Plaster for treating herpes zoster and preparation process thereof

Abstract

The invention relates to a traditional Chinese medicine plaster for treating herpes zoster and a preparation process thereof. The plaster is mainly prepared from sesame oil, red lead (white lead or yellow lead) and a plurality of traditional Chinese medicine materials such as honeysuckle, rhododendron molle, turmeric and the like according to a specific proportion. In the preparation process, a series of advanced technologies including nano emulsification, low-temperature superfine grinding, ultrasonic-assisted extraction and vacuum low-temperature concentration are adopted, so that maximum extraction and stability of effective components are ensured. The plaster disclosed by the invention has a remarkable treatment effect, and particularly has outstanding performance in the aspects of quickly relieving pain caused by herpes zoster, reducing inflammation and accelerating recovery. The nano emulsification technology ensures deep skin penetration and lasting release of medicine components, and the low-temperature superfine grinding is beneficial to retaining sensitive active components in the medicinal materials. In addition, ultrasonic-assisted extraction and vacuum low-temperature concentration further optimize the concentration and stability of the medicinal components.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a plaster for treating herpes zoster and its preparation process. Background Art

[0002] Herpes zoster is a common viral skin disease caused by the varicella-zoster virus (VZV). This virus lies latent in the body after the initial infection (usually chickenpox in childhood) and may reactivate when the immune system weakens, leading to herpes zoster. The main characteristics of herpes zoster are painful rashes and blisters distributed along the nerves, usually on one side of the body. This disease occurs globally and is particularly common among the elderly. With the aging of the population, the incidence of herpes zoster is expected to continue to rise. Traditional treatment methods include antiviral drug treatment, pain medication, and topical medications. Antiviral drugs such as acyclovir, valacyclovir, and zanamivir can reduce virus replication and shorten the course of the disease, but the most effective time to use them is within the first few days after the rash appears. This is a challenge for many patients as they may not seek treatment before the symptoms are significant. Moreover, long-term use of antiviral drugs may cause adverse reactions, including kidney damage and other complications. Pain medications may cause drug dependence and other side effects. As for local treatment, such as corticosteroid creams and anesthetic creams, although they can relieve symptoms to a certain extent, they are limited in treating severe pain and long-term neuralgia. In addition, current treatment options on the market often ignore patients' needs for safe, natural, and side-effect-free treatment methods. Especially for the elderly, they are usually more sensitive to drug side effects and require safer and milder treatment options.

[0003] In view of the above problems, it is urgent to develop a new, safe, and effective treatment method for herpes zoster. The plaster provided by the present invention not only combines the efficacy of various traditional Chinese medicine ingredients but also enhances the penetration and efficacy of the drug ingredients through a special preparation process, enabling more effective pain relief and accelerating the healing of the affected area. In addition, this plaster is convenient to use and has few side effects, making it particularly suitable for the elderly and patients who have concerns about traditional drug treatment. The development of this treatment option not only fills the gap in existing treatment means but also provides a more user-friendly and comprehensive treatment choice for herpes zoster patients. Summary of the Invention

[0004] In view of the problems existing in the above-mentioned background technology, the present invention provides a novel plaster for treating herpes zoster and its preparation process. This plaster is specifically aimed at the skin lesions and neuralgia symptoms caused by herpes zoster, uses natural Chinese medicine ingredients, and has the functions of quickly relieving pain and promoting skin healing. In addition, the present invention also provides a preparation method for this plaster, which ensures the activity of the ingredients and meets the needs of industrial large-scale production. The formula described in the present invention is composed of the following raw materials in parts by weight: 500 grams of sesame oil; 210 - 250 grams of cinnabar (white cinnabar / yellow cinnabar); 10 - 15 grams of honeysuckle; 5 - 10 grams of rhododendron molle; 10 - 15 grams of turmeric; 10 - 15 grams of sparganium; 10 - 15 grams of Corydalis yanhusuo; 5 - 10 grams of Zaocys dhumnades; 10 - 15 grams of chuanxiong; 10 - 15 grams of dandelion; 10 - 15 grams of atractylodes lancea; 10 - 15 grams of angelica; 5 - 10 grams of camphor; 2 - 5 grams of calomel. Preferably, the optimal ratio is: 500 grams of sesame oil; 220 grams of cinnabar (white cinnabar / yellow cinnabar); 12 grams of honeysuckle; 8 grams of rhododendron molle; 12 grams of turmeric; 13 grams of sparganium; 14 grams of Corydalis yanhusuo; 7 grams of Zaocys dhumnades; 12 grams of chuanxiong; 13 grams of dandelion; 12 grams of atractylodes lancea; 12 grams of angelica; 5 - 10 grams of camphor; 4 grams of calomel.

[0005] The preparation method of the plaster includes the following steps: Nano-emulsified sesame oil and cinnabar: First, select 500 grams of pure sesame oil and 230 grams of cinnabar (white cinnabar or yellow cinnabar), and use a nano-emulsifier (with a temperature-adjustable control system) for mixing and emulsification. Set the temperature at 70°C and continuously emulsify for 2 hours to ensure that the particle size after emulsification is controlled within the range of 100 - 200 nanometers. This step aims to improve the skin absorption rate and stability of the drug.

[0006] Low-temperature ultrafine pulverization of medicinal materials: Use a low-temperature ultrafine pulverizer to process medicinal materials such as honeysuckle, rhododendron molle, and turmeric. Conduct pulverization at -20°C for 30 minutes to obtain a uniform and fine particle size (about 0.5 - 1 mm). Low-temperature pulverization helps to protect the sensitive active ingredients in the medicinal materials.

[0007] Ultrasonic-assisted extraction: Combining ultrasonic technology with traditional ethanol soaking extraction, mix the pulverized medicinal materials with ethanol in a ratio of 1:5. Set the ultrasonic extraction frequency at 28 kHz and the duration at 12 hours to accelerate the extraction process of active ingredients and improve the extraction efficiency.

[0008] Vacuum low-temperature concentration of the extract: Transfer the extract to a vacuum low-temperature evaporator for concentration. Conduct this under a water bath condition at 60°C, set the rotation speed to 100 revolutions per minute, and concentrate to 1 / 3 of the original volume. This step ensures that the active ingredients are concentrated under low-temperature conditions, minimizing the loss of heat-sensitive components.

[0009] Secondary nanoemulsification and mixing: After mixing the previously decocted black paste with the concentrated extract, perform secondary nanoemulsification treatment. This step is carried out at 80°C for 1 hour to ensure the uniformity and stability of the mixture.

[0010] Automated coating and packaging: Finally, use an automated coating and packaging device guided by a machine vision system to evenly apply the mixed plaster onto the plaster cloth. Control the coating thickness within 0.8 - 1.2 mm, and then perform automatic cutting and packaging to ensure the specification consistency and hygienic safety of each plaster. Overview of pharmacological effects: Honeysuckle: It has the effects of clearing heat and detoxifying, and dispersing wind-heat. It is commonly used to treat symptoms such as wind-heat colds, sores and ulcers, etc.

[0011] Rhododendron molle (Sheep Moss): Traditionally used for clearing heat and detoxifying, reducing swelling and alleviating pain. Suitable for swelling and pain caused by various heat toxins, such as sores, carbuncles, etc. Turmeric: It has the effects of promoting blood circulation to remove stasis, soothing the liver and relieving depression, and is commonly used to treat various symptoms caused by stagnation of liver qi and blood stasis.

[0012] Sparganium stoloniferum: Mainly used for breaking blood stasis, reducing swelling and relieving pain, and has a certain therapeutic effect on traumatic injuries and blood stasis blockage.

[0013] Corydalis yanhusuo: It has the effects of breaking blood and relieving pain, and regulating qi and blood, and is used to treat pain caused by blood stasis.

[0014] Zaocys dhumnades: Used to treat symptoms such as rheumatic arthralgia, blood stasis blockage, etc., and has a good anti-inflammatory and pain-relieving effect.

[0015] Chuanxiong: Promotes blood circulation to remove stasis, regulates qi and blood, and is used to treat symptoms such as headache, dysmenorrhea, traumatic injuries, etc.

[0016] Dandelion: Clears heat and detoxifies, reduces swelling and dissipates nodules. Commonly used to treat symptoms such as heat toxin blood syndrome, sores and ulcers swelling and pain, etc.

[0017] Atractylodes lancea: Dries dampness and strengthens the spleen, regulates the middle qi, and is used to treat various symptoms caused by dampness blocking the middle jiao and spleen deficiency.

[0018] Angelica sinensis: Nourishes blood and regulates menstruation, promotes blood circulation and relieves pain. Suitable for symptoms such as blood deficiency, dysmenorrhea, traumatic injuries, etc.

[0019] Camphor: Clears heat and detoxifies, cools blood and relieves pain, and is used to treat symptoms such as inflammation and pain.

[0020] Calomel (talc powder): It has the effects of absorbing moisture and relieving itching, and promoting blood circulation and relaxing muscles, and is applicable to skin problems such as eczema and itching.

[0021] The combination of these medicinal materials aims to exert their respective pharmacological effects, enhance the overall efficacy through interaction, and is especially applicable to the treatment of skin diseases such as herpes zoster. The formulation principle is as follows: Overall treatment principle: This prescription is based on the principle of "syndrome differentiation and treatment" in traditional Chinese medicine, and comprehensively treats the main symptoms presented by herpes zoster (such as pain, inflammation, blood stasis, swelling, etc.). The purpose is to achieve multiple effects such as clearing heat and detoxifying, promoting blood circulation to remove blood stasis, and detumescence and relieving pain through the interaction of various medicinal materials.

[0022] Clearing heat and detoxifying: The lesions of herpes zoster are usually accompanied by heat toxin. Honeysuckle, rhododendron molle, dandelion, etc. have the effects of clearing heat and detoxifying, and can help eliminate local heat toxin and reduce inflammation.

[0023] Promoting blood circulation to remove blood stasis: Patients with herpes zoster often have blood stasis blockage. Medicinal materials such as chuanxiong, rhizoma sparganii, and yuanhu have the efficacy of promoting blood circulation to remove blood stasis, can improve local blood circulation, and relieve pain and swelling.

[0024] Relieving pain and relaxing muscles: Ingredients such as zaocys dhumnades, camphor, and calomel help relieve pain and soothe muscles. Especially for the neuropathic pain caused by herpes zoster, these ingredients can provide direct soothing effects.

[0025] Regulating the properties of medicinal herbs: Medicinal materials such as turmeric, atractylodes rhizome, and angelica are used to regulate the properties of the prescription, improve the efficacy, and reduce the irritation to normal skin.

[0026] Matrix and carrier: Sesame oil and cinnabar not only serve as the boiling matrix, but also enhance the penetration of other ingredients, enabling the effective ingredients of the medicine to better reach the lesion site.

[0027] Overall synergistic effect: Each medicinal material synergizes with each other, can not only target the symptoms at the lesion site, but also help restore health fundamentally by promoting blood circulation, adjusting the local environment, etc. Beneficial effects

[0028] Broad-spectrum treatment effect: This plaster formula can effectively treat herpes zoster and the symptoms such as pain, inflammation, and blood stasis caused by it through the comprehensive action of various medicinal materials, and has a broad-spectrum treatment effect.

[0029] Quickly relieve pain: The pain-relieving ingredients in the formula such as zaocys dhumnades and camphor can quickly relieve the neuropathic pain and local discomfort caused by herpes zoster.

[0030] Improve local blood circulation: Containing ingredients for promoting blood circulation to remove blood stasis such as chuanxiong and rhizoma sparganii, it helps improve the blood circulation at the affected area and accelerate the recovery process of the lesion area.

[0031] Reduce inflammation and swelling: Medicinal materials with heat-clearing and detoxifying properties, such as honeysuckle and dandelion, can effectively reduce the inflammatory response and swelling, and accelerate recovery.

[0032] Enhance skin absorption and penetration: The matrix sesame oil and cinnabar of the plaster can enhance the skin absorption and penetration of other drug components, ensuring that the effective drug components can reach the lesion directly.

[0033] Safety and mildness: Since the main ingredients are natural Chinese herbs, this plaster is safer and milder than chemical drugs, with less irritation to normal skin and the gastrointestinal tract, and is suitable for long-term use. Specific implementation methods

[0034] In order to make the objectives, technical solutions and advantages of the present invention clearer, the following further details the present invention in conjunction with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention. In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of the present invention, "a plurality" means two or more, unless otherwise specifically defined. Implementation cases Raw material preparation 500 grams of sesame oil, 220 grams of cinnabar (white cinnabar / yellow cinnabar), 12 grams of honeysuckle, 8 grams of rhododendron molle, 12 grams of turmeric, 13 grams of sparganium, 14 grams of Corydalis yanhusuo, 7 grams of Zaocys dhumnades, 12 grams of Chuanxiong, 13 grams of dandelion, 12 grams of Atractylodes lancea, 12 grams of Angelica sinensis, 7 grams of camphor, 4 grams of calomel.

[0035] Nanometer emulsified sesame oil and cinnabar Using a nanometer emulsifier (with a temperature-adjustable control system), mix and emulsify the sesame oil and cinnabar at 70°C for 2 hours to form a nanoemulsion with a particle size of 100 - 200 nanometers, so as to improve the skin absorption rate and drug stability.

[0036] Low-temperature ultrafine grinding of medicinal materials Using a low-temperature ultrafine grinder, grind medicinal materials such as honeysuckle at -20°C for 30 minutes to obtain ultrafine powder with a particle size of 0.5 - 1 mm, so as to protect the sensitive components in the medicinal materials.

[0037] Ultrasonic-assisted extraction Combining ultrasonic technology and ethanol soaking, mix the ultrafine ground medicinal materials and ethanol in a ratio of 1:5, set the ultrasonic frequency at 28 kHz, and the extraction time at 12 hours to accelerate the extraction of effective components.

[0038] Vacuum Low-temperature Concentrated Extract Concentrate the extract in a vacuum low-temperature evaporator, set the water bath temperature at 60°C, and the rotation speed at 100 revolutions per minute until it is concentrated to 1 / 3 of the original volume to ensure the preservation of active ingredients.

[0039] Secondary Nano-emulsification and Mixing Mix the concentrated extract with the nano-emulsified black paste and conduct nano-emulsification treatment again for 1 hour at 80°C to form a homogeneous and stable drug system.

[0040] Automated Smearing and Packaging Use an automated smearing device guided by a machine vision system to evenly smear the plaster on the plaster cloth, and control the smearing thickness at 0.8 - 1.2 mm. Then, conduct standardized cutting and sterile packaging through automatic cutting and packaging equipment to ensure that each plaster has the same specifications and is hygienically safe.

[0041] Quality Control and Inspection Conduct quality control inspections on the final product, including ingredient content, microbial limit, heavy metal content, etc., to ensure that the product meets drug safety standards. Therapeutic effects: Pain Relief On the first day after using the plaster, the average pain level (pain score out of 10) of patients decreased from 7 points to 4 points.

[0042] After continuously using the plaster for 3 days, more than 80% of the patients reported that the pain level dropped below 3 points.

[0043] Reduction of Inflammation and Swelling The swollen area decreased by approximately 30% within 24 hours after using the plaster and by more than 60% after continuously using it for 3 days. The erythema and inflammation were significantly relieved, and 70% of the patients' skin returned to normal color.

[0044] Recovery Speed After using the plaster for 7 days, more than 50% of the herpes zoster patients completely returned to the normal skin state. After a 14-day treatment cycle, the cure rate reached over 90%.

[0045] Incidence of Side Effects Among the treated patients, only 5% reported mild local skin irritation, and no serious side effects were reported.

[0046] Long-term Effects After completing the treatment cycle, follow-up for 6 months showed that the recurrence rate was less than 10%.

[0047] The vast majority of patients (more than 90%) have no sequelae of neuralgia within 6 months after the end of treatment.

[0048] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or perform equivalent replacements on some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A traditional Chinese medicine plaster for treating herpes zoster, characterized in that, The plaster is composed of the following raw materials by weight: 500 grams of sesame oil; 230 grams of elixir (white elixir / yellow elixir); 12 grams of honeysuckle; 8 grams of rhododendron molle; 12 grams of turmeric; 13 grams of rhizoma sparganii; 14 grams of Corydalis yanhusuo; 7 grams of Zaocys dhumnades; 12 grams of Ligusticum chuanxiong; 13 grams of dandelion; 12 grams of Atractylodes lancea; 12 grams of Angelica sinensis; 7 grams of camphor; 4 grams of calomel.

2. The traditional Chinese medicine plaster according to claim 1, characterized in that, The preparation process of the plaster includes: S1 Raw material preparation 500 grams of sesame oil, 220 grams of elixir (white elixir / yellow elixir); 12 grams of honeysuckle, 8 grams of rhododendron molle, 12 grams of turmeric, 13 grams of rhizoma sparganii, 14 grams of Corydalis yanhusuo, 7 grams of Zaocys dhumnades, 12 grams of Ligusticum chuanxiong, 13 grams of dandelion, 12 grams of Atractylodes lancea, 12 grams of Angelica sinensis, 7 grams of camphor, 4 grams of calomel; S2 Nano-emulsification of sesame oil and elixir Using a nano-emulsifier (with a temperature adjustable control system), mix and emulsify the sesame oil and the elixir at 70°C for 2 hours to form a nano-emulsion with a particle size of 100 - 200 nanometers, so as to improve the skin absorption rate and drug stability; S3 Low-temperature ultrafine grinding of medicinal materials Use a low-temperature ultrafine grinder to grind medicinal materials such as honeysuckle at -20°C for 30 minutes to obtain ultrafine powder with a particle size of 0.5 - 1 mm, so as to protect the sensitive components in the medicinal materials; S4 Ultrasonic-assisted extraction Combine ultrasonic technology and ethanol soaking, mix the ultrafine ground medicinal materials and ethanol in a ratio of 1:5, set the ultrasonic frequency at 28 kHz, and the extraction time at 12 hours to accelerate the extraction of active ingredients; S5 Vacuum low-temperature concentration of the extract Concentrate the extract in a vacuum low-temperature evaporator, set the water bath temperature at 60°C and the rotation speed at 100 revolutions per minute until it is concentrated to 1 / 3 of the original volume to ensure the preservation of active ingredients; S6 Secondary nano-emulsification and mixing Mix the concentrated extract with the nano-emulsified black paste and conduct nano-emulsification treatment again, operating at 80°C for 1 hour to form a homogeneous and stable drug system.

3. The traditional Chinese medicine plaster according to claim 2, wherein The temperature of the nano-emulsification treatment is 70°C and the time is 2 hours.

4. The traditional Chinese medicine plaster according to claim 2, characterized in that, The frequency of the ultrasonic-assisted extraction is 28 kHz and the extraction time is 12 hours.

5. The traditional Chinese medicine plaster according to claim 2, wherein The water bath temperature of the vacuum low-temperature concentration is 60°C and the rotation speed is 100 revolutions per minute.