Precise antibody screening equipment for phage antibody library
By using spiral tubes and adjusting the piping system to control the temperature in the phage antibody library equipment, the problem of phage particle disintegration was solved, and the accuracy and efficiency of antibody screening were achieved.
CN120714489APending Publication Date: 2025-09-30XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information
- Application Number
- CN202510926256.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-07
- Publication Date
- 2025-09-30
AI Technical Summary
Technical Problem
During the centrifugation of the phage antibody library, excessively high temperature can cause the phage particles to disintegrate, affecting antibody display and screening results.
Method used
By installing a first spiral tube and a regulating pipe system in the equipment, an external air cooler is connected to control the temperature of the centrifugal barrel and the mixing barrel to ensure that the temperature is within a certain range and avoid excessive temperature.
Benefits of technology
Effectively maintain temperature stability during centrifugation and mixing, prevent phage particle disintegration, and ensure the accuracy of antibody display and screening results.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the technical field of antibody screening equipment, in particular to precise antibody screening equipment for a phage antibody library, which comprises an equipment shell, a screening assembly is mounted in the equipment shell, the screening assembly comprises a mixing barrel, a stirring rod is rotatably mounted in the mixing barrel, one end of the stirring rod is connected with a blocking block, and the other end of the stirring rod is connected with a connecting rod. A one-way gear set is installed at the other end of the stirring rod, a rotating rod is connected to one end of the one-way gear set, a centrifugal barrel is installed at the lower end of the rotating rod in a transmission mode, a water pump is fixedly installed in the centrifugal barrel, and an auxiliary assembly is installed on the equipment shell; a constructor is externally connected with an air conditioner through a first spiral pipe access port, cold air surrounds the outside of the centrifugal barrel through the first spiral pipe and then is discharged through an adjusting pipeline and a first multi-way pipe, the centrifugal barrel absorbs the cold air for cooling, the temperature is maintained within a certain range, and the situation that phage particles are disintegrated due to the too high centrifugal temperature is avoided; the antibody display and screening results are influenced.
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