Duodenal mucosal surface replacement and electrotransfection integrated device and parameter feedback-based operation method

Through the intelligent control system of the integrated duodenal mucosal surface replacement and electrotransfection equipment, real-time monitoring and dynamic adjustment of electrotransfection parameters are carried out, which solves the problems of incomplete mucosal repair and low gene expression efficiency after DMR surgery and achieves personalized and efficient treatment effects.

CN120436779BActive Publication Date: 2025-09-30QINGDAO RES INST OF BEIHANG UNIV +1
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Patent Information

Application Number
CN202510899100.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-07-01
Publication Date
2025-09-30
Estimated Expiration
2045-07-01

AI Technical Summary

Technical Problem

There are individual differences in the mucosal repair process after existing duodenal mucosal resurfacing (DMR) surgery. Some patients have slow mucosal regeneration or incomplete functional recovery, lack the ability to actively regulate the expression of metabolism-related genes, have unclear timing of electrotransfection, have no physiological basis for parameter adjustment, and lack control over gene expression efficiency.

Method used

Provides an integrated device for duodenal mucosal surface replacement and electrotransfection, equipped with an intelligent control system. Through multimodal physiological parameter acquisition, data processing and feedback learning, it monitors tissue status in real time, dynamically adjusts electrotransfection parameters, and realizes personalized gene therapy.

Benefits of technology

It significantly improved the quality of mucosal repair and metabolic function after DMR surgery, achieved individualized treatment effects, and improved the safety and effectiveness of treatment.

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Abstract

The present invention belongs to the field of biomedical information analysis technology, and specifically relates to an integrated device for duodenal mucosal surface replacement and electrotransfection and a method for operation based on parameter feedback. The present invention first provides an integrated device for duodenal mucosal surface replacement and electrotransfection, which includes an endoscopic guidance module, a radiofrequency ablation module, an electrotransfection module, and an intelligent terminal control module. The present invention also provides a method for operating a DMR-EP integrated device based on tissue parameter feedback. The present invention proposes for the first time the realization of individualized strategy generation and data-driven treatment path selection in local gene therapy after DMR surgery, which significantly improves the safety, effectiveness, and breadth of indications of the treatment.
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