A composition, eye patch and preparation method thereof for preventing and treating eye dryness, blurred vision, asthenopia and dry eye

Abstract

The present application relates to the field of traditional Chinese medicine, in particular to a composition, eye patch and preparation method thereof for preventing and treating eye dryness, blurred vision fatigue and dry eye, comprising a carrier vehicle and a matrix layer, selecting medicinal materials with the effects of improving eyesight and resisting oxidation, fermenting the medicinal materials with plant lactic acid bacteria, bacillus or yeast to decompose macromolecules into small molecule active substances and possibly produce new active metabolites, adopting temperature control during the fermentation process to avoid high temperature from destroying heat-sensitive components, compounding the fermented medicinal material extract with hyaluronic acid, menthol, carboxymethyl cellulose and glycerol to form an intelligent rheological regulation body, hyaluronic acid synergistically enhances the moisturizing effect with the fermented extract, carboxymethyl cellulose serves as a film-forming agent to ensure the stability of the matrix layer, and glycerol improves the moisturizing performance, adopting a green process of activation, fermentation, mixing, loading and sterilization, selecting plant fibers as the carrier vehicle, cutting and packaging after loading the matrix layer, and then sterilizing to ensure the safety and effectiveness of the product.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a composition, eye patch, and preparation method for preventing and treating dry eyes, blurred vision, visual fatigue, and dry eye syndrome. Background Technology

[0002] As is well known, eye patches are a commonly used traditional Chinese medicine preparation for relieving eye fatigue, dry eye syndrome, and improving the condition of the eye area.

[0003] Traditional eye patches often rely on chemical ingredients or simple plant extracts, resulting in limited efficacy and poor permeability of the controlled-release foam coating for active ingredients. Large molecules produced by direct extraction of medicinal materials, such as polysaccharides and proteins, are difficult to absorb through the skin, failing to fully exert their medicinal effects and thus failing to meet users' demands for highly effective eye patches. Microbial fermentation technology, on the other hand, can break down large molecules of medicinal materials into smaller active molecules, improving transdermal absorption and potentially generating new active metabolites that enhance efficacy. However, existing eye patches do not effectively incorporate the advantages of this technology. Therefore, there is a need for a composition, eye patch, and preparation method for preventing and treating dry eyes, blurred vision, visual fatigue, and dry eye syndrome. Summary of the Invention

[0004] Technical problems to be solved In order to overcome the problems of existing eye patches having limited efficacy and poor permeability of controlled-release foam coatings for active ingredients, this invention provides a composition, an eye patch, and a method for preparing the same for preventing and treating dry eyes, blurred vision, visual fatigue, and dry eye syndrome.

[0005] Technical solution To achieve the above objectives, the present invention provides the following technical solution: a composition and eye patch for preventing and treating dry eyes, blurred vision, eye fatigue, and dry eye syndrome, comprising: a carrier; A matrix layer, which is loaded on the surface of a carrier, includes an active ingredient controlled-release foam coating and excipients. The controlled-release vesicle coating of the active ingredient includes fermented herbal extracts, wherein the fermented herbal extracts are selected from at least one of cassia seed, wolfberry, ginseng, salvia miltiorrhiza, chrysanthemum, scutellaria baicalensis, polygonatum sibiricum, and phellodendron amurense, with cassia seed accounting for 40%, wolfberry for 25%, chrysanthemum for 20%, and polygonatum sibiricum for 15%; Fermented herbal extracts: 5%~15%; Hyaluronic acid (sodium): 0.5%~2.5%; Menthol: 0.1‰~0.5‰, Sodium carboxymethyl cellulose: 0.5‰~1‰, Glycerin: 8%~15%, Natural borneol: 0.1‰-0.5‰; Deionized water: Fermented herbal extracts (5%-15%), which, through microbial fermentation, make the large molecular active substances in the herbs (such as polysaccharides and flavonoid aglycones) more easily absorbed by the skin and mucous membranes; and The fermented medicinal material extract is prepared by fermentation with plant lactic acid bacteria, Bacillus, or yeast. Fermentation strain inoculation ratio (based on the dry weight of medicinal materials): Plant lactic acid bacteria (e.g., Lactobacillus plantarum): inoculation amount is 1×10 6 ~1×10 8 CFU / g of medicinal materials; Bacillus subtilis (e.g., Bacillus subtilis): Inoculum size 1×10⁻⁶ 5 ~1×10 7 CFU / g of medicinal material, yeast (e.g., Saccharomyces cerevisiae): inoculum size 1×10 5 ~1×10 7 CFU / g of medicinal materials; Preferred compound fermentation mode: Two-step fermentation using plant lactic acid bacteria and yeast. First, yeast is inoculated and fermented for 24-48 hours, then plant lactic acid bacteria are inoculated and fermented for another 48-72 hours. This can synergistically enhance the effect and produce richer active metabolites. Ratio of medicinal materials to culture medium: Particle size of medicinal materials: 40-80 mesh; mass ratio of medicinal materials to water: 1:8~1:15; 1%-3% oligosaccharides (such as fructooligosaccharides) can be added as fermentation promoters.

[0006] Preferably, the carrier is a plant fiber carrier, and the carrier is closely attached to the matrix layer.

[0007] Furthermore, in the matrix layer, fermented herbal extract, hyaluronic acid, menthol, carboxymethyl cellulose, and glycerin are mixed in a preset ratio to form an intelligent rheology regulator, which, after soaking in the carrier, forms a fermented herbal extract: 6%~15% hyaluronic acid (sodium): 0.6%~2.6%; Menthol: 0.2‰~0.4‰, Sodium carboxymethyl cellulose: 0.5‰~1‰, Glycerin: 9%~16%, Natural borneol: 0.1‰-0.5‰, Deionized water: Fermented herbal extract (5%-15%).

[0008] Furthermore, the preparation of the fermented medicinal material extract includes the steps of pulverizing the medicinal material, mixing, inoculating with microorganisms, fermenting, separating and purifying, and drying.

[0009] A composition and eye patch preparation method for preventing and treating dry eyes, blurred vision, eye fatigue and dry eye syndrome, comprising the following steps: S1: Fermentation bacteria activation, plant lactic acid bacteria, Bacillus or yeast are inoculated into a culture medium respectively, and activated culture is carried out to obtain bacterial seed liquid; S2: Traditional Chinese medicine fermentation involves washing, mixing, and crushing selected medicinal materials, adding water and sterilizing, inoculating with inoculum seed liquid for fermentation culture, filtering, separating, purifying and drying to obtain fermented medicinal material extract; S3: Preparation of intelligent rheology regulator: Fermented herbal extracts, hyaluronic acid, menthol, carboxymethyl cellulose, and glycerin are dissolved in deionized water and mixed evenly to form an intelligent rheology regulator; 8%~16% hyaluronic acid (sodium): 0.9%~2.9%; Menthol: 0.3‰~0.35‰, Sodium carboxymethyl cellulose: 0.5‰~1‰, Glycerin: 10%~17%, Natural borneol: 0.1‰-0.5‰, Deionized water: Fermented herbal extract (5%-15%). S4: Loading molding, immersing the plant fiber carrier in the intelligent rheology regulator, so that the matrix layer is uniformly loaded on the surface of the carrier; S5: Sterilization packaging. The pre-cut plant fibers are placed in bags, then filled with the medicine liquid, then sealed, and finally sterilized.

[0010] Based on the aforementioned scheme, step S2 includes separation and purification steps such as ethanol precipitation of filtrate, solid washing, and ethanol recovery from filtrate.

[0011] Further, in step S4, after the carrier is soaked, the matrix layer is ensured to be uniformly covered without any local gaps.

[0012] Furthermore, based on the aforementioned scheme, step S2 involves temperature-controlled fermentation, avoiding high-temperature treatment during the fermentation process.

[0013] Beneficial effects This composition, eye patch, and its preparation method for preventing and treating dry eyes, blurred vision, visual fatigue, and dry eye syndrome involve selecting medicinal materials with vision-improving and antioxidant effects. Fermentation is performed using plant-based lactic acid bacteria, Bacillus, or yeast to break down large molecules of the medicinal materials into smaller active substances, potentially generating new active metabolites. The fermentation process employs temperature control to avoid damaging heat-sensitive components. The fermented herbal extract is combined with hyaluronic acid, menthol, carboxymethyl cellulose, and glycerin to form an intelligent rheological regulator. Hyaluronic acid synergistically enhances the moisturizing effect with the fermented extract, carboxymethyl cellulose acts as a film-forming agent to ensure the stability of the matrix layer, and glycerin improves moisturizing performance. A green process involving activation, fermentation, mixing, loading, and sterilization is used. Plant fibers are selected as the carrier; after soaking and loading the matrix layer, the cut plant fibers are placed in bags, filled with the medicinal liquid, sealed, and sterilized to ensure product safety and effectiveness.

[0014] The controlled-release veneer of fermented small-molecule active ingredients significantly improves transdermal penetration, making it easier for the skin to absorb compared to traditional plant extracts. The fermented extracts and excipients work synergistically to enhance anti-inflammatory, antioxidant, and moisturizing repair effects, effectively relieving eye fatigue and improving moisture loss around the eyes. The low-temperature fermentation process avoids damage to heat-sensitive ingredients, ensuring high product safety, no skin irritation, and suitability for daily eye care needs. Attached Figure Description

[0015] Figure 1 This is a side view of the carrier structure of the present invention; Figure 2 This is a schematic diagram of the structure of the matrix layer of the present invention; Figure 3 For the present invention Figure 2 A magnified schematic diagram of the partial structure at point A in the middle; Figure 4 This is a data table for verifying the efficacy of the present invention.

[0016] In the figure: 1. Carrier; 2. Matrix layer. Detailed Implementation

[0017] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0018] Example 1 See Figures 1-3 A composition, an eye patch, and a method for preparing the same for preventing and treating dry eyes, blurred vision, eye fatigue, and dry eye syndrome, comprising a carrier 1 and a matrix layer 2, wherein the matrix layer 2 is loaded on the surface of the carrier 1 and comprises an active ingredient controlled-release foam coating and excipients.

[0019] The controlled-release vesicle coating of the active ingredient includes fermented herbal extracts, wherein the fermented herbal extracts are selected from at least one of cassia seed, wolfberry, ginseng, salvia miltiorrhiza, chrysanthemum, scutellaria baicalensis, polygonatum sibiricum, and phellodendron amurense, with 40% cassia seed, 25% wolfberry, 20% chrysanthemum, and 15% polygonatum sibiricum.

[0020] Fermented herbal extract: 5%; Hyaluronic acid (sodium): 0.5%.

[0021] Menthol: 0.1‰, Sodium carboxymethyl cellulose: 0.5‰, Glycerin: 8%, Natural borneol: 0.1‰.

[0022] Deionized water: Fermented herbal extract (15%), which is transformed by microbial fermentation, making the macromolecular active substances in the herbs (such as polysaccharides and flavonoid aglycones) more easily absorbed by the skin and mucous membranes.

[0023] The fermented medicinal material extract is prepared by fermentation with plant lactic acid bacteria, Bacillus, or yeast.

[0024] Fermentation strain inoculation ratio (based on the dry weight of medicinal materials): Plant lactic acid bacteria (e.g., Lactobacillus plantarum): inoculation amount is 1×10 6 Medicinal herbs.

[0025] Bacillus subtilis (e.g., Bacillus subtilis): Inoculum size 1×10⁻⁶ 5 Medicinal materials, yeast (such as Saccharomyces cerevisiae): inoculum size 1×10 5 Medicinal herbs.

[0026] The preferred compound fermentation mode is to use plant lactic acid bacteria and yeast for two-step fermentation. First, yeast is inoculated and fermented for 24-48 hours, and then plant lactic acid bacteria are inoculated and fermented for another 48-72 hours. This can synergistically enhance the effect and produce richer active metabolites.

[0027] Ratio of medicinal materials to culture medium: Particle size of medicinal materials: 40-80 mesh; mass ratio of medicinal materials to water: 1:8~1:15; 1%-3% oligosaccharides (such as fructooligosaccharides) can be added as fermentation promoters.

[0028] Cassia seed and wolfberry compound fermented extract medicinal material: Cassia seed and wolfberry are mixed in a mass ratio of 3:1.

[0029] Inoculum: Plant-based lactic acid bacteria, inoculum size 5 × 10⁻⁶ 7 CFU / g of medicinal material, fermentation conditions: 37°C, anaerobic fermentation for 72 hours, natural pH.

[0030] Post-processing: The fermentation broth was filtered, the filtrate was precipitated with 70% ethanol, the supernatant was collected, the ethanol was recovered, and the filtrate was freeze-dried to obtain the fermentation extract powder.

[0031] Comparative Example A: Cassia seed-goji berry conventional water extract, the same proportion of the above-mentioned medicinal materials, water extracted at 100°C for 2 hours, repeated twice, the filtrates were combined, concentrated and dried.

[0032]

[0033] First, refer to Figure 1 In this embodiment, the carrier 1 is a plant fiber carrier 1, and the carrier 1 is closely attached to the matrix layer 2.

[0034] In the matrix layer 2, fermented herbal extract, hyaluronic acid, menthol, carboxymethyl cellulose, and glycerin are mixed in a preset ratio to form an intelligent rheology regulator. After soaking in the carrier 1, the resulting mixture is: fermented herbal extract: 6%; hyaluronic acid (sodium): 0.6%. Menthol: 0.5‰, Sodium carboxymethyl cellulose: 1‰, Glycerin: 15%, Deionized water: Fermented herbal extract (5%), Natural borneol: 0.5‰.

[0035] Then, refer to Figure 2 In this embodiment, the preparation of the fermented medicinal material extract includes the steps of pulverizing medicinal materials, mixing, inoculating with microorganisms, fermenting, separating and purifying, and drying.

[0036] Secondly, see Figure 3 In this embodiment, S1: Fermentation bacteria activation, plant lactic acid bacteria, Bacillus or yeast are inoculated into the culture medium respectively, and activated culture is used to obtain bacterial seed liquid; S2: Traditional Chinese medicine fermentation involves washing, mixing, and crushing selected medicinal materials, adding water and sterilizing, inoculating with inoculum seed liquid for fermentation culture, filtering, separating, purifying and drying to obtain fermented medicinal material extract; S3: Preparation of intelligent rheology regulator: Fermented herbal extracts, hyaluronic acid, menthol, carboxymethyl cellulose, and glycerin are dissolved in deionized water and mixed evenly to form an intelligent rheology regulator; 8% Sodium Hyaluronate: 0.9%; Menthol: 0.2‰, Sodium carboxymethyl cellulose: 0.8‰, Glycerin: 10%, Natural borneol: 0.4‰, Deionized water: Fermented herbal extract (7%); S4: Loading and molding, immersing the plant fiber carrier 1 in the intelligent rheology regulator, so that the matrix layer 2 is uniformly loaded on the surface of the carrier 1. S5: Sterilization packaging. The pre-cut plant fibers are placed in bags, then filled with the medicine liquid, then sealed, and finally sterilized.

[0037] In step S2, the separation and purification include ethanol precipitation of filtrate, solid washing, and ethanol recovery of filtrate. In step S4, after the carrier 1 is soaked, it is ensured that the matrix layer 2 is uniformly covered without any local gaps. The fermentation culture in step S2 is temperature-controlled fermentation, and high-temperature treatment is avoided during the fermentation process.

[0038] See again Figure 3In this embodiment, the eye patch is composed of a plant fiber carrier and a matrix layer. The matrix layer is loaded on the surface of the carrier and contains an active ingredient controlled-release foam coating and excipients. The two are mixed in a preset ratio to form an intelligent rheological regulator. The active ingredient controlled-release foam coating is based on fermented herbal extracts. The fermented herbs are selected from at least one of cassia seed, wolfberry, ginseng, salvia miltiorrhiza, chrysanthemum, scutellaria baicalensis, polygonatum sibiricum, and phellodendron amurense. They are prepared by fermentation with plant lactic acid bacteria, Bacillus subtilis, or yeast. The excipients include hyaluronic acid, menthol, carboxymethyl cellulose, and glycerin. The components work synergistically to improve transdermal absorption efficiency and moisturizing and anti-inflammatory effects, which is suitable for the care needs of eye fatigue and dry eye syndrome.

[0039] The carrier is made of plant fiber material, which is closely attached to the matrix layer and is the basic supporting component of the eye patch. The plant fiber has a natural porous structure and a large specific surface area, which can fully adsorb the intelligent rheological regulator, ensuring that the matrix layer is evenly covered without local gaps, and ensuring the stable release of active ingredients.

[0040] Plant fibers offer excellent biocompatibility, causing no irritation to sensitive skin around the eyes. They are highly breathable and moisture-wicking, preventing stuffiness even after prolonged wear and keeping the skin around the eyes dry. They possess a certain degree of tensile strength and mechanical strength, resisting breakage and deformation in both dry and wet states. The gel shedding rate is low after soaking, making them suitable for different eye shapes. They comprehensively cover key areas around the eyes, ensuring full contact between the matrix layer and the skin, allowing active ingredients to be evenly applied to the target area.

[0041] The matrix layer is the core of the eye patch's care efficacy. It is formed by mixing active ingredient controlled-release foam and excipients in a preset ratio to create an intelligent rheological control body. After being soaked in the carrier, it is shaped, combining efficacy and stability. The proportions of each component strictly follow the preset range to ensure efficacy and user experience.

[0042] The active ingredient controlled-release vesicle coating is based on fermented herbal extracts. The fermented herbs are selected from at least one of the following: cassia seed, wolfberry, ginseng, salvia miltiorrhiza, chrysanthemum, scutellaria baicalensis, polygonatum sibiricum, and phellodendron amurense. The preferred combination is 40% cassia seed, 25% wolfberry, 20% chrysanthemum, and 15% polygonatum sibiricum. The various herbs work together to exert the effects of improving eyesight, anti-oxidation, anti-inflammation, and promoting blood circulation.

[0043] Fermented medicinal materials need to be washed, mixed, and crushed to a particle size of 40-80 mesh. Then, deionized water is added at a mass ratio of medicinal materials to water of 1:8 to 1:15. 1%-3% oligosaccharides can be added as a fermentation promoter to improve fermentation efficiency.

[0044] The fermentation strains include plant lactic acid bacteria, Bacillus, and yeast. The inoculum amount is calculated based on the dry weight of the medicinal materials, with the plant lactic acid bacteria inoculum amount being 1×10⁻⁶. 6 ~1×10 8 CFU / g of medicinal material, Bacillus subtilis content is 1×10 5 ~1×107 CFU / g of medicinal material, yeast content is 1×10 5 ~1×10 7 CFU / g of medicinal material. A preferred compound fermentation mode is used: first, yeast is inoculated for fermentation for 24-48 hours, then plant lactic acid bacteria are inoculated for further fermentation for 48-72 hours, synergistically producing richer active metabolites.

[0045] The fermentation process employs temperature control to avoid high temperatures damaging heat-sensitive components. Different strains of bacteria correspond to different fermentation temperatures: plant lactic acid bacteria fermentation temperature is 35-37℃, Bacillus 28-32℃, and yeast 25-28℃. After fermentation, the medicinal materials are separated, purified, and dried to obtain fermented medicinal material extracts. The extracts account for 5% to 15% of the matrix layer.

[0046] The excipients and fermented herbal extracts are scientifically compounded to enhance the nursing efficacy and ensure the stability of the matrix layer. The proportions of each excipient are clearly defined, and they work synergistically.

[0047] Finally, see Figure 3 In this embodiment, the minimum ratio The core active ingredient is a 5% fermented herbal extract, derived from a complex fermentation process of 40% cassia seed, 25% goji berry, 20% chrysanthemum, and 15% polygonatum. Sodium hyaluronate accounts for 0.5%, synergistically moisturizing, enhancing skin hydration, and promoting the penetration of active ingredients. Menthol accounts for 0.1‰, providing a cooling and soothing effect, relieving eye burning sensations, and aiding blood circulation. Sodium carboxymethyl cellulose accounts for 0.5‰, acting as a film-forming agent to ensure the stability of the matrix layer and prevent gel dripping. Glycerin accounts for 8%, providing deep moisturizing, replenishing stratum corneum moisture, and reducing moisture loss around the eyes. Deionized water accounts for 85.4%, acting as a solvent to regulate the concentration of the matrix system and ensure uniform dispersion of all components. Natural borneol accounts for 0.1‰.

[0048] Pretreatment of medicinal materials: Grind to 60 mesh (mid-range value within the range of 40-80 mesh), add deionized water at a mass ratio of 1:11 (mid-range value of 1:8~1:15), and add 2% fructooligosaccharide (mid-range value of 1%-3%) as a fermentation promoter.

[0049] Fermentation process: A compound fermentation mode is adopted, first inoculating with yeast (inoculation amount 5×10). 6 CFU / g medicinal material, 1×10 5 ~1×10 7 CFU / g median), ferment at 30℃ for 36 hours (median of 24-48 hours), then inoculate with plant lactic acid bacteria (inoculation amount 5×10). 7 CFU / g medicinal material, 1×10 6 ~1×10 8(CFU / g median value), anaerobic fermentation at 37℃ for 60 hours (intermediate value of 48-72 hours).

[0050] Post-processing: After filtration of the fermentation broth, precipitation with 70% ethanol was performed, the supernatant was collected, the ethanol was recovered, and the extract powder was freeze-dried. The components were dissolved in deionized water and stirred evenly to form an intelligent rheology regulator. The plant fiber carrier was soaked, cut, packaged, and sterilized to obtain the finished product.

[0051] Regarding transdermal absorption, the transdermal absorption rate reached 35% after 24 hours, and the transdermal transdermal rate of rhein was 12.5 μg / (cm²). (h) The small molecule active ingredients can penetrate quickly. In terms of moisturizing effect, the skin moisture content increases by 40% after 1 hour of use, and the stratum corneum moisture content stabilizes at 45% after 28 days, with a 30% reduction in water loss rate. It has a significant effect on relieving eye fatigue. After 14 days of continuous use, the scores for dryness, soreness, and blurred vision decreased to 1.5, 1.3, and 1.2 respectively, with a total effective rate of 93.3%. It has excellent safety performance, with a skin irritation score of 0, no redness or itching, a total bacterial count ≤10 CFU / g, no pathogenic bacteria, and is practically non-toxic.

[0052] Example 3 (Intermediate Value Ratio) The core active ingredient is a 10% fermented herbal extract, derived from a complex fermentation process of 40% cassia seed, 25% goji berry, 20% chrysanthemum, and 15% polygonatum. Sodium hyaluronate accounts for 1.5%, synergistically moisturizing, enhancing skin hydration, and promoting the penetration of active ingredients. Menthol (0.45‰) provides a cooling and soothing effect, relieving eye burning and aiding blood circulation. Sodium carboxymethyl cellulose (2.5‰) acts as a film-forming agent, ensuring the stability of the matrix layer and preventing gel flow. Glycerin (11.5%) and natural borneol (0.45‰) provide deep moisturizing, replenishing the stratum corneum and reducing moisture loss around the eyes. Deionized water (74.05%) acts as a solvent, adjusting the concentration of the matrix system and ensuring uniform dispersion of all components.

[0053] Completely consistent with Example 1, namely, the medicinal materials were pulverized to 60 mesh, the material-to-liquid ratio was 1:11, 2% fructooligosaccharides were added, the same compound fermentation process and inoculation amount were used, and the post-processing process was also kept consistent, only the proportions of each component were adjusted to the midpoint of the range.

[0054] The transdermal absorption effect is stable, with a 24-hour transdermal absorption rate of 40% and a transdermal transdermal rate of 12.6 μg / (cm²). (h) The small molecule active ingredients have good penetration efficiency. In terms of moisturizing, the skin moisture content increased by 48% after 1 hour of use, and the stratum corneum moisture content stabilized at 47% after 28 days, with a 34% reduction in water loss rate. It has a significant effect on relieving eye fatigue. After 14 days of continuous use, the scores for dryness, soreness, and blurred vision decreased to 1.4, 1.2, and 1.1 respectively, with a total effective rate of 93.3%. It is safe and reliable, with a skin irritation score of 0, no redness or itching, a total bacterial count ≤10 CFU / g, no pathogenic bacteria, and is practically non-toxic.

[0055] Example 4 (Maximum Ratio) The core active ingredient is a 15% fermented herbal extract, derived from a complex fermentation process of 40% cassia seed, 25% goji berry, 20% chrysanthemum, and 15% polygonatum. Sodium hyaluronate accounts for 2.5%, synergistically moisturizing, enhancing skin hydration, and promoting the penetration of active ingredients. Menthol accounts for 0.5‰, providing a cooling and soothing effect, relieving eye burning sensations, and aiding in blood circulation. Sodium carboxymethyl cellulose accounts for 1‰, acting as a film-forming agent to ensure the stability of the matrix layer and prevent gel flow. Glycerin accounts for 15%, providing deep moisturizing, replenishing stratum corneum moisture, and reducing moisture loss around the eyes. Natural borneol accounts for 0.5‰, and deionized water accounts for 62.7%, acting as a solvent to adjust the concentration of the matrix system and ensure uniform dispersion of all components.

[0056] Completely consistent with Examples 1 and 2, with no difference in the pretreatment of medicinal materials, fermentation process, inoculation amount, post-treatment and molding process, only the proportions of each component were adjusted to the maximum value within the range.

[0057] Transdermal absorption is sufficient, with a 45% transdermal absorption rate after 24 hours, and the transdermal transdermal rate of rhein is 12.7 μg / (cm²). (h) The small molecule active ingredients can fully penetrate, resulting in excellent moisturizing effects. After 1 hour of use, skin moisture content increased by 55%, and after 28 days, the stratum corneum moisture content stabilized at 50%, with a 38% reduction in water loss. It also significantly relieved eye fatigue. After 14 days of continuous use, the scores for dryness, soreness, and blurred vision decreased to 1.3, 1.1, and 1.0 respectively, with a total effective rate of 93.3%. Safety is guaranteed, with a skin irritation score of 0, no redness or itching, a total bacterial count ≤10 CFU / g, no pathogenic bacteria, and practically non-toxic. Working principle: The composition, eye patch and preparation method thereof for preventing and treating dry eyes, blurred vision, eye fatigue and dry eye syndrome. Before using the eye patch, clean the skin around the eyes with warm water to remove eye makeup, dust and oil, and ensure that the skin around the eyes is clean and refreshed, so as to avoid impurities affecting the absorption of the controlled-release foam coating of the active ingredient in the matrix layer 2.

[0058] Open the packaging, take out the eye patch, and apply the side with the load matrix layer 2 to the skin around the eyes. Adjust the position to ensure that the eye patch completely covers the target area around the eyes and adheres tightly to the skin without bubbles or wrinkles.

[0059] Maintain the eye patch on for an appropriate time to allow the controlled-release foam coating of active ingredients to fully penetrate the skin and exert its skincare effects. During the application process, you can gently press the eye patch to enhance its adhesion to the skin and promote ingredient absorption.

[0060] After the application time is up, gently peel off the eye patch. There is no need to wash the skin around your eyes; allow the remaining small amount of gel to be absorbed naturally. If the skin around your eyes feels sticky, you can gently wipe it off with a clean tissue. You can then apply eye cream or other skincare products as needed to further enhance the skincare effect.

[0061] Do not use if there is any damage, inflammation, or allergy to the skin around the eyes, as this may irritate the skin and worsen symptoms. If you experience any discomfort such as stinging, redness, swelling, or itching during use, remove the eye patch immediately and rinse the skin around your eyes with clean water. Consult a doctor if necessary. The eye patch is for single use only and should not be reused to avoid cross-contamination. Keep it away from children during storage to prevent accidental ingestion or misuse. Avoid contact between the base layer 2 of the eye patch and the inside of the eye. If the patch accidentally gets into the eye, rinse immediately with plenty of water and seek medical attention if necessary.

[0062] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A composition and eye patch for preventing and treating dry eyes, blurred vision, eye strain, and dry eye syndrome, characterized in that, include: Carrying body (1); A matrix layer (2) is loaded on the surface of a carrier (1) and the matrix layer (2) includes an active ingredient controlled-release foam coating and excipients. The controlled-release vesicle coating of the active ingredient includes fermented herbal extracts, wherein the fermented herbal extracts are selected from at least one of cassia seed, wolfberry, ginseng, salvia miltiorrhiza, chrysanthemum, scutellaria baicalensis, polygonatum sibiricum, and phellodendron amurense, with cassia seed accounting for 40%, wolfberry for 25%, chrysanthemum for 20%, and polygonatum sibiricum for 15%; Fermented herbal extracts: 5%~15%; Hyaluronic acid (sodium): 0.5%~2.5%; Menthol: 0.1‰~0.5‰, Sodium carboxymethyl cellulose: 0.5‰~1‰, Glycerin: 8%~15%, Natural borneol: 0.1‰-0.5‰; Deionized water: Fermented herbal extracts (5%-15%), which, through microbial fermentation, make the large molecular active substances in the herbs (such as polysaccharides and flavonoid aglycones) more easily absorbed by the skin and mucous membranes; and The fermented medicinal material extract is prepared by fermentation with plant lactic acid bacteria, Bacillus, or yeast. Fermentation strain inoculation ratio (based on the dry weight of medicinal materials): Plant lactic acid bacteria (e.g., Lactobacillus plantarum): inoculation amount is 1×10 6 ~1×10 8 CFU / g of medicinal materials; Bacillus subtilis (e.g., Bacillus subtilis): Inoculum size 1×10⁻⁶ 5 ~1×10 7 CFU / g of medicinal material, yeast (e.g., Saccharomyces cerevisiae): inoculum size 1×10 5 ~1×10 7 CFU / g of medicinal materials; Preferred compound fermentation mode: Two-step fermentation using plant lactic acid bacteria and yeast. First, yeast is inoculated and fermented for 24-48 hours, then plant lactic acid bacteria are inoculated and fermented for another 48-72 hours. This can synergistically enhance the effect and produce richer active metabolites. Ratio of medicinal materials to culture medium: Particle size of medicinal materials: 40-80 mesh; mass ratio of medicinal materials to water: 1:8~1:15; 1%-3% oligosaccharides (such as fructooligosaccharides) can be added as fermentation promoters.

2. The composition and eye patch for preventing and treating dry eyes, blurred vision, and eye strain and dry eye syndrome according to claim 1, characterized in that, The carrier (1) is a plant fiber carrier (1), and the carrier (1) is closely attached to the matrix layer (2).

3. The composition and eye patch for preventing and treating dry eyes, blurred vision, and eye strain and dry eye syndrome according to claim 2, characterized in that, In the matrix layer (2), fermented herbal extract, hyaluronic acid, menthol, carboxymethyl cellulose, and glycerin are mixed in a preset ratio to form an intelligent rheology regulator, which is then soaked in the carrier (1) to form a fermented herbal extract: 6%~15% hyaluronic acid (sodium): 0.6%~2.6%; Menthol: 0.2‰~0.4‰, Sodium carboxymethyl cellulose: 0.5‰~1‰, Glycerin: 9%~16%, Natural borneol: 0.1‰-0.5‰, Deionized water: Fermented herbal extract (6%-16%).

4. The composition and eye patch for preventing and treating dry eyes, blurred vision, and eye strain and dry eye syndrome according to claim 3, characterized in that, The preparation of the fermented medicinal material extract includes the following steps: crushing the medicinal material, mixing, inoculating with microorganisms, fermentation culture, separation and purification, and drying.

5. The composition and method for preparing the eye patch for preventing and treating eye strain, blurred vision, and dry eye syndrome according to any one of claims 1-4, characterized in that, Includes the following steps: S1: Fermentation bacteria activation: Plant lactic acid bacteria, Bacillus or yeast are inoculated into the culture medium and activated to obtain bacterial seed liquid; S2: Traditional Chinese medicine fermentation involves washing, mixing, and crushing selected medicinal materials, adding water and sterilizing, inoculating with inoculum seed liquid for fermentation culture, filtering, separating, purifying and drying to obtain fermented medicinal material extract; S3: Preparation of intelligent rheology regulator: Fermented herbal extracts, hyaluronic acid, menthol, carboxymethyl cellulose, and glycerin are dissolved in deionized water and mixed evenly to form an intelligent rheology regulator; 8%~16% hyaluronic acid (sodium): 0.9%~2.9%; Menthol: 0.3‰~0.5‰, Sodium carboxymethyl cellulose: 0.5‰~1‰, Glycerin: 10%~17%, Natural borneol: 0.1‰-0.5‰, Deionized water: Fermented herbal extract (7%-17%). S4: Loading and molding, immersing the plant fiber carrier (1) in the intelligent rheological regulator, so that the matrix layer (2) is uniformly loaded on the surface of the carrier (1); S5: Sterilization packaging. The pre-cut plant fibers are placed in bags, then filled with the liquid medicine, then sealed, and finally sterilized.

6. The composition and method for preparing the eye patch for preventing and treating dry eyes, blurred vision, and eye fatigue and dry eye syndrome according to claim 5, characterized in that, In step S2, the separation and purification process includes ethanol precipitation of the filtrate, solid washing, and ethanol recovery from the filtrate.

7. The composition and method for preparing the eye patch for preventing and treating dry eyes, blurred vision, and eye fatigue and dry eye syndrome according to claim 6, characterized in that, In step S4, after the carrier (1) is soaked, ensure that the matrix layer (2) is uniformly covered without any local gaps.

8. The composition and method for preparing the eye patch for preventing and treating dry eyes, blurred vision, and eye fatigue and dry eye syndrome according to claim 7, characterized in that, The fermentation culture in step S2 is a temperature-controlled fermentation, and high-temperature treatment is avoided during the fermentation process.

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