Traditional Chinese medicine composition for treating intestinal inflammation as well as preparation method and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating intestinal inflammation, and the traditional Chinese medicine composition at least comprises the following components in parts by weight: 27-33 g of humifuse euphorbia herb, 27-33 g of dandelion, 8-10 g of smoked plum charcoal, 8-10 g of rhizoma bletillae, 13-17 g of hairyvein agrimony, and 27-33 g of nodus nelumbinis rhizomatis charcoal. The preparation method of the traditional Chinese medicine composition for treating intestinal inflammation comprises the following steps: mixing the raw materials, adding 400ml of clear water, boiling with strong fire, continuously decocting for 30 minutes, filtering and extracting liquid medicine; adding 400ml of clear water into medicine residues, boiling with strong fire, continuing to decoct for 30 minutes, filtering and extracting medicine liquid; and combining the medicine liquid extracted twice. The traditional Chinese medicine composition for treating intestinal inflammation is used for treating heat toxin injury and intestinal collateral stasis type ulcerative colitis, and has the effects of clearing away heat and toxic materials, regulating intestines, dispersing blood stasis, cooling blood and stopping bleeding.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating intestinal inflammation, a preparation method and an application thereof. Background Art

[0002] Heat-toxin injury and stasis of collaterals in the intestine, such as the acute attack stage of ulcerative colitis, acute hemorrhagic enteritis, and the acute attack stage of other digestive system diseases. The symptoms include obvious abdominal pain, increased frequency of diarrhea, dysentery with purulent and bloody stools, more red than white, or pure bloody stools, yellowish-brown and foul-smelling stools, burning sensation in the anus, short and red urine, thirst with preference for cold drinks, red tongue, thin yellow or slightly greasy tongue coating, slippery and rapid or floating and rapid pulse.

[0003] For such diseases, there is a lack of effective traditional Chinese medicines in the prior art. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating intestinal inflammation, a preparation method and an application thereof, which can be used to treat ulcerative colitis of heat-toxin injury and stasis of collaterals in the intestine type, and has the effects of clearing heat and detoxifying, regulating the intestine, removing stasis, cooling blood and stopping bleeding.

[0005] To solve the above technical problems, the present invention specifically provides the following technical solutions:

[0006] The present invention provides a traditional Chinese medicine composition for treating intestinal inflammation. Calculated by weight, the formula of the traditional Chinese medicine composition at least includes:

[0007] 27-33 grams of Euphorbia humifusa, 27-33 grams of Taraxacum mongolicum, 8-10 grams of carbonized Fructus Mume, 8-10 grams of Bletilla striata, 13-17 grams of Agrimonia pilosa, 27-33 grams of carbonized Nelumbo nucifera rhizome.

[0008] Preferably, calculated by weight, the formula of the traditional Chinese medicine composition is:

[0009] 30 grams of Euphorbia humifusa, 30 grams of Taraxacum mongolicum, 9 grams of carbonized Fructus Mume, 9 grams of Bletilla striata, 15 grams of Agrimonia pilosa, 30 grams of carbonized Nelumbo nucifera rhizome.

[0010] Preferably, calculated by weight, the formula of the traditional Chinese medicine composition is:

[0011] 27 grams of Euphorbia humifusa, 27 grams of Taraxacum mongolicum, 8 grams of carbonized Fructus Mume, 8 grams of Bletilla striata, 13 grams of Agrimonia pilosa, 27 grams of carbonized Nelumbo nucifera rhizome.

[0012] Preferably, calculated by weight, the formula of the traditional Chinese medicine composition is:

[0013] 33 grams of Euphorbia humifusa, 33 grams of Taraxacum mongolicum, 10 grams of carbonized Fructus Mume, 10 grams of Bletilla striata, 17 grams of Agrimonia pilosa, 33 grams of carbonized Nelumbo nucifera rhizome.

[0014] Preferably, by weight, the formula of the traditional Chinese medicine composition further includes one or any combination of stir-fried Coptis chinensis, stir-fried Paeonia lactiflora, and Pulsatilla chinensis.

[0015] Preferably, by weight, the formula of the traditional Chinese medicine composition further includes one or any combination of stir-fried Saposhnikovia divaricata, dried tangerine peel, and stir-fried Atractylodes macrocephala.

[0016] In the second aspect of the present invention, a preparation method of a traditional Chinese medicine composition for treating intestinal inflammation is provided. According to the formula of the traditional Chinese medicine composition, all the traditional Chinese medicine raw materials are mixed, 400 ml of clear water is added, and after boiling over high heat, continue to decoct for 30 minutes, then filter to extract the medicinal liquid;

[0017] Add 400 ml of clear water to the medicinal residues, boil over high heat and then continue to decoct for 30 minutes, filter to extract the medicinal liquid;

[0018] Combine the medicinal liquids extracted twice.

[0019] In the third aspect of the present invention, an application of a traditional Chinese medicine composition for treating intestinal inflammation is provided. The traditional Chinese medicine composition for treating intestinal inflammation is used for treating ulcerative colitis of the type of heat-toxin injury and stasis-blocked intestinal collaterals, and has the effects of clearing heat and detoxifying, regulating the intestines, promoting blood circulation to remove stasis, cooling blood and stopping bleeding.

[0020] The present invention has the following beneficial effects compared with the prior art:

[0021] The present invention can treat ulcerative colitis of the type of heat-toxin injury and stasis-blocked intestinal collaterals, and has good effects of clearing heat and detoxifying, regulating the intestines, promoting blood circulation to remove stasis, cooling blood and stopping bleeding.

[0022] This traditional Chinese medicine composition is used for treating ulcerative colitis of the type of heat-toxin injury and stasis-blocked intestinal collaterals, and has the effects of clearing heat and detoxifying, regulating the intestines, promoting blood circulation to remove stasis, cooling blood and stopping bleeding.

[0023] Euphorbia humifusa is bitter, pungent and has a neutral nature, and belongs to the liver and large intestine meridians. Its effects are clearing heat and detoxifying, cooling blood and stopping bleeding, and Euphorbia humifusa also has the effect of regulating blood and qi; Taraxacum mongolicum is bitter and has a cold nature, and belongs to the liver and stomach meridians. Its effects are clearing heat and detoxifying, dispersing swelling and dissipating nodules. The combination of the two enhances the effect of clearing heat and detoxifying and regulating the intestines.

[0024] The effects of Fructus Mume are astringing the lung and arresting diarrhea, promoting the production of body fluid and expelling roundworms, and stir-frying it into charcoal can treat blood syndromes such as hematochezia and metrorrhagia; the effects of Bletilla striata are arresting bleeding with astringents, detumescence and promoting granulation; Agrimonia pilosa has the effects of arresting bleeding with astringents, stopping dysentery and detoxifying; Nodus Nelumbinis Carbonisatus can not only arrest bleeding with astringents, but also disperse stasis, and has the characteristic of not leaving stasis after stopping bleeding. The combination of the four herbs focuses on stopping bleeding and cooling blood, promoting blood circulation to remove stasis and detoxifying. The whole formula combined can clear heat and detoxify the intestines, promote blood circulation to remove stasis, cool blood and stop bleeding. Detailed implementation manners

[0025] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0026] The present invention provides a traditional Chinese medicine composition for treating intestinal inflammation. According to parts by weight, the formula of the traditional Chinese medicine composition at least includes:

[0027] 27-33 grams of Euphorbia humifusa, 27-33 grams of Taraxacum mongolicum, 8-10 grams of carbonized smoked plum, 8-10 grams of Bletilla striata, 13-17 grams of Agrimonia pilosa, and 27-33 grams of carbonized lotus node.

[0028] Euphorbia humifusa is bitter, pungent, and has a neutral nature. It belongs to the liver and large intestine meridians. Its effects are clearing heat and detoxifying, cooling blood and stopping bleeding. Euphorbia humifusa also has the effect of regulating blood and qi; Taraxacum mongolicum is bitter and has a cold nature. It belongs to the liver and stomach meridians. Its effects are clearing heat and detoxifying, dispersing swelling and dissipating nodules. The combination of the two enhances the effect of clearing heat and detoxifying and regulating the intestines.

[0029] The effect of smoked plum is astringing the lung and astringing the intestine, promoting the production of body fluid and arresting worms. Stir-frying with carbon can treat blood stasis such as hematochezia and metrorrhagia; the effect of Bletilla striata is astringing to stop bleeding, dispersing swelling and promoting granulation; Agrimonia pilosa has the functions of astringing to stop bleeding, relieving dysentery and detoxifying; carbonized lotus node can not only astringe to stop bleeding, but also disperse stasis, with the characteristic of stopping bleeding without leaving stasis. The combination of the four herbs focuses on stopping bleeding and cooling blood, removing stasis and detoxifying. The whole formula combined can clear heat and detoxify the intestines, remove stasis, cool blood and stop bleeding.

[0030] This traditional Chinese medicine composition is used to treat ulcerative colitis of the type of heat-toxin injury and stasis obstruction of intestinal collaterals, and has the effects of clearing heat and detoxifying the intestines, removing stasis, cooling blood and stopping bleeding.

[0031] Example 1:

[0032] The formula of the traditional Chinese medicine composition is 30 grams of Euphorbia humifusa, 30 grams of Taraxacum mongolicum, 9 grams of carbonized smoked plum, 9 grams of Bletilla striata, 15 grams of Agrimonia pilosa, and 30 grams of carbonized lotus node.

[0033] Example 2:

[0034] The formula of the traditional Chinese medicine composition is 27 grams of Euphorbia humifusa, 27 grams of Taraxacum mongolicum, 8 grams of carbonized smoked plum, 8 grams of Bletilla striata, 13 grams of Agrimonia pilosa, and 27 grams of carbonized lotus node.

[0035] Example 3:

[0036] The formula of the traditional Chinese medicine composition is 33 grams of Euphorbia humifusa, 33 grams of Taraxacum mongolicum, 10 grams of carbonized smoked plum, 10 grams of Bletilla striata, 17 grams of Agrimonia pilosa, and 33 grams of carbonized lotus node.

[0037] The preparation method is to mix all the traditional Chinese medicine raw materials according to the formula of the traditional Chinese medicine composition, add 400 ml of clear water, bring to a boil over high heat and then continue to decoct for 30 minutes, filter to extract the medicinal liquid;

[0038] Add 400 ml of clear water to the medicinal residues, bring to a boil over high heat and then continue to decoct for 30 minutes, filter to extract the medicinal liquid;

[0039] Combine the medicinal liquids extracted twice.

[0040] The causes of many digestive tract diseases are mostly due to diet injury, exogenous pathogen invasion or physical factors, etc. The initial pathogenesis is mostly damp-heat accumulation, qi and blood stasis, disorder of qi transformation, blockage of the large intestine, stagnation of qi movement, heat accumulation into toxin, damage to the membrane and collaterals, so there is dysentery with bloody purulent stools; chronic dysentery is most likely to damage the spleen, with weakness of the spleen qi, qi deficiency injuring yang, and long-term illness not healed, liver invading the spleen due to spleen deficiency. At the same time, the chronic consumption of qi and blood becomes more and more serious. Qi deficiency leads to weakness in promoting blood circulation, and blood deficiency leads to sluggish blood flow and difficulty in moving forward, resulting in blood stasis turning into heat, scorching body fluids and blocking collaterals, and the disease recurs repeatedly.

[0041] Following the principle of "treating the symptoms in acute cases and the root cause in chronic cases", and in accordance with Ye Tianshi's idea of "once entering the blood aspect, fear of consuming blood and causing blood movement, directly need to cool the blood and disperse blood stasis", aiming at the fundamental pathogenesis of heat toxin damage and stasis in the intestinal collaterals, the methods of clearing heat and detoxifying and stopping bleeding and removing blood stasis are organically combined. By clearing heat and detoxifying and cooling the blood, clearing away heat, so that when the blood is cooled, the heat will clear itself and there will be no production of stasis by boiling body fluids; by dispersing blood stasis in the blood, the heat toxin will lose its attachment and will not be stuck with blood stasis and be difficult to clear. Blood moves when heated and can follow the meridians when cooled, the collaterals are unobstructed, and the bleeding can be stopped.

[0042] The combination of the two methods achieves the effects of clearing heat and detoxifying the intestine, cooling the blood, removing blood stasis and stopping bleeding. The focus of the application of this formula is on the acute attack stage of heat toxin damage and stasis in the intestinal collaterals. Herba Euphorbiae Humifusae in Dijin Wubai Decoction is quite important. Intestinal diseases are mostly accompanied by qi movement disorder. Herba Euphorbiae Humifusae can not only clear heat and detoxify, cool the blood and stop bleeding, but also benefit qi regulation, so it can achieve the effects of regulating the intestine and removing blood stasis. The two herbs of carbonized Fructus Mume and carbonized Nodus Nelumbinis Rhizomatis not only enhance the hemostatic effect, but also take into account the generation of yin fluid.

[0043] Based on the pathological mechanism of heat toxin damage and stasis in the intestinal collaterals, Dijin Wubai Decoction is formulated with the principles of clearing heat and detoxifying and removing blood stasis and stopping bleeding, and the medicine and syndrome match. Proven in clinical practice, flexibly modified according to the syndrome based on this formula, it can not only be used to treat the acute attack stage of gastrointestinal diseases, but also be used to treat diseases in various systems of internal medicine, as well as diseases in gynecology, urology, surgery, dermatology, otolaryngology, etc., and can indeed achieve relatively satisfactory results.

[0044] The following provides specific clinical data:

[0045] Zhang, male, 35 years old, information industry. Chief complaint: bloody and sticky stool for more than 3 weeks. The patient had loose stools after drinking and eating barbecue 3 weeks ago, 5 to 6 times a day, diarrhea with abdominal pain, no obvious tenesmus, no anal swelling, blood and sticky stools, dark red, moderate amount. He had a history of "ulcerative colitis" for more than 2 years, with good appetite, good sleep at night, normal urination, and no other obvious discomfort. The tongue is dark red, the fur is thin and yellow, and the pulse is stringy and slippery.

[0046] Previous auxiliary examinations: Colonoscopy showed: ulcerative colitis. Stool routine: red blood cells 10-15 / Hp, white blood cells 3-5 / Hp.

[0047] Diagnosis: ulcerative colitis (acute phase); Syndrome differentiation: damp-heat accumulating in the intestines, heat and blood stasis intertwining, damaging the intestinal network.

[0048] Embodiment 1 is preferred, and the Chinese medicine composition for treating intestinal inflammation is used for treatment.

[0049] Prescription: 30 grams of ground ivy, 30 grams of dandelion, 9 grams of black plum charcoal, 9 grams of white ginseng, 15 grams of agrimony, and 30 grams of lotus node charcoal.

[0050] 7 doses. Take 1 dose daily, divided into two doses and taken warm.

[0051] During the follow-up visit, he reported that his symptoms had improved after taking the medicine. Recently, he had 3 to 4 bowel movements a day, which were not formed, or contained a little dark red blood and sticky jelly. He also had slight night sweats. His tongue was pale red, his fur was thin, and his pulse was stringy.

[0052] This prescription can be used for various symptoms of bleeding in the middle and lower parts of the body. As long as the syndrome differentiation is accurate, it can be used if the syndrome is heat toxic injury, blood heat with blood stasis, etc. At the same time, clinical use should also take into account other considerations.

[0053] If there is internal accumulation of dampness and heat, add fried coptis root, fried peony root, and white scutellaria baicalensis.

[0054] If there is also liver depression and spleen deficiency, add fried fangfeng, tangerine peel, fried atractylodes, etc.

[0055] If there is also deficiency of Ying Yin, you can take Zengye Decoction (Shengdi, Scrophularia, Ophiopogon) etc.

[0056] In the clinical treatment of acute attacks of hemorrhagic digestive system diseases such as hemorrhagic gastritis, duodenal ulcer, ulcerative colitis, hemorrhoids, etc., this prescription is often used to increase or decrease the dosage and achieve good results.

[0057] The above embodiments are only exemplary embodiments of the present application and are not intended to limit the present application. The protection scope of the present application is defined by the claims. Those skilled in the art may make various modifications or equivalent substitutions to the present application within the essence and protection scope of the present application, and such modifications or equivalent substitutions shall also be deemed to fall within the protection scope of the present application.

Claims

1. A traditional Chinese medicine composition for treating intestinal inflammation, characterized in that, Calculated by weight parts, the formula of the traditional Chinese medicine composition at least includes: 27 - 33 grams of Euphorbia humifusa, 27 - 33 grams of Taraxacum mongolicum, 8 - 10 grams of smoked plum carbon, 8 - 10 grams of Bletilla striata, 13 - 17 grams of Agrimonia pilosa, 27 - 33 grams of lotus node carbon.

2. The traditional Chinese medicine composition for treating intestinal inflammation according to claim 1, wherein Calculated by weight parts, the formula of the traditional Chinese medicine composition is: 30 grams of Euphorbia humifusa, 30 grams of Taraxacum mongolicum, 9 grams of smoked plum carbon, 9 grams of Bletilla striata, 15 grams of Agrimonia pilosa, 30 grams of lotus node carbon.

3. The traditional Chinese medicine composition for treating intestinal inflammation according to claim 1, wherein, Calculated by weight parts, the formula of the traditional Chinese medicine composition is: 27 grams of Euphorbia humifusa, 27 grams of Taraxacum mongolicum, 8 grams of smoked plum carbon, 8 grams of Bletilla striata, 13 grams of Agrimonia pilosa, 27 grams of lotus node carbon.

4. The traditional Chinese medicine composition for treating intestinal inflammation according to claim 1, wherein, Calculated by weight parts, the formula of the traditional Chinese medicine composition is: 33 grams of Euphorbia humifusa, 33 grams of Taraxacum mongolicum, 10 grams of smoked plum carbon, 10 grams of Bletilla striata, 17 grams of Agrimonia pilosa, 33 grams of lotus node carbon.

5. The traditional Chinese medicine composition for treating intestinal inflammation according to claim 1, wherein, Calculated by weight parts, the formula of the traditional Chinese medicine composition further includes one or any combination of Coptis chinensis stir - fried, Paeonia lactiflora stir - fried, and Pulsatilla chinensis.

6. The traditional Chinese medicine composition for treating intestinal inflammation according to claim 1, wherein, Calculated by weight parts, the formula of the traditional Chinese medicine composition further includes one or any combination of Saposhnikovia divaricata stir - fried, Citrus reticulata Blanco, and Atractylodes macrocephala Koidz. stir - fried.

7. A method for preparing a traditional Chinese medicine composition for treating intestinal inflammation according to any one of claims 1-6, characterized in that, According to the formula of the traditional Chinese medicine composition, all the traditional Chinese medicine raw materials are mixed, and 400 ml of clear water is added. After boiling with strong fire, continue to decoct for 30 minutes, and filter to extract the medicinal liquid; Add 400 ml of clear water to the medicinal residues, boil with strong fire and continue to decoct for 30 minutes, and filter to extract the medicinal liquid; Combine the medicinal liquids extracted twice.

8. Use of a traditional Chinese medicine composition for treating intestinal inflammation according to any one of claims 1-6, characterized in that, The traditional Chinese medicine composition for treating intestinal inflammation is used to treat ulcerative colitis of the type of heat toxin injury and stasis - stagnation of intestinal collaterals, and has the effects of clearing heat and detoxifying, regulating the intestines, promoting blood circulation to remove stasis, cooling blood and stopping bleeding.