Dynamic osmotic pressure bionic digestion system and simulation method

Abstract

The invention relates to the crossing field of biomedical engineering and animal science, and particularly discloses a dynamic osmotic pressure bionic digestive system and a simulation method. An osmotic pressure adjusting mechanism is installed in the middle of one end of the main digestion cavity, and a human stomach simulation cavity, a monogastric animal simulation cavity, a ruminant simulation cavity and an aquatic product simulation cavity are installed in the main digestion cavity in a matched mode; through cooperative work of the multi-mode osmotic pressure adjusting liquid pool, the self-adaptive controller, the species database storage device, the liquid conveying pump, the liquid conveying pipe and the adjusting valve, the multi-mode osmotic pressure adjusting liquid pool has three osmotic pressure adjusting modes of a pulse type, a gradient type and a fluctuation type; the osmotic pressure characteristics of digestive tracts of different species such as human beings, monogastric animals, ruminants and aquatic products can be accurately simulated, and the dynamic regulation capability improves the simulation accuracy, so that the system can adapt to wider experimental requirements.

Description

Technical Field

[0001] The present invention belongs to the interdisciplinary field of biomedical engineering and animal science, and specifically relates to a dynamic osmotic pressure bionic digestion system and a simulation method. Background Art

[0002] Bionic digestion refers to the construction of an artificially simulated digestive system or process by drawing on the structure, function and mechanism of the biological digestive system through interdisciplinary methods such as engineering, biology, and chemistry. By controlling parameters such as temperature, pH value, enzyme secretion, and gastrointestinal motility, the physical, chemical and biological effects of the digestive process are simulated to study the digestion characteristics of food and the absorption mechanism of nutrients, or for use in food processing, drug development, bioenergy production and other fields.

[0003] Traditional bionic digestion equipment is only suitable for human digestion simulation. It cannot reproduce the high gastric osmotic pressure of pigs or the osmotic pressure regulation mechanism of fish. It does not consider the correlation between osmotic pressure and species physiology, nor can it simulate the dynamic regulation process of fish intestines with water salinity. Due to the lack of cross-species osmotic pressure simulation, the experimental results of existing equipment are distorted when extrapolated. Summary of the Invention

[0004] The purpose of the present invention is to provide a dynamic osmotic pressure bionic digestion system and simulation method to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A dynamic osmotic pressure bionic digestion system, comprising:

[0007] main digestive cavity;

[0008] An osmotic pressure regulating mechanism is installed in the middle of one end of the main digestive cavity, and the interior of the main digestive cavity is adapted to be equipped with a human stomach simulation cavity, a monogastric animal simulation cavity, a ruminant simulation cavity and an aquatic product simulation cavity;

[0009] The osmotic pressure regulating mechanism includes a multi-mode osmotic pressure regulating liquid pool, an adaptive controller, a species database storage device, a liquid delivery pump, a liquid delivery pipe and a regulating valve. The multi-mode osmotic pressure regulating liquid pool is installed in the middle of one end of the main digestive cavity, the adaptive controller is installed in the middle of the outer wall of the multi-mode osmotic pressure regulating liquid pool, the species database storage device is installed in the middle of one end of the adaptive controller, the liquid delivery pump is installed in the middle of the top end of the multi-mode osmotic pressure regulating liquid pool, the liquid delivery pipe is installed in the middle of the top end of the liquid delivery pump, and the regulating valve is arranged on one side of the outer surface of the liquid delivery pipe.

[0010] Preferably, the interiors of the human stomach simulation cavity, the monogastric animal simulation cavity, the ruminant animal simulation cavity and the aquatic product simulation cavity are all provided with an adaptive sensing feedback system, and the adaptive sensing feedback system includes an osmotic pressure sensor, a pH sensor and a fluid mechanics sensor.

[0011] Preferably, two mounting grooves are provided on the upper parts of the inner walls on both sides of the main digestion chamber, a peristaltic pump is installed on one side of the bottom inner wall of the main digestion chamber, a feed pipe is installed in the middle part of the top end of the main digestion chamber, a connecting sleeve is installed on the lower part of the outer surface of the feed pipe through a bearing, a one-way valve is provided on the upper part of the outer surface of the feed pipe, a sealing door is installed on the outer wall of the main digestion chamber through a hinge, a human-machine interface touch screen is installed in the middle of the outer wall of the sealing door, and a through hole is provided at the lower part of one end of the main digestion chamber.

[0012] Preferably, the multi-mode osmotic pressure regulating liquid pool has three osmotic pressure regulating modes: pulse, gradient, and fluctuation. The adaptive controller is electrically connected to the adaptive sensing feedback system, and the other end of the liquid delivery tube is installed on the outer wall of the feed tube.

[0013] Preferably, the human stomach simulation cavity includes a human stomach mounting frame, an electric extrusion wheel, a human stomach model, a human stomach connector, a human small intestine and a human large intestine. The human stomach mounting frame is installed inside the main digestive cavity through a mounting groove. There are multiple electric extrusion wheels, and the multiple electric extrusion wheels are installed between the inner walls on both sides of the human stomach mounting frame. The human stomach model is snap-fitted and installed between the multiple electric extrusion wheels. The human stomach connector is installed at the top of the human stomach model. The human small intestine is installed at the other end of the human stomach model, and the human large intestine is installed at the other end of the human small intestine.

[0014] Preferably, the monogastric animal simulation chamber includes a pig stomach mounting frame, a pig stomach model, a stirring paddle, a pig stomach connector, a pig small intestine and a pig large intestine. The pig stomach mounting frame is installed inside the main digestive chamber through a mounting groove, and the pig stomach model is installed in the middle of the top inner wall of the pig stomach mounting frame. There are multiple stirring paddles, and the multiple stirring paddles are all installed on the outer surface of the pig stomach model. The pig stomach connector is installed at the top of the pig stomach model, the pig small intestine is installed at the other end of the pig stomach model, and the pig large intestine is installed at the other end of the pig small intestine.

[0015] Preferably, the ruminant simulation chamber includes a cow stomach mounting frame, a cow stomach model, a screw propeller, a cow stomach connector, a cow small intestine and a cow large intestine. The cow stomach mounting frame is installed inside the main digestive chamber through a mounting groove, the cow stomach model is installed in the middle of the top inner wall of the cow stomach mounting frame, the screw propeller is installed in the middle of the bottom end of the cow stomach model, the cow stomach connector is installed at the top of the cow stomach model, the cow small intestine is installed at the other end of the cow stomach model, and the cow large intestine is installed at the other end of the cow small intestine.

[0016] Preferably, the aquatic simulation chamber includes a fish stomach mounting frame, a fish stomach model, a circulating water pump, a fish stomach connector, a fish large intestine and a fish small intestine. The fish stomach mounting frame is installed inside the main digestive chamber through a mounting groove, the fish stomach model is installed between the inner walls on both sides of the fish stomach mounting frame, the circulating water pump is installed on the outer surface of the fish stomach model, the fish stomach connector is installed on the top of the fish stomach model, the fish large intestine is installed at the bottom end of the fish stomach model, and the fish small intestine is installed at the other end of the fish large intestine.

[0017] Preferably, the electric extrusion wheel is configured as an eccentric wheel, the interior of the cow stomach model is provided with a reticulum and omasum simulation unit unique to ruminants, and the interior of the fish small intestine is provided with a spiral valve simulation structure of aquatic animals.

[0018] A method for simulating a dynamic osmotic pressure bionic digestive system comprises the following steps:

[0019] Step 1: Multi-model simulation: Multiple electric extrusion wheels are used to squeeze the human stomach model to simulate the peristalsis of the human stomach when digesting food. Multiple stirring paddles are used to stir the food in the pig stomach model to assist the pig stomach in digesting food. A spiral propeller is used to stir the food in the cow stomach model to simulate the cow stomach's rumination and chewing of food. A circulating water pump is used to pump water from one end of the fish stomach model and then inject it from the other end to form a water circulation, simulating the water flow in the fish stomach.

[0020] Step 2: Sensor feedback: The adaptive sensor feedback system includes an osmotic pressure sensor, a pH sensor, and a fluid dynamics sensor, which can monitor the osmotic pressure, pH value, and fluid dynamics parameters inside the human stomach simulation cavity, the monogastric animal simulation cavity, the ruminant simulation cavity, and the aquatic simulation cavity in real time, thereby realizing the environmental parameter monitoring function;

[0021] Step 3. Osmotic pressure regulation: The osmotic pressure regulation mechanism has three osmotic pressure regulation modes: pulse, gradient, and fluctuation. When different simulation chambers are selected, the simulation chamber can be adjusted for osmotic pressure pulse, fluctuation, and gradient according to the characteristics of the target species, while matching the pH, temperature, and fluid dynamics environment of the corresponding species, thereby realizing cross-species osmotic pressure simulation function;

[0022] Step 4. Replace the model: By rotating the connecting sleeve, the connection between the human stomach connector and the feeding tube can be cancelled, and the human small intestine can be removed from the peristaltic pump. Then the human stomach mounting frame can be removed from the main digestive cavity to realize the disassembly of the human stomach simulation cavity. Then, the monogastric animal simulation cavity, ruminant simulation cavity and aquatic simulation cavity can be replaced according to actual needs.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] (1) The present invention uses the coordinated work of a multi-mode osmotic pressure regulating liquid pool, an adaptive controller, a species database storage device, a liquid delivery pump, a liquid delivery pipe and a regulating valve. The multi-mode osmotic pressure regulating liquid pool has three osmotic pressure regulating modes: pulse, gradient and wave. It can achieve accurate simulation of the osmotic pressure characteristics of the digestive tracts of different species such as humans, monogastric animals, ruminants and aquatic products. This dynamic adjustment capability improves the accuracy of the simulation, enables the system to adapt to a wider range of experimental needs, and also solves the problem of extrapolation distortion of experimental results caused by the lack of cross-species osmotic pressure simulation in existing equipment.

[0025] (2) The present invention uses the collaborative work of a human stomach simulation cavity, a monogastric animal simulation cavity, a ruminant simulation cavity, and an aquatic simulation cavity. Multiple simulation cavities can respectively simulate the mechanical environments of the digestive tracts of different species, such as peristaltic waves, rumination and chewing, or water flow flushing. The detachable modular design of the simulation cavity can adapt to the osmotic pressure curves of different species, thereby reducing the error rate of nutrient absorption experiments and providing a universal platform for cross-species digestion mechanism research.

[0026] (3) The present invention sets up an adaptive sensing feedback system inside the simulation cavity. Through the osmotic pressure sensor, pH sensor and fluid dynamics sensor, it can accurately measure the osmotic pressure, pH value and fluid dynamics parameters in the simulation cavity, and transmit the data to the adaptive controller in real time for processing. The adaptive controller judges the environmental status in the simulation cavity through algorithm analysis based on the received data, and automatically adjusts the operating parameters of equipment such as the osmotic pressure regulating mechanism to maintain the stability and accuracy of the simulated environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 A perspective view of the present invention;

[0028] Figure 2 It is an open perspective view of the present invention;

[0029] Figure 3 is a three-dimensional diagram of the osmotic pressure regulating mechanism of the present invention;

[0030] Figure 4 This is a diagram showing the connection between the feeding tube and the human stomach model of the present invention;

[0031] Figure 5 is a cross-sectional view of the simulated stomach cavity of the present invention;

[0032] Figure 6 is a three-dimensional diagram of the simulated cavity of a monogastric animal according to the present invention;

[0033] Figure 7 is a perspective view of the ruminant simulation cavity of the present invention;

[0034] Figure 8 A three-dimensional diagram of the aquatic simulation chamber of the present invention;

[0035] Figure: 1. Main digestive cavity; 2. Osmotic pressure regulating mechanism; 3. Human stomach simulation cavity; 4. Monogastric animal simulation cavity; 5. Ruminant animal simulation cavity; 6. Aquatic product simulation cavity; 7. Mounting slot; 8. Peristaltic pump; 9. Feed tube; 10. Connecting sleeve; 11. One-way valve; 12. Sealing door; 13. Human-machine interface touch screen; 14. Through hole;

[0036] 21. Multi-mode osmotic pressure regulating liquid pool; 22. Adaptive controller; 23. Species database storage device; 24. Liquid delivery pump; 25. Liquid delivery pipe; 26. Control valve;

[0037] 31. Human stomach mounting frame; 32. Electric extrusion wheel; 33. Human stomach model; 34. Human stomach connector; 35. Human small intestine; 36. Human large intestine;

[0038] 41. Pig stomach mounting frame; 42. Pig stomach model; 43. Stirring paddle; 44. Pig stomach connector; 45. Pig small intestine; 46. Pig large intestine;

[0039] 51. Cow stomach mounting frame; 52. Cow stomach model; 53. Screw propeller; 54. Cow stomach connector; 55. Cow small intestine; 56. Cow large intestine;

[0040] 61. Fish stomach mounting frame; 62. Fish stomach model; 63. Circulating water pump; 64. Fish stomach connector; 65. Fish large intestine; 66. Fish small intestine. DETAILED DESCRIPTION

[0041] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0042] Example 1:

[0043] See also Figures 1 to 8 As shown, a dynamic osmotic pressure bionic digestion system comprises:

[0044] Main digestive cavity 1;

[0045] An osmotic pressure regulating mechanism 2 is installed in the middle of one end of the main digestive cavity 1. The interior of the main digestive cavity 1 is adapted to be equipped with a human stomach simulation cavity 3, a monogastric animal simulation cavity 4, a ruminant animal simulation cavity 5 and an aquatic product simulation cavity 6.

[0046] The osmotic pressure regulating mechanism 2 includes a multi-mode osmotic pressure regulating liquid pool 21, an adaptive controller 22, a species database storage device 23, a liquid delivery pump 24, a liquid delivery pipe 25 and a regulating valve 26. The multi-mode osmotic pressure regulating liquid pool 21 is installed in the middle of one end of the main digestive cavity 1, the adaptive controller 22 is installed in the middle of the outer wall of the multi-mode osmotic pressure regulating liquid pool 21, the species database storage device 23 is installed in the middle of one end of the adaptive controller 22, the liquid delivery pump 24 is installed in the middle of the top end of the multi-mode osmotic pressure regulating liquid pool 21, the liquid delivery pipe 25 is installed in the middle of the top end of the liquid delivery pump 24, and the regulating valve 26 is arranged on one side of the outer surface of the liquid delivery pipe 25.

[0047] Depend on Figures 1 to 4 It can be seen that the interiors of the human stomach simulation chamber 3, the monogastric animal simulation chamber 4, the ruminant simulation chamber 5 and the aquatic simulation chamber 6 are all equipped with an adaptive sensor feedback system, which includes an osmotic pressure sensor, a pH sensor and a fluid dynamics sensor;

[0048] Two mounting grooves 7 are provided on the upper parts of the inner walls on both sides of the main digestion chamber 1, a peristaltic pump 8 is installed on one side of the bottom inner wall of the main digestion chamber 1, a feed pipe 9 is installed in the middle part of the top of the main digestion chamber 1, a connecting sleeve 10 is installed on the lower part of the outer surface of the feed pipe 9 through a bearing, a one-way valve 11 is provided on the upper part of the outer surface of the feed pipe 9, a sealing door 12 is installed on the outer wall of the main digestion chamber 1 through a hinge, a human-machine interface touch screen 13 is installed in the middle of the outer wall of the sealing door 12, and a through hole 14 is provided at the lower part of one end of the main digestion chamber 1.

[0049] As can be seen from the above, when conducting a simulation experiment, the adaptive controller 22 directs the liquid delivery pump 24 to work according to the target species digestive tract osmotic pressure characteristic curve called from the species database storage device 23. The liquid delivery pump 24 extracts the corresponding liquid from the multi-mode osmotic pressure adjustment liquid pool 21 and delivers it to the human stomach simulation cavity 3, monogastric animal simulation cavity 4, ruminant simulation cavity 5 or aquatic simulation cavity 6 in the main digestive cavity 1 through the liquid delivery pipe 25. The regulating valve 26 is set on one side of the outer surface of the liquid delivery pipe 25, and the flow rate and speed of liquid delivery can be adjusted as needed to achieve precise osmotic pressure regulation. During the simulation process, the osmotic pressure sensor, pH sensor and fluid mechanics sensor in the adaptive sensing feedback system inside each simulation cavity can measure the osmotic pressure, pH value and fluid mechanics parameters in the simulation cavity in real time, and feed the data back to the adaptive controller 22. The adaptive controller 22 compares and analyzes the feedback data with the target osmotic pressure, calculates the adjustment concentration through the algorithm, and then controls the liquid delivery pump 24. and the working state of the regulating valve 26, ensuring that the osmotic pressure in the simulation cavity is always maintained within the osmotic pressure range corresponding to the digestive tract of the target species, realizing dynamic osmotic pressure regulation. This real-time monitoring and feedback mechanism not only improves the accuracy and reliability of the simulation, but also enables the system to adapt to more complex experimental needs, providing strong support for cross-species digestion mechanism research. The system can accurately simulate the osmotic pressure characteristics of the digestive tracts of different species such as humans, monogastric animals, ruminants and aquatic products, solving the species limitations of existing equipment. Its dynamic adjustment capability not only improves the accuracy of the simulation, but also enables the system to adapt to a wider range of experimental needs. By calling the osmotic pressure characteristic curves of different species, the system can realize multi-species simulation on the same platform, greatly improving experimental efficiency and data comparability. This multi-species universal bionic digestive system and method with integrated dynamic osmotic pressure simulation is suitable for the study of digestion and absorption mechanisms of different species such as humans, livestock, poultry, and aquatic products, and solves the problem of extrapolation distortion of experimental results caused by the lack of cross-species osmotic pressure simulation in existing equipment.

[0050] Specifically, refer to Figures 1 to 4 As shown, the multi-mode osmotic pressure regulating liquid pool 21 has three osmotic pressure regulating modes: pulse, gradient, and fluctuation. The adaptive controller 22 is electrically connected to the adaptive sensing feedback system, and the other end of the liquid delivery tube 25 is installed on the outer wall of the feed tube 9.

[0051] From the above, it can be seen that the multi-mode osmotic pressure regulating liquid pool 21 can provide three different osmotic pressure regulating modes, providing a basis for subsequent flexible osmotic pressure regulation according to different simulation requirements. This electrical connection enables the adaptive controller 22 to receive various environmental parameters collected by the adaptive sensing feedback system in real time. The liquid delivery pipe 25 delivers the regulating liquid in the multi-mode osmotic pressure regulating liquid pool 21 to the feed pipe 9, so that the regulating liquid can enter the simulation cavity in the main digestion cavity 1, thereby realizing the regulation of the osmotic pressure in the simulation cavity.

[0052] Example 2:

[0053] refer to Figures 5 to 8 As shown, the human stomach simulation chamber 3 includes a human stomach mounting frame 31, an electric extrusion wheel 32, a human stomach model 33, a human stomach connector 34, a human small intestine 35, and a human large intestine 36. The human stomach mounting frame 31 is mounted inside the main digestive cavity 1 through the mounting slot 7. A plurality of electric extrusion wheels 32 are provided, and the plurality of electric extrusion wheels 32 are mounted between the inner walls on both sides of the human stomach mounting frame 31. The human stomach model 33 is snap-fitted and mounted between the plurality of electric extrusion wheels 32. The human stomach connector 34 is mounted on the top of the human stomach model 33. The human small intestine 35 is mounted on the other end of the human stomach model 33. The human large intestine 36 is mounted on the other end of the human small intestine 35.

[0054] The monogastric animal simulation chamber 4 includes a pig stomach mounting frame 41, a pig stomach model 42, a stirring paddle 43, a pig stomach connector 44, a pig small intestine 45, and a pig large intestine 46. The pig stomach mounting frame 41 is mounted inside the main digestive chamber 1 through the mounting slot 7. The pig stomach model 42 is mounted on the middle of the top inner wall of the pig stomach mounting frame 41. A plurality of stirring paddles 43 are provided, and the plurality of stirring paddles 43 are all mounted on the outer surface of the pig stomach model 42. The pig stomach connector 44 is mounted on the top of the pig stomach model 42. The pig small intestine 45 is mounted on the other end of the pig stomach model 42. The pig large intestine 46 is mounted on the other end of the pig small intestine 45.

[0055] The ruminant simulation chamber 5 includes a cow stomach mounting frame 51, a cow stomach model 52, a screw propeller 53, a cow stomach connector 54, a cow small intestine 55, and a cow large intestine 56. The cow stomach mounting frame 51 is mounted inside the main digestive chamber 1 through the mounting slot 7. The cow stomach model 52 is mounted in the middle of the top inner wall of the cow stomach mounting frame 51. The screw propeller 53 is mounted in the middle of the bottom end of the cow stomach model 52. The cow stomach connector 54 is mounted on the top of the cow stomach model 52. The cow small intestine 55 is mounted at the other end of the cow stomach model 52. The cow large intestine 56 is mounted at the other end of the cow small intestine 55.

[0056] The aquatic simulation chamber 6 includes a fish stomach mounting frame 61, a fish stomach model 62, a circulating water pump 63, a fish stomach connector 64, a fish large intestine 65 and a fish small intestine 66. The fish stomach mounting frame 61 is installed inside the main digestive chamber 1 through the mounting groove 7, the fish stomach model 62 is installed between the inner walls on both sides of the fish stomach mounting frame 61, the circulating water pump 63 is installed on the outer surface of the fish stomach model 62, the fish stomach connector 64 is installed on the top of the fish stomach model 62, the fish large intestine 65 is installed at the bottom end of the fish stomach model 62, and the fish small intestine 66 is installed at the other end of the fish large intestine 65.

[0057] As can be seen from the above, during use, multiple simulation chambers simulate the digestion process of different species through their own unique structures and working principles. Specifically, in the human stomach simulation chamber 3, the human stomach model 33 is clamped between multiple electric extrusion wheels 32, and the rotation of the electric extrusion wheels 32 simulates the peristaltic movement of the human stomach. Food enters from the human stomach connector 34, and after being digested by the human stomach model 33, it enters the human small intestine 35 and the human large intestine 36 in turn, thereby completing the simulation of the digestion process of the human stomach; in the monogastric animal simulation chamber 4, a pig stomach model 42 is installed in the middle of the top inner wall of the pig stomach mounting frame 41, and multiple stirring paddles 43 rotate on the outer surface of the pig stomach model 42 to simulate the stirring and digestion action of the pig stomach. Food enters from the pig stomach connector 44, and after being digested by the pig stomach model 42, it enters the pig small intestine 45 and the pig large intestine 46 in turn, thereby simulating the digestion process of monogastric animals; in the ruminant simulation chamber 5, a cow stomach model 52 is installed in the top inner wall of the cow stomach mounting frame 51 In the aquatic simulation chamber 6, a fish stomach model 62 is installed between the inner walls of the fish stomach mounting frame 61, and a circulating water pump 63 operates on the outer surface of the fish stomach model 62 to simulate the water flow flushing and digestion process of the intestinal tract of aquatic animals. Food enters through the fish stomach connector 64, is digested by the fish stomach model 62, and then enters the fish small intestine 66 and fish large intestine 65, thereby completing the simulation of the digestive process of aquatic animals. Multiple simulation chambers can respectively simulate the mechanical environments of the digestive tracts of different species, such as peristaltic waves, rumination and chewing, or water flow flushing. In addition, the detachable modular design of the simulation chamber can adapt to the osmotic pressure curves of different species, significantly reducing the error rate of nutrient absorption experiments, and providing a universal platform for cross-species digestion mechanism research.

[0058] Preferably, reference Figures 5 to 8 As shown, the electric extrusion wheel 32 is set as an eccentric wheel, the interior of the cow stomach model 52 is provided with the reticulum and omasum simulation units unique to ruminants, and the interior of the fish small intestine 66 is provided with the spiral valve simulation structure of aquatic animals.

[0059] As can be seen from the above, the electric extrusion wheel 32 can produce an uneven extrusion effect during rotation, thereby more realistically simulating the peristaltic process of the human stomach when digesting food. By setting these simulation units inside the cow stomach model 52, the digestion process of the ruminant stomach can be more accurately simulated. The spiral valve is a unique structure in the small intestine of aquatic animals. It can increase the internal surface area of ​​the small intestine, and can more realistically simulate the digestion and absorption function of the small intestine of aquatic animals, thereby improving the absorption efficiency of nutrients.

[0060] Example 3:

[0061] refer to Figures 1 to 8 As shown in Figure 2, the adjustment formula of the species-specific adjustment algorithm is:

[0062] ΔC=Kp×(Cset-Crea1)+f(Sp)×Ki×∫(Cset-Crea1)dt

[0063] Where ΔC is the adjustment concentration, Cset is the target osmotic pressure, Creal is the real-time osmotic pressure, Kp = 0.6-1.0, and f(Sp) is the species correction function (human f = 1.0, pig f = 1.2, fish f = 0.8);

[0064] Monogastric animals (pigs / chickens): gastric osmotic pressure peak is 300-350mOsm / kg, small intestine fluctuation frequency is 0.1-0.2Hz; ruminants (cattle / sheep): rumen osmotic pressure is maintained at 290-310mOsm / kg, and changes gradually in the reticulum and omasum stages; aquatic products (fish / shrimp): intestinal osmotic pressure is dynamically adjusted with water salinity, ranging from 250-320mOsm / kg.

[0065] From the above, we can see that the PID parameters can be adjusted by the f(Sp) species correction function. For example, for pigs, f = 1.2 enhances the sensitivity of osmotic pressure regulation to match their rapid gastric emptying characteristics; for fish, f = 0.8 reduces the adjustment frequency to adapt to the slow changes in the aquatic environment.

[0066] Pulse mode: simulates the sudden increase in osmotic pressure after feeding in monogastric animals, with the peak value adjusted according to the species (300mOsm / kg for humans → 320mOsm / kg for pigs); Gradient mode: applies to the osmotic pressure gradient of the rumen and abomasum of ruminants (290 → 310mOsm / kg); Fluctuation mode: matches the osmotic pressure fluctuations of fish intestines with water salinity (frequency 0.05-0.1Hz);

[0067] Comparison of osmotic pressure simulation between pigs and humans: In the pig model, the peak gastric osmotic pressure was 320 mOsm / kg, the small intestinal fluctuation frequency was 0.15 Hz, and f(Sp) = 1.2; in the human model, the peak gastric osmotic pressure was 300 mOsm / kg, the small intestinal fluctuation frequency was 0.1 Hz, and f(Sp) = 1.0. In the pig model, the soybean meal protein digestibility was 92% consistent with in vivo pig experiments and 71% consistent with traditional equipment; in the human model, the consistency was 90% with clinical data, verifying the accuracy of cross-species simulation.

[0068] Simulation of sea bass intestinal osmotic pressure: When the water salinity is 30‰, the intestinal osmotic pressure is maintained at 300mOsm / kg; when the salinity drops sharply to 15‰, the equipment simulates that the intestinal osmotic pressure drops to 280mOsm / kg within 2 hours, with a fluctuation frequency of 0.05Hz; the error between the simulated value and the measured value of the sea bass intestinal glucose absorption rate is 4.7%, while the error of the traditional static osmotic pressure experiment is 28.3%.

[0069] Example 4:

[0070] refer to Figures 1 to 8 As shown, a method for simulating a dynamic osmotic pressure bionic digestive system comprises the following steps:

[0071] Step 1: Multi-model simulation: The human stomach model 33 is squeezed by multiple electric squeezing wheels 32 to simulate the peristalsis of the human stomach when digesting food. The food in the pig stomach model 42 is stirred by multiple stirring paddles 43 to assist the pig stomach in digesting food. The food in the cow stomach model 52 is stirred by a screw propeller 53 to simulate the cow stomach's rumination and chewing of food. The circulating water pump 63 draws water from one end of the fish stomach model 62 and then injects water from the other end to form a water circulation, simulating the water flow in the fish stomach.

[0072] Step 2: Sensor feedback: The adaptive sensor feedback system includes an osmotic pressure sensor, a pH sensor, and a fluid dynamics sensor, which can monitor the osmotic pressure, pH value, and fluid dynamics parameters inside the human stomach simulation chamber 3, the monogastric animal simulation chamber 4, the ruminant simulation chamber 5, and the aquatic simulation chamber 6 in real time, thereby realizing the environmental parameter monitoring function;

[0073] Step 3: Osmotic pressure regulation: The osmotic pressure regulation mechanism 2 has three osmotic pressure regulation modes: pulse, gradient, and fluctuation. When different simulation chambers are selected, the simulation chamber can be subjected to osmotic pressure pulse, fluctuation, and gradient compound regulation according to the characteristics of the target species, while matching the pH, temperature, and fluid dynamics environment of the corresponding species, thereby realizing cross-species osmotic pressure simulation function;

[0074] Step 4. Replace the model: By rotating the connecting sleeve 10, the connection between the human stomach connector 34 and the feeding tube 9 can be cancelled, and the human small intestine 35 can be removed from the peristaltic pump 8. Then the human stomach mounting frame 31 can be removed from the main digestive cavity 1 to realize the disassembly of the human stomach simulation cavity 3. Then, the monogastric animal simulation cavity 4, ruminant animal simulation cavity 5 and aquatic product simulation cavity 6 can be replaced according to actual needs.

[0075] Application examples:

[0076] This design is applied to the experimental research environment of biomedical engineering and animal science, covering scenarios such as laboratories, scientific research institutions, and teaching demonstrations. Its design principles are based on dynamic osmotic pressure regulation, modular design, adaptive sensor feedback, and fluid dynamics simulation. By setting up a human stomach simulation cavity 3, a monogastric animal simulation cavity 4, a ruminant simulation cavity 5, and an aquatic simulation cavity 6, the system can accurately simulate the digestive tract environment of different species such as humans, monogastric animals, ruminants, and aquatic products. In actual applications, the osmotic pressure regulation mechanism 2 adjusts the osmotic pressure to match the digestive tract characteristics of different species, thereby effectively improving the accuracy of the simulation and reducing experimental errors. For example, in the osmotic pressure simulation comparison experiment between pigs and humans, the consistency of soybean meal protein digestibility was significantly improved. In addition, the system provides a universal platform for cross-species digestion mechanism research, supports simulation experiments of different species on the same system, optimizes the experimental process, improves experimental efficiency, and expands its application potential in related fields such as food science and nutrition.

[0077] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A dynamic osmotic pressure bionic digestion system, characterized in that: include: Main digestive cavity (1); An osmotic pressure regulating mechanism (2) is installed in the middle of one end of the main digestive cavity (1), and a human stomach simulation cavity (3), a monogastric animal simulation cavity (4), a ruminant simulation cavity (5), and an aquatic product simulation cavity (6) are adapted and installed inside the main digestive cavity (1); The osmotic pressure regulating mechanism (2) comprises a multi-mode osmotic pressure regulating liquid pool (21), an adaptive controller (22), a species database storage device (23), a liquid delivery pump (24), a liquid delivery pipe (25) and a regulating valve (26); the multi-mode osmotic pressure regulating liquid pool (21) is installed in the middle of one end of the main digestion chamber (1); the adaptive controller (22) is installed in the middle of the outer wall of the multi-mode osmotic pressure regulating liquid pool (21); the species database storage device (23) is installed in the middle of one end of the adaptive controller (22); the liquid delivery pump (24) is installed in the middle of the top end of the multi-mode osmotic pressure regulating liquid pool (21); the liquid delivery pipe (25) is installed in the middle of the top end of the liquid delivery pump (24); and the regulating valve (26) is arranged on one side of the outer surface of the liquid delivery pipe (25).

2. The dynamic osmotic pressure biomimetic digestion system according to claim 1, characterized in that: The interiors of the human stomach simulation cavity (3), the monogastric animal simulation cavity (4), the ruminant simulation cavity (5) and the aquatic product simulation cavity (6) are all provided with an adaptive sensing feedback system, and the adaptive sensing feedback system includes an osmotic pressure sensor, a pH sensor and a fluid mechanics sensor.

3. The dynamic osmotic pressure biomimetic digestion system according to claim 2, characterized in that: Two mounting grooves (7) are provided on the upper portions of the inner walls on both sides of the main digestion chamber (1), a peristaltic pump (8) is installed on one side of the bottom inner wall of the main digestion chamber (1), a feed pipe (9) is installed in the middle portion of the top end of the main digestion chamber (1), a connecting sleeve (10) is installed on the lower portion of the outer surface of the feed pipe (9) via a bearing, a one-way valve (11) is provided on the upper portion of the outer surface of the feed pipe (9), a sealing door (12) is installed on the outer wall of the main digestion chamber (1) via a hinge, a human-machine interface touch screen (13) is installed in the middle portion of the outer wall of the sealing door (12), and a through hole (14) is provided at the lower portion of one end of the main digestion chamber (1).

4. The dynamic osmotic pressure biomimetic digestion system according to claim 3, characterized in that: The multi-mode osmotic pressure regulating liquid pool (21) has three osmotic pressure regulating modes: pulse mode, gradient mode, and wave mode. The adaptive controller (22) is electrically connected to the adaptive sensing feedback system. The other end of the liquid delivery tube (25) is installed on the outer wall of the feed tube (9).

5. The dynamic osmotic pressure biomimetic digestion system according to claim 1, characterized in that: The human stomach simulation cavity (3) comprises a human stomach mounting frame (31), an electric extrusion wheel (32), a human stomach model (33), a human stomach connector (34), a human small intestine (35) and a human large intestine (36). The human stomach mounting frame (31) is mounted inside the main digestive cavity (1) through a mounting groove (7). A plurality of electric extrusion wheels (32) are provided, and the plurality of electric extrusion wheels (32) are all mounted between the inner walls on both sides of the human stomach mounting frame (31). The human stomach model (33) is snap-fitted and mounted between the plurality of electric extrusion wheels (32). The human stomach connector (34) is mounted at the top of the human stomach model (33). The human small intestine (35) is mounted at the other end of the human stomach model (33), and the human large intestine (36) is mounted at the other end of the human small intestine (35).

6. The dynamic osmotic pressure biomimetic digestion system according to claim 5, characterized in that: The monogastric animal simulation chamber (4) comprises a pig stomach mounting frame (41), a pig stomach model (42), a stirring paddle (43), a pig stomach connector (44), a pig small intestine (45) and a pig large intestine (46). The pig stomach mounting frame (41) is mounted inside the main digestive chamber (1) through a mounting groove (7). The pig stomach model (42) is mounted on the middle part of the top inner wall of the pig stomach mounting frame (41). A plurality of stirring paddles (43) are provided, and the plurality of stirring paddles (43) are all mounted on the outer surface of the pig stomach model (42). The pig stomach connector (44) is mounted on the top of the pig stomach model (42). The pig small intestine (45) is mounted on the other end of the pig stomach model (42), and the pig large intestine (46) is mounted on the other end of the pig small intestine (45).

7. The dynamic osmotic pressure biomimetic digestion system according to claim 6, characterized in that: The ruminant simulation chamber (5) comprises a cow stomach mounting frame (51), a cow stomach model (52), a screw propeller (53), a cow stomach connector (54), a cow small intestine (55) and a cow large intestine (56). The cow stomach mounting frame (51) is mounted inside the main digestive chamber (1) through a mounting groove (7). The cow stomach model (52) is mounted in the middle of the top inner wall of the cow stomach mounting frame (51). The screw propeller (53) is mounted in the middle of the bottom end of the cow stomach model (52). The cow stomach connector (54) is mounted at the top of the cow stomach model (52). The cow small intestine (55) is mounted at the other end of the cow stomach model (52). The cow large intestine (56) is mounted at the other end of the cow small intestine (55).

8. The dynamic osmotic pressure biomimetic digestion system according to claim 7, characterized in that: The aquatic simulation chamber (6) comprises a fish stomach mounting frame (61), a fish stomach model (62), a circulating water pump (63), a fish stomach connector (64), a fish large intestine (65) and a fish small intestine (66). The fish stomach mounting frame (61) is mounted inside the main digestive chamber (1) through a mounting groove (7). The fish stomach model (62) is mounted between the inner walls on both sides of the fish stomach mounting frame (61). The circulating water pump (63) is mounted on the outer surface of the fish stomach model (62). The fish stomach connector (64) is mounted on the top of the fish stomach model (62). The fish large intestine (65) is mounted on the bottom end of the fish stomach model (62). The fish small intestine (66) is mounted on the other end of the fish large intestine (65).

9. The dynamic osmotic pressure biomimetic digestion system according to claim 8, characterized in that: The electric extrusion wheel (32) is configured as an eccentric wheel, the interior of the cow stomach model (52) is provided with a reticulum and omasum simulation unit unique to ruminants, and the interior of the fish small intestine (66) is provided with a spiral valve simulation structure of aquatic animals.

10. A method for simulating a dynamic osmotic pressure bionic digestive system, applicable to a dynamic osmotic pressure bionic digestive system according to any one of claims 1 to 9, characterized in that: The following steps are involved: Step 1, multi-model simulation: a human stomach model (33) is squeezed by multiple electric squeezing wheels (32) to simulate the peristalsis of the human stomach when digesting food; a plurality of stirring paddles (43) are used to stir the food in the pig stomach model (42) to assist the pig stomach in digesting the food; a screw propeller (53) is used to stir the food in the cow stomach model (52) to simulate the cow stomach's rumination and chewing of the food; a circulating water pump (63) is used to extract water from one end of the fish stomach model (62) and then inject it from the other end to form a water flow circulation to simulate the water flow flushing in the fish stomach; Step 2: Sensor feedback: The adaptive sensor feedback system includes an osmotic pressure sensor, a pH sensor, and a fluid dynamics sensor, which can monitor the osmotic pressure, pH value, and fluid dynamics parameters inside the human stomach simulation cavity (3), the monogastric animal simulation cavity (4), the ruminant simulation cavity (5), and the aquatic product simulation cavity (6) in real time, thereby realizing the environmental parameter monitoring function; Step 3, osmotic pressure regulation: The osmotic pressure regulation mechanism (2) has three osmotic pressure regulation modes: pulse, gradient, and fluctuation. When different simulation chambers are selected, the simulation chamber can be subjected to osmotic pressure pulse, fluctuation, and gradient compound regulation according to the characteristics of the target species, while matching the pH, temperature, and fluid dynamics environment of the corresponding species, thereby realizing cross-species osmotic pressure simulation function; Step 4: Replace the model: By rotating the connecting sleeve (10), the connection between the human stomach connector (34) and the feeding tube (9) can be cancelled, and the human small intestine (35) can be removed from the peristaltic pump (8). Then, the human stomach mounting frame (31) can be removed from the main digestive cavity (1), and the human stomach simulation cavity (3) can be disassembled. Then, the monogastric animal simulation cavity (4), ruminant simulation cavity (5) and aquatic product simulation cavity (6) can be replaced according to actual needs.

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