Blood purification treatment system

Abstract

The invention provides a blood purification treatment system, and belongs to the technical field of medical equipment. Comprising a plasma collection system, a plasma adsorption system and a liquid feedback system which are connected with a blood supplier to form a blood closed-loop conveying loop, the plasma collection system comprises a blood collection tube, the blood collection tube is connected with centrifugal machines through two blood collection branch tubes, and the outlet ends of the two centrifugal machines are jointly connected with a first plasma bag; the two blood collection branch pipes are connected with a blood collection system and connected with a blood collection adsorption system through a first blood collection bag, blood collection pumps are arranged on the two blood collection branch pipes, the blood collection branch pipes are connected with first back-transfusion branch pipes, and the two first back-transfusion branch pipes are combined and then connected with a liquid back-transfusion system. The electric valve assembly is used for controlling only one of the two blood sampling branch pipes to be opened at the same time and controlling the first feedback branch pipe and the blood sampling branch pipe to be opened and closed in opposite states. In the process of pumping blood to one centrifugal machine and centrifugally separating blood plasma on line, red blood cells in the other centrifugal machine are transfused back to the human body, and the effects of continuously keeping blood sampling and liquid transfusing back and improving the blood sampling efficiency are achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to a blood purification system. Background Art

[0002] Double filtration plasmapheresis (DFPP) is a new selective plasma separation technology developed based on traditional therapeutic plasma exchange (TPE). It is a blood purification technology mainly used to treat autoimmune diseases, hyperlipidemia and certain poisoning conditions.

[0003] DFPP uses a two-stage filtration process to separate harmful substances from plasma. In the first stage, plasma is separated from blood cells. In the second stage, large, harmful molecules (such as antibodies, immune complexes, and cholesterol) are removed from the plasma, while useful substances (such as albumin) are retained. Finally, the purified plasma and blood cells are mixed and re-infused into the body. This method reduces the need for exogenous plasma, thereby reducing the risk of allergic reactions and infections caused by transfusion of allogeneic plasma.

[0004] However, during the blood collection and separation process, separation equipment such as centrifugal cups cannot completely contain and separate all the blood in the human body at one time. Multiple collection and return operations need to be performed cyclically to completely purify and treat the human blood. Frequent blood collection and return operations will cause vascular discomfort to the person whose blood is being collected, especially the elderly, children and patients with multiple underlying diseases. In addition, the separation equipment needs to complete the separation and emptying of the plasma before the next round of plasma collection operation can be carried out, and the blood separation and purification efficiency is low. Summary of the Invention

[0005] In view of the above problems, the present invention provides a blood purification system.

[0006] In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is as follows:

[0007] Provided is a blood purification treatment system, comprising a plasma collection system, a plasma adsorption system and a liquid return system, wherein the plasma collection system and the liquid return system are both connected to a blood donor to form a closed blood transport circuit, and the plasma adsorption system is arranged between the plasma collection system and the liquid return system;

[0008] The plasma collection system includes a blood collection tube, a blood collection pump, a centrifuge and a first plasma bag. One end of the blood collection tube is used to connect to the blood donor, and the other end is connected to two blood collection branches. Two groups of blood collection pumps and centrifuges are provided. The ends of the two blood collection branches away from the blood collection tube are respectively connected to the inlet ends of the two centrifuges. The two blood collection pumps are respectively provided on the two blood collection branches. The outlet ends of the two centrifuges are both connected to the inlet ends of the first plasma bag. The outlet end of the first plasma bag is connected to the plasma adsorption system. It also includes a first return tube. One end of the first return tube is connected to the liquid return system, and the other end is provided with two first return branches. The two first return branches are respectively connected to the two blood collection branches and are located between the blood collection pump and the blood collection tube. The two blood collection branches and the two first return branches are provided with electric control valve components for controlling their own opening and closing.

[0009] Furthermore, the electrically controlled valve assembly includes two first solenoid valves respectively connected to the two blood collection branches and two second solenoid valves respectively connected to the two first return branches. During blood collection, one of the two first solenoid valves is kept in an open state and the other is kept in a closed state. One of the first solenoid valves and the second solenoid valves on the connected blood collection branch and the first return branch is in an open state and the other is in a closed state.

[0010] Furthermore, the plasma adsorption system includes an adsorption pump and an adsorber, the adsorber includes an inlet end, a plasma outlet end and at least one waste outlet end, the outlet end of the first plasma bag is connected to an adsorption tube, the adsorption pump is arranged on the adsorption tube, the end of the adsorption tube farthest from the first plasma bag is connected to the inlet end of the adsorber, the plasma outlet end of the adsorber is connected to the liquid return system, and the waste outlet end is connected to the waste collection component through a waste discharge pipe.

[0011] Furthermore, the adsorber includes two waste outlet ends, which are respectively connected to a first row of waste pipes and a second row of waste pipes. The waste collection assembly includes a first waste bag, a second waste bag and a waste liquid pump. The first row of waste pipes is connected to the first waste bag, the waste liquid pump is arranged on the first row of waste pipes, the second row of waste pipes is connected to the second waste bag, the first waste bag is used to collect waste liquid, and the second waste bag is used to collect waste liquid / gas.

[0012] Furthermore, the liquid reinfusion system includes a reinfusion pump, a second reinfusion pipe, a third reinfusion pipe and a filtered plasma bag. The second reinfusion pipe connects the plasma outlet end of the adsorber with the top of the filtered plasma bag, the first reinfusion pipe is connected to the top of the filtered plasma bag, one end of the third reinfusion pipe is connected to the bottom end of the filtered plasma bag and the other end is connected to the blood donor, and the reinfusion pump is arranged on the third reinfusion pipe.

[0013] Furthermore, it also includes an anticoagulant addition system, which includes an anticoagulant bag, an anticoagulant pump and an input tube. One end of the input tube is connected to the anticoagulant bag and the other end is connected to the blood collection tube. The anticoagulant pump is arranged on the input tube.

[0014] Furthermore, it also includes a first physiological saline bag and a second physiological saline bag, the outlet end of the first physiological saline bag is connected to the adsorption tube between the first plasma bag and the adsorption pump, and the outlet end of the second physiological saline bag is connected to the second return tube between the return pump and the filtered plasma bag.

[0015] Furthermore, the outlet end of the centrifuge is connected to the first plasma bag through an outlet pipe, the outlet pipe is connected to a first pressure sensor for monitoring the pressure in its own pipeline, and a third solenoid valve is provided on the outlet pipe, and the first pressure sensor is used to control the opening / closing of the third solenoid valve.

[0016] Furthermore, a first blood filter is provided on the blood collection tube, a second blood filter is provided on the second return tube, and a third blood filter is provided on the adsorption tube;

[0017] A second pressure sensor is provided on the first blood filter, and the second pressure sensor is used to control the rotation speed of the blood collection pump that inputs plasma into the centrifuge. A third pressure sensor is provided on the second blood filter, and the third pressure sensor is used to control the rotation speed of the return pump. A fourth pressure sensor is provided on the third blood filter, and the fourth pressure sensor is used to control the rotation speed of the adsorption pump.

[0018] Furthermore, the blood collection tube, the first return tube, the second return tube, the adsorption tube, and the third return tube are all provided with air detectors;

[0019] The blood collection tube, the adsorption tube and the third return tube are all provided with a fourth electromagnetic valve.

[0020] The beneficial effects of the present invention are as follows: 1. Blood is collected from the donor's body through a plasma collection system, red blood cells and plasma are separated by centrifugation, and the plasma enters a plasma adsorption system to specifically remove and purify pathogenic substances in the plasma. Finally, the plasma and red blood cells are returned to the donor through a liquid reinfusion system, thereby achieving the purpose of removing harmful components in the donor's plasma and eliminating the need for the infusion of exogenous plasma, thereby reducing the risks of allergic reactions, infections, etc. caused by the infusion of allogeneic plasma;

[0021] 2. During the blood collection process, two sets of blood collection pumps and centrifuges are used to alternately collect blood from the blood donor. When one centrifuge collects blood and outputs red blood cells at the same time, the other centrifuge performs plasma transfusion, maintaining continuous blood collection and delivery operations for the blood donor, avoiding physical discomfort to the blood donor caused by intermittent blood collection and blood transfusion, and greatly improving the efficiency of blood filtration and purification in the blood donor's body. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the overall structure of the plasma filtration system of Example 1 of the present application.

[0023] Figure 2 This is a schematic diagram of the structure of the plasma collection system of Example 1 of the present application.

[0024] Figure 3 This is a schematic structural diagram of the plasma adsorption system of Example 1 of the present application.

[0025] Figure 4 This is a schematic structural diagram of the liquid reinfusion system of Example 1 of the present application.

[0026] Figure 5 This is a schematic diagram of the overall structure of the plasma filtration system of Example 2 of the present application.

[0027] Figure 6 This is a schematic structural diagram of the plasma adsorption system of Example 3 of the present application.

[0028] Figure 7 This is a schematic diagram of the overall structure of the plasma filtration system of Example 4 of the present application.

[0029] Among them: 1. Plasma collection system; 11. Blood collection tube; 12. Blood collection pump; 121. Blood collection branch tube; 13. Centrifuge; 14. First plasma bag; 15. First return tube; 151. First return branch tube; 16. First solenoid valve; 17. Second solenoid valve; 18. Liquid outlet tube; 181. First pressure sensor; 182. Third solenoid valve; 2. Plasma adsorption system; 21. Adsorption pump; 22. Adsorber; 23. Adsorption tube; 24. First waste pipe; 25. Second waste pipe; 26. First waste bag; 27. Second waste bag; 28. Waste liquid pump; 3. Liquid return system; 31. Return pump; 32. Second return tube; 33. Third return tube; 34. Filtered plasma bag; 41. Anticoagulant bag; 42. Anticoagulant pump; 43. Inlet tube; 51. First saline bag; 52. Second saline bag; 61. First blood filter; 611. Second pressure sensor; 62. Second blood filter; 621. Third pressure sensor; 63. Third blood filter; 631. Fourth pressure sensor; 7. Air detector; 8. Photoelectric device; 9. Fourth solenoid valve; 101. Connector; 102. Blood collection and return main tube; 103. Perfusion device; 104. Clean plasma bag; 105. Red blood cell bag. DETAILED DESCRIPTION

[0030] In order to better understand the above technical solution, the above technical solution will be described in detail below with reference to the accompanying drawings and specific implementation methods.

[0031] Example 1

[0032] The present application discloses a blood purification system. Figure 1The plasma collection system 1 comprises a plasma adsorption system 2 and a liquid reinfusion system 3. Both the plasma collection system 1 and the liquid reinfusion system 3 are connected to the blood donor to form a closed-loop blood transport circuit. The plasma adsorption system 2 is arranged between the plasma collection system 1 and the liquid reinfusion system 3. The plasma collection system 1 and the liquid reinfusion system 3 are connected to the two hands of the blood donor, respectively. The plasma collection system 1 collects the blood of the blood donor and separates it into red blood cells and plasma. The plasma enters the plasma adsorption system 2 to filter the pathogenic substances in the plasma. The filtered plasma and the red blood cells separated in the plasma collection system 1 are re-infused into the blood donor's body through the liquid reinfusion system 3, completing the blood purification operation of the blood donor.

[0033] Reference Figure 2 In this embodiment of the present application, a plasma collection system 1 includes a blood collection tube 11, a blood collection pump 12, a centrifuge 13, and a first plasma bag 14. One end of the blood collection tube 11 is used to connect to a blood donor, and the other end is connected to two blood collection branches 121. Two sets of blood collection pumps 12 and centrifuges 13 are provided. The ends of the two blood collection branches 121 away from the blood collection tube 11 are connected to the inlets of the two centrifuges 13, respectively. The two blood collection pumps 12 are respectively mounted on the two blood collection branches 121. The outlets of the two centrifuges 13 are both connected to the inlet of the first plasma bag 14, and the outlet of the first plasma bag 14 is connected to the plasma adsorption system 2. First return branches 151 are also connected to the two blood collection branches 121, located between the blood collection pumps 12 and the blood collection tube 11. The two first return branches 151 merge away from the blood collection branches 121 and connect to the first return tube 15. The other end of the first return tube 15 is connected to the liquid return system 3. The two blood sampling branches 121 and the two first return branches 151 are provided with electric control valve components for controlling their own opening and closing.

[0034] The centrifuge 13 includes at least a centrifuge cup, which includes a rotor assembly and a stator assembly. The rotor assembly includes a housing with a central opening. The stator assembly includes a stator head, a center tube, and a discharge pipe. The stator head is sealed and rotatably mounted in the housing opening. The center tube is connected to the stator head and extends downward to near the bottom of the housing. The stator head is provided with a feed port that communicates with the center tube. The stator head is fixed to the portion of the housing within which it is located, which includes a downwardly diverging conical upper and lower skirts, forming a passage between the upper and lower skirts. The stator head is also connected to a discharge pipe that communicates with the passage between the upper and lower skirts. During blood collection, blood reaches the bottom of the housing through the feed port and center tube on the stator head. Under the high-speed rotation of the rotor assembly, the blood is separated by the different weights of its various components. The light plasma is concentrated on the inner side of the housing and discharged from the discharge pipe through the passage between the upper and lower skirts of the stator head. The shell is then stopped, and the red blood cells sink back to the bottom of the shell. The blood cells are returned from the shell through negative pressure suction output at the feed port, thereby achieving the separation and output of plasma and red blood cells.

[0035] In an embodiment of the present application, the blood collection branch tube 121 is connected to the feed port of the centrifuge 13. Through the electronically controlled valve assembly, only one of the two blood collection branch tubes 121 can be controlled to be open at the same moment, and the opening and closing states of the blood collection branch tube 121 on the same side are opposite to those of the first return branch tube 151. That is, at the same moment, the blood collection pump 12 on the blood collection branch tube 121 in the open state works to pump blood to the centrifuge 13 on the pipeline, and outputs plasma online through the centrifuge 13, while the blood collection branch tube 121 on the other side performs the red blood cell return operation when the centrifuge 13 is in the shutdown state. Specifically, when the centrifuge 13 is working, blood is continuously pumped into the centrifuge 13, and the blood components are separated in the centrifuge 13. The plasma overflows from the centrifuge cup and is collected in the first plasma bag 14. The plasma entering the first plasma bag 14 is measured by the plasma electronic scale. After the centrifuge 13 stops, the blood collection branch 121 on the side is closed, and the first return branch 151 is opened, and the blood collection pump 12 reverses to pump the red blood cells in the centrifuge cup to the liquid return system 3.

[0036] In this embodiment, the electrically controlled valve assembly includes two first solenoid valves 16 connected to the two blood collection branches 121, and two second solenoid valves 17 connected to the two first return branches 151. The first solenoid valves 16 are located on the side of the first return branch 151 of the blood collection branch 121, near the blood collection tube 11. During blood collection, one of the two first solenoid valves 16 remains open, while the other remains closed. On the connected blood collection branch 121 and first return branch 151, one of the first solenoid valves 16 and the second solenoid valves 17 remains open, while the other remains closed. This ensures that one of the two centrifuges 13 is always pumping blood to the blood collection pump 12, significantly improving blood collection efficiency.

[0037] Furthermore, a bowl photoelectric device 8 is provided on the centrifuge 13. The bowl photoelectric device 8 can be used to detect the stratification of different blood components in real time during the blood centrifugation process. When the bowl photoelectric device 8 detects that the red blood cells in the centrifuge 13 have reached the maximum separation rate, it can control the switching of the opening and closing states of the first solenoid valve 16 and the second solenoid valve 17 on the two blood collection branches 121 and the two first return branches 151, stop the operation of the centrifuge 13, and control the rotation of the blood collection pump 12 to ensure the separation effect of plasma and red blood cells.

[0038] Reference Figure 3The plasma adsorption system 2 includes an adsorption pump 21 and an adsorber 22. The adsorber 22 includes an inlet end, a plasma outlet end, and at least one waste outlet end. The outlet end of the first plasma bag 14 is connected to an adsorption tube 23. The adsorption pump 21 is arranged on the adsorption tube 23. The end of the adsorption tube 23 farthest from the first plasma bag 14 is connected to the inlet end of the adsorber 22. The plasma outlet end of the adsorber 22 is connected to the liquid reinfusion system 3, and the waste outlet end is connected to the waste collection component through the waste discharge pipe. The adsorption pump 21 can be used to pump the plasma collected in the first plasma bag 14 to the adsorber 22. The adsorber 22 can specifically adopt a blood filtration adsorption column. When the plasma passes through the blood filtration adsorption column, the toxic substances in the plasma can be removed. After the toxins in the plasma are removed by the blood filtration adsorption column, it is re-injected into the blood donor's body, which plays the role of online purification and treatment of human plasma, achieving the purpose of clinical treatment of related diseases.

[0039] In the embodiment of the present application, the adsorber 22 specifically includes two waste outlets, each of which is connected to a first waste pipe 24 and a second waste pipe 25. The waste collection assembly includes a first waste bag 26, a second waste bag 27, and a waste liquid pump 28. The first waste pipe 24 is connected to the first waste bag 26, the waste liquid pump 28 is mounted on the first waste pipe 24, and the second waste pipe 25 is connected to the second waste bag 27. After the adsorber 22 purifies and separates the plasma, the waste liquid is actively pumped into the first waste bag 26 via the waste liquid pump 28. Some residual waste liquid and waste gas generated during the process are discharged into the second waste bag 27 for collection, leaving only clean plasma in the liquid discharged from the adsorber 22 to the liquid recirculation system.

[0040] Reference Figure 4 The liquid reinfusion system 3 includes a reinfusion pump 31, a second reinfusion pipe 32, a third reinfusion pipe 33, and a filtered plasma bag 34. The second reinfusion pipe 32 connects the plasma outlet of the adsorber 22 to the top of the filtered plasma bag 34. The first reinfusion pipe 15 connects to the top of the filtered plasma bag 34. One end of the third reinfusion pipe 33 is connected to the bottom of the filtered plasma bag 34 and the other end is connected to the blood donor. The reinfusion pump 31 is mounted on the third reinfusion pipe 33. The red blood cells separated and reinfused from the centrifuge 13 and the plasma filtered and purified by the adsorber 22 are pumped and collected in the filtered plasma bag 34. After being pumped by the reinfusion pump 31, the plasma is pumped back to the blood donor, reducing the burden of blood loss on the human body.

[0041] The blood collection pump 12, adsorption pump 21, return pump 31, and subsequent pumping elements mentioned in this application can all be peristaltic pumps, which are pollution-free, highly accurate, and stable, and are suitable for pumping blood. The various conduits mentioned in this application, such as the blood collection tube 11 and adsorption tube 23, can all be PVC hose consumables.

[0042] In an embodiment of the present application, an anticoagulant addition system is also included. The anticoagulant addition system includes an anticoagulant bag 41, an anticoagulant pump 42 and an input tube 43. One end of the input tube 43 is connected to the anticoagulant bag 41, and the other end is connected to the blood collection tube 11. The anticoagulant pump 42 is arranged on the input tube 43. The anticoagulant pump 42 is used to pump anticoagulant into the blood collection tube 11 during the blood collection process from the blood donor. The anticoagulant can prevent blood from coagulating in the circuit and maintain the fluidity of the circuit.

[0043] Furthermore, a first saline bag 51 and a second saline bag 52 are connected to the closed-loop blood transport circuit. The outlet of the first saline bag 51 is connected to the adsorption tube 23 between the first plasma bag 14 and the adsorption pump 21, while the outlet of the second saline bag 52 is connected to the second return tube 32 between the return pump 31 and the filtered plasma bag 34. During the blood collection, filtration, and return process, some steps require the replenishment of saline. Through the first and second saline bags 51, 52, saline can be drawn into the closed-loop blood transport circuit while the adsorption pump 21 and return pump 31 are operating, replenishing the saline in the blood.

[0044] Furthermore, the outlet of centrifuge 13 is connected to first plasma bag 14 via outlet tube 18. Outlet tube 18 is connected to a first pressure sensor 181 for monitoring the pressure within the tube. A third solenoid valve 182 is also provided on outlet tube 18. First pressure sensor 181 is used to control the opening and closing of third solenoid valve 182. Both first pressure sensor 181 and third solenoid valve 182 are electrically connected to a processing module. First pressure sensor 181 monitors the pressure within both outlet tubes 18 in real time and transmits this information to the processing module. When the pressure is excessive, the processing module promptly controls third solenoid valve 182 to close the corresponding outlet tube 18, preventing excessive pressure within the tube from damaging components within the closed-loop blood delivery circuit or harming the donor.

[0045] In the embodiment of the present application, a first blood filter 61 is further provided on the blood collection tube 11, a second blood filter 62 is provided on the second return tube 32, and a third blood filter 63 is provided on the adsorption tube 23. The blood filter can filter and intercept impurities in the passing liquid, especially impurities originally existing in the pipeline consumables, to prevent impurities from damaging the various components in the closed-loop blood delivery circuit or entering the body of the blood donor and causing harm to the blood donor.

[0046] The first blood filter 61 is also connected to a second pressure sensor 611, the second blood filter 62 is also connected to a third pressure sensor 621, and the third blood filter 63 is also connected to a fourth pressure sensor 631. The second pressure sensor 611, the third pressure sensor 621, the fourth pressure sensor 631, the blood collection pump 12, the return pump 31, and the adsorption pump 21 are all electrically connected to the processing module. The second pressure sensor 611 controls the speed of the blood collection pump 12, which supplies plasma to the centrifuge 13. The third pressure sensor 621 controls the speed of the return pump 31. The fourth pressure sensor 631 controls the speed of the adsorption pump 21. By controlling the speed of each pump, the liquid flow rate can be maintained stable during blood collection, filtration, and return.

[0047] Blood collection tube 11, first return tube 15, second return tube 32, adsorption tube 23, and third return tube 33 are each equipped with an air detector 7. Each of these tubes is also equipped with a fourth solenoid valve 9. The air detector 7, fourth solenoid valve 9, and first, second, and third solenoid valves 16, 17, and 182 are all electrically connected to the processing module. The air detector 7 detects whether air is present in the liquid passing through the pipelines. It controls the closure of the solenoid valves in its own pipeline or in nearby connected pipelines to prevent air from entering the blood vessels and potentially harming the recipient.

[0048] Example 2

[0049] Reference Figure 5 Example 2 differs from Example 1 in that the blood collection tube 11 and the third return tube 33 are connected via a three-way connector 101. This three-way connector 101 is connected to a main blood collection and return tube 102, the end of which, remote from connector 101, is connected to the donor. For donors whose median cubital vein is unsuitable for blood collection or ineffective, the blood collection tube 11 and the third return tube 33 are combined into a single channel, allowing for insertion of a needle in only one arm of the donor. This allows for time-sharing blood collection and return, meeting the needs of different donors.

[0050] Example 3

[0051] Reference Figure 6 The difference between Example 3 and Example 1 is that the structure of the plasma adsorption system 2 is different.

[0052] In this embodiment of the present application, the plasma adsorption system 2 includes a cartridge 103 having an inlet and a plasma outlet. The inlet of cartridge 103 is connected to the adsorption tube 23, and the outlet is connected to the liquid return system 3. Cartridge 103 can filter the plasma inline and trap impurities within itself. As a disposable consumable, it purifies and filters the plasma of the donor, providing an alternative plasma filtration method to the dual-position centrifugal plasma filtration system.

[0053] Example 4

[0054] Reference Figure 7 The difference between Example 4 and Example 1 is that the plasma adsorption system 2 is not provided.

[0055] In an embodiment of the present application, the blood of a blood donor is collected and separated by a plasma collection system 1 to obtain red blood cells and plasma, and pathogenic substances in the plasma remain in the plasma. In the plasma collection system 1, after separation by a dual-position centrifuge 13, the plasma is stored in a first plasma bag 14. The liquid reinfusion system 3 includes a reinfusion pump 31, a third reinfusion tube 33, a red blood cell bag 105, and a clean plasma bag 104. One end of the third reinfusion tube 33 is connected to the blood donor and the other end is connected to the plasma collection system 1. The red blood cell bag 105 is set on the third reinfusion tube 33 for temporarily storing the red blood cells separated by the plasma collection system 1, and the clean plasma bag 104 is used to store clean plasma matched with the blood donor. The clean plasma bag 104 is connected to the third reinfusion tube 33 by a pipeline. The reinfusion pump 31 is set on the third reinfusion tube 33, located on the side of the red blood cells and clean plasma bag 104 close to the blood donor. The clean plasma and red blood cells are returned to the blood donor through the reinfusion pump 31, and the blood of the blood donor is replaced and purified in the system of alternating blood sampling by the double-position centrifuge 13, thereby improving the blood replacement and purification efficiency.

[0056] Those skilled in the art will appreciate that while preferred embodiments of the present invention have been described, further variations and modifications may be made to these embodiments once those skilled in the art are aware of the underlying inventive concepts. Therefore, the appended claims are intended to be interpreted as encompassing the preferred embodiments and all variations and modifications that fall within the scope of the present invention. Clearly, those skilled in the art may make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, the present invention is intended to encompass such modifications and variations as fall within the scope of the claims and their equivalents.

Claims

1. A blood purification system, characterized by: The invention comprises a plasma collection system (1), a plasma adsorption system (2) and a liquid return system (3), wherein the plasma collection system (1) and the liquid return system (3) are both connected to a blood donor to form a blood closed-loop transmission circuit, and the plasma adsorption system (2) is arranged between the plasma collection system (1) and the liquid return system (3); The plasma collection system (1) comprises a blood collection tube (11), a blood collection pump (12), a centrifuge (13) and a first plasma bag (14). One end of the blood collection tube (11) is used to connect to a blood donor, and the other end is connected to two blood collection branches (121). The blood collection pump (12) and the centrifuge (13) are provided in two groups. One end of the two blood collection branches (121) away from the blood collection tube (11) is connected to the inlet end of the two centrifuges (13). The two blood collection pumps (12) are respectively provided on the two blood collection branches (121). The outlet ends of the two centrifuges (13) are connected to the blood collection tube (11). The inlet end of the first plasma bag (14) is connected, and the outlet end of the first plasma bag (14) is connected to the plasma adsorption system (2). The first plasma bag (14) also includes a first return pipe (15), one end of the first return pipe (15) is connected to the liquid return system (3), and the other end is provided with two first return branches (151), the two first return branches (151) are respectively connected to the two blood collection branches (121) and are located between the blood collection pump (12) and the blood collection tube (11), and the two blood collection branches (121) and the two first return branches (151) are provided with an electric control valve assembly for controlling their own opening and closing.

2. A blood purification system according to claim 1, characterized in that: The electrically controlled valve assembly comprises two first solenoid valves (16) respectively connected to the two blood sampling branches (121) and two second solenoid valves (17) respectively connected to the two first return branches (151). During blood sampling, one of the two first solenoid valves (16) is kept in an open state and the other is kept in a closed state. One of the first solenoid valves (16) and the second solenoid valve (17) on the connected blood sampling branch (121) and the first return branch (151) is kept in an open state and the other is kept in a closed state.

3. A blood purification system according to claim 2, characterized in that: The plasma adsorption system (2) comprises an adsorption pump (21) and an adsorber (22), wherein the adsorber (22) comprises an inlet end, a plasma outlet end and at least one waste outlet end, the outlet end of the first plasma bag (14) is connected to an adsorption tube (23), the adsorption pump (21) is arranged on the adsorption tube (23), the end of the adsorption tube (23) far from the first plasma bag (14) is connected to the inlet end of the adsorber (22), the plasma outlet end of the adsorber (22) is connected to the liquid return system (3), and the waste outlet end is connected to an external waste collection component through a waste discharge pipe.

4. A blood purification system according to claim 3, characterized in that: The adsorber (22) includes two waste outlet ends, the two waste outlet ends are respectively connected to a first waste pipe (24) and a second waste pipe (25), the waste collection assembly includes a first waste bag (26), a second waste bag (27) and a waste liquid pump (28), the first waste pipe (24) is connected to the first waste bag (26), the waste liquid pump (28) is arranged on the first waste pipe (24), the second waste pipe (25) is connected to the second waste bag (27), the first waste bag (26) is used to collect waste liquid, and the second waste bag (27) is used to collect waste liquid / gas.

5. A blood purification system according to claim 3, characterized in that: The liquid reinfusion system (3) includes a reinfusion pump (31), a second reinfusion pipe (32), a third reinfusion pipe (33) and a filtered plasma bag (34). The second reinfusion pipe (32) connects the plasma outlet end of the adsorber (22) with the top of the filtered plasma bag (34). The first reinfusion pipe (15) is connected to the top of the filtered plasma bag (34). One end of the third reinfusion pipe (33) is connected to the bottom end of the filtered plasma bag (34) and the other end is connected to the blood donor. The reinfusion pump (31) is arranged on the third reinfusion pipe (33).

6. A blood purification system according to claim 1, characterized in that: The invention also includes an anticoagulant addition system, which includes an anticoagulant bag (41), an anticoagulant pump (42) and an input tube (43). One end of the input tube (43) is connected to the anticoagulant bag (41) and the other end is connected to the blood collection tube (11). The anticoagulant pump (42) is arranged on the input tube (43).

7. A blood purification system according to claim 5, characterized in that: The invention also includes a first physiological saline bag (51) and a second physiological saline bag (52), wherein the outlet end of the first physiological saline bag (51) is connected to the adsorption tube (23) between the first plasma bag (14) and the adsorption pump (21), and the outlet end of the second physiological saline bag (52) is connected to the second return tube (32) between the return pump (31) and the filtered plasma bag (34).

8. A blood purification system according to claim 5, characterized in that: The outlet end of the centrifuge (13) is connected to the first plasma bag (14) via a liquid outlet pipe (18), the liquid outlet pipe (18) is connected to a first pressure sensor (181) for monitoring the pressure in the pipe itself, and the liquid outlet pipe (18) is provided with a third solenoid valve (182), and the first pressure sensor (181) is used to control the opening / closing of the third solenoid valve (182).

9. A blood purification system according to claim 5, characterized in that: The blood collection tube (11) is provided with a first blood filter (61), the second return tube (32) is provided with a second blood filter (62), and the adsorption tube (23) is provided with a third blood filter (63); The first blood filter (61) is provided with a second pressure sensor (611), and the second pressure sensor (611) is used to control the rotation speed of the blood collection pump (12) that inputs plasma into the centrifuge (13). The second blood filter (62) is provided with a third pressure sensor (621), and the third pressure sensor (621) is used to control the rotation speed of the return pump (31). The third blood filter (63) is provided with a fourth pressure sensor (631), and the fourth pressure sensor (631) is used to control the rotation speed of the adsorption pump (21).

10. A blood purification system according to claim 5, characterized in that: The blood collection tube (11), the first return tube (15), the second return tube (32), the adsorption tube (23), and the third return tube (33) are all provided with an air detector (7); The blood collection tube (11), the adsorption tube (23), and the third return tube (33) are all provided with a fourth electromagnetic valve (9).

Images