Application of temozolomide bromide as sound-sensitive agent

By preparing and applying temozolomide bromide as a sonosensitizer and combining it with specific ultrasound parameters, the problem of the lack of sonosensitizers suitable for gliomas in the existing technology has been solved. This has achieved efficient killing of glioma and melanoma cells and penetration of the blood-brain barrier, providing better tumor treatment effects.

CN120714031APending Publication Date: 2025-09-30TIANJIN MEDICAL UNIV +2
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Patent Information

Application Number
CN202511205235.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-27
Publication Date
2025-09-30

AI Technical Summary

Technical Problem

The existing technology lacks efficient, safe, and blood-brain barrier-penetrating sonosensitizers suitable for gliomas, resulting in limited effectiveness of sonodynamic therapy in the treatment of gliomas.

Method used

Temozolomide bromide is used as a sonosensitizer combined with ultrasound therapy. By preparing temozolomide bromide and activating it under specific ultrasound parameters, singlet oxygen is generated to enhance the killing effect on glioma and melanoma cells. The synthesis method is optimized to ensure that it can penetrate the blood-brain barrier.

Benefits of technology

Temozolomide bromide significantly enhances its toxic effect on glioma and melanoma cells under the synergistic effect of ultrasound. At the same time, it has relatively low toxicity to normal neuronal cells at low concentrations. It can effectively penetrate the blood-brain barrier and provide better tumor treatment effects.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to application of temozolomide bromide as a sound-sensitive agent, and the temozolomide bromide has a structure shown in a formula (I). The invention provides a novel preparation and purification scheme of the sound-sensitive agent temozolomide bromide, and compared with traditional temozolomide, the product has a better killing effect on tumor cells, and has an extremely remarkable killing effect on the tumor cells and cell cycle arrest under the ultrasonic synergistic effect. The temozolomide derivative has a low toxicity effect similar to that of temozolomide on normal neuronal cells at low concentration, and animal experiments prove that the temozolomide derivative can penetrate through a blood-brain barrier. In addition, the invention has immeasurable clinical application value in the treatment of tumors, especially glioma and / or melanoma.
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