Phase inversion composition as well as preparation method and application thereof

Abstract

The invention discloses a phase inversion composition and a preparation method and application thereof, the phase inversion composition comprises water, grease and / or wax, a surfactant, an emulsifier and a thickener, the surfactant comprises sodium stearoyl glutamate and potassium cetyl phosphate, the emulsifier comprises polyglycerol-4 diisostearate / polyhydroxystearate / sebacate, and the thickener comprises sodium stearyl glutamate and potassium cetyl phosphate. The thickening agent comprises hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sorbitan isostearate and polysorbate-60, and during preparation, the water phase is added into the oil phase to be homogenized; the phase inversion composition is presented in an oil-in-water form at the initial stage of smearing, can be refreshing and easy to push and use of the oil-in-water form, can generate phase inversion (oil-in-water is converted into water-in-oil) in the smearing process and after smearing, further can play excellent roles of water isolation, urine isolation and the like, can be used for preparing hip cream, and can be used for preparing hip cream. Meanwhile, the emulsion also has excellent stability, and emulsification can be completed in one step (dripping is not needed, and the feeding time is shortened).

Description

Technical Field

[0001] The present invention relates to the field of daily chemical products, in particular to a phase transition composition and a preparation method and application thereof. Background Art

[0002] Typically, the most common cause of diaper rash is inadequate diaper changes. The bacteria in urine and feces react with urea to produce alkaline substances, shifting the pH around the skin from slightly acidic to slightly alkaline. Prolonged contact and irritation can lead to redness. Therefore, when a baby already has diaper rash, it's important to consider whether the diaper cream provides sufficient isolation from the secondary irritation of urine and feces.

[0003] Diaper creams on the market generally achieve their barrier properties by adding oils, as oily substances are not hydrophilic and can block urine, feces, and moisture. Common diaper cream formulations are divided into two types: oil-in-water formulations and water-in-oil formulations. By forming a protective layer on the baby's skin, this layer can isolate urine and feces, reducing skin irritation, thereby preventing and assisting in the treatment of diaper rash. At the same time, diaper creams contain some beneficial ingredients, such as zinc oxide or some active ingredients that soothe and reduce redness. Zinc oxide has astringent properties and can absorb oil and water, which has a partial inhibitory effect on skin inflammation and can promote wound healing.

[0004] However, due to formulation limitations, conventional oil-in-water diaper creams have drawbacks: poor water-repellency, ineffective in shielding against urine, and prolonged contact and irritation of the skin, leading to redness. While water-in-oil formulations offer excellent urine-repellent properties, they are relatively thick and difficult to spread. Consumers generally dislike this sticky feel, and the thick oil film on the skin is difficult to clean. Summary of the Invention

[0005] The purpose of the present invention is to overcome one or more deficiencies in the prior art and to provide a new phase transition composition which is presented as an oil-in-water type at the initial stage of application and can have the refreshing and easy-to-spread properties of an oil-in-water formulation. At the same time, it can undergo a phase transition (from oil-in-water to water-in-oil) during and after application, thereby providing an excellent water-isolating effect.

[0006] Furthermore, the phase inversion composition of the present invention can also have excellent stability and can be emulsified in one step (no dripping is required, reducing the feeding time), thereby obtaining an emulsion with fine and uniformly dispersed emulsified particles.

[0007] The present invention also provides a method for preparing the phase transition composition and application of the phase transition composition in preparing diaper cream.

[0008] In order to achieve the above object, a technical solution adopted by the present invention is:

[0009] A phase inversion composition comprising water, oil and / or wax, a surfactant, an emulsifier and a thickener;

[0010] The surfactant comprises sodium stearoyl glutamate and potassium cetyl phosphate, and the mass ratio of the sodium stearoyl glutamate to the potassium cetyl phosphate is 1:1-2.5;

[0011] The emulsifier comprises polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate;

[0012] The thickener comprises hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sorbitan isostearate, and polysorbate 60, and the mass ratio of the hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, the sorbitan isostearate, and the polysorbate 60 is 10-20:0.5-1.5:1.

[0013] In the present invention, through the blending and synergistic combination of ingredients, the composition can be transformed from an oil-in-water formulation to a water-in-oil formulation during application. By employing a water-in-oil emulsification method during the emulsification process, the first phase inversion is achieved during the emulsification process, resulting in a uniform emulsion with smaller emulsified particles.

[0014] In some embodiments of the present invention, the mass ratio of the sodium stearoyl glutamate to the potassium cetyl phosphate is 1:1.5-2.2. According to a specific aspect of the present invention, the mass ratio of the sodium stearoyl glutamate to the potassium cetyl phosphate is 1:2.

[0015] In some embodiments of the present invention, the mass ratio of the hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, the sorbitan isostearate and the polysorbate 60 is 12-18:0.7-1.4:1.

[0016] According to some specific aspects of the present invention, the thickener comprises, by weight percentage, 86%-90% hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, 5%-7% sorbitan isostearate, and 5%-7% polysorbate 60. In the present invention, the hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sorbitan isostearate, and polysorbate 60 can be commercially obtained separately and then formulated, or a pre-formulated composite can be purchased.

[0017] In this invention, the use of thickeners can alter the texture and fluidity of the product, making it easier to apply and spread. By increasing viscosity, thickeners can increase the contact area between the product and the skin, improving the product's spreadability and smoothness, and making the composition easier to evenly distribute on the skin. They can also improve product stability and prevent ingredient separation and precipitation. They can increase the adhesion and cohesion of cosmetics, prevent phase separation or precipitation of various ingredients during use, and maintain product uniformity and consistency.

[0018] In some embodiments of the present invention, in the phase inversion composition, the surfactant accounts for 0.3%-1%, the emulsifier accounts for 2%-6%, and the thickener accounts for 0.5%-1.2%, calculated by weight. Furthermore, in the phase inversion composition, the surfactant accounts for 0.4%-0.8%, the emulsifier accounts for 2.5%-5.5%, and the thickener accounts for 0.6%-1.0%, calculated by weight.

[0019] In some embodiments of the present invention, the mass ratio of the surfactant, the emulsifier, and the thickener is 1:5-8:1.0-1.5. Furthermore, the mass ratio of the surfactant, the emulsifier, and the thickener is 1:5.5-7.5:1.2-1.5.

[0020] According to the present invention, during the preparation of the phase transition composition, the oil and / or wax, the emulsifier and the thickener are all used as oil phase components, and the water and surfactant are all used as water phase components, and the water phase is added to the oil phase for homogenization.

[0021] In some embodiments of the present invention, the oil accounts for 10%-20% of the phase inversion composition in terms of mass percentage.

[0022] In some embodiments of the present invention, the oil comprises a combination of one or more of coconut oil caprylate / caprate, cetyl ethylhexanoate, dimethicone, palmitic acid and stearic acid complex, and caprylic / capric triglyceride.

[0023] In some embodiments of the invention, the wax comprises cetearyl alcohol.

[0024] According to some specific aspects of the present invention, the phase inversion composition comprises a combination of cetearyl alcohol, coconut oil caprylate / caprate, and cetyl ethylhexanoate, or a combination of polydimethylsiloxane, a palmitic acid and stearic acid complex, and caprylic / capric triglyceride.

[0025] Furthermore, when the phase transition composition comprises a combination of cetearyl alcohol, coconut oil caprylate / caprate, and cetyl ethylhexanoate, in the phase transition composition, based on mass percentage, cetearyl alcohol accounts for 0.5%-2%, coconut oil caprylate / caprate accounts for 6%-15%, and cetyl ethylhexanoate accounts for 2%-6%.

[0026] Furthermore, when the phase transition composition comprises a combination of polydimethylsiloxane, a palmitic acid and stearic acid complex, and caprylic acid / capric triglyceride, in the phase transition composition, in terms of mass percentage, polydimethylsiloxane accounts for 2%-8%, the palmitic acid and stearic acid complex accounts for 0.5%-4%, and caprylic acid / capric triglyceride accounts for 3%-9%.

[0027] In some embodiments of the present invention, the phase inversion composition further comprises a combination of one or more selected from polyols, preservatives, and chelating agents.

[0028] Furthermore, the polyol can be used as a moisturizer and solvent in the system, and the polyol includes but is not limited to glycerol, 1,2-hexanediol, etc.

[0029] Furthermore, the preservative includes but is not limited to p-hydroxyacetophenone.

[0030] Furthermore, the chelating agent includes but is not limited to disodium EDTA (disodium ethylenediaminetetraacetic acid (EDTA-2Na)), which can complex with the metal ions introduced into the formula, reduce the impact of the metal ions on the formula system, and have a stabilizing effect.

[0031] According to the present invention, the phase transition composition includes a first state and a second state. When in the first state, the phase transition composition is an oil-in-water type; when in the second state, the phase transition composition is an oil-in-water type. The phase transition composition can be transformed from the first state to the second state by providing conditions for evaporating water by coating and / or evaporating water by heating.

[0032] Another technical solution provided by the present invention is a method for preparing the above-mentioned phase transition composition, the preparation method comprising:

[0033] Mixing aqueous phase raw materials uniformly to obtain an aqueous phase, wherein the aqueous phase raw materials include water and a surfactant;

[0034] Mixing oil phase raw materials uniformly to obtain an oil phase, wherein the oil phase raw materials include oil and / or wax, an emulsifier and a thickener;

[0035] In a homogenous state, add the water phase to the oil phase.

[0036] In some embodiments of the present invention, the aqueous phase raw materials and the oil phase raw materials are mixed separately and heated to 60-80° C. for use.

[0037] In some embodiments of the present invention, the homogenization temperature of the homogenization state is 60-80° C., the homogenization speed is 4000-8000 rpm, and the homogenization time is 5-10 min.

[0038] In some embodiments of the present invention, after the first homogenization is performed at a homogenization temperature of 60-80° C., the second homogenization may be performed after the temperature is lowered.

[0039] In the present invention, based on the specific formulation system of the present invention, the water phase can be slowly added to the oil phase without dropwise addition (dropwise addition is usually more conducive to forming an oil-in-water type). The emulsification is completed in one step, which greatly saves the feeding time and can also obtain an emulsion with fine and uniformly dispersed emulsion particles.

[0040] Another technical solution provided by the present invention is a use of the above-mentioned phase transition composition in the preparation of a diaper cream.

[0041] Due to the application of the above technical solution, the present invention has the following advantages compared with the prior art:

[0042] The existing diaper cream products have poor water and urine barrier properties (i.e., poor water barrier properties, cannot effectively isolate urine, long-term contact and irritation to the skin, causing redness of the buttocks), and poor feel in use (relatively thick and difficult to spread, most consumers do not like this sticky feel, and the thick oil film on the skin surface is difficult to wash off), which means that it is difficult to achieve both water and urine barrier properties and feel in use.

[0043] Based on a large number of experimental studies by the inventors of the present invention, it is found that the stability of the phase transition composition is improved by compounding potassium cetyl phosphate and sodium stearoyl glutamate, and the ratio of the two is further controlled. On the basis of preventing stratification and demulsification, excellent phase transition and moisturizing and water resistance effects can be obtained. At the same time, polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate is used as an emulsifier, which not only brings a refreshing and non-greasy skin feel, but also further promotes the formation of phase transition during the application process; in particular, a hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sorbitan isostearate, and polysorbate-60 complex is used as a composite thickener, which can further serve as an oil phase thickener. This thickener, when combined with the aforementioned surfactant and emulsifier, achieves a certain emulsifying ability and also promotes the formation of a double phase transition emulsion, resulting in smaller emulsified particles with excellent high and low temperature storage stability.

[0044] In addition, the formulation system of the present invention also achieves unexpected technical effects during the preparation process. Specifically, the formulation system of the present invention can make the preparation process simpler and the feeding faster. The conventional water-in-oil emulsification method for preparing oil-in-water emulsions involves a phase inversion, and it is preferred to drop the water phase into the oil phase. This is time-consuming and not conducive to improving production efficiency. However, the formulation system of the present invention does not require the dropwise addition method, and only requires the water phase to be slowly added to the oil phase, which greatly saves the feeding time. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Figure 1 An image of the emulsified particles of the phase inversion composition prepared in Example 1 of the present invention, taken using an Olympus trinocular microscope;

[0046] Figure 2 An image of the emulsified particles of the phase inversion composition prepared in Comparative Example 1 of the present invention, taken using an Olympus trinocular microscope;

[0047] Figure 3 An image of the emulsified particles of the phase inversion composition prepared in Comparative Example 2 of the present invention, taken using an Olympus trinocular microscope;

[0048] Figure 4 An image of the emulsified particles of the phase inversion composition prepared in Comparative Example 3 of the present invention, taken using an Olympus trinocular microscope;

[0049] Figure 5 An image of the emulsified particles of the phase inversion composition prepared in Comparative Example 4 of the present invention, taken using an Olympus trinocular microscope;

[0050] Figure 6 The stability test diagram of Comparative Example 1 and Comparative Example 4 under freezing conditions;

[0051] Figure 7 This is a microscopic image of the phase inversion composition prepared in Example 1 of the present invention after drying at 50° C. for 5 minutes;

[0052] Figure 8 This is a microscopic image of the composition prepared in Comparative Example 9 after drying at 50° C. for 5 minutes;

[0053] Figure 9 This is a microscopic image of the composition prepared in Comparative Example 10 after drying at 50° C. for 5 minutes;

[0054] Figure 10 This is a microscope image of the emulsified intermediate sample of Example 3;

[0055] Figure 11 This is a microscope image of Example 3 after emulsification is completed;

[0056] Figure 12This is a microscopic image of the phase inversion composition prepared in Example 3 after being dried at 50° C. for 5 minutes;

[0057] Figure 13 An Olympus trinocular microscope was used to photograph the emulsified particles of the composition prepared in Comparative Example 11. DETAILED DESCRIPTION

[0058] The above scheme is further described below in conjunction with specific examples; it should be understood that these examples are used to illustrate the basic principles, main features and advantages of the present invention, and the present invention is not limited to the scope of the following examples; the implementation conditions adopted in the examples can be further adjusted according to specific requirements, and the implementation conditions not specified are generally the conditions in routine experiments.

[0059] Unless otherwise specified in the following examples, all raw materials are commercially available or prepared by conventional methods in the art. In the following, unless otherwise specified, "%" represents the percentage by mass.

[0060] Sodium stearoyl glutamate, purchased from BASF, brand SG; Potassium cetyl phosphate, purchased from DSM, brand K; Polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate, purchased from EVONIK, brand GPS; hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sorbitan isostearate, polysorbate-60 complex, purchased from SEPPIC, brand SEPINOV EMT 10; sodium polyacrylate, purchased from BASF (COGNIS), brand SP; cetearyl alcohol, purchased from BASF, brand O; Coconut oil alcohol-caprylate / caprate, purchased from BASF, brand C 5C; Cetyl Ethylhexanoate, purchased from BASF, brand SN-1SD; polydimethylsiloxane, purchased from SHIN-ETSU CHEMICAL CO., LTD, brand KF-96A-6CS; palmitic acid and stearic acid complex, purchased from IOIACIDCHEM SDN BHD, brand Palmac 55-16; caprylic acid / capric triglyceride, purchased from EVONIK, brand CT MB; Polyglyceryl-2 dipolyhydroxystearate, available from BASF CORPORATION, brand PGPH; polyglyceryl-3 diisostearate, available from GATTEFOSSE, brand PLUROL DIISOSTEARIQUE CG.

[0061] Example 1

[0062] This example provides a phase inversion composition and a preparation method thereof. The formula of the phase inversion composition is shown in Table 1.

[0063] Table 1

[0064]

[0065] The preparation method of the phase inversion composition comprises:

[0066] Mix the aqueous phase raw materials evenly to obtain an aqueous phase, and heat it to 70±5°C for later use;

[0067] Mix the oil phase raw materials evenly to obtain the oil phase, and heat it to 70±5℃ for later use;

[0068] Under homogenization (homogenization speed is 2500±500rpm, homogenization temperature is 70±5℃), slowly add the water phase into the oil phase. After the feeding is completed, control the homogenization speed to 6000±500rpm and the homogenization time to 10min;

[0069] Cool to 45±5°C and homogenize again (homogenization speed is 6000±500rpm, homogenization time is 10min). After homogenization, cool to room temperature while stirring (stirring speed is 25±5rpm).

[0070] Example 2

[0071] This example provides a phase inversion composition and a preparation method thereof. The formula of the phase inversion composition is shown in Table 2.

[0072] Table 2

[0073]

[0074]

[0075] The preparation method of the phase inversion composition is the same as that of Example 1.

[0076] Example 3

[0077] This example provides a phase inversion composition and a preparation method thereof. The formula of the phase inversion composition is shown in Table 3.

[0078] Table 3

[0079]

[0080] The preparation method of the phase inversion composition is the same as that of Example 1.

[0081] Comparative Example 1

[0082] This example provides a composition and a preparation method thereof. The formula of the composition is shown in Table 4.

[0083] Table 4

[0084]

[0085] The preparation method of the composition is the same as that of Example 1.

[0086] Comparative Example 2

[0087] This example provides a composition and a preparation method thereof. The formula of the composition is shown in Table 5.

[0088] Table 5

[0089]

[0090]

[0091] The preparation method of the composition is the same as that of Example 1.

[0092] Comparative Example 3

[0093] This example provides a composition and a preparation method thereof. The formula of the composition is shown in Table 6.

[0094] Table 6

[0095]

[0096] The preparation method of the composition is the same as that of Example 1.

[0097] Comparative Example 4

[0098] This example provides a composition and a preparation method thereof. The formula of the composition is shown in Table 7.

[0099] Table 7

[0100]

[0101] The preparation method of the composition is the same as that of Example 1.

[0102] Comparative Examples 5-8

[0103] This example provides a composition and a preparation method thereof. The formula of the composition is shown in Table 8.

[0104] Table 8

[0105]

[0106]

[0107] The preparation method of the composition is the same as that of Example 1.

[0108] Comparative Examples 9-10

[0109] This example provides a composition and a preparation method thereof. The formula of the composition is shown in Table 9.

[0110] Table 9

[0111]

[0112]

[0113] The preparation method of the composition is the same as that of Example 1.

[0114] Comparative Example 11

[0115] This example provides a composition and a preparation method thereof. The formula of the composition is shown in Table 10.

[0116] Table 10

[0117]

[0118] The preparation method of the composition is the same as that of Example 1.

[0119] Performance Testing

[0120] (1) See Figure 1 As shown, it is a photo of the emulsified particles of the phase inversion composition prepared in Example 1 of the present invention taken with a microscope. It can be seen that the emulsified particles are uniform, dense, and have a small particle size;

[0121] See also Figure 2 As shown, it is a photo of the emulsified particles of the phase inversion composition prepared in Comparative Example 1 of the present invention taken with a microscope. It can be seen that the emulsified particles are uniform, dense, and have a small particle size;

[0122] See also Figure 3 As shown, it is a photo of the emulsified particles of the phase inversion composition prepared in Comparative Example 2 of the present invention taken with a microscope, and it can be seen that the emulsified particles are not formed;

[0123] See also Figure 4 As shown, it is a microscopic image of the emulsified particles of the phase inversion composition prepared in Comparative Example 3 of the present invention. It can be seen that the emulsified particles are not uniform, and there are many large-sized emulsified particles;

[0124] See also Figure 5 As shown, it is a microscopic image of the emulsified particles of the phase inversion composition prepared in Comparative Example 4 of the present invention, from which it can be seen that the emulsified particles are uniform, dense, and have a small particle size;

[0125] As can be seen from the above, when the thickener is used as the aqueous phase thickening component and only sodium stearoyl glutamate or potassium cetyl phosphate is used as the surfactant, it is difficult for the emulsified particles to obtain a small and uniform particle size. If potassium cetyl phosphate is used as the surfactant, although the structure of oil-in-water emulsified particles can still be presented, the particle size is too large and uneven. When sodium stearoyl glutamate is used as the surfactant, a complete emulsified structure cannot be formed.

[0126] (2) Stability tests were conducted on Examples 1-2, Comparative Example 1, and Comparative Examples 4-8 for one week. The specific test results are shown in Table 11.

[0127] Table 11

[0128]

[0129] From the above, it can be seen that although Comparative Examples 1 and 4 showed relatively uniform and small particles in the emulsified particle test, their stability at low temperatures could not meet the requirements and oil leakage occurred. Figure 6 shown.

[0130] (3) Consumer tests were conducted on Examples 1-2 and Comparative Examples 5-8 that passed the stability test to evaluate their instant phase transition effects and moisturizing and water resistance after 2 hours. The instant phase transition effect was a multiple-choice option, while the moisturizing and water resistance after 2 hours were single-choice options. The specific test results are shown in Table 12.

[0131] Table 12

[0132]

[0133]

[0134] It can be seen from the above test results that Examples 1-2 have obvious phase transition effects, indicating that the ratio control of sodium stearoyl glutamate and potassium cetyl phosphate has a significant effect on the phase transition during the application process, and the influence is very large. Only when they are in a specific ratio can a more ideal phase transition effect be obtained; however, the moisturizing power and water resistance test results of Example 1 are better than those of Example 2. It is speculated that the reason is that potassium cetyl phosphate has good film-forming properties and skin adhesion, and can promote the water-resistant moisturizing effect. Based on the above results, Example 1 is selected as the optimal combination.

[0135] (4) A simulated phase inversion test was performed on Example 1 and Comparative Examples 9-10. Specifically, equal amounts of the materials were dried at 50°C for 5 minutes to simulate the phase inversion caused by water evaporation during application.

[0136] For detailed test results, see Figures 7 to 9 ,in, Figure 7The microscopic image of the phase-inversion composition prepared in Example 1 of the present invention after drying at 50°C for 5 minutes shows that the oil-in-water structure is destroyed and the phase is transformed into an irregular oil-in-water structure, forming a film layer.

[0137] Figure 8 This is a microscopic image of the composition prepared in Comparative Example 9 after drying at 50°C for 5 minutes. Figure 9 From the microscope image of the composition prepared in comparative example 10 after drying at 50° C. for 5 minutes, it can be seen that the oil-in-water emulsion structure is not destroyed and the particles can still be seen, indicating that comparative examples 9-10 cannot undergo phase inversion during the coating process.

[0138] (5) A phase inversion test was performed on Example 3. The difference between Example 3 and Example 1 is that different oil components were replaced. The test results are shown in Figure 10-12 ,in, Figure 10 The emulsified intermediate sample (about one-third of the amount of water phase added to the oil phase) has begun the first phase change, that is, the transition to the water-in-oil structure. Figure 11 This is a microscope image of Example 3 after preparation. It can be seen that it has a clear oil-in-water structure, and the emulsified particles are uniform, dense, and small in size, indicating that the first phase inversion is complete and an oil-in-water structure is formed; Figure 12 The phase transition composition prepared in Example 3 was dried at 50° C. for 5 minutes to simulate the evaporation of water during application and phase transition occurred. It can be seen that the water-in-oil structure was destroyed and the phase transition was an irregular structure - oil-in-water structure, forming a film layer.

[0139] It was concluded that in a system where hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sorbitan isostearate, and polysorbate-60 complex are used as oil phase thickeners, emulsification is performed using oil-in-water phase inversion technology, potassium cetyl phosphate and sodium stearoyl glutamate surfactants are compounded, and polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate are used as emulsifiers, the choice of oil does not affect the formation of the double phase inversion emulsion, and also leaves room for adjustment of the skin feel in the later stage.

[0140] (6) The emulsified particles of the composition prepared in Comparative Example 11 were photographed using a microscope. Figure 13 As shown, it can be seen that in the system of the present invention, the use of conventional sodium polyacrylate as a thickener cannot form regular emulsified particles, presenting large flakes, and has a great risk of demulsification. This proves that in the system of the present invention, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sorbitan isostearate, and polysorbate-60 complex as a thickener is more conducive to stabilizing the system.

[0141] The above embodiments are intended only to illustrate the technical concepts and features of the present invention. Their purpose is to enable those skilled in the art to understand the contents of the present invention and implement them accordingly. They are not intended to limit the scope of protection of the present invention. Any equivalent changes or modifications made in accordance with the spirit of the present invention are intended to be covered by the scope of protection of the present invention.

[0142] The endpoints of the ranges and any values ​​disclosed herein are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoints of each range, the endpoints of each range and individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered to be specifically disclosed herein.

Claims

1. A phase inversion composition, characterized in that The phase inversion composition comprises water, oil and / or wax, surfactant, emulsifier and thickener; The surfactant comprises sodium stearoyl glutamate and potassium cetyl phosphate, and the mass ratio of the sodium stearoyl glutamate to the potassium cetyl phosphate is 1:1-2.5; The emulsifier comprises polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate; The thickener comprises hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sorbitan isostearate, and polysorbate 60, and the mass ratio of the hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, the sorbitan isostearate, and the polysorbate 60 is 10-20:0.5-1.5:

1.

2. The phase inversion composition according to claim 1, characterized in that The mass ratio of the sodium stearoyl glutamate to the potassium cetyl phosphate is 1:1.5-2.2; and / or the mass ratio of the hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, the sorbitan isostearate and the polysorbate 60 is 12-18:0.7-1.4:

1.

3. The phase inversion composition according to claim 1, characterized in that Calculated by mass percentage, in the thickener, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer accounts for 86%-90%, sorbitan isostearate accounts for 5%-7%, and polysorbate 60 accounts for 5%-7%.

4. The phase inversion composition according to claim 1, characterized in that In terms of mass percentage, in the phase inversion composition, the surfactant accounts for 0.3%-1%, the emulsifier accounts for 2%-6%, and the thickener accounts for 0.5%-1.2%; and / or the mass ratio of the surfactant, the emulsifier and the thickener is 1:5-8:1.0-1.

5.

5. The phase inversion composition according to claim 4, characterized in that In terms of mass percentage, in the phase inversion composition, the surfactant accounts for 0.4%-0.8%, the emulsifier accounts for 2.5%-5.5%, and the thickener accounts for 0.6%-1.0%; and / or the mass ratio of the surfactant, the emulsifier and the thickener is 1:5.5-7.5:1.2-1.

5.

6. The phase inversion composition according to claim 1, characterized in that During the preparation of the phase transition composition, the oil and / or wax, the emulsifier and the thickener are all used as oil phase components, and the water and surfactant are all used as water phase components. The water phase is added to the oil phase for homogenization.

7. The phase inversion composition according to claim 1, characterized in that The oil comprises a combination of one or more of coconut oil caprylate / caprate, cetyl ethylhexanoate, polydimethylsiloxane, a palmitic acid and stearic acid complex, and caprylic / capric triglyceride; and / or the wax comprises cetearyl alcohol; and / or, in terms of mass percentage, the oil accounts for 10%-20% of the phase inversion composition; and / or, the phase inversion composition further comprises a combination of one or more selected from polyols, preservatives, and chelating agents.

8. The phase inversion composition according to claim 1, characterized in that The phase transition composition includes a first state and a second state. When in the first state, the phase transition composition is an oil-in-water type; when in the second state, the phase transition composition is an oil-in-water type. The phase transition composition can be transformed from the first state to the second state by providing conditions for evaporating water by application and / or evaporating water by heating.

9. A method for preparing the phase inversion composition according to any one of claims 1 to 8, characterized in that: The preparation method comprises: Mixing aqueous phase raw materials uniformly to obtain an aqueous phase, wherein the aqueous phase raw materials include water and a surfactant; Mixing oil phase raw materials uniformly to obtain an oil phase, wherein the oil phase raw materials include oil and / or wax, an emulsifier and a thickener; In a homogenous state, add the water phase to the oil phase.

10. Use of the phase transition composition according to any one of claims 1 to 8 in the preparation of a diaper cream.

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