Biological sample low-temperature preservation box

Abstract

The invention discloses a biological sample low-temperature preservation box, and particularly relates to the technical field of DNA sample preservation, the biological sample low-temperature preservation box comprises a box body and a first box door, the first box door is movably connected with the box body through a hinge, a touch screen, a first camera and a fingerprint lock are fixedly installed at the top end of the box body, and a second camera is fixedly installed on the front side of the box body; a semiconductor refrigerator is fixedly installed in the box body, a second box door is movably arranged on the rear side of the first box door, and the second box door is movably connected with the front side of the box body through a hinge. The threaded ice storage barrel is rotated to be far away from the box body, then ice blocks are placed in the threaded ice storage barrel, finally the threaded ice storage barrel is installed and fixed, auxiliary refrigeration is conducted on the interior of the box body, and meanwhile, along with gradual melting of the ice blocks, generated water enters the water storage barrel through the guide pipe; the one-way valve can prevent water in the water storage barrel from flowing back into the threaded ice storage barrel, the structure is simple, and auxiliary refrigeration can be conveniently carried out on the interior of the box body.

Description

Technical Field

[0001] The present invention relates to the technical field of DNA sample preservation, and more specifically, the present invention relates to a cryopreservation box for biological samples. Background Art

[0002] As a carrier of genetic information of organisms, the collection and preservation of DNA samples are of extremely important significance in many fields such as biological research, medical diagnosis, and forensic identification. In biological research, by analyzing DNA samples of different biological individuals or the same organism at different developmental stages, it is possible to deeply understand the genetic characteristics, evolutionary relationships, and gene expression regulation mechanisms of organisms, etc.; in forensic identification, DNA samples have become the key basis for identifying criminal suspects, conducting paternity tests, and identifying the identities of disaster victims. The DNA samples can be stored through a cryopreservation box.

[0003] When the existing cryopreservation box is in use, a honeycomb-shaped grille is generally arranged inside the cryopreservation box. The test tube containing the DNA sample is placed into the grille. Generally, the box body is refrigerated by a refrigerator, but it is not convenient to assist in refrigerating the box body. When the refrigerator cannot work due to insufficient power, the temperature inside the box will rise rapidly, thus exceeding the suitable temperature range for DNA sample preservation, and further affecting the quality and stability of the sample. Summary of the Invention

[0004] In order to overcome the above-mentioned defects of the prior art, the present invention provides a cryopreservation box for biological samples, aiming to solve the problems raised in the above-mentioned background art.

[0005] To achieve the above object, the present invention provides the following technical solution: A cryopreservation box for biological samples, including a box body and a first box door, and the first box door is movably connected to the box body through a hinge. A touch screen, a first camera, and a fingerprint lock are fixedly installed at the top of the box body. A second camera is fixedly installed on the front side of the box body. A semiconductor refrigerator is fixedly installed inside the box body. A second box door is movably arranged at the rear side of the first box door, and the second box door is movably connected to the front side of the box body through a hinge. A storage rack is arranged at the rear side of the second box door, and the storage rack is located on top of the semiconductor refrigerator. A grille is fixedly connected inside the storage rack. A pressing plate is arranged on top of the grille. An auxiliary cooling component is arranged at the bottom of the box body. The auxiliary cooling component includes a threaded ice storage cylinder, a conduit, a water storage cylinder, and a one-way valve.

[0006] Further, the top end of the threaded ice storage cylinder extends into the interior of the box body and is threadedly connected thereto. One end of the conduit is fixedly communicated with the threaded ice storage cylinder, and the other end of the conduit is threadedly communicated with the water storage cylinder. The one-way valve is fixedly installed on the conduit.

[0007] Furthermore, a plurality of support seats are movably arranged at the bottom of the threaded ice storage cylinder, and the tops of the plurality of support seats are fixedly connected to the box body.

[0008] Furthermore, a plurality of gaskets are fixedly connected to the bottom end of the pressing plate and the inner bottom end of the storage rack. Among them, the gaskets can play a role in buffering the test tubes.

[0009] Furthermore, two limiting plates are movably arranged on both sides of the storage rack, and the plurality of limiting plates are fixedly installed inside the box body.

[0010] Furthermore, a handle is movably connected to the top of the box body through a pin. Among them, the handle can play a role in facilitating the lifting of the box body.

[0011] Furthermore, a USB interface is fixedly installed on the front side of the box body, and the USB interface is located at the bottom of the second camera.

[0012] Furthermore, a bar code scanner is fixedly installed on the front side of the box body, and the bar code scanner is located at the bottom of the USB interface.

[0013] Furthermore, a partition component is arranged on one side of the pressing plate. The partition component includes a plurality of partition plates, a plurality of sliding frames, a sliding rod and an extrusion bolt.

[0014] Furthermore, one side of each of the plurality of sliding frames is fixedly connected to one of the plurality of partition plates, and the plurality of sliding frames are movably sleeved on the sliding rod. The extrusion bolt is threadedly connected to one of the sliding frames, and the bottom end of the extrusion bolt is in contact with the sliding rod.

[0015] It can be seen that in the above technical solution, it is convenient to separate individual sets.

[0016] The technical effects and advantages of the present invention: 1. In the present invention, by rotating the threaded ice storage cylinder and moving it away from the box body, then putting ice cubes into the threaded ice storage cylinder, and finally installing and fixing the threaded ice storage cylinder, auxiliary refrigeration is carried out inside the box body. At the same time, as the ice cubes gradually melt, the generated water will enter the water storage cylinder through the conduit, and the one-way valve can prevent the water in the water storage cylinder from flowing back into the threaded ice storage cylinder. The structure is simple and it is convenient to carry out auxiliary refrigeration inside the box body; 2. In the present invention, the first user places a finger on the fingerprint lock to open the first box door, and the second user places a finger on the fingerprint lock to open the second box door. Moreover, the first camera and the second camera can take pictures of the unlocking scenario. The double-layer lock design realizes decentralized control of permissions. At the same time, the bar code scanner can quickly scan and identify the bar code pasted on the test tube containing the DNA sample, realizing accurate input and management of sample information. The structure is simple and easy to use; 3. The present invention separates individual sets through a partition plate, thereby facilitating the management and identification of two different types of sets. At the same time, the partition plate drives the sliding frame to slide on the sliding rod, which can prevent the partition plate from deflecting. Rotate the extrusion bolt to make it contact with the sliding rod, thereby limiting the partition plate. The structure is simple and easy to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The structures, ratios, sizes, etc. shown in this specification are only used to cooperate with the content disclosed in the specification for those familiar with this technology to understand and read, and are not used to limit the implementable conditions of the present invention. Therefore, they do not have technical essential significance. Any modification of the structure, change of the proportional relationship, or adjustment of the size, without affecting the effects that the present invention can produce and the purposes that can be achieved, should still fall within the scope covered by the technical content disclosed in the present invention.

[0018] Figure 1 is a schematic diagram of the overall structure of the present invention; Figure 2 is a rear view of the overall structure of the present invention; Figure 3 is a schematic diagram of the assembly structure of the box body and the second box door of the present invention; Figure 4 is a schematic diagram of the assembly structure of the box body and the semiconductor refrigerator of the present invention; Figure 5 is a schematic diagram of the assembly structure of the second box door and the storage rack of the present invention; Figure 6 is a schematic diagram of the assembly structure of the pressing plate and the grating of the present invention; Figure 7 is a schematic diagram of the structure of the separation component of the present invention.

[0019] In the figure: 1, box body; 2, touch screen; 3, first camera; 4, fingerprint lock; 5, handle; 6, first box door; 7, second camera; 8, USB interface; 9, second box door; 10, bar code reader; 11, semiconductor refrigerator; 12, limit plate; 13, storage rack; 14, pressing plate; 15, separation component; 16, support seat; 17, threaded ice storage cylinder; 18, conduit; 19, water storage cylinder; 20, one-way valve; 21, grating; 22, gasket; 1501, partition plate; 1502, sliding frame; 1503, sliding rod; 1504, extrusion bolt. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0020] The following specific embodiments illustrate the implementation manners of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts belong to the scope of protection of the present invention.

[0021] Referring to the attached drawings of the specification Figure 1-7 A cryopreservation box for biological samples in this embodiment includes a box body 1 and a first box door 6. The first box door 6 is movably connected to the box body 1 through a hinge. A touch screen 2, a first camera 3 and a fingerprint lock 4 are fixedly installed at the top of the box body 1. A second camera 7 is fixedly installed on the front side of the box body 1. A semiconductor refrigerator 11 is fixedly installed inside the box body 1. A second box door 9 is movably arranged at the rear side of the first box door 6. The second box door 9 is movably connected to the front side of the box body 1 through a hinge. A storage rack 13 is arranged at the rear side of the second box door 9, and the storage rack 13 is located on the top of the semiconductor refrigerator 11. A grille 21 is fixedly connected inside the storage rack 13. A pressing plate 14 is arranged on the top of the grille 21. An auxiliary cooling component is arranged at the bottom of the box body 1. The auxiliary cooling component includes a threaded ice storage cylinder 17, a conduit 18, a water storage cylinder 19 and a one-way valve 20. The top end of the threaded ice storage cylinder 17 extends into the box body 1 and is threadedly connected thereto. One end of the conduit 18 is fixedly communicated with the threaded ice storage cylinder 17, and the other end of the conduit 18 is threadedly communicated with the water storage cylinder 19. The one-way valve 20 is fixedly installed on the conduit 18. A plurality of support seats 16 are movably arranged at the bottom of the threaded ice storage cylinder 17, and the top ends of the plurality of support seats 16 are fixedly connected to the box body 1.

[0022] Furthermore, a plurality of gaskets 22 are fixedly connected to the bottom end of the pressing plate 14 and the inner bottom end of the storage rack 13. Among them, the gaskets 22 can play a role in buffering the test tubes. Two limiting plates 12 are movably arranged on both sides of the storage rack 13, and the plurality of limiting plates 12 are fixedly installed inside the box body 1.

[0023] Furthermore, a handle 5 is movably connected to the top end of the box body 1 through a pin. Among them, the handle 5 can play a role in facilitating the lifting of the box body 1.

[0024] Furthermore, a USB interface 8 is fixedly installed on the front side of the box body 1, and the USB interface 8 is located at the bottom of the second camera 7. A barcode scanner 10 is fixedly installed on the front side of the box body 1, and the barcode scanner 10 is located at the bottom of the USB interface 8.

[0025] Among them, the first camera 3, the second camera 7, the USB interface 8, and the barcode scanner 10 are all connected to a control circuit board (not shown in the figure) built into the box. The control circuit board is an STM32 series chip, which supplies power and transmits data signals uniformly to ensure the normal operation of each device. The first user places a finger on the fingerprint lock 4 to open the first box door 6, and the second user places a finger on the fingerprint lock 4 to open the second box door 9. Moreover, the first camera 3 and the second camera 7 can take pictures of the unlocking scenario. With a double-layer lock design and decentralized permission control, at the same time, the barcode scanner 10 scans the barcode on the sample test tube, quickly identifies the sample information and transmits it to the control circuit board, and the control circuit board stores this information. If further analysis, backup, or sharing with other devices of the sample information is required, an external device can be connected through the USB interface 8 to transmit the sample information stored in the control circuit board, realizing the efficient management and utilization of the sample information. These three devices cooperate with each other to jointly ensure the smooth progress of the sample management work. It is worth noting that a lithium battery and a charging port are provided on the box body 1 to provide continuous and stable power supply for the box body 1. A positioning and tracking module is provided to record the movement trajectory of the box body 1 in combination with GPS / base stations, and a 4G module is provided to upload the temperature and movement trajectory inside the box body 1 in real time.

[0026] Further, a partition component 15 is provided on one side of the pressing plate 14. The partition component 15 includes a plurality of partition plates 1501, a plurality of sliding frames 1502, a sliding rod 1503, and an extrusion bolt 1504. One side of each of the plurality of sliding frames 1502 is fixedly connected to one of the plurality of partition plates 1501, and each of the plurality of sliding frames 1502 is movably sleeved on the sliding rod 1503. The extrusion bolt 1504 is threadedly connected to one of the sliding frames 1502, and the bottom end of the extrusion bolt 1504 is in contact with the sliding rod 1503.

[0027] Among them, hold the storage rack 13 with the left hand and place the blood sample collection card set and the non-transferable oral cell collection card set inside the right side of the storage rack 13 (refer to the attached reference manual). Figure 6 Horizontally move the partition plate 1501 to make it contact with the blood sample collection card set or the non-transferable oral cell collection card set. The partition plate 1501 separates individual sets, thus facilitating the management and identification of the two different types of sets. At the same time, the partition plate 1501 drives the sliding frame 1502 to slide on the sliding rod 1503, thereby preventing the partition plate 1501 from deflecting. Rotate the extrusion bolt 1504 to make it contact with the sliding rod 1503, thereby limiting the partition plate 1501. The structure is simple and easy to use.

[0028] The usage method of this embodiment is as follows: In use, place the test tubes on the storage rack 13, and the partition 21 separates multiple test tubes. Press the pressing plate 14 on the tops of the multiple test tubes, and then place the storage rack 13 into the box body 1, so as to limit multiple test tubes. At the same time, the gasket 22 can buffer and protect the test tubes. The semiconductor refrigerator 11 operates to cool the inside of the box body 1, and the temperature inside the box body 1 can reach 2°C - 8°C. When the lithium battery equipped on the box body 1 is in a low state of charge, rotate the threaded ice storage cylinder 17 and move it away from the box body 1, then put ice cubes into the threaded ice storage cylinder 17, and finally install and fix the threaded ice storage cylinder 17 to assist in cooling the inside of the box body 1. At the same time, as the ice cubes gradually melt, the generated water will enter the water storage cylinder 19 through the conduit 18. The one-way valve 20 can prevent the water in the water storage cylinder 19 from flowing back into the threaded ice storage cylinder 17. The structure is simple and convenient for assisting in cooling the inside of the box body 1. At the same time, the four support seats 16 support the box body 1 and keep the threaded ice storage cylinder 17 away from the ground, avoiding the influence of ground moisture, dust and sundries on the threaded ice storage cylinder 17.

[0029] Contents not described in detail in the specification belong to the prior art well-known to those skilled in the art, and the model parameters of each electrical appliance are not specifically limited. Conventional equipment can be used. In this technical solution, since the electrical control components not mentioned belong to the prior art, they are not shown in the figure and will not be described here.

[0030] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A biological sample cryogenic storage box, comprising a box body (1) and a first box door (6), wherein the first box door (6) is movably connected to the box body (1) via a hinge, characterized in that: A touch screen (2), a first camera (3) and a fingerprint lock (4) are fixedly mounted on the top of the box (1); a second camera (7) is fixedly mounted on the front side of the box (1); a semiconductor refrigerator (11) is fixedly mounted inside the box (1); a second door (9) is movably mounted on the rear side of the first door (6); the second door (9) is movably connected to the front side of the box (1) via a hinge; a storage rack (13) is arranged on the rear side of the second door (9); the storage rack (13) is located on the top of the semiconductor refrigerator (11); a partition (21) is fixedly mounted inside the storage rack (13); a pressure plate (14) is arranged on the top of the partition (21); an auxiliary cooling assembly is arranged on the bottom of the box (1); the auxiliary cooling assembly comprises a threaded ice storage cylinder (17), a conduit (18), a water storage cylinder (19) and a one-way valve (20).

2. The biological sample cryogenic storage box according to claim 1, characterized in that: The top end of the threaded ice storage cylinder (17) extends into the interior of the box body (1) and is threadedly connected thereto; one end of the conduit (18) is fixedly connected to the threaded ice storage cylinder (17); and the other end of the conduit (18) is threadedly connected to the water storage cylinder (19); and the one-way valve (20) is fixedly mounted on the conduit (18).

3. The biological sample cryogenic storage box according to claim 1, characterized in that: A plurality of support seats (16) are movably provided at the bottom of the threaded ice storage cylinder (17), and the top ends of the plurality of support seats (16) are fixedly connected to the box body (1).

4. The biological sample cryogenic storage box according to claim 1, characterized in that: A plurality of gaskets (22) are fixedly connected to the bottom end of the pressing plate (14) and the inner bottom end of the storage rack (13), wherein the gaskets (22) can play a role in buffering the test tubes.

5. The biological sample cryogenic storage box according to claim 1, characterized in that: Two limit plates (12) are movably provided on both sides of the storage rack (13), and the plurality of limit plates (12) are fixedly mounted inside the box body (1).

6. The biological sample cryogenic storage box according to claim 1, characterized in that: The top end of the box body (1) is movably connected to a handle (5) via an axle pin, wherein the handle (5) can facilitate lifting the box body (1).

7. The biological sample cryogenic storage box according to claim 1, characterized in that: A USB interface (8) is fixedly mounted on the front side of the box (1), and the USB interface (8) is located at the bottom of the second camera (7).

8. The biological sample cryogenic storage box according to claim 1, characterized in that: A barcode reader (10) is fixedly mounted on the front side of the box (1), and the barcode reader (10) is located at the bottom of the USB interface (8).

9. The biological sample cryogenic storage box according to claim 1, characterized in that: A partition assembly (15) is provided on one side of the pressing plate (14), and the partition assembly (15) comprises a plurality of partition plates (1501), a plurality of sliding frames (1502), a sliding rod (1503), and a squeezing bolt (1504).

10. The biological sample cryogenic storage box according to claim 9, characterized in that: One side of the plurality of sliding frames (1502) is respectively fixedly connected to the plurality of partition plates (1501), and the plurality of sliding frames (1502) are movably mounted on the sliding rod (1503), the extrusion bolt (1504) is threadedly connected to one of the sliding frames (1502), and the bottom end of the extrusion bolt (1504) is in contact with the sliding rod (1503).

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