Application of dehydrotumuloic acid and / or salt thereof in preparation of medicine for resisting coxsackie virus

The treatment problem of Coxsackie virus infection is solved by inhibiting the mRNA expression, viral protein expression and MAPK signaling pathway of dehydrogenated titanium acid and/or its salt, and effective inhibition and disease treatment of Coxsackie virus are achieved.

CN120437138APending Publication Date: 2025-08-08SHENZHEN TECH UNIV
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Patent Information

Application Number
CN202510691022.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-27
Publication Date
2025-08-08

AI Technical Summary

Technical Problem

The prior art lacks effective treatment methods to deal with the infection of Coxsach virus, especially the various diseases caused by Coxsach virus A and B viruses, and the virus has many serotypes and rapid mutations, which lead to treatment difficulties.

Method used

Dehydrogenated timolic acid and/or its salts are used to inhibit the mRNA expression, viral protein expression and plaque formation of Coxsackie virus, thereby inhibiting the viral infection capacity, and inhibiting viral replication by inhibiting the phosphorylation of key proteins in the MAPK signaling pathway.

Benefits of technology

It significantly inhibits the infection ability of Coxsackie virus, reduces the infection of the virus into cells, provides an effective treatment plan, and can serve as a leading compound for anti-Coxsackie virus.

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Abstract

The invention relates to an application of dehydrotumuloic acid and / or a salt thereof in preparation of an anti-coxsackie virus drug. It is found that the dehydrotumuloic acid and / or the salt thereof have / has an extremely remarkable inhibiting effect on mRNA expression, virus protein expression and plaque formation of the coxsackie virus, the infection capacity of the coxsackie virus can be reduced, cell infection caused by the coxsackie virus can be inhibited, and therefore the dehydrotumuloic acid and / or the salt thereof have the good anti-coxsackie virus activity. A further research shows that the dehydrotumuloic acid and / or the salt thereof can effectively inhibit activation of key protein phosphorylation in an MAPK signal channel caused by coxsackie virus infection and inhibit virus replication. The good anti-coxsackie virus activity of the dehydrotumoic acid and / or the salt thereof provides an effective scheme for treating coxsackie virus infection and diseases caused by the coxsackie virus infection, and the dehydrotumoic acid and / or the salt thereof can also be used as an effective anti-coxsackie virus lead compound.
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