Antibodies against monkeypox virus A35R protein, their preparation methods and applications

CN120137014BActive Publication Date: 2026-05-26INST OF MICROBIOLOGY CHINESE ACAD OF SCI
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Patent Information

Application Number
CN202510313338.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-03-17
Publication Date
2026-05-26
Estimated Expiration
2045-03-17

AI Technical Summary

Technical Problem

Current technologies lack monkeypox virus antibodies with high affinity and good in vitro neutralization, making the prevention and control of monkeypox virus infection difficult, especially in non-endemic countries where the transmission routes are diverse and the virus mutates rapidly, and there is a lack of effective antiviral therapies.

Method used

An antibody against monkeypox virus A35R protein was developed. Specific memory B cells were obtained by screening fully humanized mice with antibodies. Multiple monkeypox virus A35R monoclonal antibodies, including A35R-9E4, A35R-9F8, A35R-10C4, A35R-10D5, A35R-10E7, A35R-10H6, A35R-18E2, and A35R-18H2, were prepared and purified, exhibiting strong binding ability and high in vitro neutralization.

Benefits of technology

These monoclonal antibodies have strong binding affinity and in vitro neutralization properties to monkeypox virus, effectively neutralizing the virus and providing in vivo protection, thus offering new product possibilities for the detection and treatment of monkeypox virus.

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Abstract

This application discloses antibodies against monkeypox virus, their preparation methods, and applications. Specifically, this application discloses eight antibodies (A35R-9E4, A35R-9F8, A35R-10C4, A35R-10D5, A35R-10E7, A35R-10H6, A35R-18E2, and A35R-18H2) that have excellent affinity for the monkeypox virus A35R protein, and that they exhibit good neutralizing activity and certain in vivo protective effects.
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Citation Information

Patent Citations

  • Monoclonal antibody 7G5 or antibody fragment thereof for resisting monkey pox virus A35R protein

    CN118496348A

  • Monoclonal antibody 2D7 or antibody fragment thereof for resisting monkey pox virus A35R protein

    CN118496349A