Cyfluthrin indoor space spray composition

Abstract

The present invention relates to a novel insecticidal spray composition for indoor spaces, which comprises the use of Renofluthrin alone or in combination with at least one other insecticide selected from the group consisting of cypermethrin, permethrin, fipronil, deltamethrin, lambda-cyhalothrin and imidaclothrin, in which the at least one other insecticide is selected from the group consisting of cypermethrin, permethrin, fipronil, deltamethrin, lambda-cyhalothrin and imidaclothrin. In particular, the present invention relates to an effective composition comprising cyfluthrin alone or in combination with at least one other insecticide and one or more chemically acceptable excipients to be delivered by aerosol or trigger spray or single propulsion.

Description

Field of the Invention

[0001] The present invention relates to a novel indoor space spray composition comprising a pyrethroid insecticide as an active ingredient. Specifically, the present invention relates to a novel and effective insecticidal composition comprising cyfluthrin (Renofluthrin) alone or in combination with at least one other insecticide, for delivery by aerosol, trigger spray, or single-shot delivery, wherein the composition exhibits significant activity in controlling flying and crawling insects. Background of the Invention

[0003] Pest control inside and outside the home is a never-ending problem. Mosquitoes and other crawling and flying insects need to be controlled to prevent the spread of vector-borne diseases. Flying insects like mosquitoes and flies, and crawling insects like cockroaches and red ants, are known to carry disease-causing bacteria. Flying insects cause significant human suffering and are a global problem. Diseases such as malaria, filariasis, chikungunya, dengue fever, yellow fever, Japanese encephalitis, Ross River virus, Burmese forest fever, and Murray Valley encephalitis are all transmitted by mosquitoes. Crawling insects like ants and cockroaches can also cause health problems. Cockroaches can be carriers of intestinal diseases such as diarrhea, dysentery, typhoid fever, and cholera.

[0004] Furthermore, dust mites should not be neglected, as they are the most common indoor allergen. They are tiny organisms, almost invisible to the naked eye, that feed on indoor dust and moisture in the air. They can trigger asthma in humans.

[0005] Aerosol cans, oil sprays, mosquito coils, and slow-release fogging systems (including mosquito mats and liquid atomizers) are the most commonly used technologies for controlling household insect infestations. Neem oil, pyrethrins, malathion, and carbaryl are all common household insecticides. However, long-term exposure to the odor or toxic chemical emissions of common commercial insecticides may pose health risks. Excessive exposure to these commonly used insecticides has been linked to negative health effects and the development of insecticide resistance in vectors, which is a concern.

[0006] Pyrethrum is a natural insecticide with high insecticidal activity and low toxicity to mammals. However, natural pyrethrum is easily oxidized by air (photooxidation) and degraded under light, making it unsuitable for insecticide use.

[0007] In order to retain insecticidal activity and reduce toxicity to mammals, many compounds with slightly modified natural pyrethrum structures have been synthesized.

[0008] While some of these compounds (synthetic pyrethroids) possess these properties, conventional aerosol compositions can be highly flammable and toxic due to inhalation, and can be harmful to the environment due to the need to continuously formulate high active concentrations. Aerosols are designed to be effective even in enclosed spaces, so exposure to such high doses of insecticide compositions could be considered a health risk to the user. Therefore, it is necessary to formulate a suitable composition that not only has higher efficacy but also protects the molecules from photooxidation as much as possible, ensuring a high degree of persistence of the insecticide action at lower active concentrations.

[0009] Recently, the inventors of IN4121 / MUM / 2013 developed an active ingredient, "Renofluthrin," which has been demonstrated to be an effective household insecticide. Renofluthrin has been shown to be effective and practical in existing formulations and also has the potential to develop novel formulations and delivery systems. The active ingredient, "Renofluthrin," is a composition of isomers of 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, with the total trans isomers (naturally occurring 1R, 3S, and 1S, 3R in nearly equal amounts) comprising 90% to 99.90% and the total cis isomers (naturally occurring 1R, 3R, and 1S, 3S in nearly equal amounts) comprising 0.1% to 10%.

[0010] There is a need in the art to formulate an indoor spray composition that is safer and more economical to use. These goals can be achieved by providing an insecticide composition that can achieve a higher knockdown effect at a lower active dose than conventional insecticides. Furthermore, there is a need in the art for a pyrethroid insecticide composition that has both insecticidal and acaricidal properties.

[0011] Therefore, the present invention aims to overcome the problems in the prior art and provide a stable and effective indoor spray composition comprising cyfluthrin alone or in combination with other insecticides / miticides known in the art. Summary of the Invention

[0012] Objects and advantages of the present invention:

[0013] The main object of the present invention is to provide a novel and effective insecticidal composition comprising cyfluthrin.

[0014] Another main object of the present invention is to provide a novel and effective indoor spray composition comprising only cyfluthrin.

[0015] Another main object of the present invention is to provide a novel and effective indoor insecticide spray composition comprising cyfluthrin and at least one other insecticide / acaricide combination.

[0016] Another object of the present invention is to provide a novel and effective composition that can be used to control / kill mosquitoes, insects and mites.

[0017] Another object of the present invention is to provide a novel and effective composition which provides broad spectrum insecticide control in household applications.

[0018] Another object of the present invention is to provide a novel and effective composition which exhibits both acaricidal and insecticidal properties.

[0019] Another object of the present invention is to provide a novel and effective composition which can be used as a "crawling insect killer" (CIK) and a "flying insect killer" (FIK).

[0020] Another object of the present invention is to provide a novel and effective composition which is safe to use.

[0021] Another object of the present invention is to provide a novel and effective composition having low inhalation toxicity.

[0022] Another object of the present invention is to provide a novel effective composition which is easy to formulate.

[0023] Another object of the present invention is to provide a novel effective composition which is "ready to use".

[0024] Another object of the present invention is to provide a novel and effective composition which can be formulated as an aerosol or a trigger spray or a single-press spray.

[0025] Another object of the present invention is to provide a novel and effective composition that is economical and affordable.

[0026] Another object of the present invention is to provide a novel effective composition having a lower concentration of active ingredient than conventional formulations.

[0027] Another object of the present invention is to provide a novel and effective insecticidal composition having a better knockdown effect than conventional aerosol compositions.

[0028] Another object of the present invention is to provide a novel effective composition that is storage stable at room temperature.

[0029] Some or all of these and other objects of the present invention may be achieved by the invention described hereinafter. SUMMARY OF THE INVENTION

[0031] Therefore, the present invention relates to a novel and effective indoor space insecticide spray composition comprising:

[0032] a) cyfluthrin alone or in combination with at least one other insecticide selected from cypermethrin, permethrin, fipronil, deltamethrin, lambda-cyhalothrin and imiprolin; and

[0033] b) one or more chemically acceptable excipients.

[0034] In one embodiment of the present invention, the novel insecticidal composition is an insecticidal / miticidal single-push spray composition.

[0035] In one embodiment of the present invention, the novel insecticidal composition is an insecticidal / mite-killing trigger spray composition.

[0036] In one embodiment of the present invention, the novel insecticidal composition is an insecticidal / miticide aerosol composition.

[0037] In another preferred embodiment of the present invention, the novel insecticidal composition is an insecticidal / miticide aerosol composition.

[0038] In another preferred embodiment of the present invention, the insecticidal composition comprises:

[0039] a) cyfluthrin is present in an amount from 0.02% to 2% by weight of the total composition; and

[0040] b) one or more chemically acceptable excipients selected from solvents, propellants, flavorings, synergists, antioxidants, corrosion inhibitors, and pH buffers.

[0041] In another preferred embodiment of the present invention, the insecticidal composition comprises:

[0042] a) cyfluthrin in an amount ranging from 0.02% to 2% by weight of the total composition, in combination with at least one other insecticide selected from cypermethrin, permethrin, fipronil, deltamethrin, lambda-cyhalothrin and imiprothrin in an amount ranging from 0.05% to 2% by weight of the total composition; and

[0043] b) one or more chemically acceptable excipients selected from solvents, propellants, fragrances, synergists, corrosion inhibitors and pH buffers.

[0044] In another preferred embodiment of the present invention, the insecticidal composition comprises:

[0045] a) cyfluthrin in an amount ranging from 0.02% to 2% by weight of the total composition, in combination with cypermethrin in an amount ranging from 0.05% to 2% by weight of the total composition; and

[0046] b) one or more chemically acceptable excipients selected from solvents, propellants, fragrances, synergists, corrosion inhibitors and pH buffers.

[0047] In one embodiment of the present invention, the insecticidal composition comprises:

[0048] a) a synergistic combination of cyfluthrin and at least one other insecticide selected from cypermethrin, permethrin, fipronil, deltamethrin, lambda-cyhalothrin and imiprolin; and

[0049] b) one or more selected from solvents, propellants, fragrances, synergists, corrosion inhibitors and pH

[0050] A chemically acceptable excipient for a buffer.

[0051] In another embodiment, the present invention provides a method for preparing an insecticidal composition, the insecticidal composition comprising:

[0052] a) cyfluthrin alone or in combination with at least one other insecticide selected from cypermethrin, permethrin, fipronil, deltamethrin, lambda-cyhalothrin and imiprolin; and

[0053] b) one or more chemically acceptable excipients.

[0054] In another preferred embodiment of the present invention, the insecticidal composition comprises cyfluthrin or 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, wherein the total trans isomers (natural forms of 1R, 3S and 1S, 3R and almost equal amounts) range from 90% to 99.90% and the total cis isomers (natural forms of 1R, 3R and 1S, 3S and almost equal amounts) range from 0.1% to 10% as active ingredients.

[0055] In another preferred embodiment of the present invention, the insecticidal composition comprises cyfluthrin and / or a combination of cypermethrins as active ingredients.

[0056] In another preferred embodiment of the present invention, the insecticidal composition comprises a synergistic combination of cyfluthrin and cypermethrin.

[0057] In a further embodiment of the present invention, the insecticidal composition is used as a mosquito repellent, insect repellent and mite repellent.

[0058] In another embodiment of the present invention, the indoor spray composition is used to effectively control / kill mosquitoes, insects and mites.

[0059] In a further embodiment of the present invention, the aerosol composition can be sprayed by an aerosol spray device, the device comprising a pressure vessel containing a liquid and a spray discharge assembly, wherein the liquid is discharged from the device via a liquefied gas propellant. The spray discharge assembly mounted on the vessel comprises a valve stem, a spray outlet, and a flow channel.

[0060] In another embodiment of the present invention, the aerosol composition of the present invention is a ready-to-use formulation for repelling / controlling mosquitoes, insects and mites in indoor spaces.

[0061] In another embodiment of the present invention, the trigger spray composition can be sprayed from a spray device that does not contain a propellant but instead contains a suitable alcohol-based solvent.

[0062] In another embodiment of the present invention, the trigger spray composition of the present invention is a ready-to-use formulation for repelling / controlling mosquitoes, insects and mites in indoor spaces. DETAILED DESCRIPTION

[0063] Some representative embodiments of the present invention are discussed below. The present invention in its broader aspects is not limited to the specific details and representative methods. This section describes illustrative examples in conjunction with the provided embodiments and methods. When read in conjunction with this specification and appropriate equivalents, the present invention is particularly pointed out according to its various aspects.

[0064] All technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this subject matter belongs. It should be noted that, as used herein, the singular forms "a," "an," and "the" include plural references unless the context clearly dictates otherwise. Thus, for example, reference to a composition comprising "a compound" may include a mixture of two or more compounds. It should also be noted that the term "or" is generally used in its sense to include "and / or," unless the context clearly dictates otherwise.

[0065] Unless otherwise indicated, various amounts expressed as "% w / w" or "%" refer to weight percentages relative to the total weight of the formulation or composition.

[0066] As used herein, the term "indoor space spray" refers to compositions with or without a propellant, including aerosol, trigger spray, or single-push spray formulations.

[0067] As used herein, the term "insect" refers to all species of flying and / or crawling insects and other insects found in public health areas, including but not limited to mosquitoes, house flies, sand flies, stable and face flies, cockroaches, ants, mites, etc.

[0068] As used herein, the term "control" means killing, knocking down and / or repelling mosquitoes, other insects and flies.

[0069] As used herein, the term "active ingredient" (ai) or "active agent" refers to the ingredient in a composition that is responsible for controlling and killing mosquitoes, other insects and flies.

[0070] As used herein, the terms "formulation" and "composition" express the same meaning and are used interchangeably.

[0071] As used herein, the term "knockdown" refers to the knockdown state of an insect following application of an insecticide and can be defined as a state of intoxication and partial paralysis that usually precedes death.

[0072] As used herein, the term "MUP" refers to any pesticide product other than the end-use product. This product may consist solely of the technical-grade active ingredient or may contain inert ingredients such as stabilizers or solvents.

[0073] As used herein, the term "RTU" refers to ready-to-use formulations.

[0074] As used herein, the term "Pitt-Grady chamber test" refers to a standardized procedure for evaluating and testing insect control compositions or products. For flying insects, the knockdown rate is determined after the insects are exposed to the composition for 60 minutes, as recommended by the World Health Organization's pesticide evaluation guidelines.

[0075] As used herein, the term "biological efficacy" refers to the efficacy of an insect control composition or insect control product in knocking down or killing a specific type of insect.

[0076] To achieve the above objectives, the present invention provides a novel and effective insecticide composition comprising the active ingredient "cyfluthrin," wherein cyfluthrin can be used alone or in combination with at least one other insecticide. In another embodiment, the present invention provides a cost-effective and simple method for producing the composition comprising "cyfluthrin."

[0077] Renofluthrin is an isomer composition with a CAS number of RN-352271-52-4 and an IUPAC name of 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, wherein the total trans isomers (the natural forms of 1R, 3S and 1S, 3R are almost equal) account for 90% to 99.90%, and the total cis isomers (the natural forms of 1R, 3R and 1S, 3S are almost equal) account for 0.1% to 10%.

[0078] The chemical structure of cyfluthrin is shown below:

[0079]

[0080] Cyfluthrin, or RNF, is a pyrethroid insecticide used to control mosquitoes and other insects in homes. In one embodiment, the insecticidal composition of the present invention is a ready-to-use aerosol / trigger spray formulation containing a relatively low concentration of cyfluthrin, prepared from the active ingredient, technical grade, or MUP formulation thereof.

[0081] In another embodiment of the present invention, the insecticidal composition comprises cyfluthrin or 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, wherein the total trans isomers (natural forms of 1R, 3S and 1S, 3R and isomers of almost equal amounts) range from 90% to 99.90%, and the total cis isomers (natural forms of 1R, 3R and 1S, 3S and isomers of almost equal amounts) range from 0.1% to 10%.

[0082] According to a main embodiment of the present invention, the insecticidal composition is an indoor spray composition comprising the insecticide alone or in combination with at least one other insecticide.

[0083] According to yet another embodiment of the present invention, the indoor space spray composition can be formulated as an aerosol, a trigger spray, and a single-push spray formulation.

[0084] In another embodiment of the present invention, the insecticidal composition is an insecticidal aerosol composition, which contains "cyfluthrin" alone or in combination with at least one other insecticide.

[0085] In yet another embodiment of the present invention, cyfluthrin is diluted in a solvent or a solvent mixture and / or diluted with an emulsifier / surfactant.

[0086] In yet another embodiment of the present invention, the insecticidal composition of the present invention is an insecticidal trigger spray composition comprising cyfluthrin alone or in combination with at least one other insecticide.

[0087] In another preferred embodiment of the present invention, the novel insecticidal composition comprises cyfluthrin in an amount ranging from 0.02% to 2% by weight of the total composition. In another preferred embodiment of the present invention, the novel insecticidal composition comprises cyfluthrin in combination with at least one other insecticide selected from cypermethrin, permethrin, fipronil, deltamethrin, lambda-cyhalothrin, and imiprolin. In another preferred embodiment, the at least one other insecticide is cypermethrin.

[0088] In another preferred embodiment of the present invention, the novel aerosol composition comprises a combination of cyfluthrin and cypermethrin and one or more suitable and chemically acceptable excipients. In another preferred embodiment of the present invention, the novel trigger spray composition comprises a combination of cyfluthrin and cypermethrin and one or more suitable and chemically acceptable excipients.

[0089] In yet another embodiment of the present invention, the at least one other pesticide is present in an amount of 0.05% to 2% by weight of the total composition.

[0090] In yet another embodiment of the present invention, chemically acceptable excipients include, but are not limited to, one or more of antioxidants, flavorings, propellants, defoaming agents, wetting agents, antimicrobial / antibacterial agents, adjuvants, synergists, fillers, preservatives, buffers, and solvents thereof.

[0091] In another embodiment of the present invention, the solvent is selected from but not limited to isopropyl alcohol, tripropylene glycol, monomethyl ether, ethylene glycol D-methyl ether, butyl cortisone, Hydrosal, Ketrul d-80, deodorized kerosene or a combination thereof.

[0092] In another embodiment of the present invention, the surfactant is selected from but not limited to fatty acid esters, sorbitan fatty acid esters (Lubricit TM SMO), alkyl alcohol ethoxylates ( AL-CS20, AL-CS25) or a combination thereof.

[0093] In another embodiment of the present invention, the propellant is selected from but not limited to nitrogen, butane, isobutane, propane, hydrofluorocarbons or combinations thereof, liquefied petroleum gas, and the like.

[0094] In another embodiment of the present invention, the synergist is selected from but not limited to piperonyl butoxide, N-octylbicycloheptenedicarboxylic acid imide, propargylpropylphenylphosphonate, and the like.

[0095] According to yet another embodiment, the present invention may include a corrosion inhibitor, such as sodium benzoate.

[0096] According to yet another embodiment, the present invention may include an antioxidant such as ethoxyquin or tert-butylhydroquinone (TBHQ).

[0097] In another embodiment of the present invention, the insecticidal composition comprises fragrance, the content of which is 0.1% to 1% of the total weight of the insecticidal composition.

[0098] In another embodiment of the present invention, the insecticidal composition comprises a solvent, wherein the content of the solvent is 30% to 99% of the total weight of the insecticidal composition.

[0099] In another embodiment of the present invention, the insecticidal composition comprises a propellant, the content of which is 0% to 70% of the total weight of the insecticidal composition.

[0100] In another embodiment of the present invention, the insecticidal composition comprises a synergist, the content of which is 0% to 2% by weight of the total weight of the insecticidal composition.

[0101] In another embodiment of the present invention, the indoor space spray composition may or may not contain a propellant.

[0102] In another embodiment of the present invention, the indoor space spray composition controls household mosquitoes, flies, insects, cockroaches, ants and mites.

[0103] In another embodiment, a method of making the aerosol composition of the present invention is disclosed, comprising:

[0104] Manufacturing process flow chart

[0105] A) Preparation method of cyfluthrin aerosol formulation:

[0106]

[0107] B) Method for manufacturing cyfluthrin + additional insecticide aerosol formulation:

[0108]

[0109] Aerosol manufacturing process

[0110] 1. Fill the premix preparation tank with weighed solvent.

[0111] 2. Charge the required weighed amount of RNF MUP alone or in combination with at least one other insecticide under stirring.

[0112] 3. Add the required weighed spices while stirring.

[0113] 4. The mixture was stirred for 2 hours to obtain a homogeneous solution.

[0114] 5. Check the appearance, active ingredient content and density of the solution sample.

[0115] 6. If acceptable, fill the can with a known amount of premix in grams.

[0116] 7. Install the valve and fill with a known amount of liquefied petroleum gas (LPG).

[0117] 8. Check the weight of the cans for final packing.

[0118] Toxicity profile of cyfluthrin

[0119] Toxicity and efficacy play crucial roles in insecticide / pesticide compounds. New insecticide compounds are developed based on their efficacy against target pests and their toxicological profiles.

[0120] Acute inhalation toxicity:

[0121] Inhalation toxicity is of paramount importance in mosquito and flying insect repellent products. Most flying insect repellent products rely on the evaporation and vaporization of the active ingredient. Household insecticide product forms such as coils, mats, aerosol sprays, trigger sprays, liquid vaporizers, and other combustion and vaporization formulations all rely on the evaporation of the active ingredient. The insecticide's airborne concentration and its evaporation are the most important aspects of an insect repellent product.

[0122] Inhalation toxicity is measured using the "lethal concentration" (LC50) value. The LC50 (lethal concentration) is expressed as the weight of the test substance per standard volume of air (i.e., mg / L). The higher the LC50 (mg / L) value, the lower the inhalation toxicity and the safer the product.

[0123] Known insecticide compounds with a similar mode of action have the following reported LC50 values:

[0124] The insecticide "Prallethrin" LC50 is 0.658 mg / L (the unit of measurement reported in the literature is 658

[0125] mg / m3, converted to mg / L is 0.658)

[0126] The LC50 of the insecticide "Transfluthrin" is 0.513 mg / L (the unit of measurement reported in the literature is

[0127] 513mg / m3, converted to mg / L is 0.513)

[0128] The insecticide "Metofluthrin" LC50 is reported to be >1.08 and <1.96 mg / L

[0129] These results have been published and reported for the respective pesticides.

[0130] An acute inhalation toxicity study of renofluthrin was conducted on rats according to OECD Guideline No. 403. In the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), the insecticide "renofluthrin" of the present invention belongs to Category 4 for dust and mist (mg / L), i.e. >1.0 and <5 mg / L.

[0131] The LC50 of the insecticide "Renofluthrin" of the present invention is greater than 3.81 mg / L, which indicates that among all compounds commonly used as active ingredients of household insecticides, Renofluthrin has the lowest inhalation toxicity. Contains Renofluthrin and its components The biological efficacy and activity of the combined insecticide aerosol composition.

[0132] The bioavailability of a cyfluthrin aerosol composition against target pests was determined by comparing it to the bioavailability of a commercial aerosol composition containing d-trans allethrin and transfluthrin. Aedes aegypti is the primary vector of dengue, chikungunya, yellow fever, and other viral diseases. Peet Grandy ) test chamber to test the effectiveness and efficacy of the aerosol composition of the present invention.

[0133] The effectiveness / efficacy of mosquito repellent formulations is often measured as "knockdown time" (KT), which is the time, measured in minutes, required to knock down a certain percentage of a test mosquito population. For example, the KT50 value refers to the time required to knock down 50% of the test insect population. The shorter the KT50 time, the more effective the insecticide. Results may vary depending on study conditions, mosquito species, and protocol.

[0134] A comparative study on the bio-effectiveness evaluation of the aerosol composition of the present invention and other aerosol compositions known in the art against Aedes aegypti and German cockroaches was conducted; the results are shown in the following table:

[0135] 1) In Pete Grady Peet Grandy test Indoor, d-TransAllethrin 0.25% aerosol and Comparison of the bioefficacy of renofluthrin 0.03% aerosol against Aedes aegypti

[0136] Methods: Two replicates of each aerosol were tested against Aedes aegypti. Before pre-treatment testing with the aerosol in the smoke, the aerosol was placed in and out of the test area 2-3 times. After filling, the weight of the aerosol can was recorded. A single spray of 0.65 ± 0.10 g of the formulation was applied to the center of the test chamber through a nozzle located on the side wall. Knockdown was recorded every 1 minute for up to 10 minutes, then every 2 minutes for up to 20 minutes, and then every 5 minutes for up to 60 minutes.

[0137] Table 1: Comparison of the bioefficacy of d-trans-allethrin 0.25% aerosol and Renofluthrin 0.03% aerosol against Aedes aegypti in a Peet Grandy test chamber

[0138]

[0139] result:

[0140] As can be seen from the table above, the Renofluthrin aerosol formulation showed better efficacy than the d-trans allethrin aerosol formulation. At an active concentration of 0.03% (relative to 0.25%), the knockdown time of Renofluthrin on 50% and 90% of mosquitoes was shorter than that of d-trans allethrin.

[0141] Thus, Renofluthrin 0.03% aerosol exhibits superior efficacy at lower active concentrations.

[0142] 2) In Peet Grandy test Initial and residual biomass of aerosols tested indoors against free-flying Aedes aegypti Efficacy testing.

[0143] Methods: Mosquitoes were released in a Peet Grady chamber and, after an acclimation period, sprayed with aerosol product at a dose of 0.65 g ± 0.1 g. Knockdown readings were recorded for up to 60 minutes and the data were plotted to calculate KT50 and KT90 values ​​using SPSS software. The product was sprayed once, and readings were recorded at 0 (fresh), 4 hours, 8 hours, and 10 hours after the start of spraying, and residual efficacy was assessed.

[0144] Table 2: RNF 0.05% aerosol, RNF 0.03% + Cypermethrin 0.1% Aerosol and Transfluthrin (TFT)

[0145] Initial and Residual Bioefficacy Testing of 0.08% Aerosol

[0146]

[0147] result:

[0148] TFT 0.08% aerosol showed residual protection for up to 4 hours.

[0149] RNF 0.03% + CYPERMETHRIN 0.1% aerosol showed residual protection for up to 8 hours.

[0150] The RNF 0.05% aerosol formulation had the highest residual efficacy, lasting 8 to 10 hours.

[0151] Under the test conditions, 100% mortality was observed within 10 hours for RNF 0.05% aerosol, however, this was up to 8 hours for RNF 0.03% + Cypermethrin 0.1% aerosol, and only up to 4 hours for the TFT 0.08% aerosol formulation.

[0152] Thus, RNF 0.05% aerosol showed enhanced residual protection against mosquitoes in the test.

[0153] 3) RNF0.05%, RNF0.03%+Cypermethrin0.1% and Deltamethrin0.02%+Allethrin0.13% Biological efficacy of aerosol samples against German cockroaches on cement surfaces

[0154] Method: The product was sprayed on the cement board. After drying, 10 cockroaches were exposed to the panel twice. The mortality was checked after 30 minutes of exposure and after 4 and 24 hours.

[0155] Table 3: Biological efficacy of aerosol samples against German cockroaches on cement surfaces

[0156]

[0157] result:

[0158] The RNF 0.05% aerosol formulation had a 30% mortality rate within 24 hours.

[0159] However, the RNF 0.03% + cypermethrin 0.1% aerosol formulation showed higher efficacy with a mortality rate of 80% compared to the art known deltamethrin 0.02% + allethrin 0.13% aerosol (24 hour mortality rate of 55%).

[0160] Therefore, even at low doses of the active ingredients, the Renofluthrin 0.03% + Cypermethrin 0.1% aerosol formula provides excellent control of crawling insects.

[0161] 4) The direct spray knockdown method was used to treat RNF0.05%, RNF0.03% + cypermethrin

[0162] Bioefficacy of 0.1% and deltamethrin 0.02% + allethrin 0.13% aerosol samples against German cockroaches

[0163] Method: Five cockroaches were placed in a 6-inch stainless steel mesh cartridge (with stainless steel mesh on both sides) and placed at a predetermined distance in the room, and then the aerosol product was sprayed on the cartridge.

[0164] Observe and record 100% mortality in seconds; if available, record 24-hour resuscitation data.

[0165]

[0166] Results: All three treatments achieved the same 100% mortality. However, RNF 0.03% + Cypermethrin 0.1% achieved 100% KD in 161 seconds. Therefore, RNF 0.03% + Cypermethrin 0.1% demonstrated superior control in the shortest time.

[0167] Example

[0168] A) 0.04% cyfluthrin aerosol formula ingredients come from technology:

[0169] Serial number Element % aerosol w / w 1 Renofluthrin Technology 0.04 2 spices 0.30 3 Ketrul d-80 (solvent) 39.65 4 LPG QS

[0170] C) 0.04% Renofluthrin aerosol formulation consisting of 5% MUP:

[0171] Serial number Element % aerosol w / w 1 Cyfluthrin 5% MUP 0.80 2 spices 0.30 3 solvent 38.90 4 LPG QS

[0172] C) 0.10% Renofluthrin aerosol formulation consists of:

[0173] Serial number Element % aerosol w / w 1 Renofluthrin Technology 0.10 2 spices 0.30 3 solvent 39.60 4 LPG QS

[0174] D) Composition of 0.04% Renofluthrin + 0.10% Cypermethrin aerosol formula:

[0175] Serial number Element % premix w / w % aerosol w / w 1 Renofluthrin 0.10 0.04 2 Cypermethrin 0.25 0.10 2 spices 0.75 0.30 3 solvent 98.90 39.56 4 LPG - QS

[0176] E) 0.04% Renofluthrin + 0.10% Cypermethrin Trigger Spray Formula:

[0177] Serial number Element % in trigger spray w / w 1 Renofluthrin 0.04 2 Cypermethrin 0.10 3 spices 0.30 4 synergist 1 5 solvent QS

[0178] As can be seen from the foregoing, various modifications and variations may be made without departing from the true spirit and scope of the novel concepts of the present invention. It should be understood that the present invention is not intended to or infer any limitation to the specific embodiments shown. It should be understood that all such modifications and improvements are appropriately encompassed within the scope of this application.

Claims

1. An indoor space insecticide spray composition comprising: A) cyfluthrin, alone or in combination with at least one other insecticide; and B) one or more chemically acceptable excipients.

2. The insecticidal composition according to claim 1, wherein The at least one other insecticide is selected from the group consisting of cypermethrin, permethrin, fipronil, deltamethrin, lambda-cyhalothrin and imiprothrin.

3. The insecticidal composition according to claim 1, wherein The content of the cyfluthrin is 0.02% to 2% of the total weight of the composition.

4. The insecticidal composition according to claim 1, wherein The at least one other pesticide is present in an amount of 0.05% to 2% by weight of the total composition.

5. The insecticidal composition according to claim 1, wherein The at least one other insecticide is cypermethrin.

6. The insecticidal composition according to claim 1, wherein The one or more chemically acceptable excipients are selected from solvents, propellants, flavors, synergists, corrosion inhibitors, and pH buffers.

7. The insecticidal composition according to claim 1 or 6, wherein The solvent is selected from isopropyl alcohol, tripropylene glycol, monomethyl ether, ethylene glycol-D-methyl ether, butyl cortisone, Hydrosal, Ketrul d-80, deodorized kerosene or a combination thereof, and its content accounts for 30% to 99% by weight of the total composition.

8. The insecticidal composition according to claim 1 or 6, wherein The propellant is selected from liquefied petroleum gas, nitrogen, butane, isobutane, propane, hydrofluorocarbons or a combination thereof, and its content accounts for 0% to 70% of the total weight of the composition.

9. The insecticidal composition according to claim 1 or 6, characterized in that The content of the fragrance is 0.2% to 1% of the total weight of the composition.

10. The insecticidal composition according to claim 1 or 6, wherein The synergist is selected from piperonyl butoxide, N-octyl bicycloheptenedicarboxylic acid imide, propargyl propyl phenyl phosphonate or a combination thereof, and its content accounts for 0% to 2% of the total weight of the composition.

11. The insecticidal composition according to claim 1 or 6, wherein Corrosion inhibitors and pH buffers are optionally present.

12. The insecticidal composition according to claim 1, wherein The cyfluthrin is used alone or in combination with at least one other insecticide for delivery via an aerosol, trigger spray, or single push.

13. The insecticide composition according to claim 1 is an insecticide / acaricide composition.

14. The insecticidal composition according to claim 1, wherein The compositions exhibit outstanding flying and crawling insect and mite controlling activity.

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