Kinesio bandage with slow release function and preparation process thereof

Abstract

The invention discloses a kinesio bandage with a slow release function and a preparation process thereof, the kinesio bandage comprises a functional spraying agent, and a contact layer, a slow release layer and a substrate layer which are laminated and compounded in sequence, and the invention relates to the technical field of kinesio. According to the kinesio bandage with the slow release function and the preparation process thereof, a functional spraying agent is independently designed, when the kinesio bandage is used, coupling of the functional spraying agent and a buffer layer is achieved by spraying the functional spraying agent to a contact layer, and under the moisture absorption effect of sodium polyacrylate moisture absorption particles, rapid gelation of the functional spraying agent on the surface of the contact layer is achieved; according to the present invention, the skin surface temperature is responded through the poloxamer 407, such that the rapid formation of the gel state of the contact layer is ensured, the drug release speed is accelerated along with the increase of the skin surface temperature, and the dynamic drug sustained release support condition is provided for the sports personnel;

Description

Technical Field

[0001] The invention relates to the technical field of kinesiology tape, in particular to a kinesiology tape bandage with a sustained-release function and a preparation process thereof. Background Art

[0002] Kinesio tape is a tape developed primarily for the treatment of joint and muscle pain. It's widely used in sports health and protection, primarily by athletes. The medical community has also begun using it to treat joint conditions. Fitness enthusiasts who don't exercise regularly but suffer from joint pain can also find relief through the application of Kinesio tape. Existing Kinesio tape bandages primarily relieve symptoms through physical compression or fixation, resulting in uncontrolled drug release. Furthermore, Kinesio tape designs often require good breathability, which accelerates drug spillage, reduces drug utilization efficiency, and shortens the duration of drug effect.

[0003] In view of this, a kinesiology bandage with sustained-release function and its preparation process are proposed. The three-layer composite structure ensures good air permeability of the bandage, and the coupling of the functional spray and the sustained-release layer is used to achieve the sustained release of the drug, thereby improving the utilization efficiency of the drug and having a long-lasting and effective use effect. Summary of the Invention

[0004] In view of the shortcomings of the existing technology, the present invention provides a kinesiology bandage with sustained-release function and a preparation process thereof, which solves the problems of uncontrollable drug release, fast drug overflow and reduced drug utilization efficiency of the existing kinesiology bandage.

[0005] To achieve the above objectives, the present invention is implemented through the following technical solutions: a kinesiology bandage with sustained-release function, comprising a functional spray, and a contact layer, a sustained-release layer, and a base layer laminated in sequence; The contact layer raw materials include, by weight: 60-75 parts of polyurethane base material, 10-18 parts of hydrophilic modifier, 5-12 parts of fluorinated hydrophobic modifier, and 5-10 parts of medical pressure-sensitive adhesive; The raw materials of the sustained-release layer include, by weight: 40-60 parts of polyethersulfone nanofibers and 20-30 parts of sodium polyacrylate moisture-absorbing particles; The raw materials of the base layer include, by weight, 50-65 parts of spandex fiber, 25-35 parts of diatomaceous earth, 75-102 parts of polyurethane emulsion, and 10-15 parts of acrylic ester copolymer.

[0006] The present invention is further configured as follows: the hydrophilic modifier is carboxyl-grafted polyethylene glycol; The fluorinated hydrophobic modifier is a fluorinated acrylic copolymer; The medical pressure-sensitive adhesive is one of an acrylic pressure-sensitive adhesive and a silicone adhesive.

[0007] The present invention is further configured as follows: the diameter of the polyethersulfone nanofiber is 200-500 nm, and the particle size of the sodium polyacrylate hygroscopic particles is 5-10 μm.

[0008] The present invention is further configured as follows: the particle size of the diatomaceous earth is 10-20 μm, and the solid content of the polyurethane emulsion is 30% to 32%.

[0009] The present invention is further configured as follows: the functional spray raw materials include, by weight, 25-35 parts of an inner water phase, 40-50 parts of an oil phase, and 25-35 parts of an outer water phase.

[0010] The present invention is further configured as follows: the raw materials of the inner aqueous phase include: diclofenac sodium, menthol, and nano-silver dispersion, wherein the weight ratio of diclofenac sodium, menthol, and nano-silver dispersion is: 3-5:1.5-2.5:0.5-1.2; The raw materials of the oil phase include: polylactic acid-glycolic acid copolymer, vitamin E acetate, and ethyl acetate, wherein the weight ratio of polylactic acid-glycolic acid copolymer, vitamin E acetate, and ethyl acetate is: 12-16:3-4:1-2; The raw materials of the external aqueous phase include: xanthan gum, poloxamer 407, and volatile silicone penetration enhancer, wherein the weight ratio of xanthan gum, poloxamer 407 and volatile silicone penetration enhancer is: 1.2-2.0:10-15:0.2-0.5.

[0011] The present invention provides a kinesiology bandage with a sustained-release function and a preparation process thereof. It has the following beneficial effects: (1) The present invention designs a functional spray separately. When in use, the functional spray is sprayed onto the contact layer to achieve coupling with the buffer layer. Under the hygroscopic effect of the sodium polyacrylate hygroscopic particles, the functional spray on the surface of the contact layer is rapidly gelled to achieve sustained release of the drug. In addition, poloxamer 407 responds to the skin surface temperature to ensure the rapid formation of the gel state of the contact layer. As the skin surface temperature increases, the drug release rate is accelerated, providing dynamic drug sustained release support conditions for athletes.

[0012] (2) The present invention achieves close fitting of the contact layer, the sustained-release layer and the base layer by hot pressing. During the process, polyurethane penetrates into the sustained-release layer to form a physical anchor point, thereby ensuring the connection stability of the contact layer, the sustained-release layer and the base layer and avoiding interface stratification. When sodium polyacrylate absorbs sweat and expands, the structural stability is ensured and the drug release rate is accelerated. Diatomaceous earth absorbs water and expands, which can effectively prevent the penetration of external sweat while filling the gaps in the base layer to form a hydrophobic barrier, reduce the volatilization waste of the drug, achieve long-lasting sustained release of the drug, and enhance the fit between the bandage and the skin, thereby alleviating muscle vibration during exercise. DETAILED DESCRIPTION

[0013] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0014] The embodiments of the present invention provide the following technical solutions: Example 1 A kinesiology bandage with a sustained-release function comprises a functional spray, and a contact layer, a sustained-release layer and a base layer which are laminated in sequence.

[0015] As a preferred embodiment, the contact layer raw materials include, by weight, 75 parts of a polyurethane base material, 18 parts of a hydrophilic modifier, 12 parts of a fluorinated hydrophobic modifier, and 10 parts of a medical pressure-sensitive adhesive. The fluorinated hydrophobic modifier is a fluorine-containing acrylic copolymer, which is used to construct a hydrophobic layer at the edge of the polyurethane base material. The hydrophilic modifier is a carboxyl-grafted polyethylene glycol, which is used to perform hydrophilic modification within the circumferential closed space after the hydrophobic layer forms a circumferential closed space, thereby ensuring stable absorption of the functional spray. In order to ensure stable skin adhesion, the medical pressure-sensitive adhesive is a silicone adhesive.

[0016] The preparation method of the contact layer is as follows: The fluorinated hydrophobic modifier is evenly mixed with the medical pressure-sensitive adhesive, and then sprayed on the edge of the polyurethane substrate to form a circumferential closed space. The hydrophilic modifier is evenly mixed with the medical pressure-sensitive adhesive, and then sprayed inside the circumferential closed space.

[0017] The raw materials of the sustained-release layer include, by weight: 40 parts of polyethersulfone nanofibers and 20 parts of sodium polyacrylate hygroscopic particles, wherein the diameter of the polyethersulfone nanofibers is 200 nm, and the particle size of the sodium polyacrylate hygroscopic particles is 5 μm.

[0018] The preparation method of the sustained-release layer is as follows: After the polyethersulfone nanofibers and sodium polyacrylate hygroscopic particles were evenly mixed, the polyethersulfone nanofiber membrane was prepared by electrospinning with a voltage of 20 kV and a receiving distance of 15 cm to obtain a sustained-release layer.

[0019] The raw materials of the base layer include, by weight, 50 parts of spandex fiber, 35 parts of diatomaceous earth, 102 parts of polyurethane emulsion, and 15 parts of acrylate copolymer, wherein the particle size of the diatomaceous earth is 10 μm and the solid content of the polyurethane emulsion is 30%.

[0020] The preparation method of the base layer is as follows: Diatomaceous earth and polyurethane emulsion were mixed into a slurry. A low-temperature plasma treatment machine with a frequency of 13.56 MHz and a vacuum degree of 10 Pa was used to perform plasma surface modification on the spandex fiber at a power of 50 W for 3 minutes. After the slurry was added, the fiber was put into a twin-screw extruder for melt blending at 180°C. A 50 μm composite fiber was obtained through a spinning process, and the composite fiber was warp-woven into a base layer.

[0021] It is further explained that after the base layer is prepared, the sustained-release layer is prepared directly on one side of the base layer by electrospinning, and then the polyurethane substrate is placed on one side of the sustained-release layer, and hot-pressed at 120°C and 0.3 MPa for 10 minutes to obtain the bandage body.

[0022] After obtaining the bandage body, honeycomb-shaped micropores are laser-engraved in the closed space around the bandage body to obtain a contact layer with a pore size of 50 μm.

[0023] The functional spray comprises, by weight, 35 parts of an inner aqueous phase, 40 parts of an oil phase, and 35 parts of an outer aqueous phase. The inner aqueous phase comprises diclofenac sodium, menthol, and a nano-silver dispersion. The weight ratio of diclofenac sodium, menthol, and the nano-silver dispersion is 5:1.5:1.2. The raw materials of the oil phase include: polylactic acid-glycolic acid copolymer, vitamin E acetate, and ethyl acetate, wherein the weight ratio of polylactic acid-glycolic acid copolymer, vitamin E acetate, and ethyl acetate is 16:3:2; The raw materials of the external water phase include: xanthan gum, poloxamer 407, and volatile silicone penetration enhancer, wherein the weight ratio of xanthan gum, poloxamer 407 and volatile silicone penetration enhancer is: 2.0:10:0.5.

[0024] The preparation method of the functional spray is: S41, dissolving diclofenac sodium and menthol in deionized water, adding the nanosilver dispersion, and ultrasonically dispersing at 300W for 15 minutes in a 40°C water bath to obtain an inner aqueous phase; S42, dissolving poly(lactic-co-glycolic acid) and vitamin E acetate in ethyl acetate, stirring magnetically at 600 rpm for 30 min, and degassing under vacuum at -0.08 MPa for 22 min to obtain an oil phase; S43, mixing xanthan gum and volatile silicone penetration enhancer uniformly to obtain an external water phase; S44, mixing the inner aqueous phase and the oil phase in a volume ratio of 1:4, passing through a microfluidizer at a pressure of 80 MPa, and circulating three times to obtain a primary emulsion with a particle size of ≤5 μm; S45, mixing the primary emulsion with the external aqueous phase at a volume ratio of 1:3, passing through a microfluidizer at a pressure of 60 MPa, and circulating twice to obtain an emulsion with a droplet size of 20 μm and a D90 of ≤ 55 μm; S46. Add Poloxamer 407 to the emulsion, stir magnetically at 400 rpm for 15 minutes, and let stand at 4°C for 24 hours to obtain a functional spray.

[0025] When in use, spray the functional spray on the closed space around the bandage body, irradiate with 980nm infrared radiation at a power of 50W for 5s to complete the bandage preparation, and then stick the bandage body on the skin surface.

[0026] Example 2 A kinesiology bandage with a sustained-release function differs from the first embodiment in that: The contact layer raw materials include, by weight: 68 parts of polyurethane base material, 16 parts of hydrophilic modifier, 8 parts of fluorinated hydrophobic modifier, and 9 parts of medical pressure-sensitive adhesive, wherein the medical pressure-sensitive adhesive is an acrylic pressure-sensitive adhesive.

[0027] The raw materials of the sustained-release layer include, by weight: 50 parts of polyethersulfone nanofibers and 25 parts of sodium polyacrylate hygroscopic particles, wherein the diameter of the polyethersulfone nanofibers is 350 nm, and the particle size of the sodium polyacrylate hygroscopic particles is 8 μm.

[0028] The raw materials of the base layer include, by weight, 58 parts of spandex fiber, 31 parts of diatomaceous earth, 92 parts of polyurethane emulsion, and 13 parts of acrylate copolymer, wherein the particle size of the diatomaceous earth is 16 μm and the solid content of the polyurethane emulsion is 31%.

[0029] The preparation method of the base layer is as follows: Diatomaceous earth and polyurethane emulsion were mixed into a slurry. A low-temperature plasma treatment machine with a frequency of 13.56 MHz and a vacuum degree of 10 Pa was used to perform plasma surface modification on the spandex fiber at a power of 50 W for 4 minutes. After the slurry was added, the fiber was put into a twin-screw extruder for melt blending at 190°C. A 65 μm composite fiber was obtained through a spinning process, and the composite fiber was warp-woven into a base layer.

[0030] After the base layer is prepared, the sustained-release layer is prepared directly on one side of the base layer by electrospinning. The polyurethane substrate is then placed on one side of the sustained-release layer and hot-pressed at 130°C and 0.4 MPa for 12 minutes to obtain the bandage body.

[0031] After obtaining the bandage body, honeycomb-shaped micropores are laser-engraved in the closed space around the bandage body to obtain a contact layer with a pore size of 80 μm.

[0032] The functional spray comprises, by weight, 30 parts of an inner aqueous phase, 45 parts of an oil phase, and 30 parts of an outer aqueous phase. The inner aqueous phase comprises diclofenac sodium, menthol, and a nano-silver dispersion, wherein the weight ratio of diclofenac sodium, menthol, and the nano-silver dispersion is 4:2:0.9. The raw materials of the oil phase include: polylactic acid-glycolic acid copolymer, vitamin E acetate, and ethyl acetate, wherein the weight ratio of polylactic acid-glycolic acid copolymer, vitamin E acetate, and ethyl acetate is 14:3.5:1.5; The raw materials of the external water phase include: xanthan gum, poloxamer 407, and volatile silicone penetration enhancer, wherein the weight ratio of xanthan gum, poloxamer 407 and volatile silicone penetration enhancer is: 1.8:13:0.4.

[0033] The preparation method of the functional spray is: S41, dissolving diclofenac sodium and menthol in deionized water, adding the nanosilver dispersion, and ultrasonically dispersing at 300W in a 40°C water bath for 20 minutes to obtain an inner aqueous phase; S42, dissolving poly(lactic-co-glycolic acid) and vitamin E acetate in ethyl acetate, stirring magnetically at 600-800 rpm for 40 min, and degassing under vacuum at -0.08 MPa for 30 min to obtain an oil phase; S43, mixing xanthan gum and volatile silicone penetration enhancer uniformly to obtain an external water phase; S44, mixing the inner aqueous phase and the oil phase in a volume ratio of 1:4, passing through a microfluidizer at a pressure of 80 MPa, and circulating three times to obtain a primary emulsion with a particle size of ≤5 μm; S45, after mixing the primary emulsion and the external aqueous phase at a volume ratio of 1:3, the mixture was passed through a microfluidizer at a pressure of 60 MPa for two cycles to obtain an emulsion with a droplet size of 35 μm; S46. Poloxamer 407 was added to the emulsion, and the mixture was magnetically stirred at 300 rpm for 25 minutes. The mixture was allowed to stand at 4° C. for 24 hours to obtain a functional spray.

[0034] When in use, spray the functional spray on the circumferential closed space of the bandage body, irradiate with 980nm infrared radiation at a power of 50W for 7s to complete the bandage preparation, and then stick the bandage body on the skin surface.

[0035] Example 3 A kinesiology bandage with a sustained-release function differs from the first embodiment in that: The raw materials of the contact layer include, by weight, 60 parts of a polyurethane base material, 10 parts of a hydrophilic modifier, 5 parts of a fluorinated hydrophobic modifier, and 5 parts of a medical pressure-sensitive adhesive.

[0036] The raw materials of the sustained-release layer include, by weight: 60 parts of polyethersulfone nanofibers and 30 parts of sodium polyacrylate hygroscopic particles, wherein the diameter of the polyethersulfone nanofibers is 500 nm, and the particle size of the sodium polyacrylate hygroscopic particles is 10 μm.

[0037] The raw materials of the base layer include, by weight, 65 parts of spandex fiber, 25 parts of diatomaceous earth, 75 parts of polyurethane emulsion, and 10 parts of acrylate copolymer, wherein the particle size of the diatomaceous earth is 20 μm and the solid content of the polyurethane emulsion is 32%.

[0038] The preparation method of the base layer is as follows: Diatomaceous earth and polyurethane emulsion were mixed into a slurry. A low-temperature plasma treatment machine with a frequency of 13.56 MHz and a vacuum degree of 10 Pa was used to perform plasma surface modification on the spandex fiber at a power of 50 W for 5 minutes. After the slurry was added, the fiber was put into a twin-screw extruder for melt blending at 200°C. A 80 μm composite fiber was obtained through a spinning process, and the composite fiber was warp-woven into a base layer.

[0039] After the base layer is prepared, the sustained-release layer is prepared directly on one side of the base layer by electrospinning. The polyurethane substrate is then placed on one side of the sustained-release layer and hot-pressed at 140°C and 0.5 MPa for 15 minutes to obtain the bandage body.

[0040] As a preferred solution, after obtaining the bandage body, honeycomb-shaped micropores are laser-engraved in the closed space around the bandage body to obtain a contact layer with a pore size of 100 μm.

[0041] The functional spray comprises, by weight, 25 parts of an inner aqueous phase, 50 parts of an oil phase, and 25 parts of an outer aqueous phase. The inner aqueous phase comprises diclofenac sodium, menthol, and a nano-silver dispersion. The weight ratio of diclofenac sodium, menthol, and the nano-silver dispersion is 3:2.5:0.5. The raw materials of the oil phase include: polylactic acid-glycolic acid copolymer, vitamin E acetate, and ethyl acetate, wherein the weight ratio of polylactic acid-glycolic acid copolymer, vitamin E acetate, and ethyl acetate is 12:4:1; The raw materials of the external water phase include: xanthan gum, poloxamer 407, and volatile silicone penetration enhancer, wherein the weight ratio of xanthan gum, poloxamer 407 and volatile silicone penetration enhancer is: 1.2:15:0.2.

[0042] The preparation method of the functional spray is: S41, dissolving diclofenac sodium and menthol in deionized water, adding the nanosilver dispersion, and ultrasonically dispersing at 300W in a 40°C water bath for 25 minutes to obtain an inner aqueous phase; S42, dissolving poly(lactic-co-glycolic acid) and vitamin E acetate in ethyl acetate, stirring magnetically at 800 rpm for 45 min, and degassing under vacuum at -0.08 MPa for 35 min to obtain an oil phase; S43, mixing xanthan gum and volatile silicone penetration enhancer uniformly to obtain an external water phase; S44, mixing the inner aqueous phase and the oil phase in a volume ratio of 1:4, passing through a microfluidizer at a pressure of 80 MPa, and circulating three times to obtain a primary emulsion with a particle size of ≤5 μm; S45, after mixing the primary emulsion and the external aqueous phase at a volume ratio of 1:3, the mixture was passed through a microfluidizer at a pressure of 60 MPa for two cycles to obtain an emulsion with a droplet size of 50 μm; S46. Poloxamer 407 was added to the emulsion, and the mixture was magnetically stirred at 200 rpm for 30 minutes. The mixture was allowed to stand at 4° C. for 24 hours to obtain a functional spray.

[0043] When in use, spray the functional spray on the closed space around the bandage body, irradiate with 980nm infrared radiation at a power of 50W for 8s to complete the bandage preparation, and then stick the bandage body on the skin surface.

[0044] The bandages obtained according to Example 1, Example 2 and Example 3 were tested for 8-hour drug release, adhesion, antibacterial effect, transdermal penetration efficiency and support.

[0045] The 8-hour drug release test method is as follows: Franz diffusion cell method, 37°C, PBS buffer, and timed sampling and high performance liquid chromatography to detect drug concentration; Adhesion was tested using a universal testing machine at a 90° peel angle according to ASTM D3330. The antibacterial effect was tested by inoculating Staphylococcus aureus using the agar diffusion method, applying the sample and culturing for 24 hours, then measuring the diameter of the inhibition zone.

[0046] The test results are shown in Table 1: Example 1 Example 2 Example 3 8h drug release (%) 65.8 62.3 57.6 <![CDATA[ Adhesion force (N / cm 2 )]]> 2.0 1.8 1.5 Antibacterial effect (mm) 11.85 10.23 8.56 Table 1 Simulation experiment Taking Example 2 as an example, KT-2024 and RT-EX sports patches were introduced as comparative examples.

[0047] To test the drug release stability under dynamic conditions, the USP IV flow cell method was used, with a medium of pH 6.8 PBS and a flow rate of 15 ml / min. Static release was measured at 25°C for 24 hours. Dynamic release was measured at 37°C for 8 hours at a stretch rate of 30% and a frequency of 1 Hz to simulate exercise conditions. The coefficient of variation of the release curve was measured by high-performance liquid chromatography after immersion in 0.9% NaCl solution, and the release fluctuation index after sweat immersion was obtained. The test results are shown in Table 2: Test indicators KT-2024 RT-EX Example 2 25℃ static 24h release (%) none 5.2 18.5 Dynamic release at 37℃ for 8 hours (%) none 8.1 62.3 Sweat immersion release fluctuation (%) Adhesive layer peeling off 21.4 4.8 Table 2 As can be seen from Table 2, the dynamic release of the present invention at 37° C. is 7.7 times that of KT-2024 and 7.5 times that of RT-EX, and has a good dynamic release.

[0048] In order to test the fixing ability and structural integrity in motion, longitudinal breaking strength, adhesion retention, motion displacement and peel strength after sweat absorption were used as indicators for testing and comparison. The test results are shown in Table 3: Test indicators KT-2024 RT-EX Example 2 Longitudinal breaking strength (N / cm) 18.7 22.5 26.9 Adhesion retention rate (%) 58 73 89 Movement displacement (mm) 5.2 3.8 1.3 Peel strength after sweat absorption (N / cm) 6.8 9.5 17.6 Table 3 As can be seen from Table 3, the peel strength retention rate of the present invention after sweat absorption is improved by 159% compared with KT-2024 and 85% compared with RT-EX, and the movement displacement is reduced by more than 75%.

[0049] In summary, it can be seen that the Kinesiology tape bandage provided by the present invention not only has a good dynamic sustained-release effect, but also has good connection strength and environmental adaptability, and can be better adapted to use in sports conditions.

[0050] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A kinesiology bandage with sustained-release function, characterized in that: It comprises a functional spray, and a contact layer, a sustained-release layer and a base layer which are laminated in sequence; The contact layer raw materials include, by weight: 60-75 parts of polyurethane base material, 10-18 parts of hydrophilic modifier, 5-12 parts of fluorinated hydrophobic modifier, and 5-10 parts of medical pressure-sensitive adhesive; The raw materials of the sustained-release layer include, by weight: 40-60 parts of polyethersulfone nanofibers and 20-30 parts of sodium polyacrylate moisture-absorbing particles; The raw materials of the base layer include, by weight, 50-65 parts of spandex fiber, 25-35 parts of diatomaceous earth, 75-102 parts of polyurethane emulsion, and 10-15 parts of acrylic ester copolymer.

2. The kinesiology bandage with sustained-release function according to claim 1, characterized in that: The hydrophilic modifier is carboxyl-grafted polyethylene glycol; The fluorinated hydrophobic modifier is a fluorinated acrylic copolymer; The medical pressure-sensitive adhesive is one of an acrylic pressure-sensitive adhesive and a silicone adhesive.

3. The kinesiology bandage with sustained-release function according to claim 1, characterized in that: The diameter of the polyethersulfone nanofiber is 200-500 nm, and the particle size of the sodium polyacrylate hygroscopic particles is 5-10 μm.

4. The kinesiology bandage with sustained-release function according to claim 1, characterized in that: The particle size of the diatomaceous earth is 10-20 μm, and the solid content of the polyurethane emulsion is 30% to 32%.

5. The kinesiology bandage with sustained-release function according to claim 1, characterized in that: The functional spray raw materials include, by weight, 25-35 parts of an inner water phase, 40-50 parts of an oil phase, and 25-35 parts of an outer water phase.

6. The kinesiology bandage with sustained-release function according to claim 5, characterized in that: The raw materials of the inner aqueous phase include: diclofenac sodium, menthol, and nano-silver dispersion, wherein the weight ratio of diclofenac sodium, menthol, and nano-silver dispersion is: 3-5:1.5-2.5:0.5-1.2; The raw materials of the oil phase include: polylactic acid-glycolic acid copolymer, vitamin E acetate, and ethyl acetate, wherein the weight ratio of polylactic acid-glycolic acid copolymer, vitamin E acetate, and ethyl acetate is: 12-16:3-4:1-2; The raw materials of the external aqueous phase include: xanthan gum, poloxamer 407, and volatile silicone penetration enhancer, wherein the weight ratio of xanthan gum, poloxamer 407 and volatile silicone penetration enhancer is: 1.2-2.0:10-15:0.2-0.

5.

7. A kinesiology bandage with sustained-release function according to any one of claims 1 to 6, characterized in that: The preparation process specifically comprises the following steps: S1. Diatomaceous earth and polyurethane emulsion are mixed into a slurry, and the spandex fiber is subjected to plasma surface modification at a power of 50 W for 3-5 minutes using a low-temperature plasma treatment machine. After the slurry is added, the mixture is put into a twin-screw extruder at 180-200° C. for melt blending, and a 50-80 μm composite fiber is obtained through a spinning process, and the composite fiber is warp-knitted into a base layer; S2. After uniformly mixing polyethersulfone nanofibers and sodium polyacrylate hygroscopic particles, electrospinning is performed on one side of the base layer to prepare a polyethersulfone nanofiber membrane to obtain a sustained-release layer; S3. Evenly mix a fluorinated hydrophobic modifier with a medical pressure-sensitive adhesive, and spray the mixture on the edge of the polyurethane substrate to form a circumferential closed space. Evenly mix a hydrophilic modifier with a medical pressure-sensitive adhesive, and spray the mixture inside the circumferential closed space. Place the polyurethane substrate on one side of the sustained-release layer, and perform hot pressing and lamination at 120-140° C. and 0.3-0.5 MPa for 10-15 minutes. Laser carve honeycomb micropores in the circumferential closed space to obtain a contact layer with a pore size of 50-100 μm. S4. After spraying the functional spray inside the circumferential space, perform 980nm infrared radiation at a power of 50W for 5-8s to complete the bandage preparation.

8. The kinesiology bandage with sustained-release function according to claim 7, characterized in that: The preparation method of the functional spray comprises: S41, dissolving diclofenac sodium and menthol in deionized water, adding the nanosilver dispersion, and ultrasonically dispersing at 300W in a 40°C water bath for 15-25 minutes to obtain an inner aqueous phase; S42, dissolving poly(lactic acid-co-glycolic acid) and vitamin E acetate in ethyl acetate, stirring magnetically at 600-800 rpm for 30-45 minutes, and degassing under vacuum at -0.08 MPa for 22-35 minutes to obtain an oil phase; S43, mixing xanthan gum and volatile silicone penetration enhancer uniformly to obtain an external water phase; S44, mixing the inner aqueous phase and the oil phase in a volume ratio of 1:4, passing through a microfluidizer at a pressure of 80 MPa, and circulating three times to obtain a primary emulsion; S45, mixing the primary emulsion with the external aqueous phase at a volume ratio of 1:3, passing through a microfluidizer at a pressure of 60 MPa, and circulating twice to obtain an emulsion; S46. Add poloxamer 407 to the emulsion, stir magnetically at 200-400 rpm for 15-30 minutes, and let stand at 4°C for 24 hours to obtain a functional spray.