Traditional Chinese medicine composition for treating dysentery
Through the synergistic effect of montmorillonite and scorched rice flour, a traditional Chinese medicine composition is prepared, which solves the problem of poor effect when used alone and achieves better dysentery treatment effect and gastrointestinal protection.
Patent Information
- Application Number
- CN202511064189.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-31
- Publication Date
- 2025-09-12
AI Technical Summary
Existing montmorillonite is not effective in treating dysentery alone. Although scorched rice flour has the effect of astringing the intestines and stopping diarrhea, it can easily cause abdominal distension and lacks a synergistic therapeutic effect.
Montmorillonite is combined with scorched rice flour to enhance adsorption capacity through synergistic effect, reduce the irritation of montmorillonite, strengthen gastrointestinal digestion ability, and prepare a traditional Chinese medicine composition for treating dysentery.
The adsorption capacity of diarrhea-causing substances is enhanced, the irritation of montmorillonite is reduced, the effect of treating dysentery is improved, and the raw materials are easy to obtain and the cost is low.
Smart Images
Figure BDA0005526457200000051
Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition for treating dysentery. Background Art
[0002] Dysentery is characterized by increased bowel movements, abdominal pain, tenesmus, and red, white, sticky, and frozen stool. It is caused by a bacterial infection and is a common infectious disease in summer and autumn. The Neijing (Inner Canon of Medicine) refers to this disease as "intestinal diarrhea" and "red diarrhea," citing exposure to external pathogens and an unhealthy diet as key contributors.
[0003] The principle of dysentery treatment is to clear heat-related dysentery and warm cold-related dysentery. Initial dysentery should be treated with astringent therapy, while chronic dysentery should be treated with tonifying therapy. For patients with alternating cold and heat syndromes, both clearing and warming therapy should be used, while for patients with a mixture of deficiency and excess, both attacking and tonifying therapy should be used. In the initial stage of dysentery, symptoms of excess and heat are more common, and clearing heat, removing dampness, and detoxifying are recommended. For chronic dysentery with deficiency and cold syndromes, tonifying and warming the middle, regulating the spleen and stomach, and clearing the intestines, as well as astringing and strengthening the bowels, are recommended. For dysentery with both exterior symptoms, combined with antipyretics, external purgatives, and internal purgatives are recommended. For those with food stagnation, digestive agents can be used to eliminate stagnation. In addition, in the treatment of dysentery, avoid premature tonifying and astringent therapy, harsh purgatives, and diuretics. There are various treatment options, the most common being medication, but Traditional Chinese Medicine (TCM) is also an option. The appropriate treatment is tailored to the individual patient's condition. Treatment of bacillary dysentery includes general therapy, antimicrobial therapy, and other therapies. The most appropriate treatment is determined by whether the patient suffers from toxic bacillary dysentery or other types of bacillary dysentery, the cause, and the severity of the condition. In terms of medication, antibiotics and quinolones can be used. Besides some commonly used medications, other medications can treat dysentery, such as montmorillonite and scorched rice flour. Montmorillonite can have a certain therapeutic effect on dysentery, but simply taking montmorillonite is not particularly effective for dysentery patients. It can help stop diarrhea, but in terms of therapeutic effect, it is not the best.
[0004] In an experiment on the clinical efficacy of montmorillonite in treating acute bacterial dysentery in children, Liao Shuxia and others took montmorillonite orally in addition to conventional antibiotic treatment techniques. By observing changes in body temperature and stool, they found that oral administration of montmorillonite in addition to conventional antibiotic treatment techniques could better treat dysentery. The final conclusion was that montmorillonite can directly adsorb pathogens, enhance the mucus barrier, and adsorb toxins to achieve the effect of treating diseases, reduce the damage of inflammation to the mucosa, effectively improve clinical efficacy, shorten the course of treatment, and is worthy of clinical promotion and use.
[0005] Scorched rice flour has the effect of astringing the intestines and stopping diarrhea. The ingredients in scorched rice flour have a constricting and astringent effect, effectively helping to repair the intestinal mucosa, thereby achieving the purpose of stopping diarrhea. Scorched rice flour contains a certain amount of carbohydrates that are easily digested and absorbed by the human body. Eating a moderate amount can absorb the intestinal mucosa and promote the excretion of harmful substances, thereby alleviating diarrhea symptoms. For those with more severe diarrhea symptoms, eating a moderate amount of scorched rice flour can improve them. However, be careful to avoid excessive consumption to avoid causing discomfort such as abdominal distension. Summary of the Invention
[0006] The present invention provides a traditional Chinese medicine composition for treating dysentery. The synergistic effect between montmorillonite and scorched rice flour enhances the adsorption capacity of diarrhea-causing substances, thereby enhancing the adsorption capacity of both, reducing the irritation of montmorillonite alone, strengthening the gastrointestinal digestion ability, and having excellent efficacy in treating dysentery.
[0007] In order to achieve the purpose of the present invention, the technical solution of the present invention is as follows:
[0008] A traditional Chinese medicine composition for treating dysentery is composed of the following materials in parts by weight: 1-3 parts of montmorillonite powder, 6-8 parts of burnt rice powder, and 0.1-0.5 part of a dispersant.
[0009] Furthermore, the preparation method comprises the following steps:
[0010] S1: Grind montmorillonite and sieve it.
[0011] S2: Take rice, add water and soak it at 25°C for a set time, take it out and drain the water, stir-fry it, stir-fry it at 120°C for 10 minutes, and then stir-fry it at 200°C for 5 minutes, then grind the rice and sieve it.
[0012] S3: taking the burnt rice powder and montmorillonite powder produced in steps S1 and S2, mixing them to obtain a traditional Chinese medicine composition for treating dysentery.
[0013] Furthermore, in the preparation method S1, a 80-200 mesh sieve is used for sieving, preferably a 90-100 mesh sieve is used; and in S2, a 80-120 mesh sieve is used for sieving, preferably a 90-100 mesh sieve is used.
[0014] Furthermore, in the preparation method S2, the soaking time of the rice is 30-120 minutes, and the weight of the added water is 1-2 times the weight of the rice.
[0015] Furthermore, the Chinese medicine composition is for oral administration and is taken with water, with the amount of water being 1-10 times the total mass of the composition.
[0016] Compared with existing technologies, the present invention has the following advantages: the traditional Chinese medicine composition provided by the present invention enhances the adsorption capacity of diarrheal substances through the synergistic effect between montmorillonite and burnt rice flour, thereby enhancing the adsorption capacity of both, reducing the irritation of montmorillonite alone, and enhancing gastrointestinal digestion, thereby having excellent efficacy in treating dysentery. In addition, the raw materials of the present invention are readily available, the cost is low, and the effect is excellent. DETAILED DESCRIPTION
[0017] The present invention is further explained below with reference to the following examples, but the examples do not limit the present invention in any form.
[0018] In this embodiment, the montmorillonite is pharmaceutical grade montmorillonite purchased from Wuhu Shuohua New Materials Co., Ltd.; and the rice is purchased from Bozhou Bencaotang Biotechnology Co., Ltd.
[0019] Example 1
[0020] Take 100g of montmorillonite and grind it into powder. Pass it through a 100-mesh sieve to obtain 91g of montmorillonite powder for later use.
[0021] Take 100 grams of rice, soak it in an equal amount of water for 30 minutes, take it out and drain the water, stir-fry it at 120°C for 10 minutes, and then stir-fry it at 200°C for 5 minutes, then grind the rice into scorched rice flour, pass it through a 100-mesh sieve, and obtain 92 grams of scorched rice flour for later use;
[0022] Take 3 grams of montmorillonite powder, 6 grams of burnt rice powder, and 0.3 grams of sodium carboxymethyl cellulose, and mix them thoroughly to obtain a traditional Chinese medicine composition for treating dysentery.
[0023] Example 2
[0024] Take 2.5 grams of montmorillonite powder, 6.5 grams of scorched rice flour, and 0.3 grams of sodium carboxymethyl cellulose and mix them thoroughly to obtain a traditional Chinese medicine composition for treating dysentery, wherein the preparation methods of montmorillonite powder and scorched rice flour are the same as those in Example 1.
[0025] Example 3
[0026] Take 2.0 g of montmorillonite powder, 7.0 g of scorched rice flour, and 0.3 g of sodium carboxymethyl cellulose and mix them thoroughly to obtain a traditional Chinese medicine composition for treating dysentery, wherein the preparation methods of montmorillonite powder and scorched rice flour are the same as those in Example 1.
[0027] Example 4
[0028] Take 1.5 grams of montmorillonite powder, 7.5 grams of scorched rice flour, and 0.3 grams of sodium carboxymethyl cellulose and mix them thoroughly to obtain a traditional Chinese medicine composition for treating dysentery, wherein the preparation methods of montmorillonite powder and scorched rice flour are the same as those in Example 1.
[0029] Example 5
[0030] Take 1.0 g of montmorillonite powder, 8.0 g of scorched rice flour, and 0.3 g of sodium carboxymethyl cellulose and mix them thoroughly to obtain a traditional Chinese medicine composition for treating dysentery, wherein the preparation methods of montmorillonite powder and scorched rice flour are the same as those in Example 1.
[0031] Comparative Example 1
[0032] 9.0 g of montmorillonite powder and 0.3 g of sodium carboxymethyl cellulose were taken and mixed thoroughly, and the mixture was used as a single drug. The montmorillonite powder was prepared in the same manner as in Example 1.
[0033] Comparative Example 2
[0034] Take 9.0 g of burnt rice powder and 0.3 g of sodium carboxymethyl cellulose, mix them thoroughly, and use them as a medicine alone. The burnt rice powder is prepared in the same manner as in Example 1.
[0035] Drug trials
[0036] The following experimental examples further illustrate that the use of a mixed solution of montmorillonite powder and scorched rice powder in the present invention to treat dysentery has a more effective therapeutic effect than using montmorillonite powder or scorched rice powder alone.
[0037] 90 ICR mice aged 4 to 6 weeks and weighing 18-22 g were randomly divided into 9 groups (10 model mice per group, half male and half female), including a positive control group (20 mg / ml ciprofloxacin hydrochloride aqueous solution), a blank control group (0.9% sodium chloride solution), Example groups 1-5, and Comparative Example groups 1-2. The bacterial dysentery model was established using pathogenic Escherichia coli serotype 139, with 0.58×10 8 CFU / ml, 0.2 ml per 10 grams of body weight, intraperitoneally injected. After the mice developed diarrhea, all Example and Comparative Example groups were gavaged with the drug powder, mixed with an equal weight of water, at a drug dosage of 1% of the mouse's body weight. The positive control group was gavaged with a 20 mg / ml ciprofloxacin hydrochloride aqueous solution, at a gavage volume of 2 ml / 100 g of mouse body weight. The blank control group was gavaged with a 0.9% sodium chloride solution, at a gavage volume of 2 ml / 100 g of mouse body weight.
[0038] Observe the amount of stool (expressed as the number of dry fecal pellets or loose stool piles) and the diarrhea rate (the presence of unformed loose stools as an indicator of diarrhea) 1 hour before dosing and every hour after dosing for 4 consecutive hours. Dry fecal pellets were counted directly, and loose stools were measured by piles (each pile ≥ 3g was considered 1 unit). Diarrhea was determined as the presence of unformed loose stools. Diarrhea rate = number of animals with diarrhea / total number of animals × 100%.
[0039] During the experiment, mice were free to drink water and eat. Finally, the amount of feces during the period of maximum feces (1-3 hours) after drug administration and the diarrhea rate of mice within 1-4 hours were used as indicators for statistical analysis. The results are shown in Table 1.
[0040] Table 1: Effects of Chinese herbal medicine combination on diarrhea rate and feces volume in mice with bacillary dysentery
[0041]
[0042] The results showed that the diarrhea rate and stool volume of mice in the positive control group were lower than those in the blank control group, indicating that the drug experimental design was reasonable. The mice in the Chinese medicine composition group 3 had the smallest stool volume and the lowest diarrhea rate after administration, only 10%, indicating the best effect.
[0043] Compared with the blank control group (pure 0.9% sodium chloride solution), Example Groups 1 to 5 have obvious antidiarrheal effects, and Comparative Example 1 has a better antidiarrheal effect than Comparative Example 2.
[0044] In Example Groups 1 to 5, the amount of stool and the diarrhea rate varied with the different ratios of montmorillonite to scorched rice powder. The antidiarrheal effect was best when the ratio of montmorillonite to scorched rice powder was 2:7, and the antidiarrheal effect was better when the ratio ranged from 1:2 to 1:8.
[0045] When montmorillonite and scorched rice flour are used together, a synergistic effect can occur to treat dysentery, with better results than using either alone. Montmorillonite can have a good antidiarrheal effect on dysentery. The ingredients in scorched rice flour can have astringent and firming effects, effectively helping to repair the intestinal mucosa, thereby achieving the purpose of stopping diarrhea. Scorched rice flour contains a certain amount of carbohydrates, which are easily digested and absorbed by the human body and can reduce the irritation of montmorillonite to the stomach and intestines. The combination of the two can reduce the irritation of montmorillonite and enhance the adsorption capacity of scorched rice flour, so that the composition can cover and protect the digestive tract mucosa, repair and enhance the mucosal barrier function, and achieve the purpose of treating dysentery.
[0046] The above only lists the preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereto. Any changes made by those skilled in the art within the scope of the claims of the present invention shall fall within the protection scope of the present invention.
Claims
1. A Chinese medicine composition for treating dysentery, characterized in that: The composition is prepared by mixing 1-3 weight parts of montmorillonite powder as component A, 6-8 weight parts of coked rice powder as component B, and 0.1-0.5 weight part of a dispersant.
2. The Chinese medicine composition according to claim 1, wherein Mix component A and component B in a ratio of 1:2 to 1:8 parts by weight.
3. The Chinese medicine composition according to claim 1, wherein The preparation method comprises the following steps: S1: Grind montmorillonite into granules and pass through 80-200 mesh sieve. S2: soak rice in water, drain the water, stir-fry at 120°C for 10 minutes, and then stir-fry at 200°C for 5 minutes, then grind the rice into burnt rice flour and pass it through an 80-120 mesh sieve. S3: Take the montmorillonite powder and burnt rice powder prepared in S1 and S2, mix them evenly, and obtain.
4. The Chinese medicine composition according to claim 3, wherein The soaking time of rice in S2 is 30-40 minutes, and the weight of water is 1-2 times the weight of the medicinal materials.
5. The Chinese medicine composition according to claim 1, wherein The dispersant is a mixture of one or more of carboxymethyl cellulose and sodium polyacrylate.
6. The Chinese medicine composition according to claim 1, characterized in that For oral use.