Traditional Chinese medicine composition for treating allergic rhinitis, external oiling agent as well as preparation method and application of external oiling agent

Abstract

The invention discloses a traditional Chinese medicine composition for treating allergic rhinitis, an external oiling agent as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5 to 15 parts of herba asari, 15 to 25 parts of cortex phellodendri, 15 to 25 parts of herba ephedrae, 10 to 18 parts of rhizoma chuanxiong, 15 to 25 parts of muskmelon pedicel, 10 to 18 parts of radix sophorae flavescentis, 10 to 18 parts of flos magnoliae, 25 to 35 parts of fructus mume, 15 to 25 parts of calcined oyster shell, 55 to 65 parts of periostracum cicada, 15 to 25 parts of cortex moutan and 5 to 15 parts of mentholum. According to the formula, flos magnoliae, herba asari and herba ephedrae are taken as monarch drugs, periostracum cicada and fructus mume are taken as ministerial drugs, cortex phellodendri, rhizoma chuanxiong, radix sophorae flavescentis, muskmelon pedicel, calcined oyster shell and cortex moutan are taken as adjuvant drugs, mentholum is taken as a conductant drug, the drugs are guided to move upwards, and a compound structure capable of dispelling wind, opening orifices, clearing heat, drying dampness, astringing lung and resisting allergy is formed. According to the core pathology of the allergic rhinitis, orifice opening and anti-allergy are combined, flos magnoliae, periostracum cicada and smoked plum form an orifice opening-anti-allergy-lung astringing chain, and the traditional Chinese medicine is suitable for phlegm-heat congestion type allergic rhinitis and is short in time, quick in effect, low in cost and high in cure rate.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine pharmaceutical preparation, and particularly relates to a traditional Chinese medicine composition for treating allergic rhinitis and application thereof. Background Art

[0002] Allergic rhinitis, also known as allergic rhinitis, refers to a non-infectious inflammatory disease of the nasal mucosa, which is caused by the release of mediators (mainly histamine) mediated by IgE after an atopic individual comes into contact with an allergen, and involves the participation of a variety of immune active cells and cytokines. The typical symptoms of allergic rhinitis are mainly paroxysmal sneezing, clear nasal discharge, nasal congestion and nasal itching, and some are accompanied by loss of smell. At present, the following methods are mainly used to treat allergic rhinitis: (1) avoid contact with allergens; (2) drug treatment; (3) immunotherapy; (4) surgical treatment. Among them, drug treatment is currently an important treatment method, and its commonly used drugs are mostly Western medicine, such as antihistamines, glucocorticoids, anti-leukotriene drugs, etc. Western medicine treatment can temporarily relieve symptoms after taking it, but it has the disadvantages of being easily dependent, drug-resistant and having large adverse reactions. Chinese patent medicines include Tongqiao Rhinitis Capsules, Tongqiao Rhinitis Granules, Rhinitis Drops, Rhinitis Tablets, Tongqiao Rhinitis Water, Qianbai Rhinitis Tablets, etc. After use, patients will have certain side effects to a greater or lesser extent, and long-term use can easily lead to drug-induced rhinitis.

[0003] Traditional Chinese Medicine (TCM) has a long history of treating allergic diseases. Allergic rhinitis, classified as "allergic rhinitis" in TCM, is often caused by deficiency of the lungs, spleen, and kidneys, invasion of the nasal passages by wind, cold, foreign air, or obstruction by phlegm, dampness, and blood stasis. Treatment typically focuses on invigorating qi and strengthening the exterior, dispelling wind and opening the orifices, and combating allergies. Research has shown that TCM, through syndrome differentiation and treatment, combining disease identification with syndrome differentiation, holistically regulates the patient's body, improves allergic constitutions, and enhances resistance. This approach boasts significant efficacy, minimal side effects, and a high safety profile, avoiding issues such as drug resistance and residual drug residues.

[0004] CN 119857122 A discloses a Chinese medicine composition for treating allergic rhinitis and a preparation method thereof. The Chinese medicine composition comprises the following raw materials in parts by weight: 5-50 parts of Atractylodes lancea, 5-50 parts of Sinapis alba seeds, 5-50 parts of cinnamon bark, 5-50 parts of cassia twig, 5-50 parts of Atractylodes macrocephala, 5-50 parts of Peucedanum chinense, 5-50 parts of Perilla seeds, 3-10 parts of Asarum, 5-50 parts of Schisandra chinensis, 5-50 parts of Morus alba, 5-50 parts of Cornus officinalis, 5-50 parts of Ligustrum lucidum fruits, 5-50 parts of White ginseng, and 5-50 parts of Coltsfoot root. The Chinese medicine composition provided by the present invention has abundant raw materials, a simple production process (traditional decoction method), is stable and reliable, and has good therapeutic effect.

[0005] CN 119770614 A discloses a Chinese medicine composition for treating allergic rhinitis, which comprises the following raw materials in parts by weight: 6-30 parts of mulberry leaves, 6-30 parts of chrysanthemums, 1-9 parts of ginseng, 10-30 parts of jujubes, 3-10 parts of ginger, 3-10 parts of liquorice, 10-30 parts of astragalus, 3-12 parts of angelica, 6-15 parts of ophiopogon, 1-6 parts of kudzu root, 3-12 parts of angelica, 3-9 parts of mint, and 3-10 parts of platycodon. The preparation method of the Chinese medicine composition comprises the following steps: step 1) respectively preparing the following ingredients according to the formula of the formula: The raw materials are taken in parts by weight and soaked in water for 1 hour; step 2) boiling the mixture twice with 400-900 parts by volume of water added each time, boiling the mixture over high heat for the first time and boiling the mixture over low heat for the second time, and combining the decoctions; step 3) adding pharmaceutically acceptable adjuvants according to conventional processes to prepare clinically acceptable granules, pills, tablets, powders or capsules; the traditional Chinese medicine composition has anti-allergic, anti-inflammatory, antibacterial and other effects, and can relieve symptoms such as nasal congestion, runny nose, and sneezing in patients with allergic rhinitis.

[0006] Although the above-mentioned traditional Chinese medicine therapies have the advantages of being safe, reliable, having few side effects, having sustained efficacy, and reducing recurrence, the orally taken drugs are metabolized and absorbed by the gastrointestinal tract and flow through the whole body before being concentrated in the lesions. They are slow in effect and have side effects.

[0007] CN 117244000 A discloses a traditional Chinese medicine composition for treating rhinitis, its preparation method, and its use, belonging to the field of medical pharmaceutical technology. The present invention provides a traditional Chinese medicine composition for treating rhinitis, comprising ingredients including honeycomb, black plum pulp, pomegranate peel, sophora flavescens, bitter clove, white mustard seed, borax, alum, borneol, cassia twig, cuttlebone, dandelion, genkwa, asarum, and cimicifuga. The traditional Chinese medicine composition provided by the present invention can reduce toxic and side effects and synergistically enhance the therapeutic effect on rhinitis. It has excellent efficacy for nasal concha hypertrophy, various sinusitis, allergic rhinitis, and nasal polyps. This prescription is suitable for patients with multiple rhinitis types, but is not suitable for patients with simple allergic rhinitis with clear symptoms.

[0008] Therefore, there is an urgent need to develop a Chinese medicine preparation and treatment method for treating allergic rhinitis that has good efficacy, rapid effect, high safety and strong pertinence to improve the quality of life of patients. Summary of the Invention

[0009] In response to the problems of existing Western medicines for treating allergic rhinitis, such as the human body's dependence on and resistance to drugs and adverse reactions, the long-term use of Chinese patent medicines that easily lead to drug-induced rhinitis, the slow efficacy and side effects of traditional Chinese medicine preparations, and the lack of targeted Chinese medicine compositions for allergic rhinitis, the present invention provides a targeted Chinese medicine composition for the treatment of allergic rhinitis, an external ointment, and its preparation method and use. Allergic rhinitis is classified as "nasal drip" in Traditional Chinese Medicine and is mostly caused by deficiency of the lungs, spleen, and kidneys, invasion of the nasal cavity by wind-cold and foreign air, or obstruction by phlegm and blood stasis. Treatment is usually based on invigorating qi and strengthening the exterior, dispelling wind and opening the orifices, and anti-allergic treatment.

[0010] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0011] A traditional Chinese medicine composition for treating allergic rhinitis is composed of the following raw materials in parts by weight: 5-15 parts of asarum, 15-25 parts of phellodendron, 15-25 parts of ephedra, 10-18 parts of chuanxiong, 15-25 parts of melon stalks, 10-18 parts of sophora flavescens, 10-18 parts of magnolia, 25-35 parts of ebony plums, 15-25 parts of calcined oyster shells, 55-65 parts of cicada shells, 15-25 parts of moutan bark, and 5-15 parts of ice mint.

[0012] As a preferred technical solution of the present invention, the traditional Chinese medicine composition for treating allergic rhinitis is composed of the following raw materials in parts by weight: 8-12 parts of asarum, 18-22 parts of phellodendron, 18-22 parts of ephedra, 13-16 parts of chuanxiong, 18-22 parts of melon stalks, 13-16 parts of sophora flavescens, 14-17 parts of magnolia, 28-32 parts of ebony, 18-22 parts of calcined oyster shell, 58-62 parts of cicada shell, 18-22 parts of moutan bark, and 8-12 parts of mint ice.

[0013] As a preferred technical solution of the present invention, the traditional Chinese medicine composition for treating allergic rhinitis is composed of the following raw materials in parts by weight: 10 parts of asarum, 20 parts of phellodendron, 20 parts of ephedra, 15 parts of chuanxiong, 20 parts of melon stalks, 15 parts of sophora flavescens, 15 parts of magnolia, 30 parts of ebony, 20 parts of calcined oyster, 60 parts of cicada shell, 20 parts of moutan bark, and 10 parts of mint ice.

[0014] The present invention also provides the use of the Chinese medicine composition for treating allergic rhinitis in preparing a medicament for preventing and / or treating allergic rhinitis. The medicament further comprises a pharmaceutically acceptable excipient, such as sesame oil.

[0015] An external oil for treating allergic rhinitis is prepared by adopting the traditional Chinese medicine composition for treating allergic rhinitis.

[0016] The present invention also provides a preparation method of an external oil for treating allergic rhinitis, comprising the following steps: firstly, preparing muskmelon stems with vinegar (to reduce their toxicity and enhance their astringency), then, carefully picking and removing impurities from phellodendron chinense, chuanxiong, sophora flavescens, black plum, calcined oyster shell, cicada shell, and moutan bark, drying them in the sun, and then, airtightly soaking the muskmelon stems with an appropriate amount of sesame oil for 7 days, pouring the mixture into a temperature-controlled machine frying pan, firstly heating the oil to 160-180°C over medium heat, boiling the oil for 15-20 minutes, simmering the oil over low heat at 75-85°C for three days, adjusting the heat to 55-65°C, and simmering the oil for another three days, then adding asarum, magnolia flower, and ephedra that have been carefully picked and removed of impurities, simmering the oil for 30 minutes, filtering, and, when the oil temperature reaches 30-40°C, adding an appropriate amount of mint, and sealing the container.

[0017] Preferably, the amount of sesame oil is 2-4 times that of the traditional Chinese medicine composition in parts by weight.

[0018] Preferably, when used, the solution is dispensed into 5 ml, 10 ml, etc. glass dropper bottles and then sterilized for nasal dripping.

[0019] The method of use of the present invention is to drop 1-2 drops into each nostril on the upturned face, apply 4-6 times a day, keep it in the nasal cavity for about 10 minutes and then blow it out.

[0020] It should be noted that the medicine for treating sinusitis prepared according to the traditional Chinese medicine composition for treating allergic rhinitis of the present invention can be prepared into a variety of dosage forms by adding pharmaceutically acceptable excipients, not limited to oils, but also aqueous solutions, ointments, etc.

[0021] The efficacy of each component of the Chinese medicine composition for treating allergic rhinitis of the present invention:

[0022] Asarum: pungent and warm, enters the lung and kidney meridians, can dispel wind and cold, open the orifices and relieve pain, and is often used for nasal congestion and rhinitis.

[0023] Huang Bai: bitter and cold, enters the kidney and bladder meridians, clears heat and dampness, purges fire and detoxifies, used for internal accumulation of damp heat.

[0024] Ephedra: Pungent, slightly bitter and warm, enters the lung and bladder meridians, induces sweating and relieves exterior symptoms, promotes lung function and relieves asthma, promotes diuresis and reduces swelling, and can open the nasal passages.

[0025] Chuanxiong: Pungent and warm, enters the Liver, Gallbladder, and Pericardium meridians, promotes blood circulation and Qi, dispels wind and relieves pain, and may be used to improve nasal Qi and blood.

[0026] Melon stem: bitter and cold, slightly toxic, enters the stomach meridian, and is used to expel phlegm and dampness, and to remove phlegm and turbidity in the nose.

[0027] Sophora flavescens: bitter and cold, enters the heart, liver, stomach and bladder meridians, clears heat and dampness, kills insects and promotes diuresis, and is used for damp-heat.

[0028] Magnolia: pungent and warm, enters the lung and stomach meridians, dispels wind and cold, and clears the nasal passages. It is often used for sinusitis.

[0029] Black plum: sour, astringent and neutral, enters the liver, spleen, lung and large intestine meridians, astringes the lungs and relieves cough, astringes the intestines and stops diarrhea, promotes fluid production and quenches thirst, and may be used to astringe lung qi.

[0030] Calcined oyster: salty, astringent and slightly cold, enters the liver and kidney meridians, calms the liver and suppresses yang, astringes and consolidates, reduces acidity and relieves pain, used for calming the mind or astringing.

[0031] Cicada shell: sweet and cold, enters the lung and liver meridians, dispels wind-heat, relieves sore throat and rashes, removes cataracts and improves eyesight, used for anti-allergy and relief of nasal itching.

[0032] Cortex Moutan: bitter, pungent and slightly cold, enters the Heart, Liver and Kidney meridians, clears heat and cools blood, promotes blood circulation and removes blood stasis, used for blood heat or blood stasis.

[0033] Peppermint ice: also known as peppermint oil, it is pungent and cool, enters the lung and liver meridians, dispels wind-heat, clears the head and eyes, relieves sore throat and rashes, and may be used to relieve nasal congestion and headaches.

[0034] The Chinese medicine composition for treating allergic rhinitis and the external application ointment thereof provided by the present invention are based on the compatibility principle of "monarch, minister, assistant and envoy", and the formula thereof is explained as follows:

[0035] This prescription uses magnolia, asarum, and ephedra as the main herbs, cicada shell and black plum as the auxiliary herbs, phellodendron, chuanxiong, sophora flavescens, (vinegar) melon pedicle, calcined oyster shell, and moutan bark as the adjuvant herbs, and mint ice as the guiding herb. This formula promotes the upward movement of the herbs, creating a complex structure that "dispels wind, clears heat, dries dampness, and strengthens the lungs to combat allergies." It is suitable for allergic rhinitis caused by phlegm-heat congestion, but should be avoided for deficiency-cold syndromes.

[0036] Junyao (Junyao): The main herb targeting the primary symptom. The primary symptoms of allergic rhinitis are nasal congestion, runny nose, and sneezing, often related to cold and allergies. Asarum, magnolia, and ephedra are all nasal clearing herbs. Asarum is warm in nature, dispelling cold and clearing the orifices; magnolia is warm in nature, effectively clearing the nasal passages; and ephedra is pungent, slightly bitter, and warm in nature, promoting lung function and clearing the orifices. These herbs are considered Junyao (Junyao).

[0037] Assistant herbs: Assist the main herbs to enhance their efficacy. Plum blossoms nourish the lungs, reduce mucus secretions, and alleviate excessive nasal mucosal secretions. Cicada shells dispel wind and relieve itching, fighting allergies and relieving nasal itching and sneezing.

[0038] Adjuvant: Assisting or assisting. Phellodendron chinense and Sophora flavescens clear heat and dry dampness; Chuanxiong promotes blood circulation and qi, guiding drugs upward, improving nasal qi and blood stasis and promoting local drug absorption; vinegar-sweet melon stems penetrate the skin, promoting drug penetration, assisting in opening the orifices, and expels phlegm and dampness, and can be used for expectoration; calcined oyster is astringent and used to reduce secretions; and red peony root cools blood and promotes blood circulation, potentially treating blood heat.

[0039] Guiding drug: Guiding or harmonizing. Peppermint ice, as a guiding drug, cools and relieves itching, dispels wind-heat, and is used to relieve nasal congestion. It guides the drug upward to the nasal passages.

[0040] Drug compatibility and indications. Allergic rhinitis is often associated with wind-evil, phlegm-dampness, and allergies. Prescriptions often incorporate herbs that dispel wind (cicada shell, ephedra, asarum), open the orifices (magnolia, Chuanxiong), and clear heat and dampness (Phellodendron amurense, Sophora flavescens), effectively targeting either wind-heat or phlegm-heat syndromes. Black plum and calcined oyster are astringent and are used to reduce nasal discharge.

[0041] 1. Monarch Drug (Core Drug for Main Symptom)

[0042] Magnolia's effects: It is pungent, warm, and dispersing, clearing the nasal passages and dispelling wind and cold. It is the main herb for treating sinusitis (allergic rhinitis). Its volatile oil can constrict nasal mucosal blood vessels, reduce secretions, and relieve nasal congestion.

[0043] Effects of Asarum: dispels wind and cold, opens the orifices and relieves pain, and can also warm the lungs and transform fluid. It is suitable for allergic rhinitis of cold and dampness type, and is especially effective for nasal itching and frequent sneezing.

[0044] Significance of compatibility: It works synergistically with magnolia to enhance the power of opening the orifices and can guide the medicine upward to the nasal orifices.

[0045] Ephedra's effects: It clears the lungs and relieves asthma, induces sweating and relieves exterior symptoms, opens the nasal passages, and improves nasal mucosal edema. Modern research shows that ephedrine can constrict nasal mucosal blood vessels, relieving nasal congestion.

[0046] Dosage basis: The largest dosage reflects its core role in clearing the nasal passages.

[0047] Second, assistant medicine (assisting the main medicine to strengthen the treatment of the main symptoms)

[0048] Cicada shells have the following effects: dissipating wind-heat, clearing rashes and relieving itching, and are anti-allergic. Modern pharmacology has confirmed that cicada shells can inhibit histamine release and reduce nasal mucosal inflammation.

[0049] Significance of compatibility: Aiming at the pathogenesis of allergic rhinitis "wind evil hidden heat", it forms a "wind-dispelling-orifice-anti-allergy" triangle with magnolia and ephedra.

[0050] Wumei's benefits: It astringes the lungs and intestines, promotes thirst, and regulates the immune system. Wumei's sour and astringent properties can reduce clear nasal discharge, and modern research shows it contains anti-allergic properties.

[0051] Significance of compatibility: Works together with cicada shells to regulate allergic constitution and prevent the dissipation of lung qi.

[0052] 3. Adjuvant drugs (assisting or restraining the main and auxiliary drugs, treating multiple symptoms)

[0053] Huangbai and Sophora flavescens: Clear away heat and dampness, purge fire and detoxify. They are suitable for allergic rhinitis caused by internal accumulation of damp heat, such as yellow and sticky mucus and red and swollen nasal mucosa.

[0054] Significance of the combination: Clears away latent heat, prevents wind-cold from binding externally and dampness-heat.

[0055] Chuanxiong: Promotes blood circulation and qi, dispels wind and relieves pain. Improves nasal microcirculation, relieves nasal congestion and headaches.

[0056] Significance of the combination: Assists in opening the orifices and preventing "long-term illness from entering the meridians".

[0057] Vinegar Melon Stem Effects: It can induce spitting out phlegm and eliminate nasal mucus. It is suitable for sinusitis with severe phlegm congestion, but be aware of its toxicity and control the dosage.

[0058] Significance of compatibility: For short-term use to "expel turbidity", it is necessary to use a combination of herbs to harmonize the medicinal properties.

[0059] Calcined oyster has the following effects: calming the liver and suppressing yang, astringing and firming, reducing clear nasal discharge and sneezing, and regulating immune function.

[0060] Significance of the combination: restrains the pungent and dispersing nature of ephedra and asarum, and prevents the consumption of qi and damage to yin.

[0061] The effects of Danpi: clearing heat and cooling blood, promoting blood circulation and removing blood stasis, used for blood heat or blood stasis.

[0062] 4. Guiding drugs (leading the meridians or harmonizing the other drugs)

[0063] Mint Ice's effects: It has a pungent and cool effect, clears the head and eyes, and guides the medicine upward to the nasal cavity. It relieves nasal congestion and itching.

[0064] Significance of compatibility: Harmonize the warm and dry nature of the whole formula, so that the medicinal power is concentrated in the nasal cavity.

[0065] 5. Characteristics of the formula: The combination of pungent and warm drugs (magnolia, asarum, ephedra) and cold and cool drugs (phellodendron, sophora flavescens, cicada shell) takes into account the complex pathogenesis of external wind-cold and internal latent heat.

[0066] The beneficial effects of this invention are as follows: This prescription uses magnolia, asarum, and ephedra as the main herbs, directly targeting the nasal passages; cicada shell and black plum as the auxiliary herbs, providing astringency and anti-allergic properties; phellodendron, ligusticum chuanxiong, sophora flavescens, vinegar melon stalk, calcined oyster shell, and moutan bark as the adjuvant herbs, harmonizing the medicinal properties; and mint ice as the guiding herb, guiding the meridians and relieving itching. This creates a compound structure that "dispels wind, clears heat and dampness, and astringes the lungs and combats allergies." This combination of orifice-opening and anti-allergic properties targets the core pathology of allergic rhinitis, combining magnolia, cicada shell, and black plum to form a "orifice-opening-anti-allergic-astringing-lung" chain, making it suitable for allergic rhinitis characterized by phlegm-heat congestion.

[0067] The traditional Chinese medicine composition provided by the invention has a simple processing process, few operating steps, and is easy to prepare.

[0068] The traditional Chinese medicine composition provided by the present invention is simple to use and can be used by one person at home or in a clinic, effectively achieving safe, effective, simple operation, no toxic side effects, a wide range of treatment, no surgery, no injection, no puncture, and no pain, and is short in time, quick in effect, low in cost, and high in cure rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0069] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0070] Figure 1 This is a nasoscopic photo of clinical case 1.

[0071] Figure 2 This is a nasoscopic photo of clinical case 2.

[0072] Figure 3 This is a nasoscopic photo of clinical case 3. DETAILED DESCRIPTION

[0073] The present invention will be further described below with reference to the accompanying drawings and specific examples. It should be understood that the following examples are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. Those skilled in the art may make some non-essential improvements and adjustments based on the contents of the above invention.

[0074] The invention provides a traditional Chinese medicine composition for treating allergic rhinitis. The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 5-15 parts of asarum, 15-25 parts of phellodendron, 15-25 parts of ephedra, 10-18 parts of chuanxiong, 15-25 parts of vinegar melon stems, 10-18 parts of sophora flavescens, 10-18 parts of magnolia, 25-35 parts of ebony plums, 15-25 parts of calcined oyster shells, 55-65 parts of cicada shells, 15-25 parts of moutan bark, and 5-15 parts of iced mint.

[0075] Unless otherwise specified, the present invention has no special limitation on the sources of the raw materials, and any conventional commercially available products in the art can be used.

[0076] In some embodiments, the traditional Chinese medicine composition for treating allergic rhinitis provided by the present invention includes 5-15 parts of asarum, preferably 8-12 parts, and more preferably 10 parts. The dried roots and rhizomes of asarum are used, and the leaves of asarum are not used. It is preferably Liao Xixin. The asarum described in the present invention can dispel wind and cold, open the orifices and relieve pain, and can also warm the lungs and transform fluid. It is suitable for cold and dampness type allergic rhinitis, and is especially effective for nasal itching and frequent sneezing.

[0077] In some embodiments, the traditional Chinese medicine composition for treating allergic rhinitis provided by the present invention comprises 15-25 parts, preferably 18-22 parts, and more preferably 20 parts, of Phellodendron chinense bark, preferably Phellodendron chinense bark. The Phellodendron chinense described in the present invention has the effects of clearing heat and dampness, purging fire and detoxifying, and is suitable for allergic rhinitis caused by internal accumulation of dampness and heat, such as yellow, sticky mucus, and red and swollen nasal mucosa.

[0078] In some embodiments, the Chinese medicine composition provided herein for treating allergic rhinitis comprises 15-25 parts, preferably 18-22 parts, and more preferably 20 parts, of ephedra, with ephedra stems being used instead of ephedra roots. The ephedra described herein has the effects of clearing the lungs and relieving asthma, inducing sweating and relieving exterior symptoms, opening the nasal passages, and improving nasal mucosal edema. Modern research shows that ephedrine can constrict nasal mucosal blood vessels and relieve nasal congestion.

[0079] In some embodiments, the Chinese medicine composition for treating allergic rhinitis provided by the present invention includes 10-18 parts of Chuanxiong, preferably 13-16 parts, and more preferably 15 parts, and is produced in Sichuan. The Chuanxiong described in the present invention has the effects of promoting blood circulation and qi, dispelling wind and relieving pain, improving nasal microcirculation, and relieving nasal congestion and headache. The significance of its compatibility as an adjuvant is to help open the orifices and prevent "long-term disease from entering the meridians."

[0080] In some embodiments, the traditional Chinese medicine composition for treating allergic rhinitis provided by the present invention includes 15-25 parts of melon stems, preferably 18-22 parts, and more preferably 20 parts. (Melon stems are selected and made with vinegar to reduce toxicity. In the present invention, the vinegared melon stems can spit out phlegm and eliminate nasal mucus. It is suitable for sinusitis with severe phlegm congestion, but attention should be paid to toxicity, dosage should be controlled, and short-term use to "remove turbidity" requires compatibility and coordination of medicinal properties.

[0081] In some embodiments, the traditional Chinese medicine composition for treating allergic rhinitis provided by the present invention comprises 10-18 parts, preferably 13-16 parts, and more preferably 15 parts, of Sophora flavescens, with Sophora flavescens selected as the herbal medicine. The Sophora flavescens described in the present invention has the effects of clearing heat and dampness, killing insects and promoting diuresis, and is used for damp-heat syndrome. Its compatibility with Phellodendron chinense is beneficial in clearing away latent heat and preventing wind-cold syndrome accompanied by damp-heat syndrome.

[0082] In some embodiments, the traditional Chinese medicine composition provided herein for treating allergic rhinitis comprises 10-18 parts, preferably 14-17 parts, and more preferably 15 parts, of magnolia buds, using whole, dried flower buds, by weight. In the present invention, magnolia buds have a pungent, warming, and dispersing effect, clearing the nasal passages and dispelling wind and cold, making them a prime agent for treating sinusitis (allergic rhinitis). Their volatile oil can constrict nasal mucosal blood vessels, reduce secretions, and alleviate nasal congestion.

[0083] In some embodiments, the traditional Chinese medicine composition provided herein for treating allergic rhinitis comprises 25-35 parts, preferably 28-32 parts, and more preferably 30 parts, of dried black plums by weight. The black plums described herein have astringent properties that can astringe the lungs and intestines, quench thirst, and regulate immunity. The sour and astringent properties of black plums can reduce clear nasal discharge, and modern research indicates they contain anti-allergic compounds.

[0084] In some embodiments, the traditional Chinese medicine composition provided herein for treating allergic rhinitis includes 15-25 parts, preferably 18-22 parts, and more preferably 20 parts, of calcined oyster shell. The calcined oyster shell, as described herein, calms the liver and suppresses yang, providing astringency and firming properties. It reduces clear nasal discharge and sneezing, and regulates immune function. Its compatibility with other herbs is beneficial: it counteracts the pungent and dispersing properties of ephedra and asarum, preventing the depletion of qi and yin.

[0085] In some embodiments, the present invention provides a traditional Chinese medicine composition for treating allergic rhinitis comprising 55-65 parts, preferably 58-62 parts, and more preferably 60 parts, of cicada shells. In the present invention, the cicada shells can dispel wind-heat, relieve rash and itching, and fight allergies. Modern pharmacology confirms that cicada shells can inhibit histamine release and alleviate nasal mucosal inflammation. As an adjuvant, it, along with magnolia and ephedra, forms a "wind-dispelling, orifice-opening, and allergy-fighting" triangle, targeting the "wind-evil-hidden-heat" pathogenesis of allergic rhinitis.

[0086] In some embodiments, the Chinese medicine composition for treating allergic rhinitis provided by the present invention includes 15-25 parts of moutan bark, preferably 18-22 parts, and more preferably 20 parts. In the present invention, the moutan bark clears heat and cools blood, promotes blood circulation and removes blood stasis, and is used for blood heat or blood stasis.

[0087] In some embodiments, the traditional Chinese medicine composition for treating allergic rhinitis provided herein comprises 5-15 parts, preferably 8-12 parts, and more preferably 10 parts, of mint ice. In the present invention, mint ice has a pungent and cooling effect that penetrates the surface, clears the head and eyes, and guides the drug upward to the nasal cavity. It relieves nasal congestion and itching. As an adjuvant, it can balance the warming and drying properties of the entire formula, concentrating the drug's efficacy in the nasal cavity.

[0088] In some embodiments, the traditional Chinese medicine composition for treating allergic rhinitis provided by the present invention includes 10 parts of asarum, 20 parts of phellodendron, 20 parts of ephedra, 15 parts of chuanxiong, 20 parts of cucurbitacin, 15 parts of sophora flavescens, 15 parts of magnolia, 30 parts of ebony, 20 parts of calcined oyster, 60 parts of cicada shell, 20 parts of moutan bark, and 10 parts of mint ice.

[0089] The present invention provides a traditional Chinese medicine composition for treating allergic rhinitis. This formula comprises magnolia bud, asarum, and ephedra as the main ingredients, cicada shell and black plum as the auxiliary ingredients, phellodendron chinense, ligusticum chuanxiong, sophora flavescens, cucumis melon stem, calcined oyster shell, and moutan bark as the adjuvant ingredients, and mint ice as the guiding ingredient. This formula forms a compound structure that "dispels wind, clears heat, and dampness, and strengthens the lungs and combats allergies." This formula targets the core pathology of allergic rhinitis, combining orifice-opening and anti-allergy effects. The magnolia bud, cicada shell, and black plum form a "orifice-opening-anti-allergy-strengthening" chain, while the cicada shell, magnolia bud, and ephedra form a "wind-clearing-orifice-anti-allergy" triangle mechanism. This formula is effective for allergic rhinitis characterized by phlegm-heat congestion.

[0090] The present invention also provides an external oil prepared by using the above-mentioned traditional Chinese medicine composition for treating allergic rhinitis, comprising the following steps: first, pick and vinegar the melon stems to reduce their toxicity and enhance their astringent effect; then, pick and remove impurities from Phellodendron amurense, Chuanxiong rhizome, Sophora flavescens, Prunus mume, calcined oyster shell, cicada shell, and Cortex Moutan; dry them in the sun; and then, soak them in a proper amount of sesame oil with the vinegar melon stems in a sealed container for 6-8 days; then, pour the mixture into a temperature-controlled machine frying pan; first, heat the oil to 160-180°C over medium heat; after the oil boils for 15-20 minutes, simmer the oil over low heat at 75-85°C for 2-4 days; then, adjust the heat to 55-65°C and simmer for another 2-4 days; then, add the picked and removed impurities of Asarum, Magnolia bud, and Ephedra; simmer for 25-35 minutes, and filter; and when the oil temperature reaches 30-40°C, add mint ice; fill the container and seal it. The amount of sesame oil used is 2-4 times that of the traditional Chinese medicine composition in parts by weight.

[0091] When used, the mixture is divided into 5 ml or 10 ml glass dropper bottles and then sterilized for nasal dripping. The traditional Chinese medicine composition provided by the invention has a simple processing process, few operation steps, and is easy to prepare.

[0092] The present invention provides a method for using the traditional Chinese medicine composition described in the above technical solution, comprising the following steps (taking "Bitongjing health oil" as an example):

[0093] Use a dropper bottle of "Dulitong Nasal Cleansing Health Oil" and drop 1-2 drops into each nostril with your face up, apply 4-6 times a day, keep it in the nasal cavity for about 10 minutes and then blow it out.

[0094] Example 1

[0095] The traditional Chinese medicine composition for treating allergic rhinitis in this embodiment is composed of the following raw materials in parts by weight: 10 parts of asarum, 20 parts of phellodendron, 20 parts of ephedra, 15 parts of ligusticum chuanxiong, 20 parts of melon stalks, 15 parts of sophora flavescens, 15 parts of magnolia, 30 parts of ebony, 20 parts of calcined oyster shell, 60 parts of cicada shell, 20 parts of moutan bark, and 10 parts of mint ice.

[0096] The preparation method of the external-use oil for the treatment of allergic rhinitis of the present embodiment, comprises the following steps: first muskmelon pedicle is made into vinegar (reducing its toxicity, enhancing its astringent effect), then cortex phellodendri, rhizoma chuanxiong, sophora flavescens, ume plum, calcined oyster, pericarp of cicada, cortex moutan are picked up for decontamination, after drying, and appropriate sesame oil (by weight, the consumption of described sesame oil is 3 times of Chinese medicine composition) of vinegar muskmelon pedicle is airtight and soaked for 7 days, pour in the machine frying oil pan of temperature control, first medium heat is heated to 180 ℃, after oil boils 15 minutes, after three days with low fire 80 ℃, be adjusted to 60 ℃ and boil again for three days, then add asarum, flos magnoliae, ephedrae that are picked up for decontamination and boil for 30 minutes and filter, treat that oil temperature 30-40 ℃ adds airtight in appropriate mint ice filling container.Preferably, in use, drip nose after disinfection in glass dropper bottles such as 5 milliliters and 10 milliliters.

[0097] The method of use of the present invention is to drop 1-2 drops into each nostril on the upturned face, apply 4-6 times a day, keep it in the nasal cavity for about 10 minutes and then blow it out.

[0098] Example 2

[0099] The traditional Chinese medicine composition for treating allergic rhinitis of this embodiment is composed of the following raw materials in parts by weight: 9 parts of asarum, 19 parts of phellodendron, 19 parts of ephedra, 14 parts of chuanxiong, 19 parts of melon stalks, 14 parts of sophora flavescens, 15 parts of magnolia, 29 parts of ebony, 19 parts of calcined oyster shell, 59 parts of cicada shell, 19 parts of moutan bark, and 9 parts of mint ice.

[0100] The preparation method of the external-use oil for the treatment of allergic rhinitis of the present embodiment, comprise the following steps: first muskmelon pedicle is vinegar-processed (reducing its toxicity, enhancing its astringent effect), then cortex phellodendri, rhizoma chuanxiong, sophora flavescens, ume plum, calcined oyster, pericarp of cicada, cortex moutan are picked up for impurity removal, after drying, with vinegar muskmelon pedicle, appropriate sesame oil (by weight, the consumption of described sesame oil is 2 times of Chinese medicine composition) is airtight and soaked for 7 days, pour in the machine frying oil pan of temperature control, first medium heat is heated to 160 ℃, after oil boils 20 minutes, after 75 ℃ of boiling 4 days with low fire, be adjusted to 65 ℃ and boil again 2 days, then add the asarum, flos magnoliae, ephedrae that are picked up for impurity removal and boil 25 minutes and filter, treat that oil temperature 30-40 ℃ adds airtight in appropriate mint ice filling container.Preferably, in use, drip nose after disinfection in 5 milliliters, 10 milliliters etc. glass dropper bottles.

[0101] The method of use of the present invention is to drop 1-2 drops into each nostril on the upturned face, apply 4-6 times a day, keep it in the nasal cavity for about 10 minutes and then blow it out.

[0102] Example 3

[0103] The traditional Chinese medicine composition for treating allergic rhinitis of this embodiment is composed of the following raw materials in parts by weight: 10 parts of asarum, 19 parts of phellodendron, 19 parts of ephedra, 14 parts of chuanxiong, 20 parts of melon stalks, 15 parts of sophora flavescens, 16 parts of magnolia, 30 parts of ebony, 20 parts of calcined oyster shell, 60 parts of cicada shell, 20 parts of moutan bark, and 10 parts of mint ice.

[0104] The preparation method of the external-use oil for the treatment of allergic rhinitis of the present embodiment, comprise the following steps: first muskmelon pedicle is vinegar-processed (reducing its toxicity, enhancing its astringent effect), then cortex phellodendri, rhizoma chuanxiong, sophora flavescens, ebony root, calcined oyster, pericarp of cicada, cortex moutan are picked up for impurity removal, after drying, with vinegar muskmelon pedicle, appropriate sesame oil (by weight, the consumption of described sesame oil is 4 times of Chinese medicine composition) is airtight and soaked for 7 days, pour in the machine frying oil pan of temperature control, first medium heat is heated to 170 ℃, after oil boils 20 minutes, after boiling 2 days with low fire 85 ℃, be adjusted to 55 ℃ and boil again 5 days, then add the asarum, flos magnoliae, ephedrae that are picked up for impurity removal and boil 35 minutes and filter, treat that oil temperature 30-40 ℃ adds airtight in appropriate mint ice filling container.Preferably, in use, drip nose after disinfection in glass dropper bottles such as 5 milliliters, 10 milliliters.

[0105] The method of use of the present invention is to drop 1-2 drops into each nostril on the upturned face, apply 4-6 times a day, keep it in the nasal cavity for about 10 minutes and then blow it out.

[0106] Example 4

[0107] The traditional Chinese medicine composition for treating allergic rhinitis of this embodiment is composed of the following raw materials in parts by weight: 11 parts of asarum, 21 parts of phellodendron, 21 parts of ephedra, 16 parts of chuanxiong, 22 parts of melon stalks, 16 parts of sophora flavescens, 16 parts of magnolia, 31 parts of ebony, 21 parts of calcined oyster shell, 61 parts of cicada shell, 21 parts of moutan bark, and 11 parts of mint ice.

[0108] The preparation method and use method of the external oil for treating allergic rhinitis in this embodiment are the same as those in Example 1.

[0109] Example 5

[0110] The traditional Chinese medicine composition for treating allergic rhinitis of this embodiment is composed of the following raw materials in parts by weight: 12 parts of asarum, 22 parts of phellodendron, 22 parts of ephedra, 16 parts of chuanxiong, 22 parts of melon stalks, 16 parts of sophora flavescens, 17 parts of magnolia, 32 parts of ebony, 22 parts of calcined oyster shell, 62 parts of cicada shell, 22 parts of moutan bark, and 12 parts of mint ice.

[0111] The preparation method and use method of the external oil for treating allergic rhinitis in this embodiment are the same as those in Example 1.

[0112] Example 6

[0113] A traditional Chinese medicine composition for treating allergic rhinitis is composed of the following raw materials in parts by weight: 11 parts of asarum, 20 parts of phellodendron, 21 parts of ephedra, 15 parts of chuanxiong, 19 parts of melon stalks, 14 parts of sophora flavescens, 15 parts of magnolia, 30 parts of ebony plums, 22 parts of calcined oyster shells, 60 parts of cicada shells, 20 parts of moutan bark, and 9 parts of mint ice.

[0114] The preparation method and use method of the external oil for treating allergic rhinitis in this embodiment are the same as those in Example 1.

[0115] Example 7

[0116] A traditional Chinese medicine composition for treating allergic rhinitis is composed of the following raw materials in parts by weight: 8 parts of asarum, 18 parts of phellodendron, 18 parts of ephedra, 13 parts of chuanxiong, 18 parts of melon stalks, 13 parts of sophora flavescens, 14 parts of magnolia, 28 parts of ebony plums, 18 parts of calcined oyster shells, 58 parts of cicada shells, 18 parts of moutan bark, and 8 parts of mint ice.

[0117] The preparation method and use method of the external oil for treating allergic rhinitis in this embodiment are the same as those in Example 1.

[0118] Example 8

[0119] A traditional Chinese medicine composition for treating allergic rhinitis is composed of the following raw materials in parts by weight: 12 parts of asarum, 22 parts of phellodendron, 22 parts of ephedra, 16 parts of chuanxiong, 22 parts of melon stalks, 16 parts of sophora flavescens, 17 parts of magnolia, 32 parts of ebony plums, 22 parts of calcined oyster shells, 62 parts of cicada shells, 22 parts of moutan bark, and 12 parts of mint ice.

[0120] The preparation method and use method of the external oil for treating allergic rhinitis in this embodiment are the same as those in Example 1.

[0121] Comparative Example 1

[0122] A traditional Chinese medicine composition for treating allergic rhinitis, the components and preparation method are the same as those in Example 1, except that magnolia florid is not added.

[0123] Treatment effect: There is still a lot of secretions and nasal congestion improves slowly.

[0124] Comparative Example 2

[0125] A traditional Chinese medicine composition for treating allergic rhinitis, the components and preparation method are the same as those in Example 1, except that cicada shells are not added.

[0126] Treatment effect: No obvious improvement in nasal itching and sneezing.

[0127] Comparative Example 3

[0128] A traditional Chinese medicine composition for treating allergic rhinitis, the components and preparation method are the same as those in Example 1, except that black plum is not added.

[0129] Treatment effect: There is a lot of secretion, the edema of the nasal mucosa is not significantly reduced, and the nasal congestion is severe.

[0130] Comparative Example 4

[0131] A traditional Chinese medicine composition for treating allergic rhinitis, the components and preparation method are the same as those in Example 1, except that ephedra is not added.

[0132] Treatment effect: Nasal mucosal edema disappears slowly and nasal congestion improves slowly.

[0133] Application Example 1

[0134] The effect verification is described below using the Chinese medicine composition prepared in Example 1. In the following effect verification, the external use oil prepared using the Chinese medicine composition of the present invention is referred to as "Dulitong Bitongjing Health Oil".

[0135] "Dulitong Nasal Cleansing Oil" has been used to treat nasal discomfort, including itchy nose, nasal congestion, sneezing, runny nose, and itchy eyes, in 327 cases, achieving satisfactory results. It is now introduced as follows:

[0136] Clinical case observations from June 2023 to June 2025 at Du Xicheng Clinic, Xinmi City, Henan Province:

[0137] 1. There were 307 cases of nasal discomfort in this group.

[0138] 189 cases of allergic rhinitis;

[0139] 118 cases of allergic complex rhinitis (allergic rhinitis with turbinate hypertrophy or sinusitis)

[0140] All cases ranged in age from 6 to 65 years old. 167 cases were between 6 and 18 years old, and 140 cases were between 19 and 65 years old. There were 129 males and 178 females.

[0141] 2. Case selection object

[0142] Allergic rhinitis lasts for more than 2 years, with symptoms such as itchy nose, sneezing, runny nose, and itchy eyes, mostly seasonal in spring and autumn, and not accompanied by nasal congestion.

[0143] Allergic rhinitis has caused discomfort for more than 2 years, with itchy nose, sneezing, runny nose, and itchy eyes all year round, accompanied by bilateral nasal mucosal edema without blood color, hypertrophy of nasal concha, and sensitivity to hormone nasal sprays and vasoconstrictors, which are only transiently effective.

[0144] Allergic rhinitis for more than two years, with symptoms of itchy nose, sneezing, runny nose, and itchy eyes year-round, accompanied by nasal congestion and sinusitis, including frontal, maxillary, ethmoid, and sphenoid sinusitis. The discharge can be thick, sticky, clear, or with yellow pus, and can be difficult to blow out. This can also include headaches, dizziness, and hearing, vision, and memory loss.

[0145] 3. All types should use "Dulitong Nasal Cleansing Health Oil".

[0146] 4. Usage and observation

[0147] Use a dropper bottle of "Dulitong Nasal Cleansing Oil" and place 1-2 drops in each nostril with your face tilted back. Apply 4-6 times daily. Leave the oil in your nasal cavity for about 10 minutes before blowing it out. You should feel less stuffy and itchy, and your nose will feel extra cool. Mucus will soon clear, and your nostrils will gradually become airy. Use this for 2-3 months.

[0148] 5. Effect Standards

[0149] Recovery: The itchy nose and sneezing disappeared, ventilation was good, the nasal mucosa shrank significantly, the nasal concha returned to normal without thick and sticky mucus or yellow mucus, and the headache and dizziness disappeared.

[0150] Improvement: The patient feels better in nasal itching, sneezing and ventilation. Although the nasal mucosa has shrunk, it is still somewhat thickened or swollen. There is not much thick or yellow mucus, and the headache and dizziness have basically disappeared.

[0151] Ineffective: The patient feels itchy nose, sneezing, and nasal ventilation that is sometimes better and sometimes worse, and blows out pus from time to time.

[0152] The longest observation time is more than 2 years and the shortest is 6 months (no recurrence for more than 6 months is considered cured).

[0153] Among 179 cases of allergic rhinitis: 142 cases were cured, accounting for 79.3%; 164 cases were significantly effective, accounting for 91.6%; 176 cases were effective, accounting for 98.3%; and 3 cases were ineffective, accounting for 1.7%.

[0154] Among 128 cases of allergic complex rhinitis: 92 cases were cured, accounting for 71.9%; 102 cases were significantly effective, accounting for 79.7%; 121 cases were effective, accounting for 94.5%; and 7 cases were ineffective, accounting for 5.5%.

[0155] Through the analysis of this group of cases, "Dulitong Nasal Cleansing Health Oil" is the most effective for allergic rhinitis, and slightly better for allergic combined rhinitis; the incidence of allergic rhinitis is higher in adolescents and children; the incidence is slightly lower in middle-aged and elderly people; and the incidence is higher in women than in men.

[0156] Application Example 2

[0157] Toxicological testing was performed on the Chinese medicine composition prepared in Example 1 of the present invention (Appendix).

[0158] Sample name: Dulitong Nasal Cleansing Oil Test item: Acute eye irritation test

[0159] 1. Materials

[0160] 1.1 Experimental animals: 3 female New Zealand rabbits, standard grade, weighing 2.0 kg to 2.5 kg.

[0161] 1.2 Experimental animal environment: Ordinary environment, license number for use: SYXK(Yu)2023 - 0008, environmental temperature: 20°C - 25°C, environmental relative humidity: 40% - 70%.

[0162] 1.3 Animal source: Provided by Shaanxi Junxing Biotechnology Co., Ltd., certificate number: 61003200002769.

[0163] 1.4 Feed: Rabbit maintenance feed, provided by Henan Huanyu Hekang Biotechnology Co., Ltd., certificate number: 4109782500033448.

[0164] 2. Test methods and procedures

[0165] 2.1 Inspection basis: "Cosmetics Safety Technical Specifications" (2015 edition), Chapter 6 (5) "Acute Eye Irritation / Corrosion Test".

[0166] 2.2 Sample treatment method: No treatment.

[0167] 2.3 Test procedures: Gently pull down the lower eyelid of one eye of the rabbit, and drop 0.1 mL of the test substance into the conjunctival sac. Passively close the eye for 1 s to prevent the test substance from being lost. The other eye is not treated as a control. After dropping the test substance, close the eye for 1 s. At the 30th s, rinse the eye with a sufficient amount of water flowing at a relatively fast rate but without causing eye damage to the animal for 30 s. Check the animal's eyes at 1 h, 24 h, 48 h, 72 h, on the 4th day, and on the 7th day after eye drops. If no irritation reaction occurs within 72 h, the test can be terminated提前结束试验. If an irritation reaction occurs and does not recover within 7 days, the observation time needs to be extended, generally not exceeding 21 days. Observe the conjunctiva, iris, cornea, and other damage conditions. Evaluate the irritation degree and eye irritation intensity according to the scoring criteria.

[0168] 3. Results:

[0169] The test results and scores are shown in the following table.

[0170]

[0171] 4. Conclusions:

[0172] The acute eye irritation of Dulitong Bitonjing Health Oil to rabbits: At 1 hour after eye drops, the conjunctivas of all 3 rabbits were significantly swollen, and all 3 rabbits fully recovered at 24 hours. The highest integral mean of the irritation reactions of the corneas, irises, and conjunctivas of the 3 rabbits at the 24 h, 48 h, and 72 h observation points after giving the test substance was 0, indicating no irritation.

[0173] Application Example 3

[0174] The Chinese medicine composition prepared in Example 1 of the present invention was tested for harmful components such as lead, arsenic, and mercury (attached), and the test results are shown in Table 2.

[0175] 1. Test items: lead, arsenic, mercury, cadmium, total colony count, total mold and yeast count, Pseudomonas aeruginosa, Staphylococcus aureus, and heat-resistant coliform bacteria.

[0176] 2.Testing basis: Technical Specifications for Safety of Cosmetics (2015 edition).

[0177] 3. Test conclusion: The tested items of this product meet the requirements of the Henan Health Industry Development Research Association group standard T / HNIK03-2020 "Technical Specifications for the Production of Wipe-Type Health Care Products".

[0178] Table 2 Test results of harmful components such as lead, arsenic, and mercury in the traditional Chinese medicine composition prepared in Example 1

[0179]

[0180] Application Example 4

[0181] Specific clinical trial cases include:

[0182] Clinical Case 1

[0183] Wang Guanhe, a 9-year-old boy, suffered from frequent nasal congestion, itchy nose, itchy eyes, sneezing, blowing clear and yellow purulent nasal discharge, headaches, dizziness, and cough for over two years. He had been treated with multiple diagnoses and treatments, but the results were poor. Nasal endoscopy revealed pale and enlarged inferior turbinates on both sides, with yellow purulent nasal discharge visible in the nasal passages. He was diagnosed with allergic rhinitis with nasal concha enlargement and sinusitis. He was treated with the "Dulitong Nasal Cleansing Health Oil" of the present invention, 2 drops per nostril, 6 times a day. The oil should remain in the nasal cavity for about 10 minutes before blowing out. He was cured after 2 months of continuous use and had no recurrence for 2 years of follow-up.

[0184] Clinical Case 2

[0185] Lv Xinguo, a 10-year-old female, had allergic rhinitis accompanied by itchy eyes and coughs for over two years. Attacks were more common in spring and autumn, aggravated by cold air. Attacks were severe, with runny nose, watery eyes, sneezing, coughing, and difficulty breathing. Multiple diagnoses and treatments were ineffective. The diagnosis of allergic rhinitis was given. She was treated with the "Dulitong Bitongjing Health Oil" of the present invention: one drop per nostril, four times daily. The oil should remain in the nasal cavity for about 10 minutes before blowing out. After one month of continuous use, the condition was completely cured. Follow-up was conducted for two years with no recurrence.

[0186] Clinical Case 3

[0187] Zhang Zunhe, a 9-year-old male, had allergic rhinitis and sinusitis for five years with a left-sided nasal septum deviation. He frequently experienced itchy nose and eyes, sneezing, blowing clear and yellow nasal discharge, headaches, and dizziness. Exposure to cold air aggravated the symptoms, with episodes becoming severe. He had undergone multiple diagnoses with poor results. He presented with allergic rhinitis and sinusitis. He was treated with the "Dulitong Nasal Cleansing Health Oil" of the present invention, applying two drops to each nostril five times a day. The oil remained in the nasal cavity for about 10 minutes before blowing out. He was cured after two months of continuous use and experienced no recurrence during two years of follow-up.

[0188] The basic principles, main features, and advantages of the present invention are shown and described above. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and modifications are intended to fall within the scope of the present invention. The scope of protection claimed in the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating allergic rhinitis, characterized in that: The invention is composed of the following raw materials in parts by weight: 5-15 parts of asarum, 15-25 parts of phellodendron, 15-25 parts of ephedra, 10-18 parts of chuanxiong, 15-25 parts of melon stalks, 10-18 parts of sophora flavescens, 10-18 parts of magnolia, 25-35 parts of black plum, 15-25 parts of calcined oyster shell, 55-65 parts of cicada shell, 15-25 parts of moutan bark and 5-15 parts of mint ice.

2. A Chinese medicine composition for treating allergic rhinitis according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 8-12 parts of asarum, 18-22 parts of phellodendron, 18-22 parts of ephedra, 13-16 parts of chuanxiong, 18-22 parts of melon stalks, 13-16 parts of sophora flavescens, 14-17 parts of magnolia, 28-32 parts of ebony, 18-22 parts of calcined oyster shell, 58-62 parts of cicada shell, 18-22 parts of moutan bark and 8-12 parts of mint ice.

3. A Chinese medicine composition for treating allergic rhinitis according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 10 parts of asarum, 20 parts of phellodendron, 20 parts of ephedra, 15 parts of chuanxiong, 20 parts of melon stalks, 15 parts of sophora flavescens, 15 parts of magnolia, 30 parts of ebony, 20 parts of calcined oyster shell, 60 parts of cicada shell, 20 parts of moutan bark and 10 parts of mint ice.

4. Use of the traditional Chinese medicine composition for treating allergic rhinitis according to any one of claims 1 to 3 in the preparation of a medicament for preventing and / or treating allergic rhinitis.

5. The use according to claim 4, characterized in that Pharmaceutically acceptable excipients are also included.

6. An external oil for treating allergic rhinitis, characterized in that: The invention is prepared by using the traditional Chinese medicine composition for treating allergic rhinitis according to any one of claims 1 to 3.

7. The method for preparing the external oil for treating allergic rhinitis according to claim 6, characterized in that The following steps are involved: First, make the melon stems with vinegar to reduce their toxicity and enhance their astringent effect. Then, pick out impurities from Phellodendron amurense, Chuanxiong, Sophora flavescens, Prunus mume, calcined oyster shell, cicada shell, and Cortex Moutan. After drying, soak the melon stems with vinegar in a proper amount of sesame oil for 6-8 days. Pour the mixture into a temperature-controlled oil fryer. Heat it to 160-180℃ on medium heat. After the oil boils for 15-20 minutes, simmer it at low heat at 75-85℃ for 2-4 days, then adjust to 55-65℃ and simmer for another 2-4 days. Then add the carefully picked out asarum, magnolia, and ephedra, simmer for 25-35 minutes, filter, and when the oil temperature reaches 30-40℃, add mint and ice filling container, seal tightly.

8. The method for preparing the external oil for treating allergic rhinitis according to claim 6, characterized in that: Calculated by weight, the amount of sesame oil is 2-4 times that of the traditional Chinese medicine composition.

9. The method for preparing the external oil for treating allergic rhinitis according to claim 6, characterized in that: When using, dispense into 5 ml, 10 ml, etc. glass dropper bottles, disinfect them, and then apply to the nose.

10. The method for using the external oil for treating allergic rhinitis according to claim 6, characterized in that: Place 1-2 drops into each nostril on the back of the face, apply 4-6 times a day, keep it in the nasal cavity for about 10 minutes and then blow it out.

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