Lactic acid-responsive high-efficiency anti-tumor chemotherapy-immunotherapy nano composite material and preparation method thereof

Through lactic acid-responsive nanocomposites to activate chemotherapy and chemokinetic therapy, the problem of immune tolerance of chemotherapy-immunotherapy in tumor treatment is solved, achieving a safe and efficient tumor suppression effect.

CN120346345APending Publication Date: 2025-07-22NANJING UNIV OF INFORMATION SCI & TECH +1
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Patent Information

Application Number
CN202510515960.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-23
Publication Date
2025-07-22

AI Technical Summary

Technical Problem

Existing chemotherapy-immunotherapy is difficult to effectively activate natural immune cells in tumor treatment, and tumor tissues have immune tolerance, which limits its application effect.

Method used

Design a lactic acid-responsive nanocomposite material consisting of PEGylated virus vaccine proteins, lactic acid oxidase and hollow manganese dioxide loaded with hypoxia-sensitive chemotherapy drugs. Through lactic acid activation of chemotherapy and chemokinetic therapy, it promotes tumor release of antigens and improves immune tolerance.

Benefits of technology

Safe and efficient anti-tumor chemotherapy-immunotherapy is achieved, and the natural immunity of the tumor is regulated through multiple aspects, activate the natural immune response of the tumor site, and overcome the immune tolerance of the tumor.

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Abstract

The invention discloses a lactic acid-responsive nano composite material for antitumor chemotherapy-immunotherapy. The structure of the nano composite material is a nano structure formed by compounding PEGylated viral vaccine protein, lactate oxidase and hollow manganese dioxide loaded with a hypoxia-sensitive chemotherapeutic drug; the nano composite material provided by the invention can simultaneously induce a tumor to release a large amount of antigens, promote an antigen cell presentation process and improve the tolerance of the tumor to immunotherapy, can efficiently activate natural immune response of a tumor part, realizes a tumor inhibition effect, can regulate and control natural immunity of the tumor from multiple aspects, and has a wide application prospect. And safe and efficient anti-tumor chemotherapy-immunotherapy is realized.
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