsy, nasal administration does not require skin cleaning and dressing fixation, avoiding contact dermatitis caused by traditional plasters. And it can exert its medicinal effect faster, shortening the treatment cycle and improving the treatment efficiency. It avoids the possible side effects of chemical drugs, providing a safer and milder treatment option for patients. The synergistic effect of traditional Chinese medicine ingredients helps to regulate the balance of qi and blood in the body, promote the recovery and regeneration of the nervous system, thus effectively relieving the symptoms of nerve palsy, improving the motor function of facial expression muscles, and then achieving the effects of precise delivery, time - effect advantage, ingredient preservation, and convenient operation. Detailed implementation mode

[0031] Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

[0032] Embodiment 1

[0033] Specifically, a preparation process of a nasal traditional Chinese medicine pill is composed of the following raw materials: 3 parts by mass of aconite root, 2 parts by mass of notopterygium root, 2 parts by mass of skullcap root, 2 parts by mass of cassia twig, 3 parts by mass of plantain herb, 2 parts by mass of divaricate saposhnikovia root, 2 parts by mass of nutgrass galingale rhizome, 1 part by mass of cinnamon bark, 3 parts by mass of mulberry twig, 2 parts by mass of menthol, and 1 part by mass of hydroxypropyl methylcellulose.

[0034] The method for the above - mentioned preparation process of a nasal traditional Chinese medicine pill is as follows:

[0035] S1: Select aconite root, notopterygium root, skullcap root, cassia twig, plantain herb, divaricate saposhnikovia root, nutgrass galingale rhizome, cinnamon bark, and mulberry twig with bright color, plump shape, no impurities, no mildew, and no insect damage. Place them in a container, rinse with water, and dry in the shade for later use.

[0036] S2: Take out the aconite, skullcap root, nutgrass galingale rhizome, and cassia bark, respectively process them through baking and then dry them in the shade. Place them in a pulverizer, pulverize and sieve through 800 meshes. Put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture A.

[0037] S3: Place the notopterygium root, cassia twig, plantain herb, divaricate saposhnikovia root, and mulberry twig in a pulverizer, pulverize and sieve through 800 meshes. Put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture B.

[0038] S4: Place the two particle mixtures A and B together in a traditional Chinese medicine pill making machine. During the process, add menthol and hydroxypropyl methylcellulose, and spray supramolecular water to finally obtain the nasal traditional Chinese medicine pills.

[0039] Note: The processing methods of each component in S2 are as follows. After washing the aconite, it needs to be decocted with water for 5 hours. After washing the skullcap root, it needs to be placed in a boiling water bath for 30 minutes. After washing the nutgrass galingale rhizome, place it in the steam of a 15% vinegar solution for steaming and fumigating. After washing the cassia bark, place it in a low-temperature baking dryer and set it at 45°C for low-temperature baking. (The processing methods in the examples and comparative examples mentioned later are the same.)

[0040] Example 2

[0041] Specifically, it is a preparation process of nasal traditional Chinese medicine pills, which is composed of the following raw materials: 3 parts by mass of aconite, 3 parts by mass of notopterygium root, 2 parts by mass of skullcap root, 3 parts by mass of cassia twig, 4 parts by mass of plantain herb, 3 parts by mass of divaricate saposhnikovia root, 2 parts by mass of nutgrass galingale rhizome, 1 part by mass of cassia bark, 5 parts by mass of mulberry twig, 4 parts by mass of menthol, and 2 parts by mass of hydroxypropyl methylcellulose.

[0042] The method of the above preparation process of nasal traditional Chinese medicine pills is as follows:

[0043] S1: Select aconite, notopterygium root, skullcap root, cassia twig, plantain herb, divaricate saposhnikovia root, nutgrass galingale rhizome, cassia bark, and mulberry twig with bright color, plump shape, no impurities, no mildew, and no insect damage. Place them in a container, rinse them with water, and dry them in the shade for standby.

[0044] S2: Take out the aconite, skullcap root, nutgrass galingale rhizome, and cassia bark, respectively process them through baking and then dry them in the shade. Place them in a pulverizer, pulverize and sieve through 800 meshes. Put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture A.

[0045] S3: Place the notopterygium root, cassia twig, plantain herb, divaricate saposhnikovia root, and mulberry twig in a pulverizer, pulverize and sieve through 800 meshes. Put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture B.

[0046] S4: Place the two particle mixtures A and B together in a traditional Chinese medicine pill making machine. During the process, add menthol and hydroxypropyl methylcellulose, and spray supramolecular water to finally obtain the nasal traditional Chinese medicine pills.

[0047] Example 3

[0048] Specifically, it is a preparation process of a traditional Chinese medicine nasal pill, which is composed of the following raw materials: 3 parts by mass of aconite, 5 parts by mass of notopterygium root, 2 parts by mass of scutellaria baicalensis, 5 parts by mass of cassia twig, 6 parts by mass of plantain herb, 5 parts by mass of ledebouriella root, 2 parts by mass of cyperus rotundus, 1 part by mass of cinnamon, 6 parts by mass of mulberry twig, 6 parts by mass of menthol, and 3 parts by mass of hydroxypropyl methylcellulose.

[0049] The method for the above preparation process of a traditional Chinese medicine nasal pill is as follows:

[0050] S1: Select aconite, notopterygium root, scutellaria baicalensis, cassia twig, plantain herb, ledebouriella root, cyperus rotundus, cinnamon, and mulberry twig with bright color, plump shape, no impurities, no mildew, and no insect damage. Place them in a container, rinse them with water, and dry them in the shade for later use.

[0051] S2: Take out aconite, scutellaria baicalensis, cyperus rotundus, and cinnamon, respectively process them by roasting and drying in the shade, place them in a pulverizer, pulverize and sieve them through 800 meshes, and put the obtained powder into a spray dryer to form spherical particles, obtaining particle mixture A.

[0052] S3: Place notopterygium root, cassia twig, plantain herb, ledebouriella root, and mulberry twig in a pulverizer, pulverize and sieve them through 800 meshes, and put the obtained powder into a spray dryer to form spherical particles, obtaining particle mixture B.

[0053] S4: Place the two particle mixtures A and B together in a traditional Chinese medicine pill making machine, add menthol and hydroxypropyl methylcellulose during the process, and spray supramolecular water to finally obtain the traditional Chinese medicine nasal pill.

[0054] Example 4

[0055] Specifically, it is a preparation process of a traditional Chinese medicine nasal pill, which is composed of the following raw materials: 9 parts by mass of aconite, 2 parts by mass of notopterygium root, 6 parts by mass of scutellaria baicalensis, 2 parts by mass of cassia twig, 3 parts by mass of plantain herb, 2 parts by mass of ledebouriella root, 6 parts by mass of cyperus rotundus, 3 parts by mass of cinnamon, 3 parts by mass of mulberry twig, 2 parts by mass of menthol, and 1 part by mass of hydroxypropyl methylcellulose.

[0056] The method for the above preparation process of a traditional Chinese medicine nasal pill is as follows:

[0057] S1: Select aconite, notopterygium root, scutellaria baicalensis, cassia twig, plantain herb, ledebouriella root, cyperus rotundus, cinnamon, and mulberry twig with bright color, plump shape, no impurities, no mildew, and no insect damage. Place them in a container, rinse them with water, and dry them in the shade for later use.

[0058] S2: Take out aconite, scutellaria baicalensis, cyperus rotundus, and cinnamon, respectively process them by roasting and drying in the shade, place them in a pulverizer, pulverize and sieve them through 800 meshes, and put the obtained powder into a spray dryer to form spherical particles, obtaining particle mixture A.

[0059] S3: Put Notopterygium root, Cassia twig, Asiatic plantain herb, Ledebouriella root, Mulberry branch into a pulverizer, pulverize and sieve through 800 meshes, put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture B.

[0060] S4: Put the two kinds of particle mixtures A and B together into a traditional Chinese medicine pill making machine, add menthol and hydroxypropyl methylcellulose during the process, spray supramolecular water, and finally obtain the traditional Chinese medicine pills for the nasal cavity.

[0061] Example 5

[0062] Specifically, it is a preparation process of traditional Chinese medicine pills for the nasal cavity, which is composed of the following raw materials: 9 parts by mass of aconite, 3 parts by mass of notopterygium root, 6 parts by mass of scutellaria baicalensis, 3 parts by mass of cassia twig, 4 parts by mass of asiatic plantain herb, 3 parts by mass of ledebouriella root, 6 parts by mass of cyperus rotundus, 3 parts by mass of cinnamon, 5 parts by mass of mulberry branch, 4 parts by mass of menthol, and 2 parts by mass of hydroxypropyl methylcellulose.

[0063] The method of the above preparation process of traditional Chinese medicine pills for the nasal cavity is as follows:

[0064] S1: Select aconite, notopterygium root, scutellaria baicalensis, cassia twig, asiatic plantain herb, ledebouriella root, cyperus rotundus, cinnamon, and mulberry branch with bright color, plump shape, no impurities, no mildew, and no insect damage. Place them in a container, rinse them with water, and dry them in the shade for later use.

[0065] S2: Take out aconite, scutellaria baicalensis, cyperus rotundus, and cinnamon, respectively process them and dry them in the shade, put them into a pulverizer, pulverize and sieve through 800 meshes, put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture A.

[0066] S3: Put notopterygium root, cassia twig, asiatic plantain herb, ledebouriella root, and mulberry branch into a pulverizer, pulverize and sieve through 800 meshes, put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture B.

[0067] S4: Put the two kinds of particle mixtures A and B together into a traditional Chinese medicine pill making machine, add menthol and hydroxypropyl methylcellulose during the process, spray supramolecular water, and finally obtain the traditional Chinese medicine pills for the nasal cavity.

[0068] Example 6

[0069] Specifically, it is a preparation process of traditional Chinese medicine pills for the nasal cavity, which is composed of the following raw materials: 9 parts by mass of aconite, 5 parts by mass of notopterygium root, 6 parts by mass of scutellaria baicalensis, 5 parts by mass of cassia twig, 6 parts by mass of asiatic plantain herb, 5 parts by mass of ledebouriella root, 6 parts by mass of cyperus rotundus, 3 parts by mass of cinnamon, 6 parts by mass of mulberry branch, 6 parts by mass of menthol, and 3 parts by mass of hydroxypropyl methylcellulose.

[0070] The method of the above preparation process of traditional Chinese medicine pills for the nasal cavity is as follows:

[0071] S1: Select aconite roots, notopterygium roots, skullcap roots, cassia twigs, plantain herb, divaricate saposhnikovia roots, nutgrass galingale rhizomes, cassia bark, and mulberry twigs that are bright in color, plump in shape, free of impurities, mildew, and insect damage. Place them in a container, rinse them with rushing water, and dry them in the shade for later use.

[0072] S2: Take out the aconite roots, skullcap roots, nutgrass galingale rhizomes, and cassia bark, process them respectively and dry them in the shade. Then place them in a pulverizer, pulverize and sieve them through 800 meshes. Put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture A.

[0073] S3: Place the notopterygium roots, cassia twigs, plantain herb, divaricate saposhnikovia roots, and mulberry twigs in a pulverizer, pulverize and sieve them through 800 meshes. Put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture B.

[0074] S4: Place the two particle mixtures A and B together in a traditional Chinese medicine pill-making machine. During the process, add menthol and hydroxypropyl methylcellulose, and spray supramolecular water to finally obtain the nasal traditional Chinese medicine pills.

[0075] Example 7

[0076] Specifically, it is a preparation process for nasal traditional Chinese medicine pills, which consists of the following raw materials: 3 parts by mass of aconite roots, 2 parts by mass of notopterygium roots, 2 parts by mass of skullcap roots, 2 parts by mass of cassia twigs, 3 parts by mass of plantain herb, 2 parts by mass of divaricate saposhnikovia roots, 2 parts by mass of nutgrass galingale rhizomes, 1 part by mass of cassia bark, 3 parts by mass of mulberry twigs, 2 parts by mass of menthol, and 1 part by mass of hydroxypropyl methylcellulose.

[0077] The method for the above preparation process of nasal traditional Chinese medicine pills is as follows:

[0078] S1: Select aconite roots, notopterygium roots, skullcap roots, cassia twigs, plantain herb, divaricate saposhnikovia roots, nutgrass galingale rhizomes, cassia bark, and mulberry twigs that are bright in color, plump in shape, free of impurities, mildew, and insect damage. Place them in a container, rinse them with rushing water, and dry them in the shade for later use.

[0079] S2: Take out the aconite roots, skullcap roots, nutgrass galingale rhizomes, and cassia bark, process them respectively and dry them in the shade. Then place them in a pulverizer, pulverize and sieve them through 1000 meshes. Put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture A.

[0080] S3: Place the notopterygium roots, cassia twigs, plantain herb, divaricate saposhnikovia roots, and mulberry twigs in a pulverizer, pulverize and sieve them through 1000 meshes. Put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture B.

[0081] S4: Place the two particle mixtures A and B together in a traditional Chinese medicine pill-making machine. During the process, add menthol and hydroxypropyl methylcellulose, and spray supramolecular water to finally obtain the nasal traditional Chinese medicine pills.

[0082] Example 8

[0083] Specifically, it is a preparation process of nasal traditional Chinese medicine pills, which consists of the following raw materials: 3 parts by mass of aconite, 3 parts by mass of notopterygium root, 2 parts by mass of skullcap root, 3 parts by mass of cassia twig, 4 parts by mass of plantain herb, 3 parts by mass of divaricate saposhnikovia root, 2 parts by mass of nutgrass galingale rhizome, 1 part by mass of cinnamon, 5 parts by mass of mulberry branch, 4 parts by mass of menthol, and 2 parts by mass of hydroxypropyl methylcellulose.

[0084] S1: Select aconite, notopterygium root, skullcap root, cassia twig, plantain herb, divaricate saposhnikovia root, nutgrass galingale rhizome, cinnamon, and mulberry branch that are bright in color, plump in shape, free of impurities, mildew, and insect pests. Place them in a container, rinse them with water, and dry them in the shade for later use.

[0085] S2: Take out aconite, skullcap root, nutgrass galingale rhizome, and cinnamon, respectively process and dry them in the shade, place them in a pulverizer, pulverize and sieve them through 1000 meshes, and put the obtained powder into a spray dryer to form spherical particles, obtaining particle mixture A.

[0086] S3: Place notopterygium root, cassia twig, plantain herb, divaricate saposhnikovia root, and mulberry branch in a pulverizer, pulverize and sieve them through 1000 meshes, and put the obtained powder into a spray dryer to form spherical particles, obtaining particle mixture B.

[0087] S4: Place the two particle mixtures A and B together in a traditional Chinese medicine pill making machine, add menthol and hydroxypropyl methylcellulose during the process, spray supermolecular water, and finally obtain nasal traditional Chinese medicine pills.

[0088] Example 9

[0089] Specifically, it is a preparation process of nasal traditional Chinese medicine pills, which consists of the following raw materials: 3 parts by mass of aconite, 5 parts by mass of notopterygium root, 2 parts by mass of skullcap root, 5 parts by mass of cassia twig, 6 parts by mass of plantain herb, 5 parts by mass of divaricate saposhnikovia root, 2 parts by mass of nutgrass galingale rhizome, 1 part by mass of cinnamon, 6 parts by mass of mulberry branch, 6 parts by mass of menthol, and 3 parts by mass of hydroxypropyl methylcellulose.

[0090] S1: Select aconite, notopterygium root, skullcap root, cassia twig, plantain herb, divaricate saposhnikovia root, nutgrass galingale rhizome, cinnamon, and mulberry branch that are bright in color, plump in shape, free of impurities, mildew, and insect pests. Place them in a container, rinse them with water, and dry them in the shade for later use.

[0091] S2: Take out aconite, skullcap root, nutgrass galingale rhizome, and cinnamon, respectively process and dry them in the shade, place them in a pulverizer, pulverize and sieve them through 1000 meshes, and put the obtained powder into a spray dryer to form spherical particles, obtaining particle mixture A.

[0092] S3: Place notopterygium root, cassia twig, plantain herb, divaricate saposhnikovia root, and mulberry branch in a pulverizer, pulverize and sieve them through 1000 meshes, and put the obtained powder into a spray dryer to form spherical particles, obtaining particle mixture B.

[0093] S4: Place the mixture of two kinds of particles A and B together in a traditional Chinese medicine pill-making machine, add menthol and hydroxypropyl methylcellulose during the process, and spray supermolecular water to finally obtain the nasal traditional Chinese medicine pills.

[0094] Example 10

[0095] Specifically, it is a preparation process of nasal traditional Chinese medicine pills, which consists of the following raw materials: 9 parts by mass of aconite root, 2 parts by mass of notopterygium root, 6 parts by mass of scutellaria root, 2 parts by mass of cassia twig, 3 parts by mass of plantain herb, 2 parts by mass of ledebouriella root, 6 parts by mass of nutgrass galingale rhizome, 3 parts by mass of cinnamon bark, 3 parts by mass of mulberry branch, 2 parts by mass of menthol, and 1 part by mass of hydroxypropyl methylcellulose.

[0096] S1: Select aconite root, notopterygium root, scutellaria root, cassia twig, plantain herb, ledebouriella root, nutgrass galingale rhizome, cinnamon bark, and mulberry branch with bright color, plump shape, no impurities, no mildew, and no insect damage. Place them in a container, rinse them with water, and dry them in the shade for later use.

[0097] S2: Take out aconite root, scutellaria root, nutgrass galingale rhizome, and cinnamon bark, respectively process them and dry them in the shade, place them in a pulverizer, pulverize and sieve them through 1000 meshes, and put the obtained powder into a spray dryer to form spherical particles to obtain particle mixture A.

[0098] S3: Place notopterygium root, cassia twig, plantain herb, ledebouriella root, and mulberry branch in a pulverizer, pulverize and sieve them through 1000 meshes, and put the obtained powder into a spray dryer to form spherical particles to obtain particle mixture B.

[0099] S4: Place the two kinds of particle mixtures A and B together in a traditional Chinese medicine pill-making machine, add menthol and hydroxypropyl methylcellulose during the process, and spray supermolecular water to finally obtain the nasal traditional Chinese medicine pills.

[0100] Example 11

[0101] Specifically, it is a preparation process of nasal traditional Chinese medicine pills, which consists of the following raw materials: 9 parts by mass of aconite root, 3 parts by mass of notopterygium root, 6 parts by mass of scutellaria root, 3 parts by mass of cassia twig, 4 parts by mass of plantain herb, 3 parts by mass of ledebouriella root, 6 parts by mass of nutgrass galingale rhizome, 3 parts by mass of cinnamon bark, 5 parts by mass of mulberry branch, 4 parts by mass of menthol, and 2 parts by mass of hydroxypropyl methylcellulose.

[0102] S1: Select aconite root, notopterygium root, scutellaria root, cassia twig, plantain herb, ledebouriella root, nutgrass galingale rhizome, cinnamon bark, and mulberry branch with bright color, plump shape, no impurities, no mildew, and no insect damage. Place them in a container, rinse them with water, and dry them in the shade for later use.

[0103] S2: Take out aconite root, scutellaria root, nutgrass galingale rhizome, and cinnamon bark, respectively process them and dry them in the shade, place them in a pulverizer, pulverize and sieve them through 1000 meshes, and put the obtained powder into a spray dryer to form spherical particles to obtain particle mixture A.

[0104] S3: Put Notopterygium root, Cassia twig, Asiatic plantain herb, Ledebouriella root, Mulberry branch into a pulverizer, pulverize and sieve through 1000 meshes, put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture B.

[0105] S4: Put the two kinds of particle mixtures A and B together into a traditional Chinese medicine pill making machine, add menthol and hydroxypropyl methylcellulose during the process, spray supramolecular water, and finally obtain nasal traditional Chinese medicine pills.

[0106] Example 12

[0107] Specifically, it is a preparation process of nasal traditional Chinese medicine pills, which is composed of the following raw materials: 9 parts by mass of Aconite root, 5 parts by mass of Notopterygium root, 6 parts by mass of Scutellaria root, 5 parts by mass of Cassia twig, 6 parts by mass of Asiatic plantain herb, 5 parts by mass of Ledebouriella root, 6 parts by mass of Cyperus rotundus, 3 parts by mass of Cinnamon twig, 6 parts by mass of Mulberry branch, 6 parts by mass of menthol, and 3 parts by mass of hydroxypropyl methylcellulose.

[0108] S1: Select Aconite root, Notopterygium root, Scutellaria root, Cassia twig, Asiatic plantain herb, Ledebouriella root, Cyperus rotundus, Cinnamon twig, and Mulberry branch with bright color, plump shape, no impurities, no mildew, and no insect damage. Place them in a container, rinse with water, and dry in the shade for later use.

[0109] S2: Take out Aconite root, Scutellaria root, Cyperus rotundus, and Cinnamon twig, carry out processing respectively and dry in the shade, put them into a pulverizer, pulverize and sieve through 1000 meshes, put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture A.

[0110] S3: Put Notopterygium root, Cassia twig, Asiatic plantain herb, Ledebouriella root, Mulberry branch into a pulverizer, pulverize and sieve through 1000 meshes, put the obtained powder into a spray dryer to form spherical particles, and obtain particle mixture B.

[0111] S4: Put the two kinds of particle mixtures A and B together into a traditional Chinese medicine pill making machine, add menthol and hydroxypropyl methylcellulose during the process, spray supramolecular water, and finally obtain nasal traditional Chinese medicine pills.

[0112] Comparative Example 1

[0113] Compared with Example 1, the difference is that a blank control is used for the experiment.

[0114] Comparative Example 2

[0115] Compared with Example 1, the same as Example 1, the difference is that all the drugs are directly made into pills after being pulverized and sieved.

[0116] Record the various parameters of the preparation processes of the nasal traditional Chinese medicine pills in Examples 1 - 12 and Comparative Examples 1 - 2 respectively, and obtain the following results, as shown in Table 1 specifically:

[0117] Table 1: Comparison of test parameters in Examples 1 - 12 and Comparative Examples 1 - 2

[0118]

[0119]

[0120] Note: (1) For the nerve cell protection experiment, after damaging the facial nerve cell model with 300 μmol / L H 2 O 2 for 2 hours, the drug extract was added and reacted for 24 hours, and the effects of the drug on cell survival rate and apoptosis rate were detected.

[0121] (2) Rats were used as the animal model. They have strong regenerative ability and anti-infection ability. The main trunk of their facial nerve is relatively shallow and thick, and is relatively similar to that of humans. After damaging the facial nerve of the rats, drugs were administered, and the recovery of the blink reflex and whisker movement were observed.

[0122] The nasal traditional Chinese medicine pill prepared by this method can effectively treat facial nerve paralysis and facial expression muscle movement disorder. It can be found from the comparison between Examples 1-12 and Comparative Example 1 in Table 1 that this nasal traditional Chinese medicine pill has a significant protective and promoting recovery effect on the damaged nerve cell model. It can be found from the comparison between Examples 1-12 and Comparative Example 2 in Table 1 that after mixing different components and then placing them together in a spray dryer to prepare spherical particles, the treatment efficiency is greatly improved, thus better solving the problems of treating facial nerve paralysis and facial expression muscle movement disorder.

[0123] In summary, preparing the nasal traditional Chinese medicine pill with this preparation process of the nasal traditional Chinese medicine pill can more effectively relieve the symptoms of facial nerve paralysis, improve the motor function of facial expression muscles, shorten the treatment cycle, improve the treatment efficiency, and is a safer and milder treatment method.

[0124] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A nasal Chinese medicine pill, characterized in that: The invention is composed of the following ingredients: 3-9 parts by weight of aconite root, 2-5 parts by weight of notopterygium root, 2-5 parts by weight of scutellaria root, 2-5 parts by weight of cinnamon twig, 3-6 parts by weight of plantain, 2-5 parts by weight of siler, 2-6 parts by weight of cyperus rotundus, 1-3 parts by weight of cinnamon bark, 3-6 parts by weight of mulberry twig, 2-8 parts by weight of menthol and 1-3 parts by weight of hydroxypropyl methylcellulose.

2. A nasal Chinese medicine pill according to claim 1, characterized in that: The ratio of aconite root, scutellaria baicalensis, cyperus rotundus and cinnamon bark is 3:2:2:

1.

3. A nasal Chinese medicine pill according to claim 1, characterized in that: The aconite, scutellaria, cyperus and cinnamon need to be processed. After the aconite is washed, it needs to be decocted in water for 5 hours, after the scutellaria is washed, it needs to be boiled in water for 30 minutes, after the cyperus is washed, it needs to be steamed in 15% vinegar solution steam, and after the cinnamon is washed, it needs to be placed in a low-temperature processing dryer and baked at 45°C.

4. A process for preparing nasal Chinese medicine pills according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1: Select aconite root, notopterygium root, scutellaria root, cinnamon twig, plantain, siler, cyperus rotundus, cinnamon bark, and mulberry branch that are bright in color, full in shape, free of impurities, mildew, and insects, place them in a container, rinse with water, and dry them in the shade for later use; S2: Take out Aconite root, Scutellaria root, Cyperus rotundus and Cinnamomum cassia, process them separately and dry them in the shade, grind them in a grinder and sieve them to 800-1000 mesh, put the obtained powder into a spray dryer to form spherical particles, and obtain a particle mixture A; S3: Put the Notopterygium wilfordii, cinnamon twig, plantain, siler twig into a grinder, grind and sieve through 800-1000 mesh, put the obtained powder into a spray dryer to form spherical particles, and obtain a particle mixture B; S4: placing the mixture of particles A and B in a traditional Chinese medicine pill making machine, adding menthol and hydroxypropyl methylcellulose during the process, spraying supramolecular water, and finally obtaining nasal traditional Chinese medicine pills.

5. The process for preparing nasal Chinese medicine pills according to claim 4, characterized in that: The different drugs are crushed and sieved to a mesh number within the range of 800-1000 meshes.

6. The process for preparing a nasal Chinese medicine pill according to claim 4, characterized in that: The aconite root, scutellaria root, cyperus rotundus and cinnamon bark need to be processed and crushed to form spherical particles before use.

7. The process for preparing nasal Chinese medicine pills according to claim 4, characterized in that: The aconite root, scutellaria baicalensis, cyperus rotundus and cinnamon bark are used as a group to prepare a granular mixture A, which is then mixed with another group of granular mixture B made of notopterygium wilfordii, cassia twig, plantain, siler and mulberry twig to prepare pills.

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