Traditional Chinese medicine composition for treating migraine and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating migraine and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition is prepared from the following raw materials: radix bupleuri, ligusticum wallichii, radix paeoniae alba, asarum, radix angelicae, mint, motherwort fruit, gastrodia elata, fried stiff silkworm, wine-processed radix scutellariae, fructus viticis, fried semen cassiae, radix aconiti preparata, chrysanthemum, radix puerariae and honey-fried licorice root; the invention further discloses a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition provided by the invention has stronger and more specific effects of soothing liver-qi stagnation, dispelling wind and relieving pain, can improve common symptoms such as severe headache, nausea and vomiting, photophobia and afraid of sound and the like of migraine patients, has the advantage of reducing relapse, and provides a preparation method of a plurality of medicine dosage forms. The traditional Chinese medicine composition can be flexibly selected by migraine patients, so that the medicine taking convenience is enhanced, the patients can conveniently insist on medicine treatment, and the curative effect is enhanced.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating migraine, a preparation method thereof, and an application thereof. Background Art

[0002] Migraine is a common primary headache disorder characterized by paroxysmal unilateral or bilateral throbbing headaches of moderate to severe severity, which may be accompanied by symptoms such as nausea, vomiting, and photophobia. It typically lasts 4-72 hours and is characterized by recurrent attacks. It is a chronic neurovascular disease. Treatment for migraine is divided into acute migraine treatment and prevention. According to the "Guidelines for the Diagnosis and Treatment of Migraine in China (2022 Edition)", acute treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen can be used for mild to moderate attacks. For moderate to severe attacks or those refractory to NSAIDs, caffeine-containing combination preparations (such as aspirin, acetaminophen, and caffeine) or migraine-specific medications (such as triptans) can be used. For prevention, calcium channel blockers, antiepileptic drugs, beta-blockers, gamma-blockers, antidepressants, and monoclonal antibodies against CGRP or its receptors can be used. The above drugs are easily affected by factors such as the patient's age and migraine type, which often leads to excessive use of analgesics. As the drug dosage increases, adverse reactions increase significantly. In severe cases, a series of side effects such as gastrointestinal bleeding and myocardial infarction may occur.

[0003] Migraine falls under the category of "headache" in Traditional Chinese Medicine. It is characterized by the patient experiencing pain in the head, often called "brain wind," "head wind," or "syncope headache." Its causes can be categorized as both external and internal. These include the invasion of the six pathogenic factors, which can affect the top of the head; phlegm and blood stasis, which can obstruct the meridians; or imbalances in the liver, spleen, and kidney, leading to liver qi failure, spleen qi failure, and insufficient marrow. Multiple factors can contribute to headaches. Migraine is particularly closely linked to the liver. Depression and anger can disrupt liver function, disrupting Qi flow and disturbing the clear orifices. Furthermore, wind and cold attack the Shaoyang meridian. These combined internal and external factors can cause sporadic headaches, often on the left or right side, more prone to cold and exacerbated by emotional stimulation. Therefore, treatment should focus on the liver, using both wind-dispelling and wind-removing methods. By dispersing liver qi internally and dispersing wind and cold externally, headaches can resolve.

[0004] Because the pathogenesis of migraine remains unclear and is easily affected by the patient's mood, physical condition, and other factors, the efficacy of existing drugs remains unsatisfactory, which can easily lead to the abuse of analgesics and has varying degrees of adverse reactions, hindering patients' continued adherence to treatment. Although Traditional Chinese Medicine (TCM) has a variety of treatments for migraine, it is often only effective in alleviating symptoms during an attack and cannot further improve patient prognosis. Furthermore, considering the low rates of patient consultations and correct diagnosis rates, as well as the TCM diagnosis and treatment model, the high professional level of TCM physicians is highly demanding, which greatly hinders the control and improvement of patients' conditions.

[0005] In view of this, the inventor conducted in-depth research on this demand, and thus came up with this case. Summary of the Invention

[0006] The present invention is based on the common pathogenesis of some migraine patients having liver failure to release and exogenous wind-cold, and provides a Chinese medicine composition for treating migraine, which can be used for the treatment and prevention of migraine, and has high safety while taking into account clinical efficacy. It is especially suitable for migraine patients caused by liver qi stagnation and wind-cold attacking the meridians. In addition, the present invention also provides a preparation method for multiple dosage forms, which ensures efficacy while facilitating patients to choose the corresponding dosage form according to their own conditions, enhancing the convenience of taking the medicine, facilitating patients to adhere to drug treatment, and enhancing efficacy. In order to achieve the above purpose, the present invention adopts the following technical solutions:

[0007] A traditional Chinese medicine composition for treating migraine comprises the following raw materials, measured by weight: 5-15 parts of bupleurum, 10-20 parts of ligusticum chuanxiong, 10-20 parts of white peony root, 1-6 parts of asarum, 5-15 parts of angelica dahurica, 5-15 parts of peppermint, 10-20 parts of cuneiformis seeds, 5-15 parts of gastrodia elata, 5-15 parts of stir-fried bombyx batryticatus, 5-15 parts of wine-soaked scutellaria baicalensis, 6-18 parts of vitex rotundifolia, 10-20 parts of stir-fried cassia seeds, 1-6 parts of processed aconite, 5-15 parts of chrysanthemum, 10-20 parts of kudzu root, and 6-12 parts of roasted liquorice.

[0008] Preferably, the Chinese medicine composition comprises the following raw materials in parts by weight: 7-13 parts of bupleurum, 12-18 parts of chuanxiong, 12-18 parts of white peony root, 1-5 parts of asarum, 7-13 parts of angelica dahurica, 7-13 parts of mint, 12-18 parts of cnidaria seed, 7-13 parts of gastrodia elata, 7-13 parts of stir-fried bombyx batryticatus, 7-13 parts of wine-soaked scutellaria, 8-16 parts of vitex rotundifolia, 12-18 parts of stir-fried cassia seed, 1-5 parts of processed aconite, 7-13 parts of chrysanthemum, 12-18 parts of kudzu root, and 7-11 parts of roasted liquorice.

[0009] Preferably, the Chinese medicine composition comprises the following raw materials in parts by weight: 9-11 parts of bupleurum, 14-16 parts of chuanxiong, 14-16 parts of white peony root, 2-4 parts of asarum, 9-11 parts of angelica dahurica, 9-11 parts of mint, 14-16 parts of cnidii seeds, 9-11 parts of gastrodia elata, 9-11 parts of stir-fried bombyx batryticatus, 9-11 parts of wine-soaked scutellaria baicalensis, 10-14 parts of vitex rotundifolia, 14-16 parts of stir-fried cassia seeds, 2-4 parts of processed aconite, 9-11 parts of chrysanthemum, 14-16 parts of kudzu root, and 8-10 parts of roasted liquorice.

[0010] The present invention also provides the use of the above-mentioned traditional Chinese medicine composition for treating migraine in preparing medicine for treating migraine caused by liver qi stagnation and wind-cold attacking the meridians.

[0011] Patients with migraine caused by liver qi stagnation and wind-cold invading the meridians often present with dizziness, swelling and pain in the head, which is more severe on both sides, or extends to the neck and back, and is often accompanied by a feeling of tightness. The pain is aggravated by cold, and they also experience irritability, restless sleep, and sometimes bitter taste in the mouth and pain in the ribs.

[0012] The present invention provides a medicine for treating migraine, comprising the above-mentioned traditional Chinese medicine composition for treating migraine and pharmaceutically acceptable excipients.

[0013] Preferably, the dosage form of the drug is a traditional Chinese medicine decoction, decoction, granules, pills, capsules, tablets, tea, suspension, powder or oral solution.

[0014] Preferably, the drug is a granule, and its preparation method is as follows:

[0015] Step 1: weigh the raw materials according to the weight ratio, select, dry, cut, crush, sieve and mix evenly;

[0016] Step 2: Add water to the raw material drug of step 1 and soak it for 40 to 60 minutes, boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to obtain a first filtrate; then add water to the drug residue and boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to remove the drug residue to obtain a second filtrate;

[0017] Step 3: Evenly mix the first filtrate and the second filtrate of step 2, and dry them in a vacuum dryer until the weight no longer decreases, thereby obtaining granules.

[0018] Preferably, the drug is a pill, and its preparation method is as follows:

[0019] Step 1: weigh the raw materials according to the weight ratio, select, dry, cut, crush, sieve and mix evenly;

[0020] Step 2: Add water to the raw material drug of step 1 and soak it for 40 to 60 minutes, boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to obtain a first filtrate; then add water to the drug residue and boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to remove the drug residue to obtain a second filtrate;

[0021] Step 3: Evenly mix the first filtrate and the second filtrate of step 2, place in a vacuum dryer and dry until the weight no longer decreases to obtain a medicinal powder, add honey and boil at 100-120° C. for 20-30 minutes, with the mass ratio of honey to medicinal powder being 1:1.2;

[0022] Step 4: Add the mixed medicines prepared in step 3 into a pill making machine to obtain pills.

[0023] Preferably, the medicine is an ointment, and its preparation method is as follows:

[0024] Step 1: weigh the raw materials according to the weight ratio, select, dry, cut, crush, sieve and mix evenly;

[0025] Step 2: Add water to the raw material drug of step 1 and soak it for 40 to 60 minutes, boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to obtain a first filtrate; then add water to the drug residue and boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to remove the drug residue to obtain a second filtrate;

[0026] Step 3: Evenly mix the first filtrate and the second filtrate of step 2, place in a vacuum dryer and dry until the weight no longer decreases to obtain a medicinal powder, add honey and water to the medicinal powder and stir evenly, the mass ratio of medicinal powder, honey and water being 1:1.2:2;

[0027] Step 4: Boil the mixed medicine in step 3 over low heat and stir continuously. When the ointment turns red, it is ready.

[0028] The beneficial effects produced by the technical solution of the present invention are as follows:

[0029] The traditional Chinese medicine composition provided by the present invention uses Chuanxiong as the main ingredient, which ascends to the head and eyes to dredge meridians and relieve pain, making it a key medicine for treating headaches. The auxiliary ingredient, white peony root, enters the liver and gallbladder meridians to nourish blood and soften the liver. The sour and astringent properties of white peony root enter the liver meridian, which not only softens the liver and relieves pain, but also prevents excessive dispersion of wind-clearing herbs, which damage yin fluid. Bupleurum, asarum, angelica dahurica, and peppermint are also used as auxiliary ingredients. Bupleurum leads the herbs into the Shaoyang meridians on both sides, carrying the herbs upward and directly reaching the head and face; angelica leads the herbs into the Yangming meridian in the forehead, and together with asarum, they dispel wind, dissipate cold, and relieve pain, making them suitable for headaches caused by external wind-cold attacks; peppermint has a light and pungent dispersing effect, clearing the head and eyes, and dispelling external pathogens from the upper burners. Gastrodia elata and Bombyx batryticatus are used to calm the liver and relieve wind, dispel wind and unclog the meridians, and relieve headaches caused by internal liver wind. Chrysanthemum, Cassia seed, and Cnidium monnieri are also used to clear liver heat and calm liver yang, treating headaches caused by excessive liver fire. Scutellaria baicalensis is added to clear the liver and purge fire, combining with Bupleurum chinense to both dispersant and clearing properties, effectively targeting the Shaoyang meridian. Vitex mangifera is a Shaoyang meridian-inducing herb, helping Bupleurum chinense to soothe and relieve Shaoyang headaches. Pueraria root lobata unblocks the meridians and activates the meridians, working together with Angelica dahurica to treat Yangming headaches. Chuanwu warms the meridians and relieves pain, enhancing the formula's wind-dispelling and pain-relieving properties. Finally, Licorice root is used as a guiding herb to harmonize the various herbs. The formula demonstrates a well-balanced combination of monarch, minister, assistant, and envoy, combining dispersing and purging properties to treat both internal and external symptoms, achieving remarkable results in soothing the liver, relieving depression, and dispelling wind and relieving pain.

[0030] In addition, the Chinese medicine composition provided by the present invention has stronger and more specific effects of soothing the liver and relieving depression, dispelling wind and relieving pain. It can improve common symptoms such as severe headache, nausea and vomiting, photophobia and phonophobia common to such migraine patients, and has the advantage of reducing recurrence. It also provides preparation methods for a variety of drug dosage forms, which can be flexibly selected by migraine patients, thereby enhancing the convenience of taking the medicine, facilitating patients to adhere to drug treatment, and enhancing the efficacy. DETAILED DESCRIPTION

[0031] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all the embodiments. Therefore, the following detailed description of the embodiments provided by the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents the selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0032] This embodiment fully analyzes patients with migraines caused by liver qi stagnation and wind-cold attacking the meridians. Based on the common pathogenesis of liver qi stagnation and exogenous wind-cold in these patients, a traditional Chinese medicine composition for treating migraines, its preparation method, and application are provided. This composition can significantly improve symptoms such as severe headaches, nausea and vomiting, photophobia, and phonophobia in these patients, and effectively reduce the frequency of recurrence. The specific implementation method is as follows:

[0033] A traditional Chinese medicine composition for treating migraine comprises the following raw materials: bupleurum root, chuanxiong rhizome, white peony root, asarum, angelica dahurica, mint, guanyin seed, gastrodia elata, stir-fried bombyx batryticatus, wine-soaked scutellaria baicalensis, vitex rotundifolia fruit, stir-fried cassia seed, processed chuanwu root, chrysanthemum, kudzu root, and roasted liquorice root.

[0034] Bupleurum: The dried root of Bupleurum chinense or Bupleurum angustifolia, both of the Umbelliferae family. It is pungent, bitter, and slightly cold in nature. It enters the liver, gallbladder, and lung meridians. Its pungent, dispersing, and bitter, descending properties can dispel pathogenic factors in the gallbladder meridian and reduce fever, unblock liver and gallbladder qi stagnation to relieve chest tightness and flank pain, and boost liver and gallbladder yang energy to improve organ ptosis. Raw Bupleurum has both dispersing and heat-clearing effects, but vinegar-processed Bupleurum has a weaker dispersing effect but enhances its liver-soothing effects. Modern research has revealed that Bupleurum contains saponins, volatile oils, polysaccharides, and other active ingredients, primarily responsible for reducing fever, relieving liver qi stagnation, and boosting yang energy.

[0035] Chuanxiong (Ligusticum chuanxiong) is the dried rhizome of the Umbelliferae plant. It is pungent and warm in nature, entering the liver, gallbladder, and pericardium meridians. It ascends to the head and penetrates deeply into the lower abdomen, promoting the flow of qi and blood while dispelling wind and cold. It is particularly effective in promoting blood circulation and is particularly effective for pain caused by blood stasis and qi stagnation due to cold. Modern research has revealed that Chuanxiong contains a variety of components, including alkaloids, volatile oils, vitamin A, and folic acid, primarily acting by promoting blood circulation and relieving pain.

[0036] White peony root: This is the dried root of the Ranunculaceae plant, Paeonia lactiflora. It is bitter, sour, and slightly cold in nature. It enters the liver and spleen meridians. It regulates menstrual cycles and relieves dysmenorrhea and abdominal pain. It is often used to treat dizziness, cramps, and other issues caused by blood deficiency. Modern research has shown that white peony contains monoterpenes, sterols, tannins, and phenols, which can promote blood production, relax muscles, and alleviate spasms.

[0037] Asarum: The dried root and rhizome of Asarum sieboldii, Asarum hanseungii, or Asarum szechwanensis, all members of the Aristolochiaceae family. It is pungent and warm in nature, activating the Heart, Lung, and Kidney meridians. It dispels wind, cold, and dampness, relieves nasal congestion and pain, and warms the lungs to dissolve cold phlegm. It is particularly effective for headaches at the back of the head, sinusitis, and toothache. Modern research has revealed that it contains lignans, volatile oils, and trace amounts of aristolochic acid I. It primarily dispels cold and relieves pain, unclogs the nasal passages, and dissolves cold phlegm in the lungs.

[0038] Angelica dahurica is the dried root of the Apiaceae plant, Angelica dahurica (also known as Angelica dahurica), which is pungent and warm in nature. It enters the stomach, large intestine, and lung meridians. It dispels wind-cold and dampness, relieves nasal congestion and joint blockage, effectively relieves pain, promotes sweating, regulates abnormal secretions, and promotes the drainage of pus from wounds. It is effective for conditions caused by wind-cold, wind-cold combined with dampness, and cold-dampness. It is particularly effective in relieving brow pain, forehead headaches, and cold-induced nasal congestion or sinus headaches. Modern research has found that Angelica dahurica contains a variety of active ingredients, including volatile oils, imperatorin, and white angelicae, which have the effects of dispelling cold and relieving pain, relieving nasal congestion, regulating secretions, and promoting wound healing.

[0039] Peppermint: The dried aerial part of the mint plant, a member of the Lamiaceae family. It is pungent and cooling in nature, and enters the lung and liver meridians. It dispels wind-heat and relieves headaches, sore throats, and skin rashes. It also helps alleviate chest tightness and depression caused by liver qi stagnation. Peppermint has a strong diaphoretic effect, particularly effective at relieving headaches. It is particularly suitable for treating cold symptoms caused by wind-heat and can also alleviate excessive liver fire. Modern research has revealed that peppermint contains menthol (menthol), menthone, isomenthone, pulegone, α-pinene, and limonene. These ingredients work together to dispel wind-heat, relieve headaches and dizziness, improve sore throats, promote the clearing of rashes, and regulate liver qi.

[0040] Chuang Weizi: For Lamiaceae plants The dried mature fruit of Leonurus japonicus. It is pungent, bitter and slightly cold. Liver Meridian .have Activate blood circulation and regulate menstruation , Cleanses the liver and improves eyesight Used for Irregular menstruation , Amenorrhea and dysmenorrhea , Mechi Cataract, dizziness, swelling and pain in the head. Modern research has found that Cnidium monnieri contains motherwort alkaloids, stachydrine, fatty oil and vitamin A substances.

[0041] Gastrodia elata (Gastrodia elata) is the dried tuber of the orchidaceae plant Gastrodia elata. It is sweet and neutral in nature, and enters the Liver Meridian. It calms abnormal tics and regulates overactive Liver Yang, alleviating various symptoms caused by excessive Liver Fire or internal Liver Wind. It also dispels wind pathogens, dredges the meridians, and alleviates joint pain and numbness in the hands and feet. Modern research has revealed that Gastrodia elata contains phenolic compounds (which have antioxidant properties), fatty acids, polysaccharides (which enhance immunity), as well as carotene, amino acids, and various trace elements. These ingredients work together to calm tics, calm Liver Yang, and dredge the meridians.

[0042] Bombyx batryticatus: The dried remains of the fourth or fifth instar larvae of the silkworm family Bombyx mori, infected (or artificially inoculated) with Beauveria bassiana, have a salty, pungent, and neutral flavor. It enters the liver, lung, and stomach meridians. Acting on the liver and lung systems, it can calm convulsions (such as those caused by febrile seizures or epileptic fits in children) and relieve headaches, red eyes, sore throats, and itchy skin caused by wind-heat. Bombyx batryticatus can also dissolve lumps caused by phlegm, such as those caused by cervical lymphadenitis or mumps. Its main components include fat, protein, amino acids, and various trace elements.

[0043] Scutellaria baicalensis is the dried root of the Lamiaceae plant Scutellaria baicalensis. It is bitter and cold in nature, and enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. Its bitter and cold properties clear internal heat and dampness, primarily targeting lung and large intestine issues, while also toning the gallbladder, spleen, and stomach. It can clear heat and reduce internal heat, cool the blood and stop bleeding, protect the fetus, and eliminate damp-heat toxins, making it a key herbal remedy for damp-heat toxicity. Modern research has revealed that Scutellaria baicalensis contains baicalin and baicalein (baicalein), which possess antibacterial and anti-inflammatory properties. It also contains β-sitosterol and baicalase, which aid in regulating bodily functions. Together, these ingredients clear heat and dampness, detoxify and reduce internal heat, stop bleeding, and stabilize the fetus.

[0044] Vitex rotundifolia (Vitex simplicifolia) or Vitex rotundifolia (Vitex rotundifolia) are the dried, mature fruits of the Verbenaceae family. It has a pungent, bitter flavor and slightly cold properties, and enters the bladder, liver, and stomach meridians. It dispels wind-heat and clears the head and eyes, and is used to treat wind-heat colds, headaches, swollen and painful gums, red and tearful eyes, blurred vision, and dizziness. It ascends to the head and face, dispelling wind-evil or wind-heat in the face and head, while clearing the eyes and eyes. It is suitable for all wind-related head and face ailments, especially those with combined heat. It also dredges the meridians, benefits the joints, and relieves pain, making it a suitable treatment for arthralgia, stiffness, and stiffness. Modern research shows that Vitex rotundifolia mainly contains flavonoids (such as vitexin, violacein, artemisinin, luteolin, and vitexin); fatty acids (such as palmitic acid, stearic acid, oleic acid, and linolenic acid); and volatile oils. It has antipyretic, analgesic, anti-inflammatory, antihypertensive, antiasthmatic, expectorant, and tumor-suppressing properties.

[0045] Cassia seeds are the dried, mature seeds of the leguminous plant Cassia or Cassia obtusifolia. They have a sweet, bitter, and salty flavor, are slightly cold, and enter the liver and large intestine meridians. They can clear liver heat and nourish the kidneys' yin fluid, making them particularly suitable for treating red, swollen, and painful eyes and blurred vision. They also promote intestinal motility and alleviate constipation caused by intestinal dryness and heat. Modern research shows that Cassia seeds contain multiple active ingredients. The alcohol extract and total aglycone extract can protect the liver by improving lipid accumulation, alleviating liver damage and inflammation, and containing anthraquinone compounds that can lower blood lipids.

[0046] Chuanwu (Aconiti Radix Aconiti Lateralis Preparata) is the dried root of the Ranunculaceae plant. It is pungent, bitter, and hot in nature. It is highly toxic and enters the Heart, Liver, Kidney, and Spleen meridians. It dispels wind and dampness, dispels cold, and relieves pain. Its potent medicinal properties make it effective for all types of pain caused by wind, cold, and dampness, and is particularly effective for treating severe cold arthritis and stubborn arthritis. It also provides analgesia and local anesthesia. Modern research shows that Chuanwu contains various alkaloids, primarily aconitine, mesaconitine, and mesaconitine, as well as aconite polysaccharides A, B, C, and D. It is used to treat wind, cold, and dampness arthritis, joint pain, heart and abdominal pain, cold hernia pain, and as an anesthetic.

[0047] Chrysanthemum: The complete dried flower cluster of the chrysanthemum plant, including petals and the center of the flower. bitter taste It is sweet, slightly cold in nature, and enters the lung and liver meridians. It can help reduce fever and headaches, relieve eye fatigue, and eliminate toxins from the body. It is often used as an adjunct treatment for sore throats, red and dry eyes, and skin suppuration caused by wind-heat colds.

[0048] Pueraria root: This is the dried root of the kudzu plant (Pueraria lobata), a leguminous plant. It is sweet, pungent, and cooling in nature. It enters the spleen, stomach, and lung meridians. It has dispersing and relieving effects, dissipating heat through the skin to reduce fever, while also promoting spleen and stomach function and promoting body fluid production, effectively quenching thirst and stopping diarrhea. It is particularly suitable for treating stiff and painful neck and back muscles. Modern research has revealed that kudzu root contains a variety of active ingredients, including flavonoids, coumarins, puerariae alcohol, and starch.

[0049] Roasted Licorice: This refers to the dried roots and rhizomes of the leguminous plants Glycyrrhiza uralensis, Glycyrrhiza glabra, and Glycyrrhiza inflata. It has a sweet taste and a neutral nature, activating the Heart, Lung, Spleen, and Stomach meridians. It has the effects of clearing heat and detoxifying, relieving phlegm and cough, tonifying the spleen and lungs, and alleviating pain. Its chemical components primarily include triterpenoid saponins, flavonoids, polysaccharides, coumarins, and alkaloids. Its pharmacological effects include anti-tumor, anti-depressant, anti-inflammatory, anti-arrhythmic, hepatoprotective, antioxidant, and immunomodulatory properties.

[0050] As a preferred embodiment, the Chinese medicine composition comprises the following raw materials in parts by weight: 5-15 parts of bupleurum, 10-20 parts of chuanxiong, 10-20 parts of white peony root, 1-6 parts of asarum, 5-15 parts of angelica dahurica, 5-15 parts of mint, 10-20 parts of cnidaria seed, 5-15 parts of gastrodia elata, 5-15 parts of stir-fried bombyx batryticatus, 5-15 parts of wine-soaked scutellaria, 6-18 parts of vitex rotundifolia, 10-20 parts of stir-fried cassia seed, 1-6 parts of processed aconite, 5-15 parts of chrysanthemum, 10-20 parts of kudzu root, and 6-12 parts of roasted licorice.

[0051] As a preferred embodiment, the Chinese medicine composition comprises the following raw materials in parts by weight: 7-13 parts of bupleurum, 12-18 parts of chuanxiong, 12-18 parts of white peony root, 1-5 parts of asarum, 7-13 parts of angelica dahurica, 7-13 parts of mint, 12-18 parts of cnidaria seed, 7-13 parts of gastrodia elata, 7-13 parts of stir-fried bombyx batryticatus, 7-13 parts of wine-soaked scutellaria baicalensis, 8-16 parts of vitex rotundifolia, 12-18 parts of stir-fried cassia seed, 1-5 parts of processed aconite, 7-13 parts of chrysanthemum, 12-18 parts of kudzu root, and 7-11 parts of roasted licorice.

[0052] As a preferred embodiment, the Chinese medicine composition comprises the following raw materials in parts by weight: 9-11 parts of bupleurum, 14-16 parts of chuanxiong, 14-16 parts of white peony root, 2-4 parts of asarum, 9-11 parts of angelica dahurica, 9-11 parts of mint, 14-16 parts of cnidii seeds, 9-11 parts of gastrodia elata, 9-11 parts of stir-fried bombyx batryticatus, 9-11 parts of wine-soaked scutellaria baicalensis, 10-14 parts of vitex rotundifolia, 14-16 parts of stir-fried cassia seeds, 2-4 parts of processed aconite, 9-11 parts of chrysanthemum, 14-16 parts of kudzu root, and 8-10 parts of roasted licorice.

[0053] The present invention also provides the use of the above-mentioned traditional Chinese medicine composition for treating migraine in preparing medicine for treating migraine caused by liver qi stagnation and wind-cold attacking the meridians.

[0054] The present invention provides a medicine for treating migraine, comprising the above-mentioned traditional Chinese medicine composition for treating migraine and pharmaceutically acceptable excipients.

[0055] As a preferred embodiment, the dosage form of the drug is a traditional Chinese medicine decoction, decoction, granules, pills, capsules, tablets, tea, suspension, powder or oral liquid.

[0056] As a preferred embodiment, the drug is a granule, and its preparation method is as follows:

[0057] Step 1: weigh the raw materials according to the weight ratio, select, dry, cut, crush, sieve and mix evenly;

[0058] Step 2: Add water to the raw material drug of step 1 and soak it for 40 to 60 minutes, boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to obtain a first filtrate; then add water to the drug residue and boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to remove the drug residue to obtain a second filtrate;

[0059] Step 3: Evenly mix the first filtrate and the second filtrate of step 2, and dry them in a vacuum dryer until the weight no longer decreases, thereby obtaining granules.

[0060] As a preferred embodiment, the drug is a pill, and its preparation method is as follows:

[0061] Step 1: weigh the raw materials according to the weight ratio, select, dry, cut, crush, sieve and mix evenly;

[0062] Step 2: Add water to the raw material drug of step 1 and soak it for 40 to 60 minutes, boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to obtain a first filtrate; then add water to the drug residue and boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to remove the drug residue to obtain a second filtrate;

[0063] Step 3: Evenly mix the first filtrate and the second filtrate of step 2, place in a vacuum dryer and dry until the weight no longer decreases to obtain a medicinal powder, add honey and boil at 100-120° C. for 20-30 minutes, with the mass ratio of honey to medicinal powder being 1:1.2;

[0064] Step 4: Add the mixed medicines prepared in step 3 into a pill making machine to obtain pills.

[0065] As a preferred embodiment, the medicine is an ointment, and its preparation method is as follows:

[0066] Step 1: weigh the raw materials according to the weight ratio, select, dry, cut, crush, sieve and mix evenly;

[0067] Step 2: Add water to the raw material drug of step 1 and soak it for 40 to 60 minutes, boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to obtain a first filtrate; then add water to the drug residue and boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to remove the drug residue to obtain a second filtrate;

[0068] Step 3: Evenly mix the first filtrate and the second filtrate of step 2, place in a vacuum dryer and dry until the weight no longer decreases to obtain a medicinal powder, add honey and water to the medicinal powder and stir evenly, the mass ratio of medicinal powder, honey and water being 1:1.2:2;

[0069] Step 4: Boil the mixed medicine in step 3 over low heat and stir continuously. When the ointment turns red, it is ready.

[0070] The present invention is further described in detail below in conjunction with specific embodiments:

[0071] Example 1

[0072] This Example 1 provides a drug for treating migraine, and the raw materials of the Chinese medicine formula are grabbed according to the following mass parts: 5 parts of bupleurum, 10 parts of chuanxiong, 10 parts of white peony root, 1 part of asarum, 5 parts of angelica dahurica, 5 parts of mint, 10 parts of cuneiformis, 5 parts of gastrodia, 5 parts of fried bombyx batryticatus, 5 parts of wine-smelling scutellaria, 6 parts of vitex rotundifolia, 10 parts of fried cassia seed, 1 part of processed aconite, 5 parts of chrysanthemum, 10 parts of kudzu root, and 6 parts of roasted liquorice. The drug for treating migraine in this Example 1 is a granule, and its preparation method is as follows:

[0073] Step 1: weigh the raw materials according to the weight ratio, select, dry, cut, crush, sieve and mix evenly;

[0074] Step 2: Add water to the raw material drug of step 1 and soak it for 40 minutes, boil it with high heat, then simmer it with low heat for 60 minutes, and filter it with a Chinese medicine sieve to obtain a first filtrate; then add water to the drug residue and boil it with high heat, then simmer it with low heat for 60 minutes, and filter it with a Chinese medicine sieve to remove the drug residue to obtain a second filtrate;

[0075] Step 3: Evenly mix the first filtrate and the second filtrate of step 2, and dry them in a vacuum dryer until the weight no longer decreases, thereby obtaining granules.

[0076] Example 2

[0077] This Example 2 provides a drug for treating migraine, and the raw materials of the Chinese medicinal formula are obtained according to the following mass parts: 7 parts of Bupleurum, 12 parts of Chuanxiong, 12 parts of White Peony Root, 1 part of Asarum, 7 parts of Angelica Dahurica, 7 parts of Mentha, 12 parts of Cnidium monnieri, 7 parts of Gastrodia elata, 7 parts of Stir-fried Bombyx Batryticatus, 7 parts of Scutellaria baicalensis, 8 parts of Vitex rotundifolia, 12 parts of Stir-fried Cassia Seed, 1 part of Processed Chuanwu, 7 parts of Chrysanthemum, 12 parts of Puerariae Radix, and 7 parts of Preserved Licorice. The drug for treating migraine in this Example 2 is a granule, and its preparation method is the same as that of Example 1.

[0078] Example 3

[0079] This Example 3 provides a drug for treating migraine. The raw materials of the Chinese medicinal formula are collected according to the following mass parts: 9 parts of Bupleurum, 14 parts of Chuanxiong, 14 parts of White Peony Root, 2 parts of Asarum, 9 parts of Angelica Dahurica, 9 parts of Mentha, 14 parts of Cnidium monnieri, 9 parts of Gastrodia elata, 9 parts of Stir-fried Bombyx Batryticatus, 9 parts of Scutellaria baicalensis, 10 parts of Vitex rotundifolia, 14 parts of Stir-fried Cassia Seed, 2 parts of Processed Chuanwu, 9 parts of Chrysanthemum, 14 parts of Puerariae Radix, and 8 parts of Preserved Licorice. The drug for treating migraine in this Example 3 is a granule, and its preparation method is the same as that of Example 1.

[0080] Example 4

[0081] This Example 4 provides a drug for treating migraine. The following Chinese medicinal ingredients are prepared by weight: 10 parts of bupleurum, 15 parts of ligusticum chuanxiong, 15 parts of white peony root, 3 parts of asarum, 10 parts of angelica dahurica, 10 parts of peppermint, 15 parts of cuneiformis, 10 parts of gastrodia, 10 parts of fried bombyx batryticatus, 10 parts of wine-smelling scutellaria, 10 parts of vitex rotundifolia, 15 parts of fried cassia seed, 3 parts of processed aconite, 10 parts of chrysanthemum, 15 parts of kudzu root, and 9 parts of roasted liquorice. The drug for treating migraine in this Example 4 is a granule, and its preparation method is the same as that of Example 1.

[0082] Example 5

[0083] This Example 5 provides a drug for treating migraine. The raw materials of the Chinese medicinal formula are as follows: 11 parts of bupleurum, 16 parts of ligusticum chuanxiong, 16 parts of white peony root, 4 parts of asarum, 11 parts of angelica dahurica, 11 parts of peppermint, 16 parts of cuneiformis, 11 parts of gastrodia, 11 parts of fried bombyx batryticatus, 11 parts of wine-smelling scutellaria, 14 parts of vitex rotundifolia, 16 parts of fried cassia seed, 4 parts of processed aconite, 11 parts of chrysanthemum, 16 parts of kudzu root, and 10 parts of roasted liquorice. The drug for treating migraine in this Example 5 is a granule, and its preparation method is the same as that of Example 1.

[0084] Example 6

[0085] This Example 6 provides a drug for treating migraine, and the following Chinese medicinal ingredients are prepared by weight: 13 parts of bupleurum, 18 parts of ligusticum chuanxiong, 18 parts of white peony root, 5 parts of asarum, 13 parts of angelica dahurica, 13 parts of peppermint, 18 parts of cuneiformis, 13 parts of gastrodia, 13 parts of fried bombyx batryticatus, 13 parts of wine-smelling scutellaria, 16 parts of vitex rotundifolia, 18 parts of fried cassia seed, 5 parts of processed aconite, 13 parts of chrysanthemum, 18 parts of kudzu root, and 11 parts of roasted liquorice. This Example 6 drug for treating migraine is a granule, and its preparation method is the same as that of Example 1.

[0086] Example 7

[0087] This Example 7 provides a drug for treating migraine, and the following Chinese medicinal ingredients are prepared by weight: 15 parts of bupleurum, 20 parts of ligusticum chuanxiong, 20 parts of white peony root, 6 parts of asarum, 15 parts of angelica dahurica, 15 parts of peppermint, 20 parts of cuneiformis, 15 parts of gastrodia, 15 parts of fried bombyx batryticatus, 15 parts of wine-smelling scutellaria, 18 parts of vitex rotundifolia, 20 parts of fried cassia seed, 6 parts of processed aconite, 15 parts of chrysanthemum, 20 parts of kudzu root, and 12 parts of roasted liquorice. This Example 7 drug for treating migraine is a granule, and its preparation method is the same as that of Example 1.

[0088] To verify the efficacy of the Chinese medicine composition provided by the present invention in treating migraine, the following clinical treatment studies were conducted:

[0089] 1. Source of cases

[0090] The cases included in this study were all patients who were admitted to the Renmin Road Clinic of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from March 2021 to January 2025. A total of 60 migraine patients who met the inclusion criteria were admitted for clinical treatment research.

[0091] 2. Inclusion criteria

[0092] (1) 18 years old ≤ age < 75 years old;

[0093] (2) Meet the Western medical diagnostic criteria for migraine;

[0094] (3) Meet the TCM diagnostic criteria for head wind disease;

[0095] (4) TCM diagnosis of liver qi stagnation syndrome;

[0096] (5) Sign the informed consent form.

[0097] 3. Exclusion criteria

[0098] (1) Other types of migraine cases, such as tension-type headache, cluster headache, and secondary migraine cases, were excluded. Patients who were unwilling to receive Chinese medicine treatment would not be included in the study.

[0099] 4. Diagnostic criteria

[0100] 4.1 Western medicine diagnostic standards: According to the migraine classification and diagnostic standards in the "International Classification of Headache Disorders, Third Edition" published by the Classification Committee of the International Headache Society in 2018.

[0101] (1) Headache attacks lasting 4 to 72 hours (untreated or ineffective).

[0102] (2) The headache has at least two of the following four characteristics: ① lateral distribution; ② pulsating; ③ moderate or severe pain; ④ daily physical activities aggravate the headache or avoid daily activities (such as walking or climbing stairs) due to the headache.

[0103] (3) At least one of the following symptoms occurs during a headache attack: ① nausea and / or vomiting; ② photophobia and / or phonophobia.

[0104] At least five headache attacks that meet all of (1), (2), or (3) and are not better explained by another ICHD-3 headache disorder diagnosis.

[0105] 4.2 Traditional Chinese Medicine (TCM) diagnostic standards: Refer to the TCM diagnosis of “head wind” in the “TCM Disease Diagnosis and Efficacy Standards” issued by the State Administration of Traditional Chinese Medicine in 2016.

[0106] (1) The headache is usually located on one side of the head, in the forehead, or at the top of the head, and can occur on either the left or right side, or may be a generalized headache. The headache may be characterized by throbbing pain, stabbing pain, fullness, dull pain, or a splitting headache. Each headache attack can last for minutes, hours, days, or even weeks.

[0107] (2) The disease starts insidiously and gradually worsens or recurs repeatedly.

[0108] (3) A blood test and blood pressure measurement should be performed. If necessary, lumbar puncture, bone marrow puncture, and electroencephalogram should be performed. If conditions permit, transcranial Doppler, CT, MRI, and other examinations should be performed to clarify the cause of the headache and rule out organic diseases.

[0109] 5. Treatment plan

[0110] (1) Control group: Oral administration of flunarizine hydrochloride capsules (produced by Xi'an Janssen Pharmaceutical Co., Ltd., national medicine approval number H10930003, 5 mg × 20 capsules / box, trade name "Sibelium"), 1 capsule per night, for 4 weeks.

[0111] (2) Treatment group: The granules prepared in Example 4 were taken twice a day, half an hour after meals in the morning and evening, each time about 250-300 g. A course of treatment was 7 days. The efficacy was calculated after 4 courses of treatment.

[0112] 6. Efficacy standards

[0113] (1) Total score of clinical symptoms: evaluated in accordance with the "Guiding Principles for Clinical Research of New Chinese Medicines (Trial)", including the number of attacks, headache severity, headache duration and accompanying symptoms (photophobia, nausea, vomiting):

[0114] ① The number of attacks was scored as 0, 2, 4, and 6 points respectively, according to none, less than or equal to 2 times per month, 3 to 4 times per month, and more than 5 times per month;

[0115] ② The severity of headache is scored as 0, 2, 4, and 6 points, respectively, based on the criteria of none, no effect on work, effect on work, and requiring bed rest. The higher the score, the more severe the pain.

[0116] ③ The duration of headache was scored as 0, 2, 4, and 6 points according to the criteria of none, <12 hours, 12 to 47 hours, and ≥48 hours, respectively;

[0117] ④ The accompanying symptoms were evaluated as none, one, two, or three or more, with scores of 0, 1, 2, or 3, respectively.

[0118] 7. Statistical methods

[0119] Statistical analysis was performed using SPSS 21. Measurement data were presented as (x ± s), and enumeration data were presented as rates or percentages. Normally distributed measurement data were compared before and after treatment using the paired sample t-test, while data that did not conform to a normal distribution were compared using the Wilcoxon signed-rank test. Enumeration data were compared before and after treatment using the chi-square test or Fisher's exact test. P < 0.05 was considered statistically significant.

[0120] 8. Treatment effect

[0121] (1) Comparison of total clinical symptom scores before and after treatment

[0122] Table 1 Comparison of total clinical symptom scores of patients before and after treatment ( ±s)

[0123]

[0124] (2) Comparison of clinical symptom scores before and after treatment

[0125] Table 2 Comparison of clinical symptom scores before and after treatment ( ±s)

[0126]

[0127] As shown in Table 1, there was no statistically significant difference in scores between the treatment group and the control group before treatment (P>0.05), indicating that the two groups were comparable. After treatment, the total score of clinical symptoms decreased in both groups (P<0.05), indicating that the drug provided in this application and flunarizine hydrochloride capsules can improve the clinical symptoms of migraine. After treatment, the score of the treatment group decreased more significantly than that of the control group, with a significant difference between the two groups (P<0.05), indicating that the Qufeng Zhitong Decoction is superior to flunarizine hydrochloride capsules in relieving migraine symptoms.

[0128] As shown in Table 2, all clinical symptom sub-scores decreased (P < 0.05), indicating that both the drug provided in this application and the flunarizine hydrochloride capsules can effectively reduce the number of headache attacks, alleviate headache severity, shorten the duration of attacks, and alleviate associated symptoms. There were differences between the two groups in reducing headache frequency, reducing headache severity, and alleviating associated symptoms (P < 0.05), but there was no significant difference in reducing duration (P > 0.05), indicating that the drug provided in this application performed better than flunarizine hydrochloride in improving headache frequency, headache severity, and associated symptoms.

[0129] In summary, the drug provided in this application can better reduce the frequency of attacks, relieve headaches and associated symptoms than flunarizine hydrochloride, has good therapeutic effects, and can be used as an effective drug for treating migraine.

[0130] Typical cases:

[0131] Case 1: Jing Moumou, female, 66 years old, first visit on January 4, 2025. Main complaint: headache for 1 week. The patient had paroxysmal headaches, dizziness and pain at the top of the head, heaviness of the head as if wrapped, and even nausea and vomiting. It is easy to do in winter, but the appetite is good, sleep is poor, the two bowel movements are normal, fantasy, irritability, depression, dark red tongue, thick white fur, and deep and fine pulse. Western medicine diagnosis: headache, Chinese medicine diagnosis: headache, liver qi stagnation syndrome, treated with soothing the liver and relieving depression, dispelling wind and relieving pain. Oral administration of the granules prepared by Example 4 of the present invention, 2 doses per day, taken in the morning and evening. After taking the medicine for 1 week, the patient's condition improved significantly, the headache basically disappeared, and he only felt that his head was not refreshed, his appetite was good, sleep improved, fantasy was reduced, the two bowel movements were normal, the tip of the tongue was red, the fur was thin, and the pulse was deep and fine.

[0132] Case 2: Chu, female, 34 years old, first visit on July 3, 2024. Main complaint: migraine for 4 years. The patient has throbbing pain in both temporal regions, which is easy to occur after catching a cold. It can be induced by factors such as anger, fatigue, and staying up late. The patient has good appetite, good sleep, normal bowel movements, regular menstruation, pale red tongue, yellow greasy fur, and deep and thin pulse. Western medicine diagnosis: headache, Chinese medicine diagnosis: headache, wind-cold syndrome, treated with soothing the liver and relieving depression, dispelling wind and relieving pain. Orally take the granules prepared by Example 4 of the present invention, 2 doses per day, taken in the morning and evening. After taking the medicine for one week, the patient's condition improved significantly, the degree of headache was reduced, the number of headaches decreased, and there were occasional attacks after fatigue, anger, and catching a cold. The patient has good appetite, good sleep, normal bowel movements, regular menstruation, pale red tongue, thick yellow fur, and deep and thin pulse.

[0133] Case 3: Guo, female, 47 years old, first visit on November 1, 2023. Main complaint: paroxysmal headache for more than 10 years. The patient has a monthly headache. During the attack, there is a throbbing pain at the top of the head, even nausea and vomiting, back discomfort before and after the attack, stiff neck, poor rest, cold, emotional stimulation, easy menstruation, dark menstruation with clots, pain in the waist and abdomen during menstruation, appetite, sleep, and bowel movements are normal, tongue is pale, with more ecchymosis, thin white fur, and deep and thin pulse. Western medicine diagnosis: headache, Chinese medicine diagnosis: headache, liver qi stagnation syndrome, treated with soothing the liver and relieving depression, expelling wind and relieving pain. Oral administration of the granules prepared by Example 3 of the present invention, 2 doses per day, taken in the morning and evening. After two weeks of medication, the patient's condition improved significantly, the headache did not occur, the spirit improved, the sleep quality was good, the neck stiffness was significantly reduced, the dizziness disappeared, the bowel movements were normal, the tongue was pale red, there were a few ecchymosis, thin white fur, and a stringy and smooth pulse.

[0134] The foregoing description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Those skilled in the art will readily appreciate that various modifications and variations are possible. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention are intended to be within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating migraine, characterized in that: The invention comprises the following raw materials by weight: 5-15 parts of bupleurum, 10-20 parts of chuanxiong, 10-20 parts of white peony root, 1-6 parts of asarum, 5-15 parts of angelica dahurica, 5-15 parts of mint, 10-20 parts of cnidaria seed, 5-15 parts of gastrodia elata, 5-15 parts of stir-fried bombyx batryticatus, 5-15 parts of wine-soaked scutellaria, 6-18 parts of vitex rotundifolia, 10-20 parts of stir-fried cassia seed, 1-6 parts of processed aconite, 5-15 parts of chrysanthemum, 10-20 parts of kudzu root, and 6-12 parts of roasted liquorice.

2. The Chinese medicine composition for treating migraine according to claim 1, characterized in that The invention comprises the following raw materials by weight: 7-13 parts of bupleurum, 12-18 parts of chuanxiong, 12-18 parts of white peony root, 1-5 parts of asarum, 7-13 parts of angelica dahurica, 7-13 parts of mint, 12-18 parts of cnidaria seed, 7-13 parts of gastrodia elata, 7-13 parts of stir-fried bombyx batryticatus, 7-13 parts of wine-soaked scutellaria baicalensis, 8-16 parts of vitex rotundifolia, 12-18 parts of stir-fried cassia seed, 1-5 parts of processed aconite, 7-13 parts of chrysanthemum, 12-18 parts of kudzu root, and 7-11 parts of roasted liquorice.

3. The Chinese medicine composition for treating migraine according to claim 1, characterized in that The invention comprises the following raw materials by weight: 9-11 parts of bupleurum, 14-16 parts of chuanxiong, 14-16 parts of white peony root, 2-4 parts of asarum, 9-11 parts of angelica dahurica, 9-11 parts of mint, 14-16 parts of cnidaria seed, 9-11 parts of gastrodia elata, 9-11 parts of stir-fried bombyx batryticatus, 9-11 parts of wine-soaked scutellaria baicalensis, 10-14 parts of vitex rotundifolia, 14-16 parts of stir-fried cassia seed, 2-4 parts of processed aconite, 9-11 parts of chrysanthemum, 14-16 parts of kudzu root, and 8-10 parts of roasted liquorice.

4. Use of a Chinese medicine composition for treating migraine according to any one of claims 1 to 3 in the preparation of a medicament for treating migraine caused by liver qi stagnation and wind-cold attacking the collaterals.

5. A drug for treating migraine, characterized in that: The invention comprises the traditional Chinese medicine composition for treating migraine according to any one of claims 1 to 3 and pharmaceutically acceptable excipients.

6. The medicament for treating migraine according to claim 5, characterized in that The dosage form of the medicine is traditional Chinese medicine decoction, decoction, granules, pills, capsules, tablets, tea, suspension, powder or oral solution.

7. The medicament for treating migraine according to claim 6, characterized in that The medicine is a granule, and its preparation method is as follows: Step 1: weigh the raw materials according to the weight ratio, select, dry, cut, crush, sieve and mix evenly; Step 2: Add water to the raw material drug of step 1 and soak it for 40 to 60 minutes, boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to obtain a first filtrate; then add water to the drug residue and boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to remove the drug residue to obtain a second filtrate; Step 3: Evenly mix the first filtrate and the second filtrate of step 2, and dry them in a vacuum dryer until the weight no longer decreases, thereby obtaining granules.

8. The medicament for treating migraine according to claim 6, characterized in that The medicine is a pill, and its preparation method is as follows: Step 1: weigh the raw materials according to the weight ratio, select, dry, cut, crush, sieve and mix evenly; Step 2: Add water to the raw material drug of step 1 and soak it for 40 to 60 minutes, boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to obtain a first filtrate; then add water to the drug residue and boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to remove the drug residue to obtain a second filtrate; Step 3: Evenly mix the first filtrate and the second filtrate of step 2, place in a vacuum dryer and dry until the weight no longer decreases to obtain a medicinal powder, add honey and boil at 100-120° C. for 20-30 minutes, with the mass ratio of honey to medicinal powder being 1:1.2; Step 4: Add the mixed medicines prepared in step 3 into a pill making machine to obtain pills.

9. The medicament for treating migraine according to claim 6, characterized in that The medicine is an ointment, and its preparation method is as follows: Step 1: weigh the raw materials according to the weight ratio, select, dry, cut, crush, sieve and mix evenly; Step 2: Add water to the raw material drug of step 1 and soak it for 40 to 60 minutes, boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to obtain a first filtrate; then add water to the drug residue and boil it with high heat, and then simmer it with low heat for 60 to 80 minutes, and filter it with a Chinese medicine sieve to remove the drug residue to obtain a second filtrate; Step 3: Evenly mix the first filtrate and the second filtrate of step 2, place in a vacuum dryer and dry until the weight no longer decreases to obtain a medicinal powder, add honey and water to the medicinal powder and stir evenly, the mass ratio of medicinal powder, honey and water being 1:1.2:2; Step 4: Boil the mixed medicine in step 3 over low heat and stir continuously. When the ointment turns red, it is ready.

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