Beverage for losing weight and dispelling effects of alcohol and preparation method thereof

Abstract

The invention provides a weight-losing and hangover-alleviating beverage and a preparation method thereof, and belongs to the field of traditional health preservation, and the beverage is prepared from the following raw materials: 12-50 parts of paederia scandens, 6-8 parts of poria peel, 2-4 parts of pericarpium citri reticulatae and 0.05-0.2 part of green tea leaves. The beverage belongs to herbal agricultural products and also belongs to traditional health-preserving beverages, the preparation method is simple, industrial production is easy, natural raw materials including paederia scandens, poria peel, pericarpium citri reticulatae and green tea leaves are selected for scientific compatibility, no obvious toxic or side effect is generated, the beverage has remarkable effects in the aspects of losing weight and dispelling the effects of alcohol, and the beverage meets the requirements of large health-preserving channels and is worthy of popularization and application. The tea is high-quality, healthy, natural, safe and traditional health-preserving, is a homologous drink tea capable of losing weight, giving up to alcohol and protecting liver and kidney, and provides a new effective way for solving the problems of obesity and drinking discomfort.

Description

Technical Field

[0001] The invention belongs to the field of traditional health preservation, and particularly relates to a weight-loss and hangover-relieving beverage and a preparation method thereof. Background Art

[0002] With the improvement of living standards, the problem of obesity has become increasingly prominent. Obesity not only affects personal image, but also causes a variety of chronic diseases, such as hypertension, diabetes, cardiovascular disease, etc., posing a serious threat to people's health. In addition, the pace of life is getting faster and faster, and people are more willing to relieve stress and cheer up by drinking. However, after drinking, the human body will feel uncomfortable, such as headache, dizziness, nausea, vomiting and other symptoms. Long-term excessive drinking will also cause damage to organs such as the liver and stomach.

[0003] Although there are many weight loss products on the market, most of them have problems such as poor effect and serious side effects. In addition, most of the existing hangover products can only relieve superficial symptoms and cannot fundamentally solve the problem of alcohol's damage to the body. Moreover, these products often have a single function and cannot meet the needs of weight loss and hangover at the same time. Therefore, for people who need to drink frequently and have weight loss needs, there is an urgent need for a safe, efficient and comprehensive product that can not only effectively lose weight, but also reduce the damage of alcohol to the body, so as to improve people's health and improve their quality of life.

[0004] Therefore, developing a safe and effective beverage that can simultaneously have the functions of weight loss and hangover relief has important practical significance and market value. Summary of the Invention

[0005] In order to solve the problems existing in the background technology, the present invention provides a weight loss and hangover relief beverage and a preparation method thereof. The beverage uses pure natural Chinese medicinal ingredients, has no toxic side effects, and is scientifically formulated and prepared in a scientific manner to ensure the reliability and durability of its weight loss and hangover relief effects, providing a new and effective way to solve the problems of obesity and drinking discomfort.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] A weight-loss and hangover-relieving beverage is prepared from the following raw materials, calculated by weight: 12-50 parts of Cercidiphyllum nobile, 6-8 parts of Poria cocos peels, 2-4 parts of dried tangerine peels and 0.05-0.2 parts of green tea leaves.

[0008] Furthermore, a weight loss and hangover-relieving beverage is prepared from the following raw materials, by weight: 30 parts of Cercidiphyllum nobile, 7 parts of Poria cocos peel, 3 parts of dried tangerine peel and 0.1 part of green tea leaves.

[0009] Furthermore, the Cistanche deserticola is pretreated, and the pretreatment process includes the following steps: soaking or spraying the Cistanche deserticola with salt water, and then drying it.

[0010] Furthermore, the brine is edible brine with a mass concentration of 4-6%.

[0011] Furthermore, the tangerine peel and green tea leaves are aged materials that have been stored for more than 8-10 years and have an oxidation function.

[0012] A method for preparing a weight-loss and hangover-relieving beverage comprises the following steps:

[0013] S1. Weighing: Weigh according to the raw material formula, take Cistanche deserticola, Poria cocos peel, dried tangerine peel and green tea leaves;

[0014] S2 grinding: The weighed raw materials were ground into powder, sieved to obtain a mixed powder;

[0015] S3. Distillation and aging: placing the mixed powder in water, wherein the mixed powder is isolated from the water and does not come into direct contact with it, heating the water to boiling, performing distillation to obtain a distilled medicinal liquid, and cooling the liquid to obtain the weight loss and hangover relieving drink.

[0016] Furthermore, the particle size of the mixed powder in step S2 is 60-250 mesh.

[0017] Furthermore, at the end of distillation in step S3, the mass ratio of the mixed powder to the distilled liquid medicine is 4:10-15.

[0018] A weight loss and hangover relieving drink is used in weight loss. A treatment course is seven days, twice a day, with a dosage of 400-600 mL each time, and the drink is taken for more than three treatment courses.

[0019] The invention discloses an application of a weight-loss and hangover-relieving drink in hangover-relieving. The drink is taken before and after drinking alcohol, with a dosage of 400-600 mL and the drink completed within 20 minutes.

[0020] In terms of weight loss, the mechanism of action of each raw material is as follows:

[0021] Cistanche deserticola: It can eliminate accumulation and turbidity, reduce stomach qi, expel intestinal stagnation, restore the ascending and descending functions of the spleen and stomach, clear the body's dirt, enter a virtuous cycle, facilitate bowel movements, and reduce weight.

[0022] Poria peel: It can promote diuresis and eliminate dampness, strengthen the spleen, promote metabolism, improve the body's immunity, help the body consume calories and fat, and achieve weight loss effects.

[0023] Tangerine peel: It can promote the flow of qi and regulate the middle, dry up dampness and resolve phlegm, promote the secretion of digestive juices, eliminate gas accumulated in the intestines, enhance gastrointestinal motility, help digestion and metabolism, and reduce weight.

[0024] Green tea leaves: Its aromatic compounds can dissolve fat, and catechins can promote metabolism, reduce the accumulation of fat cells, and help digestion and absorption of food.

[0025] In terms of hangover relief, the mechanism of action of each raw material is as follows:

[0026] Cistanche deserticola: It has a sweet and sour taste and a neutral nature. It enters the heart, liver, spleen, and kidney meridians. It has the effect of detoxification and swelling. It can relieve the discomfort caused by alcohol toxicity, promote the excretion of alcohol metabolites, and reduce the burden on the liver.

[0027] Poria peel: sweet and mild in taste, neutral in nature, enters the kidney and bladder meridians, has a beneficial effect on water and dampness, can promote urine production, accelerate the excretion of alcohol and its metabolites through urine, thereby reducing the alcohol concentration in the body;

[0028] Tangerine peel: It tastes bitter and is warm in nature. It enters the spleen and lung meridians, regulating qi and strengthening the spleen, drying dampness and resolving phlegm. It can regulate spleen and stomach function, promote the secretion of digestive juices, enhance gastrointestinal motility, aid digestion, and relieve symptoms such as abdominal distension and nausea after drinking. Its volatile oils can also promote metabolism and accelerate alcohol excretion.

[0029] Green tea leaves: Contain tea polyphenols, caffeine and other ingredients, which can neutralize alcohol. Tea polyphenols have antioxidant effects and can reduce the damage of alcohol to the liver; caffeine can stimulate the central nervous system, play a role in refreshing the mind, relieve drowsiness after drinking, and promote metabolism and accelerate the decomposition of alcohol.

[0030] This application has the following beneficial effects:

[0031] 1. The weight loss and hangover relieving beverage provided by the present invention has a simple preparation method and is easy to industrialize. It uses a scientific combination of natural raw materials, such as Caulis Aconiti Lateralis Preparata, Poria peel, Tangerine peel and green tea leaves, has no obvious toxic side effects, and has significant effects on weight loss and hangover relieving. In weight loss applications, it can gradually adjust the body's metabolism and achieve healthy weight loss. In hangover relieving applications, it can effectively alleviate the discomfort caused by drinking and protect liver health.

[0032] 2. The weight loss and hangover-relieving beverage provided by the present invention is both a herbal agricultural product and a traditional health beverage. It meets the needs of a large health and wellness channel, is committed to high-quality health, natural safety and traditional health, and is a homologous beverage tea for weight loss, quitting alcohol, and protecting the liver and kidneys. It provides an effective solution for people to improve their health and quality of life, and has broad market application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 , a statistical graph showing the survival rate of 5 dpf zebrafish treated with samples made from the beverage of Example 1 of the present invention for 96 hours;

[0034] Figure 2, Statistical graph of the swimming distance of zebrafish treated with samples made from the beverage of Example 1 of the present invention (statistical analysis was performed using GraphicPad 8.3.0, ** represents p < 0.01, *** represents p < 0.001, **** represents p < 0.0001);

[0035] Figure 3 , a diagram of the movement trajectory of zebrafish treated with a sample made from the beverage of Example 1 of the present invention;

[0036] Figure 4 2. The relative expression level of the slc5a1 gene in zebrafish treated with the sample prepared from the beverage according to Example 1 of the present invention (statistical analysis was performed using GraphPad 8.3.0, ** represents p < 0.01, *** represents p < 0.001, **** represents p < 0.0001). DETAILED DESCRIPTION

[0037] The present application is further described in detail below with reference to the embodiments.

[0038] Unless otherwise specified, the raw materials used in the examples and comparative examples of the present application are all commercially available.

[0039] Example 1

[0040] A weight-loss and hangover-relieving beverage is prepared by the following steps:

[0041] S1 weighing: according to the raw material formula weighing, take Cistanche 30 parts, Poria peel 7 parts, tangerine peel 3 parts and green tea 0.1 parts, wherein Cistanche pretreatment: soaked with 5% salt water, then dried, tangerine peel for 9 years old tangerine peel, green tea for 9 years old green tea leaves;

[0042] S2 grinding: The weighed raw materials were ground into powder, sieved 100 mesh to obtain a mixed powder;

[0043] S3. Distillation and aging: placing the mixed powder in water, wherein the mixed powder is isolated from the water and does not come into direct contact with it, heating the water to boiling, and distilling it to obtain a distilled liquid. The final mass ratio of the mixed powder to the distilled liquid is 4:12. After cooling, the weight loss and hangover relieving drink can be obtained.

[0044] Example 2

[0045] S1 weighing: according to the raw material formula weighing, take Cephalexin 12 parts, Poria peel 6 parts, 2 parts of dried tangerine peel and green tea 0.05 parts, wherein Cephalexin was pretreated: soaked with 4% salt water and then dried, dried tangerine peel was placed 10 years old tangerine peel, green tea was placed 10 years old green tea leaves;

[0046] S2 grinding: The weighed raw materials were ground into powder, sieved through 60 mesh to obtain a mixed powder;

[0047] S3. Distillation and aging: placing the mixed powder in water, wherein the mixed powder is isolated from the water and does not come into direct contact with it, heating the water to boiling, and distilling it to obtain a distilled liquid. The final mass ratio of the mixed powder to the distilled liquid is 4:10. After cooling, the weight loss and hangover relieving drink can be obtained.

[0048] Example 3

[0049] S1 weighing: according to the raw material formula weighing, take 50 parts of Cistanche deserticola, 8 parts of Poria peel, 4 parts of tangerine peel and 0.2 parts of green tea leaves, wherein Cistanche deserticola was pretreated: soaked in 6% salt water and then dried, tangerine peel was placed for 8 years old tangerine peel, green tea leaves were placed for 8 years old green tea leaves;

[0050] S2 grinding: The weighed raw materials were ground into powder, sieved 250 mesh to obtain a mixed powder;

[0051] S3. Distillation and aging: placing the mixed powder in water, wherein the mixed powder is isolated from the water and does not come into direct contact with it, heating the water to boiling, and distilling it to obtain a distilled liquid. The final mass ratio of the mixed powder to the distilled liquid is 4:15. After cooling, the weight loss and hangover relieving drink can be obtained.

[0052] Proven effectiveness

[0053] 1. Zebrafish test: Toxicity testing, alcohol detoxification efficacy testing, and weight loss efficacy testing were performed using zebrafish. The specific experimental procedures are as follows:

[0054] 1. Toxicity testing: Two groups were set up, including a control group and a sample group (with three concentration gradients: 10 μg / mL, 50 μg / mL, and 100 μg / mL). Zebrafish at 6 days post-fertilization (dpf) were exposed to the samples in six-well plates (5 mL / well), with 10 fish per well. The medium was changed daily, and dead fish were promptly picked out and recorded. The mortality rate of zebrafish in each group was observed 96 hours after treatment with the beverage of the present invention.

[0055] 2. Alcohol-detoxifying efficacy test: The tested zebrafish were divided into three groups, namely the control group, the model group and the sample group, for a total of 5 groups, with 10 zebrafish in each group. Among them: the control group did not consume alcohol, the model group and the sample group consumed an equal amount of 5% (v / v) anhydrous ethanol (anhydrous ethanol was dissolved in the fish water and then ingested into the zebrafish). The sample group consumed the test sample at the same time as the anhydrous ethanol. After incubation for 24 hours, the zebrafish were placed in a zebrafish behavior instrument to detect the zebrafish's autonomous behavioral activities for 30 minutes, and the average swimming distance and speed of each group of zebrafish were calculated.

[0056] 3. Weight Loss Efficacy Testing: The tested zebrafish were divided into three groups: a control group, a model group, and a sample group, for a total of five groups, with 10 zebrafish in each group. Among them, the zebrafish in the control group were not treated and served as a blank control; the zebrafish in the model group and the sample group were fed a high-fat diet for 7 days to induce obesity; the sample group was dissolved in the breeding water of the successfully modeled zebrafish at a concentration of 100 μg / mL and treated for 3 days; after the treatment, the zebrafish were dissected to collect small intestinal tissue, and total RNA was extracted. The RNA was converted into cDNA using reverse transcriptase in preparation for qPCR analysis, and the relative gene expression levels of each experimental group were calculated.

[0057] 2. Human hangover effect test: 180 volunteers aged between 25 and 40 were selected and divided into 3 groups, with 60 people in each group. They drank the beverages prepared in Examples 1-3 before and after drinking, respectively, with a dosage of 500 mL, which was completed within 20 minutes. Then they fell asleep for about 8 hours. After waking up, the subjective feelings of the volunteers were compared with those before and after drinking the same level of alcohol, and without taking the beverage of the present invention. The evaluation was divided into two levels: 1. Effective: No obvious dizziness, headache, vomiting, and spirit returned to normal; 2. Ineffective: No obvious change in the above symptoms. The effective number of people was counted and the hangover efficiency was calculated. The specific results are shown in Table 1:

[0058] 3. Human Weight Loss Effect Test: 180 volunteers aged 25-40 were selected and divided into three groups, with 60 people in each group. They drank the beverages prepared in Examples 1-3 for seven days, twice a day, with each dose of 500 mL. After three courses of treatment, their weight was measured and divided into two levels: 1. Effective: weight loss of more than 1.5 kg; 2. Ineffective: weight loss of less than 1.5 kg. The effective number of people was counted and the weight loss efficiency was calculated. The specific results are shown in Table 1:

[0059] Table 1

[0060] Effective in sobering up Effective weight loss Example 1 86.7 93.3 Example 2 86.7 91.7 Example 3 85.0 90.0

[0061] Result Analysis

[0062] Toxicity testing: e.g. Figure 1 As shown, after sample treatment, the survival rate indicators of zebrafish in the 10μg / ml, 50μg / ml and 100μg / ml concentration groups showed no obvious abnormalities compared with the control group. It can be seen that this drink has no toxic side effects on zebrafish.

[0063] Alcohol detoxification efficacy test: Figure 2 and Figure 3As shown, compared with the control group, the swimming speed of the zebrafish in the model group was significantly faster and the swimming distance was significantly increased, indicating that the zebrafish were in a state of drunkenness after being stimulated by anhydrous ethanol, and the drunkenness model was successfully constructed; compared with the model group, the average swimming speed of the zebrafish in the three sample treatment groups of 10μg / ml, 50μg / ml and 100μg / ml was significantly reduced, and the swimming distance was significantly reduced, and with the increase of the treatment concentration, there was a certain concentration dependence. The swimming speed and swimming distance of the zebrafish in the high concentration sample group (100μg / ml) were comparable to those of the control group, indicating that the drunken state of the zebrafish in the sample group was significantly suppressed after being treated with the sample, revealing that the beverage of the present invention has a significant alcohol-relieving effect on zebrafish.

[0064] Weight loss efficacy test: Figure 4 As shown, compared with the control group, after high-fat feeding modeling treatment, the relative expression of the slc5a1 gene in the model group zebrafish was significantly increased, proving that the high-fat animal model of zebrafish was successfully established; compared with the model group, the relative expression of the slc5a1 gene in the zebrafish treated with three concentrations of 10μg / ml, 50μg / ml and 100μg / ml was significantly reduced, and with the increase of the sample treatment concentration, there was a certain concentration dependence, and the relative expression of the slc5a1 gene in the zebrafish in the high-concentration sample group (100μg / ml) was equivalent to that in the control group, indicating that the sample can effectively reduce the relative expression of the slc5a1 gene in zebrafish, thereby inhibiting the body's absorption of sugar in carbohydrates and achieving significant weight loss effect.

[0065] As can be seen from Examples 1-3 and the data in Table 1, the beverage provided by the present invention has significant efficacy in sobering up and losing weight. In a human sobering effect test, after drinking the beverage, most volunteers awoke without significant symptoms such as dizziness, headache, or vomiting, and their energy levels returned to normal, with an efficacy rate exceeding 85.0%. In a human weight loss test, most volunteers lost more than 1.5 kg, with an efficacy rate exceeding 90.0%, demonstrating that the beverage also has a significant weight loss effect on humans.

[0066] In summary, after zebrafish experiments and tests on the hangover and weight loss effects on humans, we can conclude that the beverage provided by the present invention has significant weight loss and hangover relief effects, and has no toxic side effects. It is a safe, efficient and multifunctional product.

[0067] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any appropriate manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

[0068] In addition, the various embodiments of the present invention may be arbitrarily combined, and as long as they do not violate the concept of the present invention, they should also be regarded as the contents disclosed by the present invention.

Claims

1. A weight loss and hangover relieving beverage, characterized in that: The product is prepared from the following raw materials in parts by weight: 12-50 parts of Caulis Aconiti Lateralis Preparata, 6-8 parts of Poria cocos peel, 2-4 parts of dried tangerine peel and 0.05-0.2 parts of green tea leaves.

2. The weight loss and hangover relieving drink according to claim 1, characterized in that: The product is prepared from the following raw materials in parts by weight: 30 parts of Caulis Aconiti Lateralis Preparata, 7 parts of Poria cocos peel, 3 parts of dried tangerine peel and 0.1 part of green tea leaves.

3. The weight loss and hangover relieving drink according to claim 1, characterized in that: The Cistanche deserticola is pretreated, and the pretreatment process includes the following steps: soaking or spraying the Cistanche deserticola with salt water, and then drying it.

4. The weight loss and hangover relieving drink according to claim 3, characterized in that: The brine is edible brine with a mass concentration of 4-6%.

5. The weight loss and hangover relieving drink according to claim 1, characterized in that: The tangerine peel and green tea leaves are both aged materials that have been stored for more than 8-10 years and have an oxidation function.

6. A method for preparing a weight loss and hangover relieving beverage, for preparing the weight loss and hangover relieving beverage according to any one of claims 1 to 5, characterized in that: The steps include: S1. Weighing: Weigh Ceratonia suffruticosa, Poria cocos peel, dried tangerine peel, and green tea leaves according to the raw material formula; S2 grinding: The weighed raw materials were ground into powder, sieved to obtain a mixed powder; S3. Distillation and aging: placing the mixed powder in water, wherein the mixed powder is isolated from the water and does not come into direct contact with it, heating the water to boiling, performing distillation to obtain a distilled medicinal liquid, and cooling the liquid to obtain the weight loss and hangover relieving drink.

7. The preparation method according to claim 6, characterized in that: The particle size of the mixed powder in step S2 is 60-250 mesh.

8. The preparation method according to claim 6, characterized in that: When the distillation is completed in step S3, the mass ratio of the mixed powder to the distilled liquid medicine is 4:10-15.

9. Use of the weight loss and hangover relieving drink according to any one of claims 1 to 5 in weight loss, characterized in that: One course of treatment is seven days, twice a day, each dose is 400-600mL, and it should be taken for more than three courses.

10. Use of the weight loss and hangover relieving drink according to any one of claims 1 to 5 in the aspect of hangover relief, characterized in that: The drink is taken before and after drinking alcohol, with a dosage of 400-600 mL, and the drink should be consumed within 20 minutes.

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