Boa oil composition for treating herpes zoster and pompholyx as well as preparation method and application of boa oil composition

Abstract

The invention provides a boa oil composition for treating herpes zoster and pompholyx as well as a preparation method and application of the boa oil composition, and relates to the technical field of deep processing of boa oil. The python oil composition for treating herpes zoster and pompholyx is prepared from the following raw materials in parts by weight: 40 to 50 parts of python oil extract, 20 to 25 parts of composite plant extract, 10 to 20 parts of ceramide, 5 to 10 parts of panthenol, 3 to 8 parts of sodium hyaluronate cross-linked polymer and 3 to 6 parts of menthol. The composite plant extract is prepared from a sargentgloryvine stem extract, an evodia lepta extract and a perfoliote knotweed herb extract according to the mass ratio of 10 to (4 to 6) to (7 to 9). The boa oil composition prepared by the invention has a relatively good treatment effect on herpes zoster or pompholyx, and the cure time can be shortened to the greatest extent; the boa oil composition prepared by the invention is used for treating herpes zoster or pompholyx, can quickly stop blisters, can well relieve pain, is quick in incrustation, and can well recover healthy skin; and the prepared boa oil composition is good in safety.

Description

Technical Field

[0001] The invention relates to the technical field of deep processing of python oil, in particular to a python oil composition for treating herpes zoster and dyshidrotic eczema, and a preparation method and application thereof. Background Art

[0002] Python oil has the properties of dispelling wind, detoxifying, clearing heat and moisturizing the skin. It is used to treat a variety of ailments, including leprosy, fistulas (anal fistulas), frostbite, burns, and chapped skin. Modern research shows that python oil also has therapeutic effects on hemorrhoids. Furthermore, python oil is used to treat skin conditions such as chronic eczema, offering anti-inflammatory, anti-allergic, and antipruritic properties.

[0003] Shingles is an acute herpes zoster skin disease caused by the varicella-zoster virus. Most people contract the virus during infancy and childhood, developing chickenpox. However, the virus is not completely cleared and instead remains hidden within certain nerve ganglia. When the body's immune system weakens, the virus can reactivate, causing shingles. Dyshidrotic eczema is a recurring blistering skin disease that often occurs on the palms, sides of the fingers, soles of the feet, and lateral edges of the toes.

[0004] However, studies have found that using python oil can help treat herpes zoster and dyshidrosis, but it is difficult to completely heal. Developing a python oil composition that can improve treatment efficacy and shorten healing time is of great significance. Summary of the Invention

[0005] In view of this, the present invention proposes a python oil composition for treating herpes zoster and dyshidrosis, as well as a preparation method and application thereof. The composition is used to treat herpes zoster or dyshidrosis, has good efficacy, and can significantly shorten the healing time.

[0006] The technical solution of the present invention is achieved as follows: A python oil composition for treating herpes zoster and dyshidrotic eczema is prepared by including the following raw materials in parts by weight: 40-50 parts of python oil extract, 20-25 parts of a composite plant extract, 10-20 parts of ceramide, 5-10 parts of panthenol, 3-8 parts of a sodium hyaluronate cross-linked polymer, and 3-6 parts of menthol. The composite plant extract is composed of a red safflower extract, a trifoliate bitter extract, and a radix scutellariae extract in a mass ratio of 10:4-6:7-9.

[0007] A further technical solution is that the composite plant extract is composed of Sanguisorba officinalis extract, Tripterygium wilfordii extract, and Coptis chinensis extract in a mass ratio of 10:5:8.

[0008] A further technical solution is that the preparation method of the Sanguinea chinensis extract includes the following steps: taking Sanguinea chinensis, crushing it, refluxing and extracting it 2-3 times with a 65%-75% v / v ethanol solution, each extraction time being 2-3 hours, combining the extracts, concentrating under reduced pressure, and drying to obtain the Sanguinea chinensis extract.

[0009] A further technical solution is that the preparation method of the trifoliate bitter extract includes the following steps: taking trifoliate bitter, crushing it, adding ethyl acetate, the solid-liquid ratio kg / L is 1:3-5, extracting under ultrasonic conditions for 1-2 hours, the ultrasonic power is 200-300W, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the trifoliate bitter extract.

[0010] A further technical solution is that the preparation method of the Radix Glehniae extract includes the following steps: taking Radix Glehniae, crushing it, adding it to water, using enzyme-assisted ultrasonic extraction, the solid-liquid ratio of Radix Glehniae to water (kg / L) is 1:14-16, the enzyme addition amount is 1%-2% of the mass of Radix Glehniae, the enzyme is cellulase, the ultrasonic power is 750-850W, the ultrasonic time is 80-100min, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the Radix Glehniae extract.

[0011] A further technical solution is that it is prepared by including the following raw materials in parts by weight: 45 parts of python oil extract, 23 parts of compound plant extract, 15 parts of ceramide, 8 parts of panthenol, 5 parts of sodium hyaluronate cross-linked polymer, and 4 parts of menthol.

[0012] A further technical solution is a method for preparing a python oil composition for treating herpes zoster and dyshidrotic eczema, comprising the following steps: placing a composite plant extract (Sansevieria cyperus extract + Tripterygium wilfordii extract + Radix Codonopsis pilosulae extract) into a python oil extract and hot-soaking it at 70-80°C for 1-2 hours; then adding ceramide, sodium hyaluronate cross-linked polymer, and panthenol, stirring at 40-50°C for 10-20 minutes; finally, adding menthol, stirring at 20-30°C for 2-4 minutes to obtain the python oil composition.

[0013] The python oil composition of the present invention is used in preparing medicines for treating herpes zoster and / or dyshidrosis.

[0014] Compared with the prior art, the present invention has the following beneficial effects:

[0015] (1) The present invention is based on python oil extract, adds a composite plant extract consisting of a certain proportion of red blood vine extract, trifoliate bitter extract, and radix scutellariae extract, and adds ceramide, panthenol, sodium hyaluronate cross-linked polymer, and menthol. The prepared python oil composition has a good therapeutic effect on herpes zoster or dyshidrosis, and can shorten the healing time to the greatest extent.

[0016] (2) The python oil composition prepared by the present invention is used to treat herpes zoster or dyshidrotic eczema, can quickly stop blisters, effectively relieve pain, quickly form scabs, and better restore healthy skin.

[0017] (3) The python oil composition prepared by the present invention has good safety. DETAILED DESCRIPTION

[0018] In order to better understand the technical content of the present invention, specific examples are provided below to further illustrate the present invention.

[0019] Unless otherwise specified, the experimental methods used in the examples of the present invention are all conventional methods.

[0020] Unless otherwise specified, the materials, reagents, etc. used in the examples of the present invention can be obtained from commercial sources.

[0021] The preparation method of the python oil extract of the embodiment of the present invention comprises: removing fat from the abdomen of the python, removing impurities and thin films on the surface of the fat, placing the fat in an oil refining pot, refining the fat at a temperature of 85-105° C., filtering to remove impurities, and cooling to obtain the python oil extract.

[0022] Example 1

[0023] A python oil composition for treating herpes zoster and dyshidrotic eczema is prepared from the following raw materials in parts by weight: 45 parts of python oil extract, 23 parts of a composite plant extract, 15 parts of ceramide, 8 parts of panthenol, 5 parts of a sodium hyaluronate cross-linked polymer, and 4 parts of menthol, wherein the composite plant extract comprises a Sanguisorba officinalis extract, a Tripterygium wilfordii extract, and a Corydalis lappa extract in a mass ratio of 10:5:8.

[0024] The preparation method of the above-mentioned python oil composition comprises the following steps:

[0025] (1) The preparation method of the Caulis Sanguinea var. erythrorhizonii extract comprises the following steps: taking Caulis Sanguinea var. erythrorhizonii, washing, drying, crushing, refluxing and extracting twice with 70% v / v ethanol solution, each extraction time being 2.5 h, combining the extracts, concentrating under reduced pressure, and drying to obtain the Caulis Sanguinea var. erythrorhizonii extract;

[0026] (2) The preparation method of the trifoliate bitter extract comprises the following steps: taking trifoliate bitter, washing, drying, crushing, adding ethyl acetate, with a solid-liquid ratio of kg / L of 1:4, extracting under ultrasonic conditions for 1.5 h, with an ultrasonic power of 250 W, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the trifoliate bitter extract;

[0027] (3) The preparation method of the extract of Radix Corydalis comprises the following steps: taking Radix Corydalis, washing, drying, crushing, adding to water, using enzyme-assisted ultrasonic extraction, the solid-liquid ratio of Radix Corydalis to water is 1:15 kg / L, the enzyme addition amount is 1.5% of the mass of Radix Corydalis, the enzyme is cellulase, the ultrasonic power is 800 W, the ultrasonic time is 90 min, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the Radix Corydalis extract;

[0028] (4) mixing the Caulis Sanguisorbae Officinalis extract, the Tripterygium wilfordii extract, and the Radix Codonopsis pilosulae extract to obtain a composite plant extract;

[0029] (5) The composite plant extract was placed in the python oil extract and hot-soaked at 75°C ± 5°C for 1.5 hours; ceramide, sodium hyaluronate cross-linked polymer, and panthenol were then added and stirred at 45°C ± 5°C for 15 minutes; finally, menthol was added and stirred at 25°C ± 5°C for 3 minutes to obtain a python oil composition.

[0030] Example 2

[0031] A python oil composition for treating herpes zoster and dyshidrotic eczema is prepared from the following raw materials in parts by weight: 42 parts of python oil extract, 25 parts of a composite plant extract, 12 parts of ceramide, 10 parts of panthenol, 8 parts of sodium hyaluronate cross-linked polymer, and 3 parts of menthol, wherein the composite plant extract comprises a Sanguisorba officinalis extract, a Tripterygium wilfordii extract, and a Corydalis lappa extract in a mass ratio of 10:6:9.

[0032] The preparation method of the above-mentioned python oil composition comprises the following steps:

[0033] (1) The preparation method of the Caulis Sanguinea var. erythrorhizonii extract comprises the following steps: taking Caulis Sanguinea var. erythrorhizonii, washing, drying, crushing, refluxing and extracting twice with 70% v / v ethanol solution, each extraction time being 2.5 h, combining the extracts, concentrating under reduced pressure, and drying to obtain the Caulis Sanguinea var. erythrorhizonii extract;

[0034] (2) The preparation method of the trifoliate bitter extract comprises the following steps: taking trifoliate bitter, washing, drying, crushing, adding ethyl acetate, with a solid-liquid ratio of kg / L of 1:4, extracting under ultrasonic conditions for 1.5 h, with an ultrasonic power of 250 W, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the trifoliate bitter extract;

[0035] (3) The preparation method of the extract of Radix Corydalis comprises the following steps: taking Radix Corydalis, washing, drying, crushing, adding to water, using enzyme-assisted ultrasonic extraction, the solid-liquid ratio of Radix Corydalis to water is 1:15 kg / L, the enzyme addition amount is 1.5% of the mass of Radix Corydalis, the enzyme is cellulase, the ultrasonic power is 800 W, the ultrasonic time is 90 min, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the Radix Corydalis extract;

[0036] (4) mixing the Caulis Sanguisorbae Officinalis extract, the Tripterygium wilfordii extract, and the Radix Codonopsis pilosulae extract to obtain a composite plant extract;

[0037] (5) The composite plant extract was placed in the python oil extract and hot-soaked at 75°C ± 5°C for 1.5 hours; ceramide, sodium hyaluronate cross-linked polymer, and panthenol were then added and stirred at 45°C ± 5°C for 15 minutes; finally, menthol was added and stirred at 25°C ± 5°C for 3 minutes to obtain a python oil composition.

[0038] Example 3

[0039] A python oil composition for treating herpes zoster and dyshidrotic eczema is prepared from the following raw materials in parts by weight: 47 parts of python oil extract, 21 parts of a composite plant extract, 18 parts of ceramide, 5 parts of panthenol, 3 parts of sodium hyaluronate cross-polymer, and 6 parts of menthol, wherein the composite plant extract comprises a Sanguisorba officinalis extract, a Tripterygium wilfordii extract, and a Corydalis lappa extract in a mass ratio of 10:4:7.

[0040] The preparation method of the above-mentioned python oil composition comprises the following steps:

[0041] (1) The preparation method of the Caulis Sanguinea var. erythrorhizonii extract comprises the following steps: taking Caulis Sanguinea var. erythrorhizonii, washing, drying, crushing, refluxing and extracting twice with 70% v / v ethanol solution, each extraction time being 2.5 h, combining the extracts, concentrating under reduced pressure, and drying to obtain the Caulis Sanguinea var. erythrorhizonii extract;

[0042] (2) The preparation method of the trifoliate bitter extract comprises the following steps: taking trifoliate bitter, washing, drying, crushing, adding ethyl acetate, with a solid-liquid ratio of kg / L of 1:4, extracting under ultrasonic conditions for 1.5 h, with an ultrasonic power of 250 W, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the trifoliate bitter extract;

[0043] (3) The preparation method of the extract of Radix Corydalis comprises the following steps: taking Radix Corydalis, washing, drying, crushing, adding to water, using enzyme-assisted ultrasonic extraction, the solid-liquid ratio of Radix Corydalis to water is 1:15 kg / L, the enzyme addition amount is 1.5% of the mass of Radix Corydalis, the enzyme is cellulase, the ultrasonic power is 800 W, the ultrasonic time is 90 min, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the Radix Corydalis extract;

[0044] (4) mixing the Caulis Sanguisorbae Officinalis extract, the Tripterygium wilfordii extract, and the Radix Codonopsis pilosulae extract to obtain a composite plant extract;

[0045] (5) The composite plant extract was placed in the python oil extract and hot-soaked at 75°C ± 5°C for 1.5 hours; ceramide, sodium hyaluronate cross-linked polymer, and panthenol were then added and stirred at 45°C ± 5°C for 15 minutes; finally, menthol was added and stirred at 25°C ± 5°C for 3 minutes to obtain a python oil composition.

[0046] Example 4

[0047] The difference from Example 1 is that the preparation method of the python oil composition comprises the following steps:

[0048] (1) The preparation method of the Caulis Sanguinea var. erythrorhizonii extract comprises the following steps: taking Caulis Sanguinea var. erythrorhizonii, washing, drying, crushing, refluxing and extracting with 65% v / v ethanol solution for 3 times, each extraction time being 2 hours, combining the extracts, concentrating under reduced pressure, and drying to obtain the Caulis Sanguinea var. erythrorhizonii extract;

[0049] (2) The preparation method of the trifoliate bitter extract comprises the following steps: taking trifoliate bitter, washing, drying, crushing, adding ethyl acetate, with a solid-liquid ratio of kg / L of 1:3, extracting under ultrasonic conditions for 1.0 h, with an ultrasonic power of 300 W, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the trifoliate bitter extract;

[0050] (3) The preparation method of the extract of Radix Corydalis comprises the following steps: taking Radix Corydalis, washing, drying, crushing, adding to water, using enzyme-assisted ultrasonic extraction, the solid-liquid ratio of Radix Corydalis to water is 1:16 kg / L, the enzyme addition amount is 2% of the mass of Radix Corydalis, the enzyme is cellulase, the ultrasonic power is 750 W, the ultrasonic time is 80 min, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the Radix Corydalis extract;

[0051] (4) mixing the Caulis Sanguisorbae Officinalis extract, the Tripterygium wilfordii extract, and the Radix Codonopsis pilosulae extract to obtain a composite plant extract;

[0052] (5) The composite plant extract was placed in the python oil extract and hot-soaked at 75°C ± 5°C for 1 hour; ceramide, sodium hyaluronate cross-linked polymer, and panthenol were then added and stirred at 45°C ± 5°C for 20 minutes; finally, menthol was added and stirred at 25°C ± 5°C for 4 minutes to obtain a python oil composition.

[0053] Example 5

[0054] The difference from Example 1 is that the preparation method of the python oil composition comprises the following steps:

[0055] (1) The preparation method of the Caulis Sanguisorba officinalis extract comprises the following steps: taking Caulis Sanguisorba officinalis, washing, drying, crushing, refluxing and extracting twice with 75% v / v ethanol solution, each extraction time being 3 hours, combining the extracts, concentrating under reduced pressure, and drying to obtain the Caulis Sanguisorba officinalis extract;

[0056] (2) The preparation method of the trifoliate bitter extract comprises the following steps: taking trifoliate bitter, washing, drying, crushing, adding ethyl acetate, with a solid-liquid ratio of kg / L of 1:5, extracting under ultrasonic conditions for 2.0 h at an ultrasonic power of 200 W, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the trifoliate bitter extract;

[0057] (3) The preparation method of the extract of Radix Corydalis comprises the following steps: taking Radix Corydalis, washing, drying, crushing, adding to water, using enzyme-assisted ultrasonic extraction, the solid-liquid ratio of Radix Corydalis to water is 1:14 kg / L, the enzyme addition amount is 1% of the mass of Radix Corydalis, the enzyme is cellulase, the ultrasonic power is 850 W, the ultrasonic time is 100 min, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the Radix Corydalis extract;

[0058] (4) mixing the Caulis Sanguisorbae Officinalis extract, the Tripterygium wilfordii extract, and the Radix Codonopsis pilosulae extract to obtain a composite plant extract;

[0059] (5) The composite plant extract was placed in the python oil extract and hot-soaked at 75°C ± 5°C for 2 hours; ceramide, sodium hyaluronate cross-linked polymer, and panthenol were then added and stirred at 45°C ± 5°C for 10 minutes; finally, menthol was added and stirred at 25°C ± 5°C for 2 minutes to obtain a python oil composition.

[0060] Comparative Example 1

[0061] The difference from Example 1 is that the composite plant extract is replaced by a single plant extract: Sanguisorba officinalis extract.

[0062] A python oil composition for treating herpes zoster and dyshidrotic eczema is prepared from the following raw materials in parts by weight: 45 parts of python oil extract, 23 parts of Sanguisorba officinalis extract, 15 parts of ceramide, 8 parts of panthenol, 5 parts of sodium hyaluronate cross-linked polymer, and 4 parts of menthol. Other preparation methods are consistent with those in Example 1.

[0063] Comparative Example 2

[0064] This differs from Example 1 in that the composite plant extract is replaced with a single plant extract: Trigona oleracea extract. A python oil composition for treating herpes zoster and dyshidrotic eczema is prepared from the following raw materials in parts by weight: 45 parts python oil extract, 23 parts Trigona oleracea extract, 15 parts ceramide, 8 parts panthenol, 5 parts sodium hyaluronate crosspolymer, and 4 parts menthol. Other preparation methods are consistent with those in Example 1.

[0065] Comparative Example 3

[0066] The difference from Example 1 is that the composite plant extract is replaced with a single plant extract: Coleus chinensis extract. A python oil composition for treating herpes zoster and dyshidrotic eczema is prepared by including the following raw materials in parts by weight: 45 parts python oil extract, 23 parts Coleus chinensis extract, 15 parts ceramide, 8 parts panthenol, 5 parts sodium hyaluronate crosspolymer, and 4 parts menthol. Other preparation methods are consistent with those in Example 1.

[0067] Comparative Example 4

[0068] The difference from Example 1 is that the sodium hyaluronate cross-linked polymer is replaced by sodium hyaluronate.

[0069] A python oil composition for treating herpes zoster and dyshidrotic eczema is prepared by including the following raw materials in parts by weight: 45 parts of python oil extract, 23 parts of a composite plant extract, 15 parts of ceramide, 8 parts of panthenol, 5 parts of sodium hyaluronate, and 4 parts of menthol. The composite plant extract comprises a Sanguisorba officinalis extract, a Trichosanthes kirilowii extract, and a Periploca serrata extract in a mass ratio of 10:5:8. Other preparation methods are consistent with those in Example 1.

[0070] Test Example 1

[0071] 90 SPF-grade 8-week-old male C57 mice weighing 20±2g were purchased from the Animal Center of Shanghai University of Traditional Chinese Medicine. After anesthesia with sodium pentobarbital, the guinea pigs were depilated, cleaned, and disinfected according to conventional methods. The depilated part of the mouse back was divided into multiple dermatomes with a marker pen. 10 mg / kg was injected intradermally in the center of each dermatome. 7 PFU / mLVZV-pOKA virus strain virus (varicella-zoster virus VZV-pOKA virus strain was purchased from the Wuhan Institute of Virology, Chinese Academy of Sciences), 0.1 mL was injected each time. During anesthesia, the mice were kept in an incubator (30°C) for 2 hours. 90 mice were randomly divided into groups, with 10 mice in each group, including a positive control group, research groups 1-7, and a blank control group, wherein the positive control group used acyclovir; research groups 1-7 used the python oil composition of Examples 1-3 and Comparative Examples 1-4; the blank control group was smeared with PBS solution; the volume of the drug applied each time was 30 μL, until the drug dried, applied twice a day, and administered continuously for 5 days; the recovery of the lesion site of the mice was observed day by day. The results are shown in Table 1.

[0072] Table 1 The therapeutic effect on herpes zoster virus infection in mice skin

[0073] Group Recovery time (d) Blank group 19.37±1.09 Positive control group 10.97±1.22 Study Group 1 (Example 1) 3.92±1.06 Study Group 2 (Example 2) 4.51±1.18 Study Group 3 (Example 3) 4.73±1.16 Study Group 4 (Comparative Example 1) 8.96±1.13 Study Group 5 (Comparative Example 2) 7.55±1.28 Study Group 6 (Comparative Example 3) 9.70±1.10 Study Group 7 (Comparative Example 4) 6.45±1.16

[0074] The results in Table 1 show that after the mouse skin was inoculated with herpes zoster virus, the recovery time of the study groups 1-3 that were applied with the python oil compositions of Examples 1-3 of the present invention was significantly reduced compared with the positive control, and there was a statistical difference. Among them, the recovery time of study group 1 was the shortest. It can be seen that the python oil composition of Example 1 of the present invention has the best therapeutic effect on the herpes zoster virus infection of the mouse skin and can shorten the recovery time to the greatest extent.

[0075] Compared with Example 1, the therapeutic effects of Comparative Examples 1-3 using a single plant extract were significantly reduced, and the therapeutic effect of Comparative Example 4 was also reduced.

[0076] In addition, after administration, the organs of mice were tested and no substantial pathological changes were found, indicating that the python oil composition of the present invention has good safety.

[0077] Test Example 2

[0078] Sixty patients with herpes zoster (30 males and 30 females) were recruited and randomly divided into a control group and a study group, with 30 patients in each group. General information between the two groups showed no statistically significant differences (P>0.05), indicating comparability.

[0079] The control group was given conventional Western medicine treatment: oral acyclovir tablets, 0.2 g each time, 5 times a day, and oral methylcobalamin capsules, 0.5 mg each time, 3 times a day, for 10 days; the research group was treated with the python oil composition prepared in Example 1, once in the morning and once in the evening every day, evenly applied to the painful area, 5 days as a course of treatment, and the therapeutic effects were compared after 1-2 consecutive courses of treatment.

[0080] Cured: The skin recovery area is more than 90%, and the pain basically disappears;

[0081] Markedly effective: The skin recovery area is 70% to 90%, and the pain is significantly reduced compared to before;

[0082] Effective: The skin recovery area is 30% to 69%, and the pain is slightly relieved;

[0083] Ineffective: The skin recovery area is less than 30%, and the pain relief is not obvious or even worsens.

[0084] Total effective rate = cure rate + marked effective rate + effective rate. The results are shown in Table 2.

[0085] Table 2 Comparison of therapeutic effects between the study group and the control group

[0086] Group Recovered (case) Significantly effective (example) Valid (example) Invalid (example) Recovery rate Total efficiency control group 9 8 4 9 30.0％ 70.0％ Research Group 22 5 2 1 73.3％ 96.7％

[0087] As shown in Table 2, the total effective rate and cure rate of the study group were higher than those of the control group, and the differences were statistically significant (P < 0.05), which further demonstrated that the python oil composition prepared in the embodiment of the present invention was effective in treating herpes zoster.

[0088] In addition, the study found that the python oil composition prepared in the embodiment of the present invention is used to treat dyshidrotic eczema, which can quickly stop blisters, effectively relieve pain, quickly form scabs, and better restore healthy skin. The python oil composition prepared in the embodiment of the present invention is also suitable for treating dyshidrotic eczema.

[0089] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A python oil composition for treating herpes zoster and dyshidrotic eczema, characterized in that: The invention comprises the following raw materials in parts by weight: 40-50 parts of python oil extract, 20-25 parts of compound plant extract, 10-20 parts of ceramide, 5-10 parts of panthenol, 3-8 parts of sodium hyaluronate cross-linked polymer, and 3-6 parts of menthol. The compound plant extract consists of red safflower vine extract, trifoliate bitter melon extract, and scutellaria baicalensis extract.

2. A python oil composition for treating herpes zoster and dyshidrotic eczema according to claim 1, characterized in that: The composite plant extract consists of a sanguinea vine extract, a trifoliate myrtle extract, and a scutellaria baicalensis extract in a mass ratio of 10:4-6:7-9.

3. A python oil composition for treating herpes zoster and dyshidrotic eczema according to claim 1 or 2, characterized in that: The preparation method of the Caulis Sanguinea var. erythrorhizon extract comprises the following steps: taking Caulis Sanguinea var. erythrorhizon, crushing it, refluxing and extracting it 2-3 times with 65%-75% v / v ethanol solution, each extraction time being 2-3 hours, combining the extracts, concentrating under reduced pressure, and drying to obtain the Caulis Sanguinea var. erythrorhizon extract.

4. A python oil composition for treating herpes zoster and dyshidrotic eczema according to claim 1 or 2, characterized in that: The preparation method of the trifoliate bitter melon extract comprises the following steps: taking trifoliate bitter melon, crushing it, extracting it with ethyl acetate under ultrasonic conditions for 1-2 hours, with an ultrasonic power of 200-300W and a solid-liquid ratio of kg / L of 1:3-5, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the trifoliate bitter melon extract.

5. A python oil composition for treating herpes zoster and dyshidrotic eczema according to claim 1 or 2, characterized in that: The preparation method of the Radix Corydalis extract comprises the following steps: taking Radix Corydalis, crushing it, adding it to water, using enzyme-assisted ultrasonic extraction, wherein the solid-liquid ratio of Radix Corydalis to water is 1:14-16 kg / L, the enzyme addition amount is 1%-2% of the mass of Radix Corydalis, the enzyme is cellulase, the ultrasonic power is 750-850W, the ultrasonic time is 80-100min, filtering, collecting the filtrate, concentrating under reduced pressure, and drying to obtain the Radix Corydalis extract.

6. The python oil composition for treating herpes zoster and dyshidrotic eczema according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 45 parts of python oil extract, 23 parts of compound plant extract, 15 parts of ceramide, 8 parts of panthenol, 5 parts of sodium hyaluronate cross-linked polymer and 4 parts of menthol.

7. A python oil composition for treating herpes zoster and dyshidrotic eczema according to claim 2 or 6, characterized in that: The composite plant extract consists of a Sanguinea vine extract, a Tripterygium wilfordii extract, and a Coptis chinensis extract in a mass ratio of 10:5:

8.

8. A method for preparing a python oil composition for treating herpes zoster and dyshidrotic eczema according to any one of claims 1 to 7, characterized in that: The following steps are involved: The composite plant extract is added to the python oil extract, and the mixture is heated at 70-80° C. for 1-2 hours; ceramide, sodium hyaluronate cross-linked polymer, and panthenol are then added, and the mixture is stirred at 40-50° C. for 10-20 minutes; finally, menthol is added, and the mixture is stirred at 20-30° C. for 2-4 minutes to obtain a python oil composition.

9. Use of the python oil composition according to any one of claims 1 to 7 in preparing a medicament for treating herpes zoster and / or dyshidrosis.

10. Use of the python oil composition prepared by the preparation method according to claim 8 in preparing a medicine for treating herpes zoster and / or dyshidrosis.