Traditional Chinese medicinal material composition capable of refreshing breath

Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition capable of refreshing breath. The traditional Chinese medicinal material composition comprises the following components: clove, burdock, selfheal and mint. The composition capable of killing bad breath microorganisms is prepared from four medicinal and edible traditional Chinese medicinal materials, namely clove, burdock, selfheal and mint, and the traditional Chinese medicinal material composition not only can effectively inhibit the growth of bad breath-producing bacteria in the oral cavity and play a role in freshening breath, but also can clear away heat, relieve internal heat, relieve swelling, relieve pain and refresh the spirit, so that the oral cavity is free of toxic and side effects. By daily use, the common sub-health status at present can be well improved, and the life quality can be improved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition capable of freshening breath. Background Art

[0002] Oral halitosis is a common disorder caused by an imbalance in oral flora. Long-term, recurring symptoms can lead to negative emotions such as fear of communication, anxiety, depression, and low self-esteem, severely impacting social interactions and physical and mental health. The WHO no longer defines halitosis as a symptom, but rather as a disease. Most researchers believe that an imbalance in the oral flora is the root cause of oral halitosis.

[0003] Daily brushing only removes approximately 45% to 60% of dental plaque. The advent of mouthwash solved this problem. Mouthwash is highly fluid and can clean all areas of the mouth, reducing the amount of plaque and harmful bacteria, keeping the mouth fresh and odor-free. Mouthwash is also used as a therapeutic adjunct to treat oral conditions such as gingivitis, oral mucosal diseases, and periodontitis. However, mouthwashes must be selected under a doctor's guidance and should not be used long-term. Otherwise, they can cause an imbalance in oral flora and lead to more serious consequences. Furthermore, daily eating introduces different microorganisms, leading to recurring bad breath and treating only the symptoms rather than the root cause.

[0004] According to the theory of traditional Chinese medicine, many foods have both nutritional value and medicinal value, and there is no absolute dividing line between them. Ancient medical scientists applied the theory of "four properties" and "five flavors" of traditional Chinese medicine to food, believing that every kind of food also has "four properties" and "five flavors". This is the ideological basis of "medicine and food have the same origin". Therefore, items with the same origin as medicine can be used as medicine or eaten as food ingredients. They have the dual effects of treatment and health care. Many health foods use items with the same origin as medicine as their main ingredients. They can help people regulate body functions, enhance immunity, prevent diseases, etc. Through research, this patent has screened out 4 effective Chinese medicinal materials with the same origin as medicine, which can effectively inhibit the growth of odor-producing bacteria in the mouth and have the effect of freshening breath. Summary of the Invention

[0005] In order to solve the technical problems existing in the above-mentioned prior art, the present invention proposes a Chinese herbal medicine composition that can achieve fresh breath. The Chinese herbal medicine composition can not only effectively inhibit the growth of oral odor-producing bacteria and have the effect of freshening breath, but also can clear away heat and reduce internal heat, reduce swelling and pain, and refresh the mind. Daily use can effectively improve the currently prevalent sub-health status and improve the quality of life.

[0006] The technical solution of the present invention is achieved as follows:

[0007] A Chinese medicinal material composition capable of freshening breath comprises the following components in parts by weight: clove, burdock, selfheal and mint.

[0008] This patent uses four Chinese medicinal herbs, clove, burdock, prunella vulgaris, and mint, which are both medicinal and edible, to formulate a composition that can kill microorganisms that cause bad breath. The composition described in this patent can be composed of two or more of the four Chinese medicinal herbs.

[0009] Preferably, the composition described in this patent can be a tea bag for daily brewing, a mouthwash for gargling, various forms of oral candies, or Chinese patent medicines (such as granules, chewable tablets, etc.).

[0010] Preferably, the material particles of the tea bag are larger than 60 meshes, and the tea bag comprises the following raw materials in the following weight percentages: 37% to 48.5% burdock, 37% to 48.5% selfheal, 1% to 48.5% cloves, and 1.9% to 7.4% mint.

[0011] Preferably, the raw material of the mouthwash is concentrated extract of Chinese medicinal materials, which is a compound Chinese medicinal ingredient consisting of supercritical carbon dioxide extract of Prunella vulgaris and burdock, clove oil and peppermint oil.

[0012] Preferably, the burdock and prunella vulgaris extracts are concentrates extracted using supercritical carbon dioxide. The clove oil and peppermint oil are commercially available products.

[0013] Preferably, the mouthwash comprises the following raw materials in weight percentage: 1% to 10% burdock concentrate, 1% to 10% prunella vulgaris concentrate, 0.2% to 1% clove oil, 0.01% to 1% peppermint oil, 18% to 20% sorbitol, 10% to 12% food-grade ethanol, 3% to 8% Tween-40, 0.01% to 0.02% sodium saccharin, 0.15% to 0.2% sodium parabens, and 0.1% to 0.8% flavor.

[0014] Preferably, the oral confectionery comprises chewing gum.

[0015] Preferably, the Chinese medicinal materials used in the chewing gum are concentrated extracts, comprising a compound Chinese medicinal ingredient consisting of supercritical carbon dioxide extracts of Prunella vulgaris and burdock, clove oil, and peppermint oil. The burdock and Prunella vulgaris extracts are concentrates extracted using supercritical carbon dioxide. The chewing gum comprises the following ingredients by weight: 1% to 5% burdock concentrate, 1% to 5% Prunella vulgaris concentrate, 0.2% to 0.4% clove oil, 0.01% to 0.5% peppermint oil, 30% to 50% edible gum base, 18% to 40% xylitol, 10% to 30% sorbitol, 0.2% to 0.1% citric acid, and 3% to 7% edible ethanol.

[0016] Preferably, the Chinese medicinal materials used in the chewable tablets are concentrated extracts, comprising a compound Chinese medicinal ingredient consisting of supercritical carbon dioxide extracts of Prunella vulgaris and burdock, clove oil, and peppermint oil. The burdock and Prunella vulgaris extracts are concentrates extracted using supercritical carbon dioxide. The chewable tablets comprise the following raw materials in percentage by weight: 1% to 10% burdock concentrate, 1% to 10% Prunella vulgaris concentrate, 0.2% to 0.4% clove oil, 0.01% to 0.5% peppermint oil, 0.3% to 0.5% sucralose, 5% to 15% sorbitol, 5% to 15% lactose, 15% to 45% starch, 27% to 50% sucrose powder, 1% to 4% magnesium stearate, and 2% to 4.4% povidone K-30.

[0017] Beneficial effects

[0018] The beneficial effects of the present invention are summarized as follows:

[0019] The present invention uses four Chinese medicinal materials with medicinal and edible properties, namely cloves, burdock, herba prunellae and mint, to prepare a composition that can kill oral odor microorganisms, which can effectively inhibit the growth of oral odor-producing bacteria and play a role in freshening breath. According to the "Chinese Pharmacopoeia (2020)", the main functions of burdock are: evacuating wind-heat, promoting lung function and clearing rashes, detoxifying and relieving sore throat, and are used for wind-heat colds, coughs with sputum, measles, rubella, sore throat, mumps, erysipelas, carbuncles and sores. The main functions of herba prunellae are: clearing the liver and purging fire, improving eyesight, dispersing stagnation and reducing swelling, and are used for red and swollen eyes, night pain in the eyes, headaches and dizziness, scrofula, goiters, breast abscesses, breast lumps, and breast pain. The main functions of cloves are: warming the middle and lowering adverse reactions, tonifying the kidney and assisting yang, and are used for spleen and stomach deficiency and cold, hiccups and vomiting, poor appetite, vomiting and diarrhea, cold pain in the heart and abdomen, and kidney deficiency and impotence. The main functions of mint are: dispersing wind-heat. It clears the head and eyes, clears rashes, and is used for wind-heat colds, the initial onset of wind-heat, headaches, red eyes, sore throats, mouth ulcers, rubella, measles, and chest and flank distension. This medicinal and edible product, formulated with these four Chinese herbs, not only freshens breath, but also clears away heat and internal heat, reduces swelling and pain, and invigorates the mind. Daily use can significantly improve prevalent sub-health conditions and enhance quality of life. DETAILED DESCRIPTION

[0020] Antibacterial effect test

[0021] The inhibition zone test method is used, and the specific method is as follows:

[0022] (1) Pretreatment of the test sample:

[0023] The product was crushed to the minimum product size (10 mL for mouthwash), passed through a 60-mesh sieve to remove fine residue, and then placed in a non-woven bag. It was brewed with 100 mL of boiling water for 30 minutes, and the brewing water was used for antibacterial testing.

[0024] (2) Antibacterial test method - inhibition zone test method:

[0025] The filter paper method was used to measure the inhibition zone of six bacteria related to bad breath (Klebsiella oxytoca, Fusobacterium nucleatum, Porphyromonas gingivalis, anaerobic Streptococcus, Staphylococcus aureus, and Prevotella intermedia) in brewed water. Prepare a culture medium plate surface containing 200μL of bacterial suspension, evenly spread it, and wait until the plate completely absorbs the bacterial suspension. Then, use sterile tweezers to take out a sterile filter paper (6mm in diameter) that has been sterilized by high-pressure steam and soaked in the test sample for 5 minutes and stick it on the surface of the bacteria-containing plate. Place it at a constant temperature of 37℃ and incubate it for 24-36h. Observe and use a vernier caliper to record the size of the inhibition zone. This experiment was repeated 3 times and the average value was taken. It is defined that the inhibition zone is greater than 16mm as effective, between 10-16mm as slightly effective, and less than 10mm as ineffective. The test results are shown in Table 1 below.

[0026] Table 1. Antibacterial effect test results of Chinese herbal medicine composition

[0027]

[0028]

[0029] The preparation method of burdock concentrate comprises the following steps: using two extraction kettles in parallel, weighing two portions of 15 kg of pulverized burdock respectively and loading them into two extraction kettles, pre-treating the burdock by using a coarse crusher for coarse pulverization, and then passing the burdock through a 50-mesh sieve, extracting at a CO2 flow rate of 300 L / h, an extraction pressure of 30 MPa, an extraction time of 6 h, and an extraction temperature of 40°C, and obtaining a light yellow and clear vegetable oil.

[0030] The preparation method of the herbaceous prunellae concentrate comprises the following steps: crushing the herbaceous prunellae through a 40-mesh sieve and loading the mixture into an extraction tank; converting carbon dioxide gas from gas into liquid atomization at a temperature of 32°C and a pressure of 15-20 MPa, and then adding ethanol with a weight percentage concentration of 2-3% for 2-5 hours; then flowing the material into a separator for separation, separating the medicinal residue and the extract, and adsorbing the separated mixed extract for 4-7 hours to obtain the herbaceous prunellae extract.

[0031] The concentrate of cloves is commercially available as clove oil.

[0032] Peppermint concentrate is commercially available as peppermint oil.

[0033] Example 1

[0034] Preparation of Ding Xiang Qing tea bag:

[0035] The recipe is 100g burdock, 100g selfheal, 50g cloves, and 20g mint.

[0036] The commercially available dry herbs are dried at a temperature below 60°C, crushed, and passed through a 60-mesh sieve. The crushed materials are weighed by weight, mixed evenly, and packaged into 10g / bags.

[0037] Usage: Soak with boiled water, 1-2 bags per day.

[0038] Example 2

[0039] Preparation of Ding Xiang Qing tea bag:

[0040] The recipe is 200g burdock, 200g selfheal, 50g cloves, and 20g mint.

[0041] The commercially available dry herbs are dried at a temperature below 60°C, crushed, and passed through a 60-mesh sieve. The crushed materials are weighed by weight, mixed evenly, and packaged into 10g / bags.

[0042] Usage: Soak with boiled water, 1-2 bags per day.

[0043] Example 3

[0044] Preparation of Ding Xiang Qing tea bag:

[0045] The recipe is 500g burdock, 500g selfheal, 10g cloves, and 20g mint.

[0046] The commercially available dry herbs were dried at a temperature below 60°C, crushed, and passed through a 60-mesh sieve. The crushed thorny materials were weighed by weight, mixed evenly, and packaged into 10g / bags.

[0047] Usage: Soak with boiled water, 1-2 bags per day.

[0048] Examples 4-7

[0049] Preparation of Clove Mint Mouthwash

[0050] The composition and weight percentage of the mouthwashes in Examples 4 to 7 are shown in Table 2. Unless otherwise specified, all percentages are calculated by weight.

[0051] Table 2. Formulation and antibacterial effect of clove mint mouthwash in Examples 4-7

[0052]

[0053]

[0054] The preparation method of the clove mint mouthwash is as follows: first, burdock concentrate, selfheal concentrate, clove oil, mint oil, and sodium paraben mixed esters are added to edible ethanol, stirred and dissolved, and placed in a temporary pot; sorbitol, deionized water, and Tween 40 are added to the stirring pot and stirred for 10 minutes; the ethanol solution in the temporary pot is added to the stirring pot and stirred for 10 minutes; finally, essence is added and stirred for 5 minutes, stirring is stopped, and sampling is performed after passing the test.

[0055] The antibacterial effect test used the inhibition zone test method mentioned above.

[0056] Examples 8-11

[0057] Preparation of Clove Mint Chewing Gum:

[0058] The chewing gum ingredients and their weight percentages in Examples 8 to 11 are shown in Table 3. Unless otherwise specified, all percentages are calculated by weight.

[0059] Table 3. Formulation and antibacterial effect of clove mint chewing gum in Examples 8-11

[0060]

[0061]

[0062] The clove-mint chewing gum is prepared as follows: the chewing gum ingredients (edible gum base, xylitol, sorbitol, and citric acid) are heated to 90–100°C, mixed uniformly, and cooled for later use. Burdock extract, Prunella vulgaris extract, clove oil, and mint oil are dissolved in edible ethanol, then mixed uniformly with the chewing gum ingredients, extruded into a mold, and cut into pieces to produce the clove-mint chewing gum.

[0063] The antibacterial effect test used the inhibition zone test method mentioned above.

[0064] Examples 12-15

[0065] Preparation of antipyretic and anti-inflammatory chewable tablets:

[0066] The raw materials and weight percentages of the chewable tablets in Examples 12 to 15 are shown in Table 4. All percentages are calculated by weight unless otherwise specified.

[0067] Table 4. Formula and antibacterial effect of the fire-clearing and mouth-clearing chewable tablets in Examples 12-15

[0068]

[0069]

[0070] The preparation method of the antipyretic and mouth-clearing chewable tablets is as follows:

[0071] (1) Take the prescribed amount of peppermint oil, clove oil and starch, mix them evenly, and let them stand for one day for later use.

[0072] (2) Take the prescribed amount of burdock concentrate, prunella vulgaris concentrate, sucralose and sorbitol, mix them thoroughly and set aside.

[0073] (3) Take the prescribed amount of sucrose powder, calcium carbonate, and magnesium hydroxide and mix them thoroughly. Then, mix them for 6 hours under the condition of wet air circulation with a relative humidity of 85% and set aside.

[0074] (4) Lactose and the materials obtained in (2) and (3) are mixed together and uniformly mixed, and wet granulation is performed using a 10% aqueous solution of povidone K-30 as a binder. The resulting wet granules are then transferred to a forced air drying oven and dried at 70°C for 3 hours to obtain dry granules.

[0075] (5) The dry granules obtained in (4) and the material obtained in (1) are mixed with the prescribed amount of magnesium stearate to obtain final mixed granules.

[0076] (6) The final mixed granules are compressed into tablets with a tablet weight of 1 g / tablet to obtain antipyretic chewable tablets.

[0077] The antibacterial effect test used the inhibition zone test method mentioned above.

[0078] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A Chinese herbal medicine composition for freshening breath, characterized in that: Includes the following ingredients: clove, burdock, prunella vulgaris, and mint.

2. The Chinese herbal medicine composition for freshening breath according to claim 1, characterized in that: The Chinese medicinal material composition can be used as a raw material to prepare tea bags, mouthwashes, oral candies or Chinese patent medicines.

3. The Chinese herbal medicine composition for freshening breath according to claim 2, characterized in that: The bagged tea bag comprises the following raw materials in percentage by weight: 37% to 48.5% of burdock, 37% to 48.5% of selfheal, 1% to 48.5% of clove, and 1.9% to 7.4% of mint; and the material particles of the bagged tea bag are larger than 60 meshes.

4. The Chinese herbal medicine composition for freshening breath according to claim 2, characterized in that: The components of the mouthwash, oral candy and Chinese patent medicine include burdock concentrate, selfheal concentrate, clove oil and mint oil; the oral candy includes chewing gum; and the Chinese patent medicine includes granules and chewable tablets.

5. The Chinese herbal medicine composition for freshening breath according to claim 4, characterized in that: The mouthwash comprises the following raw materials in percentage by weight: 1% to 10% burdock concentrate, 1% to 10% selfheal concentrate, 0.2% to 1% clove oil, 0.01% to 1% peppermint oil, 18% to 20% sorbitol, 10% to 12% food-grade ethanol, 3% to 8% Tween-40, 0.01% to 0.02% sodium saccharin, 0.15% to 0.2% sodium parabens, and 0.1% to 0.8% essence; the selfheal concentrate is a carbon dioxide supercritical extract of selfheal; and the burdock concentrate is a carbon dioxide supercritical extract of burdock.

6. The Chinese herbal medicine composition for freshening breath according to claim 4, characterized in that: The chewing gum comprises the following raw materials in percentage by weight: 1% to 5% of burdock concentrate, 1% to 5% of selfheal concentrate, 0.2% to 0.4% of clove oil, 0.01% to 0.5% of peppermint oil, 30% to 50% of edible gum base, 18% to 40% of xylitol, 10% to 30% of sorbitol, 0.2% to 0.1% of citric acid, and 3% to 7% of edible ethanol; the selfheal concentrate is a carbon dioxide supercritical extract of selfheal; and the burdock concentrate is a carbon dioxide supercritical extract of burdock.

7. The Chinese herbal medicine composition for freshening breath according to claim 4, characterized in that: The chewable tablet comprises the following raw materials in percentage by weight: 1% to 10% burdock concentrate, 1% to 10% prunella vulgaris concentrate, 0.2% to 0.4% clove oil, 0.01% to 0.5% peppermint oil, 0.3% to 0.5% sucralose, 5% to 15% sorbitol, 5% to 15% lactose, 15% to 45% starch, 27% to 50% sucrose powder, 1% to 4% magnesium stearate, and 2% to 4.4% povidone K-30; the prunella vulgaris concentrate is a carbon dioxide supercritical extract of prunella vulgaris; and the burdock concentrate is a carbon dioxide supercritical extract of burdock.

8. The Chinese herbal medicine composition for freshening breath according to claim 4, characterized in that: The preparation method of the burdock concentrate comprises the following steps: using two extraction kettles in parallel to extract the burdock, weighing two portions of crushed burdock respectively and loading them into two extraction kettles, pre-treating the burdock by using a coarse crusher for coarse crushing, and passing the crushed burdock through a 50-mesh sieve, extracting the burdock at a CO2 flow rate of 300 L / h, an extraction pressure of 30 MPa, an extraction time of 6 hours, and an extraction temperature of 40°C, to obtain a light yellow and clear product, namely the burdock concentrate.

9. The Chinese herbal medicine composition for freshening breath according to claim 4, characterized in that: The preparation method of the Prunella vulgaris concentrate comprises the following steps: crushing the Prunella vulgaris through a 40-mesh sieve and loading the Prunella vulgaris into an extraction tank; converting carbon dioxide gas from gas into liquid atomization at a temperature of 32° C. and a pressure of 15 to 20 MPa, and then adding ethanol with a weight percentage concentration of 2 to 3% for 2 to 5 hours; then flowing the material into a separator for separation, separating the medicinal residue and the extract, and adsorbing the separated mixed extract for 4 to 7 hours to obtain the Prunella vulgaris concentrate after adsorption.

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