Liquid preparation and split charging device for radiopharmaceuticals

Abstract

The device comprises a shielding cabinet, a liquid preparation mechanism, a split charging mechanism, a cover sealing mechanism and a clamping and conveying mechanism, the shielding cabinet is provided with a liquid preparation bin and a split charging bin from right to left, storage bins are arranged below the liquid preparation bin and the split charging bin, the liquid preparation mechanism is installed in the liquid preparation bin, and the split charging mechanism is installed in the split charging bin. The split charging mechanism capable of preventing medicine from splashing is installed on the right side of the split charging bin and penetrates through the bin wall through a liquid conveying pipe to be connected with the liquid preparing mechanism, the cover sealing mechanisms are installed on the rear side bin wall and the left side bin wall of the split charging bin, and the clamping conveying mechanism is installed in the middle of the split charging bin. The device has the functions that the processing ends of the liquid preparation mechanism, the split charging mechanism, the cover sealing mechanism and the clamping and conveying mechanism are integrated in the radiation-proof shielding cabinet, liquid preparation, split charging, cover sealing and feeding and discharging can be continuously carried out, meanwhile, medicine splashing during split charging is avoided, the production safety is guaranteed, and meanwhile the production efficiency is improved.

Description

Technical Field

[0001] The patent of this invention belongs to the technical field of radioactive drug production equipment, and specifically relates to a liquid preparation and packaging device for radioactive drugs. Background Art

[0002] Radiopharmaceuticals are a special class of drugs. The radiation they emit is penetrating and can ionize tissues when passing through the human body. Therefore, their quality requirements are subject to stricter supervision and inspection than those of general drugs to ensure that they achieve the purpose of diagnosis and treatment without damaging normal tissues. During the production of radiopharmaceuticals, they usually need to be prepared and packaged under radiation protection. In the existing technology, radiopharmaceuticals are generally prepared and packaged manually by people wearing protective equipment. However, this preparation and packaging method is difficult to avoid accidents, easily causing personal injury to operators, is not conducive to labor protection, and is difficult to control the packaging accuracy. For example, in the prior art, a Chinese patent with a patent publication number of CN218841676U discloses a radioactive drug filling cabinet, which includes an outer cabinet, an inner cabinet, an air inlet mechanism, an air exhaust mechanism, a containing mechanism, a rotary drive component, a support plate, a capping mechanism, a filling and liquid injection mechanism, a first door panel, a first linear drive component and a controller. The inner cabinet is fixed to one side of the inner part of the outer cabinet, the containing mechanism includes a tray and a plurality of clamping components, the rotary drive component is arranged at the bottom of the inner cabinet and can drive the tray to rotate, the upper part of the tray is provided with a plurality of grooves, each groove is provided with a clamping component, the support plate is arranged on a side of the inner cabinet away from the first opening, the capping mechanism includes a linear motor, a second linear drive component and an adsorption component, and the filling and liquid injection mechanism includes a liquid supply component, a liquid injection component and a third linear drive component; Although it avoids radiation during packaging, it still has the following defects: The current radiopharmaceutical preparation and packaging process has gradually become intelligent, but as mentioned above, it is generally only one of the processing steps in the drug packaging process that has been improved. For example, Chinese patent publication No. CN222715091U discloses a packaging device for radiopharmaceuticals, which realizes automatic loading and unloading, but ignores the radiation protection, preparation, filling, and sealing structures; Chinese patent publication No. CN116280370B discloses a radiopharmaceutical packaging system that realizes an improvement in the sealing structure, but still uses conventional preparation and packaging methods, ignoring the fact that due to the uncapped vial of the syringe, the rapidly injected packaged drug is prone to splashing, and the slowly injected drug reduces the packaging efficiency; and Chinese patent publication No. CN113753837A discloses a small-batch radiopharmaceutical automatic packaging system and method. There are also the above problems.

[0003] Therefore, the present invention provides a liquid preparation and packaging device for radioactive drugs. Summary of the Invention

[0004] In order to solve the above problems, the present invention provides a liquid preparation and packaging device for radioactive drugs, which integrates the liquid preparation mechanism, packaging mechanism, capping mechanism, and processing end of the clamping and conveying mechanism in a radiation-proof shielding cabinet, and can continuously perform liquid preparation, packaging, capping, and material loading and unloading, while avoiding drug splashing during packaging, ensuring production safety and improving production efficiency.

[0005] In order to achieve the above technical effects, the present invention is implemented through the following technical solutions: a liquid preparation and sub-packaging device for radioactive drugs, including a shielding cabinet, a liquid preparation mechanism, a sub-packaging mechanism, a capping mechanism, and a clamping and conveying mechanism. The shielding cabinet is provided with a liquid preparation bin and a sub-packaging bin from right to left, and a storage bin is provided below both. The liquid preparation mechanism is installed in the liquid preparation bin, and the sub-packaging mechanism that can prevent drug splashing is installed on the right side of the sub-packaging bin and is connected to the liquid preparation mechanism through an infusion tube passing through the bin wall. The capping mechanism is installed on the rear side and left side bin wall of the sub-packaging bin, and the clamping and conveying mechanism is installed in the middle of the sub-packaging bin, which is used to transport the syringe bottles to be filled with liquid and capped to the bottom of the corresponding sub-packaging mechanism and capping mechanism.

[0006] Preferably, the shielding cabinet is made of lead alloy.

[0007] Preferably, the front sides of the liquid preparation bin, filling bin and storage bin are all provided with switchable bin doors, the front bin doors of the liquid preparation bin and filling bin are provided with observation windows and handles made of lead glass, a control cabinet is installed on the front bin wall of the liquid preparation bin, and a switchable bin door is also provided on the right side of the liquid preparation bin, and the tops of the liquid preparation bin and filling bin are both provided with radiation-proof filtering exhaust ducts.

[0008] Preferably, the control cabinet is electrically connected to the liquid dispensing mechanism, the packaging mechanism, the capping mechanism, and the clamping and conveying mechanism.

[0009] Preferably, the liquid dispensing mechanism further comprises a reactor, a base, a stirring mechanism, a feed port, a drain valve, an electromagnetic air valve, an air pressure sensor, a temperature control mechanism (not shown in the figure), a delivery pump, and an infusion tube. The reactor is installed on the base in the liquid dispensing bin, a stirring mechanism is installed in the reactor, the feed port, the electromagnetic air valve, and the air pressure sensor are installed on the top of the reactor, the drain valve is installed at the bottom of the reactor, the temperature control is installed in the middle of the reactor, the delivery pump is installed on the left side wall of the liquid dispensing bin and connected to the delivery pipe, and the outside of the reactor is wrapped with a lead layer.

[0010] Preferably, the subpackaging mechanism further comprises a liquid storage tank, an electric three-way valve, a liquid separation syringe, a bracket, a one-way valve inlet valve, a one-way exhaust valve, an electric push rod A, an electric push rod B, an injection liquid separation head, an injection tube, an exhaust channel, a discharge pipe, an exhaust pipe, and a bottle mouth rubber pad. The liquid storage tank is installed on the right side of the liquid separation warehouse wall and the top end is connected to the infusion pipe and the exhaust pipe. The upper end of the electric three-way valve is connected to the discharge port below the liquid storage tank, and the rear end of the electric three-way valve is connected to the liquid separation syringe. A sealing rubber ring is provided at the connection between the piston push rod in the liquid separation syringe and the liquid separation syringe. The liquid separation syringe is fixedly mounted on the warehouse wall through the bracket. The piston push rod on the rear side of the dispensing syringe is connected to the driving end of the electric push rod A installed on the warehouse wall, and the upper and lower sides of the inner cavity on the rear side of the piston of the dispensing syringe are respectively connected to the one-way valve exhaust valve and the one-way air inlet valve. The one-way valve air inlet valve is connected to the exhaust channel on the injection dispensing head through the exhaust pipe, and the one-way exhaust valve is connected to the top of the liquid storage tank through the exhaust pipe. The lower end of the electric three-way valve is connected to the injection dispensing head through the drain pipe. The injection dispensing head is installed on the driving end of the electric push rod B, and the electric push rod B is installed on the warehouse wall on the lower side of the liquid storage tank. The lower side of the injection dispensing head is provided with an injection tube and a bottle mouth rubber pad.

[0011] Preferably, the capping mechanism is composed of a rubber plug mechanism and a capping mechanism. The rubber plug mechanism is installed on the rear wall of the sub-packaging bin, and the capping mechanism is installed on the left wall of the sub-packaging bin.

[0012] Preferably, the plug pressing mechanism also includes an electric push rod C, a pressure plate, a motor A, a rotating disk, a pressure rod, an air duct, a suction cup, and an output end of a plug vibration disk. The electric push rod C is installed on the rear wall of the filling bin, and the pressure plate is installed at the driving end of the electric push rod C. The center of the pressure plate is installed with a motor A, and the driving end of the motor A is connected to the rotating disk. A pressure rod is installed on the lower side of the rotating disk, and a suction cup is installed at the lower end of the pressure rod. An air duct connected to the suction cup is provided in the pressure rod, and the air duct is connected to the air pump through an exhaust pipe. The output end of the plug vibration disk is provided at the rear side of the rotating disk and is connected to the plug vibration disk at the rear side of the shielding cabinet.

[0013] Preferably, the capping mechanism also includes an electric push rod D, a pressure plate, a motor B, a rotating disk, a pressure rod, an air duct, a suction cup, and an output end of a bottle cap vibration disk. The electric push rod D is installed on the rear wall of the filling bin, and the pressure plate is installed at the driving end of the electric push rod D. The center of the pressure plate is installed with a motor B, and the driving end of the motor B is connected to the rotating disk. A pressure rod is installed on the lower side of the rotating disk, and a suction cup is installed at the lower end of the pressure rod. An air duct connected to the suction cup is provided in the pressure rod, and the air duct is connected to the air pump through an exhaust pipe. The output end of the bottle cap vibration disk is provided at the rear side of the rotating disk and is connected to the bottle cap vibration disk at the rear side of the shielding cabinet.

[0014] Preferably, the clamping and conveying mechanism also includes a conveying tray, a bottle inlet, a bottle outlet, a semicircular positioning seat, a guide rod, a rod limiting groove, a slide, a contact sensor, an electric lifting platform, a slide, a semicircular limiting claw, and a motor C. The conveying tray is rotatably installed in the center of the filling bin and the bottom of the conveying tray is connected to the driving end of the motor C. The bottle inlet is provided in the middle of the warehouse wall on the front side of the conveying tray and the bottle outlet is provided on the left side of the warehouse wall. The conveying tray is provided with a slide on the disk surface corresponding to the working end of the liquid separation mechanism, the rubber plug pressing mechanism, and the capping mechanism, and a semicircular with a center facing the conveying tray in a clockwise direction is slidably installed in the slide. shaped positioning seat, a contact sensor is arranged between the top surface of the semicircular positioning seat and the upper bottom surface of the slide, the bottom of the semicircular positioning seat is connected to a guide rod, the bottom of the conveying disc is installed with a rod limiting groove, the third quadrant of the rod limiting groove corresponding to the bottle outlet is set to a fracture and a rotary buffer groove is provided on the side corresponding to the feed port, the electric lifting platform is arranged near the center of the disc, the slide is installed on the electric lifting platform, the semicircular limiting claw is connected to the protruding end of the slide and when the slide is located at the lower side of the electric lifting platform, the semicircular limiting claw can cooperate with the semicircular positioning seat to wrap the syringe bottle.

[0015] The beneficial effects of the present invention are: The present invention integrates the liquid dispensing mechanism, the subpackaging mechanism, the capping mechanism, and the processing end of the clamping and conveying mechanism in a radiation-proof shielding cabinet, which can continuously perform liquid dispensing, subpackaging, capping, and material loading and unloading, while avoiding drug splashing during subpackaging, ensuring production safety and improving production efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Those skilled in the art can also derive other drawings based on these drawings without inventive efforts: Figure 1 It is a structural diagram of the present invention; Figure 2 The structural diagram of the present invention is shown with the cabinet removed; Figure 3 For the present invention Figure 2 A partial schematic diagram of the middle part; Figure 4 It is the front view of the present invention; Figure 5 For the present invention Figure 4 Middle B is a schematic cross-sectional view; Figure 6 It is a cross-sectional schematic diagram of the main view of the present invention; Figure 7 For the present invention Figure 6 Partial schematic diagram of C in the middle; In the accompanying drawings, the components represented by the reference numerals are as follows: 1. Shielding cabinet; 2. Liquid preparation chamber; 3. Filling chamber; 4. Storage chamber; 5. Chamber door; 6. Observation window; 7. Handle; 8. Control cabinet; 9. Reactor; 10. Base; 11. Stirring mechanism; 12. Feed inlet; 13. Drain valve; 14. Air valve; 15. Air pressure sensor; 16. Delivery pump; 17. Infusion tube; 18. Liquid storage tank; 19. Electric three-way valve; 20. Dispensing syringe; 21. Bracket; 22. One-way valve for air inlet; 23. One-way exhaust valve; 24. Electric push rod A; 25. Electric push rod B; 26. Injection and dispensing head; 27. Injection tube; 28. Exhaust channel; 29. ​​Drain pipe; 30. Exhaust pipe; 31. Bottle mouth rubber pad; 32. Electric push rod C; 33. Press plate; 34. Motor A; 35. Rotating disk; 36. Press rod; 37. Airway; 38. Suction cup; 39. Output end of rubber plug vibration disk; 40. Electric push rod D; 41. Motor B; 42. Output end of rubber plug vibration disk; 43. Conveyor disk; 44. Bottle inlet; 45. Bottle outlet; 46. Semicircular positioning seat; 47. Guide rod; 48. Rod limiting groove; 49. Slide groove; 50. Contact sensor; 51. Motor C; 52. Rotary buffer groove. DETAILED DESCRIPTION

[0017] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present invention.

[0018] like Figures 1 to 7 As shown, the prior art in this embodiment has the following problems: the inventors found that although the prior art avoids radiation during packaging, it still has the following defects: the current radioactive drug liquid preparation and packaging process has gradually become intelligent, but as mentioned above, it is generally only one of the processing steps in the drug packaging process that has been improved. For example, Chinese Patent Publication No. CN222715091U discloses a radioactive drug packaging device, which realizes automatic loading and unloading, but ignores the radiation protection, liquid preparation, filling, and sealing structures; Chinese Patent Publication No. CN116280370B discloses a radioactive drug packaging system that realizes an improvement in the sealing structure, but still uses conventional liquid preparation and packaging methods, ignoring the fact that due to the uncapped vial of the syringe during packaging, the rapidly injected packaged drug is prone to splashing, and the slowly injected drug reduces the packaging efficiency; and Chinese Patent Publication No. CN113753837A discloses a small-batch radioactive drug liquid automatic packaging system and method. Therefore, the inventor provides a liquid preparation and filling device for radioactive drugs, including a shielding cabinet 1, a liquid preparation mechanism, a filling mechanism, a capping mechanism, and a clamping and conveying mechanism. The shielding cabinet 1 is provided with a liquid preparation bin 2 and a filling bin 3 from right to left, and a storage bin 4 is provided below both. The liquid preparation mechanism is installed in the liquid preparation bin 2, and the filling mechanism that can prevent drug splashing is installed on the right side of the filling bin 3 and is connected to the liquid preparation mechanism through an infusion tube 17 passing through the bin wall. The capping mechanism is installed on the rear side and left side bin wall of the filling bin 3, and the clamping and conveying mechanism is installed in the middle of the filling bin 3, which is used to transport the syringe bottles to be filled with liquid and capped to the corresponding filling mechanism and capping mechanism below.

[0019] Furthermore, the shielding cabinet 1 is made of lead alloy; the design of this structure can shield radiation and ensure production safety.

[0020] Furthermore, the front sides of the liquid dispensing bin 2, the sub-packaging bin 3, and the storage bin 4 are all provided with a closable bin door 5. The front bin doors 5 of the liquid dispensing bin 2 and the sub-packaging bin 3 are provided with an observation window 6 and a handle 7 made of lead glass. A control cabinet 8 is installed on the front bin wall of the liquid dispensing bin 2. A closable bin door 5 is also provided on the right side of the liquid dispensing bin 2. The tops of the liquid dispensing bin 2 and the sub-packaging bin 3 are both provided with radiation-proof filtered air extraction ducts (not shown in the figure); The effect and principle are as follows: the design of the observation window 6 made of lead glass in this structure can facilitate the user to observe the working conditions in the inner chamber, and the design of the radiation-proof filter exhaust duct can avoid radiation leakage during exhaust.

[0021] Furthermore, the control cabinet 8 is electrically connected to the liquid dispensing mechanism, the sub-packaging mechanism, the capping mechanism, and the clamping and conveying mechanism; The effect and principle are as follows: the structure can facilitate operators to control and monitor the status of each working mechanism.

[0022] Furthermore, the liquid dispensing mechanism also includes a reactor 9, a base 10, a stirring mechanism 11, a feed port 12, a drain valve 13, an electromagnetic valve 14, an air pressure sensor 15, a temperature control mechanism (not shown in the figure), a delivery pump 16, and an infusion tube 17. The reactor 9 is installed on the base 10 in the liquid dispensing bin 2. The reactor 9 is equipped with a stirring mechanism 11, the feed port 12, the electromagnetic valve 14, and the air pressure sensor 15. The stirring mechanism 11 is installed in the reactor 9. The drain valve 13 is installed at the bottom of the reactor 9. The temperature control is installed in the middle of the reactor 9. The delivery pump 16 is installed on the left side of the liquid dispensing bin 2 and connected to the delivery pipe. The outside of the reactor 9 is wrapped with a lead layer (not shown in the figure). The effect and principle are as follows: the reactor 9 designed in this structure can quickly mix the raw materials and auxiliary materials of the radioactive drug with the cooperation of the other structures, and then transport them to the liquid storage tank 18 of the liquid separation mechanism through the delivery pump 16. In addition, this structure can control the air pressure and temperature in the reactor 9 in real time through the air pressure sensor 15 and the temperature control mechanism, thereby ensuring the reaction conditions; among them, the delivery pump 16 can choose a peristaltic pump used in pharmaceutical production, and the temperature control mechanism can choose a coil water-cooled heat exchange mechanism and a heating wire surrounding the reactor 9, thereby facilitating heating or heat dissipation of the reactor 9 even in extreme weather conditions; the design of the lead layer can reduce radiation during the liquid preparation process.

[0023] Furthermore, the subpackaging mechanism also includes a liquid storage tank 18, an electric three-way valve 19, a liquid separation syringe 20, a bracket 21, a one-way valve inlet valve 22, a one-way exhaust valve 23, an electric push rod A24, an electric push rod B25, an injection liquid separation head 26, an injection tube 27, an exhaust channel 28, a discharge pipe 29, an exhaust pipe 30, and a bottle mouth rubber pad 31. The liquid storage tank 18 is installed on the right side of the liquid separation warehouse wall and the top end is connected to the infusion pipe 17 and the exhaust pipe 30. The upper end of the electric three-way valve 19 is connected to the discharge port below the liquid storage tank 18, and the rear end of the electric three-way valve 19 is connected to the liquid separation syringe 20. A sealing rubber ring (not shown in the figure) is provided at the connection between the piston push rod in the liquid separation syringe 20 and the liquid separation syringe 20. The liquid separation syringe 20 is fixed by the bracket 21 Installed on the warehouse wall, the piston push rod on the rear side of the liquid-dispensing syringe 20 is connected to the driving end of the electric push rod A24 installed on the warehouse wall, and the upper and lower sides of the inner cavity on the rear side of the piston of the liquid-dispensing syringe 20 are respectively connected to the one-way valve exhaust valve and the one-way air inlet valve, the one-way valve air inlet valve 22 is connected to the exhaust channel 28 on the injection liquid-dispensing head 26 through the exhaust pipe 30, the one-way exhaust valve 23 is connected to the top of the liquid storage tank 18 through the exhaust pipe 30, the lower end of the electric three-way valve 19 is connected to the injection liquid-dispensing head 26 through the drain pipe 29, the injection liquid-dispensing head 26 is installed on the driving end of the electric push rod B25, and the electric push rod B25 is installed on the warehouse wall on the lower side of the liquid storage tank 18. The lower side of the injection liquid-dispensing head 26 is provided with an injection tube 27 and a bottle mouth rubber pad 31; Its effect and principle are as follows: when the structure separates liquid, the liquid discharge port of the liquid storage tank 18 and the liquid separation syringe 20 are first connected through the electric three-way valve 19, and then the electric push rod A24 is controlled to pull the piston in the liquid separation syringe 20 backward, thereby drawing the liquid into the liquid separation syringe 20. At the same time, the backward piston discharges the air in the inner cavity on its rear side from the upper side and discharges it into the liquid storage tank 18 to balance the air pressure, thereby preventing the liquid storage tank 18 from deforming due to negative pressure. A scale can be set on the liquid separation syringe 20, which is convenient for debugging. After the liquid is drawn into the liquid separation syringe 20, the liquid separation syringe 20 and the discharge pipe 29 are connected through the electric three-way valve 19. When the empty syringe bottle is transported to the bottom of the injection liquid separation head 26, The electric push rod B25 pushes the injection dispensing head 26 down on the mouth of the syringe bottle, and then the electric push rod A24 pushes the piston in the dispensing syringe 20 to push the liquid medicine in its inner cavity out and then flow into the syringe bottle. In this process, the gas in the syringe bottle filled with liquid medicine will be squeezed, and the piston pushed forward will form a negative pressure at the rear, thereby drawing the slightly high-pressure gas in the syringe bottle from the exhaust pipe 30 to the dispensing syringe 20, thereby forming an air pressure balance; in this way, sealing the bottle mouth during injection can avoid splashing caused by high-speed injection of liquid medicine into the bottle and unsealing the bottle mouth; the above structure can avoid splashing pollution during high-speed liquid separation and improve the liquid separation efficiency.

[0024] Furthermore, the capping mechanism is composed of a rubber plug mechanism and a capping mechanism. The rubber plug mechanism is installed on the rear wall of the sub-packaging bin 3, and the capping mechanism is installed on the left wall of the sub-packaging bin 3. The effect and principle are as follows: the design of this structure is to facilitate the process of subpackaging, by clamping the disc on the conveying mechanism to rotate the syringe bottle filled with liquid medicine to the bottom of the stopper pressing mechanism and the cap pressing mechanism in turn for stopper pressing and cap pressing.

[0025] Furthermore, the plug pressing mechanism also includes an electric push rod C32, a pressure plate 33, a motor A34, a rotating disk 35, a pressure rod 36, an air duct 37, a suction cup 38, and a plug vibration disk output end 39. The electric push rod C32 is installed on the rear warehouse wall of the filling bin 3, the pressure plate 33 is installed on the driving end of the electric push rod C32, the center of the pressure plate 33 is installed with a motor A34, the driving end of the motor A34 is connected to the rotating disk 35, the lower side of the rotating disk 35 is installed with a pressure rod 36, the lower end of the pressure rod 36 is installed with a suction cup 38, an air duct 37 connected to the suction cup 38 is provided in the pressure rod 36, the air duct 37 is connected to the air pump (not shown in the figure) through an exhaust pipe (not shown in the figure), and the plug vibration disk output end 39 is provided on the rear side of the rotating disk 35 and is connected to the plug vibration disk (not shown in the figure) on the rear side of the shielding cabinet 1; The effect and principle are as follows: when the structure is in operation, the stopper of the syringe bottle is first input to the output end 39 of the stopper vibration disk through the stopper vibration disk, and then the pressure rod 36 is lifted to the upper side of the output end 39 of the stopper vibration disk by the electric push rod C32, and then the rotating disk 35 is driven to rotate by the motor A34 to rotate the pressure rod 36 to the top of the stopper in the output end 39 of the stopper vibration disk, and then the pressure rod 36 is pressed down by the electric push rod C32. When the suction cup 38 covers the stopper, the air pump is used to pump air so that the suction cup 38 sucks the stopper tightly, and the motor A34 drives the rotating disk 35 to rotate, aligning the stopper with the bottle mouth of the syringe bottle, and then the electric push rod C32 presses the stopper into the bottle mouth. Finally, the air pump deflates to release the stopper, and this process is repeated to continuously realize the action of pressing the stopper.

[0026] Furthermore, the capping mechanism also includes an electric push rod D40, a pressure plate 33, a motor B41, a rotating disk 35, a pressure rod 36, an airway 37, a suction cup 38, and a bottle cap vibration disk output end 42. The electric push rod D40 is installed on the rear wall of the sub-packaging bin 3, the pressure plate 33 is installed on the driving end of the electric push rod D40, the center of the pressure plate 33 is installed with a motor B41, the driving end of the motor B41 is connected to the rotating disk 35, and the lower side of the rotating disk 35 is installed with a pressure rod 3 6. A suction cup 38 is installed at the lower end of the pressure rod 36, and an air duct 37 connected to the suction cup 38 is provided in the pressure rod 36. The air duct 37 is connected to the air pump (not shown in the figure) through an exhaust pipe (not shown in the figure), and the output end 42 of the bottle cap vibration disk is provided at the rear side of the rotating disk 35 and is connected to the bottle cap vibration disk (not shown in the figure) at the rear side of the shielding cabinet 1; the operating principle of this structure is the same as that of the rubber plug pressing mechanism, and the suction cup 38 at the lower end of the pressure rod 36 can be transformed as needed, such as a mechanical claw.

[0027] Furthermore, the clamping and conveying mechanism also includes a conveying tray 43, a bottle inlet 44, a bottle outlet 45, a semicircular positioning seat 46, a guide rod 47, a rod limiting groove 48, a slide 49, a contact sensor 50, an electric lifting platform (not shown in the figure), a slide (not shown in the figure), a semicircular limiting claw (not shown in the figure), and a motor C51. The conveying tray 43 is rotatably installed in the center of the filling bin 3 and the bottom of the conveying tray 43 is connected to the driving end of the motor C51. The bottle inlet 44 is provided in the middle of the front side of the bin wall of the conveying tray 43 and the bottle outlet 45 is provided on the left side of the bin wall. The conveying tray 43 is provided with a slide 49 on the disk surface corresponding to the working end of the liquid separation mechanism, the rubber plug pressing mechanism, and the capping mechanism, and a circular A semicircular positioning seat 46 is arranged in a clockwise direction toward the conveying disc 43, and a contact sensor 50 is provided between the top surface of the semicircular positioning seat 46 and the upper bottom surface of the slide 49. A guide rod 47 is connected to the bottom of the semicircular positioning seat 46, and a rod limiting groove 48 is installed at the bottom of the conveying disc 43. The rod limiting groove 48 is set as a break at the third quadrant corresponding to the bottle outlet 45 and a rotary buffer groove 52 is provided on the side corresponding to the bottle inlet 44. The electric lifting platform is set near the center of the disc, and the slide is installed on the electric lifting platform. The semicircular limiting claw is connected to the protruding end of the slide and when the slide is located at the lower side of the electric lifting platform, the semicircular limiting claw can cooperate with the semicircular positioning seat 46 to wrap the cillin bottle; Its effect and principle are as follows: when the structure is working, a PPU manipulator can be set outside the feed port 12 to catch the empty cillin bottle to the upper side of the chute 49 of the conveying tray 43. In this way, when the conveying tray 43 rotates, the guide rod 47 is gradually lifted under the limit of the rotary buffer groove in the rod limit groove 48. When the contact sensor 50 between the top surface of the semicircular positioning seat 46 and the upper and lower surfaces of the chute 49 comes into contact, the control cabinet 8 controls the electric lifting platform to drive the slide to descend, so that the semicircular limit claw wraps the cillin bottle from the other side, thereby achieving positioning. Then, after completing the liquid separation, plug pressing and cap pressing, the rotation continues. The conveyor plate 43 will bring the guide rod 47 under the positioning seat away from the rod limiting groove 48, causing the positioning seat to fall along the slide groove 49. At the same time, after disconnecting the contact sensor 50, the control cabinet 8 controls the electric lifting platform to drive the slide to rise, so that the syringe bottle is separated from the plate under the guidance of the bottle outlet 45 and the assistance of the conveyor plate 43; this structure realizes stable positioning of the syringe bottle through the above-mentioned positioning mechanism, ensures the stability and accuracy of liquid separation, plug pressing and cap pressing, and at the same time realizes precise control of the lifting and lowering of the positioning seat and the limiting claw through the fracture in the rod limiting groove 48, and also avoids mechanical conflict.

[0028] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the invention can be embodied in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the invention is defined by the appended claims, not the foregoing description, and all variations within the meaning and range of equivalents of the claims are intended to be included therein. Any reference sign in a claim should not be construed as limiting the claim to which it relates.

[0029] In addition, it should be understood that although this specification is described in terms of implementation methods, not every implementation method contains only one independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other implementation methods that can be understood by those skilled in the art.

Claims

1. A radiopharmaceutical liquid preparation and packaging device, characterized by: The invention comprises a shielding cabinet (1), a liquid dispensing mechanism, a sub-packaging mechanism, a capping mechanism, and a clamping and conveying mechanism. The shielding cabinet (1) is provided with a liquid dispensing bin (2) and a sub-packaging bin (3) from right to left, and a storage bin (4) is provided below both of them. The liquid dispensing mechanism is installed in the liquid dispensing bin (2). The sub-packaging mechanism that can avoid drug splashing is installed on the right side of the sub-packaging bin (3) and is connected to the liquid dispensing mechanism through an infusion tube (17) passing through the bin wall. The capping mechanism is installed on the rear side and the left bin wall of the sub-packaging bin (3). The clamping and conveying mechanism is installed in the middle of the sub-packaging bin (3) and is used to convey the syringe bottles to be filled with liquid and capped to the bottom of the corresponding sub-packaging mechanism and capping mechanism.

2. The radioactive drug dispensing and packaging device according to claim 1, characterized in that: The shielding cabinet (1) is made of lead alloy.

3. The radioactive drug dispensing and packaging device according to claim 1, characterized in that: The front sides of the liquid dispensing bin (2), the sub-packaging bin (3), and the storage bin (4) are all provided with a closable bin door (5); the front bin doors (5) of the liquid dispensing bin (2) and the sub-packaging bin (3) are provided with an observation window (6) and a handle (7) made of lead glass; a control cabinet (8) is installed on the front bin wall of the liquid dispensing bin (2); the right side of the liquid dispensing bin (2) is also provided with a closable bin door (5); the tops of the liquid dispensing bin (2) and the sub-packaging bin (3) are both provided with a radiation-proof filtered exhaust duct.

4. The radioactive drug dispensing and packaging device according to claim 3, characterized in that: The control cabinet (8) is electrically connected to the liquid dispensing mechanism, the packaging mechanism, the capping mechanism, and the clamping and conveying mechanism.

5. The radioactive drug dispensing and packaging device according to claim 1, characterized in that: The liquid dispensing mechanism further comprises a reactor (9), a base (10), a stirring mechanism (11), a feed port (12), a drain valve (13), an electromagnetic valve (14), an air pressure sensor (15), a temperature control mechanism, a delivery pump (16), and a liquid infusion tube (17). The reactor (9) is mounted on the base (10) in the liquid dispensing bin (2). The reactor (9) is equipped with a stirring mechanism (11). The feed port (12), the electromagnetic valve (14), and the air pressure sensor (15) are mounted on the top of the reactor (9). The drain valve (13) is mounted on the bottom of the reactor (9). The temperature control is mounted in the middle of the reactor (9). The delivery pump (16) is mounted on the left side of the liquid dispensing bin (2) and connected to the delivery tube. The outside of the reactor (9) is wrapped with a lead layer.

6. The radioactive drug dispensing and packaging device according to claim 1, characterized in that: The packaging mechanism further comprises a liquid storage tank (18), an electric three-way valve (19), a liquid separation syringe (20), a bracket (21), a one-way valve air inlet valve (22), a one-way exhaust valve (23), an electric push rod A (24), an electric push rod B (25), an injection liquid separation head (26), an injection tube (27), an exhaust channel (28), a discharge pipe (29), an exhaust pipe (30), and a bottle mouth rubber pad (31). The liquid storage tank (18) is mounted on the right side of the liquid separation tank wall and the top end is connected to the infusion pipe (17) and the exhaust pipe (30). The upper end of the electric three-way valve (19) is connected to the discharge port below the liquid storage tank (18). The rear end of the electric three-way valve (19) is connected to the liquid separation syringe (20). A sealing rubber ring is provided at the connection between the piston push rod in the liquid separation syringe (20) and the liquid separation syringe (20). The liquid separation syringe (20) is fixed by the bracket (21). Installed on the warehouse wall, the piston push rod on the rear side of the liquid-dispensing syringe (20) is connected to the driving end of the electric push rod A (24) installed on the warehouse wall, and the upper and lower sides of the inner cavity on the rear side of the piston of the liquid-dispensing syringe (20) are respectively connected to the one-way valve exhaust valve and the one-way air inlet valve, the one-way valve air inlet valve (22) is connected to the exhaust channel (28) on the injection liquid-dispensing head (26) through the exhaust pipe (30), the one-way exhaust valve (23) is connected to the top of the liquid storage tank (18) through the exhaust pipe (30), the lower end of the electric three-way valve (19) is connected to the injection liquid-dispensing head (26) through the discharge pipe (29), the injection liquid-dispensing head (26) is installed on the driving end of the electric push rod B (25), the electric push rod B (25) is installed on the warehouse wall on the lower side of the liquid storage tank (18), and the lower side of the injection liquid-dispensing head (26) is provided with an injection tube (27) and a bottle mouth rubber pad (31).

7. The radioactive drug dispensing and packaging device according to claim 1, characterized in that: The capping mechanism is composed of a rubber plug mechanism and a capping mechanism. The rubber plug mechanism is installed on the rear wall of the sub-packaging bin (3), and the capping mechanism is installed on the left wall of the sub-packaging bin (3).

8. The radioactive drug dispensing and packaging device according to claim 7, characterized in that: The plug pressing mechanism further comprises an electric push rod C (32), a pressure plate (33), a motor A (34), a rotating disk (35), a pressure rod (36), an airway (37), a suction cup (38), and an output end (39) of the plug vibration disk. The electric push rod C (32) is mounted on the rear wall of the sub-packaging bin (3), the pressure plate (33) is mounted on the driving end of the electric push rod C (32), the center of the pressure plate (33) is equipped with a motor A (34), and the motor The driving end of A (34) is connected to a rotating disk (35), a pressure rod (36) is installed on the lower side of the rotating disk (35), a suction cup (38) is installed on the lower end of the pressure rod (36), an air duct (37) connected to the suction cup (38) is provided in the pressure rod (36), and the air duct (37) is connected to the air pump through an exhaust pipe. The output end (39) of the rubber plug vibration disk is provided at the rear side of the rotating disk (35) and is connected to the rubber plug vibration disk at the rear side of the shielding cabinet (1).

9. The radioactive drug dispensing and packaging device according to claim 7, characterized in that: The capping mechanism further comprises an electric push rod D (40), a pressure plate (33), a motor B (41), a rotating disk (35), a pressure rod (36), an airway (37), a suction cup (38), and an output end (42) of a bottle cap vibration disk. The electric push rod D (40) is mounted on the rear side wall of the sub-packaging bin (3). The pressure plate (33) is mounted on the driving end of the electric push rod D (40). The center of the pressure plate (33) is equipped with a motor B (41). The motor B The driving end of (41) is connected to a rotating disk (35), a pressure rod (36) is installed on the lower side of the rotating disk (35), a suction cup (38) is installed on the lower end of the pressure rod (36), an air duct (37) connected to the suction cup (38) is provided in the pressure rod (36), and the air duct (37) is connected to the air pump through an exhaust pipe. The output end (42) of the bottle cap vibration disk is provided at the rear side of the rotating disk (35) and is connected to the bottle cap vibration disk at the rear side of the shielding cabinet (1).

10. The radioactive drug dispensing and packaging device according to claim 1, characterized in that: The clamping conveying mechanism further comprises a conveying disc (43), a bottle inlet (44), a bottle outlet (45), a semicircular positioning seat (46), a guide rod (47), a rod limiting groove (48), a slide (49), a contact sensor (50), an electric lifting platform, a slide, a semicircular limiting claw, and a motor C (51). The conveying disc (43) is rotatably mounted at the center of the sub-packaging bin (3) and the bottom of the conveying disc (43) is connected to the driving end of the motor C (51). The conveying disc (43) is provided with a bottle inlet (44) in the middle of the front side bin wall and a bottle outlet (45) is provided on the left side of the bin wall. The conveying disc (43) is provided with a slide groove (49) on the disc surface corresponding to the working end of the liquid separation mechanism, the rubber plug pressing mechanism, and the capping mechanism, and a slide groove (49) is slidably mounted with a center of the circle facing the conveying disc ( 43) a semicircular positioning seat (46) in a clockwise direction, a contact sensor (50) is provided between the top surface of the semicircular positioning seat (46) and the upper bottom surface of the slide groove (49), the bottom of the semicircular positioning seat (46) is connected to a guide rod (47), the bottom of the conveying disc (43) is provided with a rod limiting groove (48), the rod limiting groove (48) is provided with a fracture at the third quadrant corresponding to the bottle outlet (45) and a rotary buffer groove (52) is provided on the side corresponding to the feed port (12), the electric lifting platform is provided near the center of the disc, the slide is provided on the electric lifting platform, the semicircular limiting claw is connected to the protruding end of the slide and when the slide is located at the lower side of the electric lifting platform, the semicircular limiting claw can cooperate with the semicircular positioning seat (46) to wrap the syringe bottle.

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