Beautifying medical adhesive tape base material and preparation method thereof

Abstract

The invention provides a cosmetic medical adhesive tape base material and a preparation method thereof, and relates to the technical field of medical adhesive tape base materials, the cosmetic medical adhesive tape base material comprises the following components by weight: 60-90 parts of polyethylene plastic, 10-40 parts of an ethylene-vinyl acetate copolymer, 0.5-5 parts of a chitosan derivative, 1-10 parts of a porous material, and 0.1-3 parts of a tyrosinase inhibitor. By optimizing the component proportion and introducing the functional material, the comprehensive performance of the cosmetic medical adhesive tape is improved. Through the synergistic effect of the polyethylene plastic and the ethylene-vinyl acetate copolymer, the flexibility of the base material is enhanced, the traction feeling is reduced when the base material is attached to the skin, meanwhile, the stable adhesive force is maintained, and repeated falling is avoided. The addition of the chitosan derivative endows the base material with natural antibacterial characteristics, inhibits wound infection risk, promotes epidermal cell repair, and shortens postoperative recovery cycle.

Description

Technical Field

[0001] The present invention relates to the technical field of medical tape substrates, and in particular to a cosmetic medical tape substrate and a preparation method thereof. Background Art

[0002] Cosmetic medical tape substrate is a sub-type of medical tape substrate, designed specifically for medical cosmetic scenarios. Its uses include post-operative skin tension reduction and fixation (such as double eyelid and rhinoplasty post-care), local lifting and shaping (such as improving sagging skin), and covering minor blemishes (such as scars and pigmentation).

[0003] Existing cosmetic medical tape substrates are prone to edge lift or overall displacement after application due to skin movement, compromising tension-reducing and fixation effectiveness. For example, tape detachment after double-eyelid surgery can lead to uneven tension in the incision and prolonged healing. Insufficient breathability can lead to sweat accumulation in the application area, breeding bacteria and potentially inducing contact dermatitis. This is especially true in high-temperature or high-humidity environments, requiring frequent tape changes, increasing care costs and the risk of infection. Therefore, improvements are needed. Summary of the Invention

[0004] The purpose of the present invention is to solve the shortcomings of the prior art and to propose a cosmetic medical tape substrate and a preparation method thereof.

[0005] In order to achieve the above-mentioned object, the present invention adopts the following technical solution: a cosmetic medical tape substrate, wherein the cosmetic medical tape substrate comprises the following components in parts by weight: 60-90 parts of polyethylene plastic, 10-40 parts of ethylene-vinyl acetate copolymer, 0.5-5 parts of chitosan derivative, 1-10 parts of porous material, and 0.1-3 parts of tyrosinase inhibitor.

[0006] Preferably, the chitosan derivative is carboxymethyl chitosan or chitosan oligosaccharide.

[0007] Preferably, the porous material is zeolite molecular sieve or activated carbon fiber.

[0008] Preferably, the tyrosinase inhibitor is arbutin, kojic acid dipalmitate or glabridin.

[0009] The present invention provides a method for preparing a cosmetic medical tape substrate, comprising the following steps: S1, melt blending, adding polyethylene plastic and ethylene-vinyl acetate copolymer into a twin-screw extruder to melt the materials; monitoring the mixing uniformity through a torque sensor during the melting process, and determining that the melt mixing is complete when the torque fluctuation range is stable within ±5%; the mixing time is 10-30 minutes, and the molten material is extruded through a die to obtain a uniform melt blend; S2, introducing functional additives: transferring the homogeneous molten blend to a mixer, and sequentially adding the chitosan derivative, porous material, and tyrosinase inhibitor while maintaining the material temperature at 120-180° C.; adjusting the mixer speed to 500-1000 RPM, and uniformly dispersing the additives in the melt by mechanical stirring and heat conduction; and mixing for 15-45 minutes to obtain a melt in which the functional additives are uniformly dispersed; S3, adding a microwave absorbent, adding a microwave absorbent to the melt in which the functional additives are uniformly dispersed according to the microwave heating requirements; switching the mixing equipment to a static mixer, maintaining the material temperature at 130-170°C, and forming the microwave absorbent into a nano-scale dispersed phase through laminar shear; controlling the mixing time to 5-15 minutes, and confirming that the dispersed phase particle size is less than 500nm by scanning electron microscopy; thereby obtaining a microwave-responsive melt; S4, microwave-assisted blending treatment, introducing the microwave-responsive melt into a microwave generator, setting the microwave generator frequency to 2.45-5.8 GHz and the power density to 10-50 W / cm³; the material is heated in the microwave field, and the interface temperature between the chitosan derivative and the porous material rises to 180-220° C., triggering a thermal activation reaction of the tyrosinase inhibitor, and the material residence time is 2-8 minutes, thereby obtaining a microwave-activated melt; S5, preliminary forming, the microwave-activated melt is formed by a calender, the calender roller gap is adjusted to 0.1-1.0 mm, and the roller linear speed is 5-20 m / min; during the forming process, air knife-assisted cooling is used to reduce the surface temperature of the material to 80-120°C, forming a continuous film with a thickness of 0.05-0.5 mm, thereby obtaining a plastic substrate film.

[0010] Preferably, the method further comprises: S6, hot pressing micro-embossing, performing online hot pressing treatment on the plastic substrate film, setting the temperature of the embossing mold to 90-150°C, the pressure range to 5-20 MPa, and the holding time to 10-60 seconds; the mold surface structure is an array of protrusions with a line width of 10-100 μm, a depth of 5-50 μm, and a spacing of 20-200 μm, to obtain a microstructured embossed substrate; S7, pressure-maintaining cooling and shaping, transferring the microstructured imprinted substrate together with the mold to a circulating water cooling press, setting the cooling rate to 5-20°C / min and maintaining the pressure at 5-15 MPa until the substrate temperature drops to 40-80°C; the cooling water temperature is 10-25°C and the flow rate is 10-50 L / min, to obtain a shaped microstructured substrate; S8, demolding and post-processing, peeling the shaped microstructured substrate from the mold, controlling the peeling angle at 30-60 degrees and the peeling speed at 0.5-2.0 m / min; after demolding, the substrate is cut into strip products with a width of 10-100 mm by a slitting machine, and the slitting knife temperature is maintained at 50-80°C; then the substrate is treated with an electrostatic eliminator to obtain a finished cosmetic medical tape substrate.

[0011] Preferably, in step S1, the heating temperature of the twin-screw extruder is 150-200°C, and the screw speed is 200-500RPM.

[0012] Preferably, in step S3, the microwave absorber is formed by mixing silicon carbide and ferrite in a mass ratio of 1:1-3:1.

[0013] 1. Compared with the existing technology, the present invention improves the comprehensive performance of cosmetic medical tape by optimizing the component ratio and introducing functional materials. The synergistic effect of polyethylene plastic and ethylene-vinyl acetate copolymer enhances the flexibility of the substrate, reducing the pulling sensation when it adheres to the skin, while maintaining stable adhesion to avoid repeated shedding. The addition of chitosan derivatives gives the substrate natural antibacterial properties, inhibits the risk of wound infection, promotes epidermal cell repair, and shortens the postoperative recovery period. The embedding of porous materials forms a microchannel structure, which improves breathability, reduces the stuffy and humid environment caused by long-term application, and reduces the probability of skin sensitivity or inflammation. Tyrosinase inhibitors inhibit the melanin production pathway, preventing pigment deposition in the application area due to ultraviolet rays or postoperative irritation, thereby improving the concealment and uniformity of the cosmetic effect. The components achieve functional complementarity through proportional regulation, while ensuring medical safety, taking into account the needs of cosmetic scenarios for comfort, long-term effectiveness and aesthetics, and solving the performance limitations of traditional products in complex application scenarios.

[0014] 2. Compared with the existing technology, the present invention improves the functionality and stability of the base material of cosmetic medical tape through multi-stage process collaborative optimization. In the melt blending stage, a twin-screw extruder is used in combination with real-time torque monitoring to control the mixing uniformity of polyethylene plastic and ethylene-vinyl acetate copolymer, eliminate the local performance weakening caused by uneven dispersion in the traditional melt process, and ensure the consistency of the mechanical properties of the base material. In the step-by-step introduction strategy of functional additives, the dispersion of chitosan derivatives, porous materials and tyrosinase inhibitors is achieved through gradient heating and high-speed mechanical stirring, avoiding the bottleneck of agglomeration or uneven distribution, and enhancing the persistence of antibacterial activity and pigment inhibition effect. Microwave absorber nano-scale dispersion technology is combined with static laminar shear to form a uniform microwave response interface, providing a basis for subsequent directional thermal activation in the microwave field, so that the interface temperature of chitosan and porous materials accurately triggers the tyrosinase inhibitor reaction, thereby improving its thermal stability and action efficiency. In the calendering stage, the air knife temperature control cooling and roller speed linkage adjustment are used to optimize the crystallinity and surface smoothness of the film. An online hot-press micro-embossing process, combined with an array of raised molds, enhances breathability and simulates skin texture, enhancing the invisible application effect. Compared to conventional embossing techniques, this reduces the risk of structural damage. Circulating water cooling and pressure maintenance during the pressure-holding and cooling stage suppress microstructure rebound or deformation, ensuring the long-term stability of the functionalized surface topography. Closed-loop control of process parameters at each stage and multi-scale synergy of functional components achieve a unified balance of substrate mechanical properties, bioactivity, and aesthetic requirements, addressing issues such as adhesion failure, insufficient breathability, and short-lived cosmetic effects often associated with crude manufacturing processes in traditional products.

[0015] The technical solution of the present invention is further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0017] Figure 1 The present invention provides a preparation step diagram of a method for preparing a base material for cosmetic medical tape. DETAILED DESCRIPTION

[0018] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0019] Example 1, a cosmetic medical tape substrate, the cosmetic medical tape substrate comprises the following components in parts by weight: 90 parts of polyethylene plastic, 10 parts of ethylene-vinyl acetate copolymer, 5 parts of chitosan derivatives, 10 parts of porous materials, and 3 parts of tyrosinase inhibitors.

[0020] In this embodiment, the chitosan derivative is carboxymethyl chitosan.

[0021] In this embodiment, the porous material is activated carbon fiber.

[0022] In this embodiment, the tyrosinase inhibitor is arbutin.

[0023] This embodiment provides a method for preparing a cosmetic medical tape substrate, comprising the following steps: S1, melt blending, adding polyethylene plastic and ethylene-vinyl acetate copolymer into a twin-screw extruder to melt the materials; monitoring the mixing uniformity through a torque sensor during the melting process, and determining that the melt mixing is complete when the torque fluctuation range is stable within ±5%; the mixing time is 30 minutes, and the molten material is extruded through a die to obtain a uniform melt blend; S2, functional additive introduction: the homogeneous molten blend is transferred to a mixer, and the chitosan derivative, porous material, and tyrosinase inhibitor are added in sequence while maintaining the material temperature at 180°C. The mixer speed is adjusted to 500 RPM, and the additives are uniformly dispersed in the melt through mechanical stirring and heat conduction. The mixing time is 45 minutes to obtain a melt in which the functional additives are uniformly dispersed. S3, adding microwave absorbent: adding microwave absorbent to the melt in which the functional additives are evenly dispersed according to the microwave heating requirements; switching the mixing equipment to a static mixer, maintaining the material temperature at 170°C, and forming the microwave absorbent into a nano-scale dispersed phase through laminar shear; controlling the mixing time to 5 minutes, and confirming that the dispersed phase particle size is less than 500 nm by scanning electron microscopy; thus, obtaining a microwave-responsive melt; S4, microwave-assisted blending treatment, introduces the microwave-responsive melt into a microwave generator with a frequency of 5.8 GHz and a power density of 50 W / cm³. The material is heated in the microwave field, and the interface temperature between the chitosan derivative and the porous material rises to 220°C, triggering the thermal activation reaction of the tyrosinase inhibitor. The material residence time is 2 minutes, resulting in a microwave-activated melt. S5, preliminary forming, the microwave-activated melt is formed by a calender, the calender roll gap is adjusted to 1.0 mm, and the roller linear speed is 20 m / min; an air knife is used to assist cooling during the forming process to reduce the surface temperature of the material to 80°C, forming a continuous film with a thickness of 0.5 mm to obtain a plastic substrate film; S6, hot pressing micro-embossing, in which the plastic substrate film is subjected to online hot pressing treatment, the imprinting mold temperature is set to 150°C, the pressure range is 20 MPa, and the holding time is 10 seconds; the mold surface structure is an array of protrusions with a line width of 10 μm, a depth of 50 μm, and a spacing of 20 μm, to obtain a microstructured imprinted substrate; S7, pressure-maintaining cooling and shaping, transferring the microstructured imprinted substrate together with the mold to a circulating water cooling press, setting the cooling rate to 20°C / min and the pressure to 15 MPa until the substrate temperature drops to 40°C; the cooling water temperature is 25°C and the flow rate is 10 L / min, to obtain a shaped microstructured substrate; S8, demolding and post-processing, peeling the shaped microstructured substrate from the mold, controlling the peeling angle at 30° and the peeling speed at 2.0 m / min; after demolding, the substrate is cut into strip products with a width of 100 mm by a slitting machine, and the slitting knife temperature is maintained at 50°C; then the substrate is treated with an electrostatic eliminator to obtain a finished cosmetic medical tape substrate.

[0024] In this embodiment, in step S1, the heating temperature of the twin-screw extruder is 200° C., and the screw speed is 200 RPM.

[0025] In this embodiment, in step S3, the microwave absorber is formed by mixing silicon carbide and ferrite in a mass ratio of 1:1.

[0026] In Example 2, the other steps and parameters are the same as those in Example 1, except that a cosmetic medical tape substrate is provided, which comprises the following components by weight: 80 parts of polyethylene plastic, 25 parts of ethylene-vinyl acetate copolymer, 5 parts of chitosan derivative, 6 parts of porous material, and 2 parts of tyrosinase inhibitor.

[0027] In this embodiment, the chitosan derivative is chitosan oligosaccharide.

[0028] In this embodiment, the porous material is activated carbon fiber.

[0029] In this embodiment, the tyrosinase inhibitor is kojic acid dipalmitate.

[0030] Experimental methods: 1.180° peel strength test method This test evaluates the adhesion of cosmetic medical tape substrates to standard stainless steel surfaces, primarily based on Method A in ASTM D3330 / D3330M. The core of the test is to quantify the force required to peel the tape from a pre-applied standard test panel at a 180° angle and constant speed. Key equipment includes a tensile testing machine capable of precisely controlling the pulling speed (e.g., 300 mm / min) and recording the force, a standard SUS304 stainless steel test panel, a 2.0 kg pressure roller with a standard rubber hardness, precision sample cutting tools, and a cleaning solvent (e.g., isopropyl alcohol). Specimen preparation involves cutting the substrate into strips 25 mm wide and approximately 250 mm long. These strips are then conditioned for at least 24 hours alongside the cleaned test panel in a standard environment of 23±2°C and 50±5% RH. The stainless steel panel is first thoroughly cleaned with solvent and allowed to dry. The conditioned specimen strip is then carefully applied to the center of the test panel and rolled back and forth twice with a standard pressure roller at a speed of approximately 10 mm / s to ensure a secure, bubble-free bond. After the adhesive is applied, the specimen is placed horizontally under standard conditions for 20 minutes (dwell time). The test panel is then secured to the lower fixture of the tensile testing machine, with the free end of the specimen folded upward 180° and held in the upper fixture. The machine is started and the tape is peeled off at a constant speed of 300 mm / min. The force data is recorded during the peeling process (typically over a peel distance of 20 mm to 120 mm). The final result is calculated by calculating the average force of at least five valid specimens over the specified peel length. It is reported in Newtons per 25 mm (N / 25 mm), along with the standard deviation and detailed test conditions. This indicator directly reflects the tape's ability to resist accidental peeling during use.

[0031] 2. Water Vapor Transmission Rate (WVTR) Test Method The water vapor transmission rate (WVTR) test evaluates the ability of a tape substrate to transmit water vapor. It is an important indicator of breathability and comfort, and is typically performed in accordance with ASTM E96 / E96M. The test principle is based on measuring the mass of water vapor that passes through a sample per unit area per unit time under a specific temperature and humidity gradient. Common methods include the cup method (Method B) and the inverted cup method (Method BW), the latter of which is more commonly used to simulate water evaporation from skin. Required equipment primarily includes a permeable cup with a known opening area, an analytical balance with an accuracy of at least 0.1 mg, a constant temperature and humidity chamber with precise control of temperature (e.g., 38 ± 1°C) and humidity (e.g., 90 ± 2% RH), distilled water, and a reliable sealing material (e.g., wax or a specialized sealing ring). The specimen should be cut into a circular shape slightly larger than the opening of the permeable cup, ensuring it is flat and free of defects. During testing, distilled water (for the water method) or desiccant (for the desiccant method) is added to the cup, depending on the method selected, with a specified air gap. Cover the sample on the cup mouth and use sealing material to ensure airtightness around the edge so that water vapor can only pass through the effective test area of ​​the sample. After the initial weighing of the entire test cup assembly (W0), place it in an environmental chamber with set temperature and humidity. Take it out and weigh it quickly at predetermined time intervals (e.g. 1h, 2h, 4h until stable) (W i ), recording the time and mass change. Steady state is considered reached when the rate of mass change per unit time remains constant over several consecutive measurements. Plot the mass change against time and take the slope of the line during the steady state (G = ΔW / Δt, g / h). Calculate WVTR = (G × 24) / A, where A is the cup opening area (m²). Report the results in g / m² / 24h, specifying the test method, temperature, humidity conditions, and the mean and standard deviation.

[0032] 3. In vitro release test method of tyrosinase inhibitors This method is designed to evaluate the release characteristics of tyrosinase inhibitors loaded in tape substrates under simulated in vitro conditions, usually referring to pharmacopoeias (such as ChP0931, USP <724> , <1724> ) and is often performed using the Franz diffusion cell method. The Franz diffusion cell system effectively simulates the diffusion process of the drug from the carrier (tape substrate) through the barrier to the receiving medium. The core equipment includes a Franz diffusion cell with a known diffusion area, a thermostatic circulation system with precise temperature control (typically simulating skin temperature, 32 ± 1°C), a magnetic stirrer, and a high-performance liquid chromatography (HPLC) system for quantitative analysis of inhibitor concentrations. The receiving medium is typically a buffered solution that simulates body fluids (such as PBS, pH 7.4). A cosolvent may be added if necessary to maintain sink conditions, and degassed before use. The specimen should be cut to fit the donor chamber of the diffusion cell. Before the test begins, precisely add preheated receiving medium to the receiving cell and initiate stirring. The substrate sample is positioned between the donor and receiving cells, ensuring that the active surface faces the receiving medium and that contact is airtight. At predetermined time points (e.g., 0.5, 1, 2, 4, 8, 12, or 24 hours), a specific volume of receiving medium is precisely removed from the receiving cell sampling arm and immediately replaced with an equal amount of fresh, isothermal medium. After appropriate sample treatment (e.g., filtration), the inhibitor concentration is determined using a validated HPLC method. The cumulative release (Qn) at each time point is calculated by accounting for the dilution effect of sampling. The cumulative release rate or release rate at a specific time point (e.g., 8 hours) is reported, along with the corresponding test conditions.

[0033] 4. Tensile strength and elongation at break test methods This test, based on ASTM D882, measures the mechanical properties of tape substrate films under uniaxial tension, including the maximum stress at break (tensile strength) and the relative elongation at break (elongation at break). These parameters characterize the material's strength and toughness. This test requires a universal testing machine (UTM) equipped with an appropriate load cell and film-appropriate grips to ensure secure grip without slippage or damage to the specimen. The machine must be capable of stretching the specimen at a constant rate (e.g., 50 mm / min or 500 mm / min) and simultaneously recording load and displacement data. Specimens must be cut into standard shapes, such as rectangular strips (typically 10-25 mm wide) or dumbbells, using a dedicated cutter. Ensure smooth, defect-free edges. The width and thickness of the specimen must be accurately measured (using a thickness gauge to average multiple measurements within the gauge length) to calculate the cross-sectional area. Specimens must be conditioned for at least 40 hours in a standard environment (23 ± 2°C, 50 ± 5% RH). During testing, clamp the specimen between the upper and lower clamps of the UTM. Set the initial gauge length (L0, such as 50mm or 100mm) and ensure that the specimen is straight and its axis is aligned with the tensile direction. Start the testing machine and stretch the specimen at the set rate until it breaks. Record the maximum load (F_max) and the corresponding gauge elongation (ΔL) at break. Calculate the tensile strength (σ_b = F_max / initial cross-sectional area A0), typically in MPa; calculate the elongation at break (ε_b = (ΔL / L0) × 100%). Ensure that fracture occurs within the gauge length, and test at least five valid specimens. Report the results as the mean and standard deviation, and indicate key test conditions such as the test direction (MD or TD), tensile rate, and gauge length.

[0034] 5. Surface microstructure fidelity assessment method Surface microstructure fidelity assessment is a critical quality control step designed to confirm the quality of micron-scale structures (e.g., arrayed protrusions) fabricated on the tape substrate surface via the hot-press micro-embossing process (S6). This assessment focuses on structure clarity, integrity, uniformity, and conformity to the designed mold features. This assessment typically combines macroscopic and microscopic observation techniques. Initially, the substrate surface can be inspected visually and using an optical microscope (50x-500x magnification) to observe for large-scale pattern defects, deformation, missing patterns, or non-uniformity, assessing the overall morphology and distribution of the microstructures. Subsequently, scanning electron microscopy (SEM) is employed to obtain more detailed morphological information. A representative sample area, which may require conductive treatment such as gold sputtering, is then examined under an SEM at high magnification (e.g., 1000x or higher) to examine the details of individual microstructure units, including shape contours, edge sharpness, sidewall morphology, and the regularity of the array arrangement. The observed dimensions (e.g., line width, depth, and spacing) are compared with the nominal values ​​specified in the mold design. Based on the observations, the fidelity of the microstructure is qualitatively graded, for example, as excellent, good, fair, or poor, where "excellent" represents clear and complete structure, high dimensional conformity, good uniformity, and the absence of obvious defects. Evaluation results are typically described as qualitative grades, supported by representative optical or SEM images. For quantitative data, atomic force microscopy (AFM) can be used to precisely measure the three-dimensional dimensional parameters of the microstructure.

[0035] Experiments were conducted on the finished materials prepared in Examples 1-2, where Comparative Example 1 was the tape substrate disclosed in Chinese Patent Publication No. CN108659722A. The experimental results are as follows: Table 1 Performance test data Performance indicators unit Comparative Example 1 Example 1 Example 2 180° peel strength (to stainless steel) N / 25mm 4.5 7.8 7.5 Water vapor transmission rate (WVTR) g / m² / 24h 650 1850 2100 8-hour cumulative release rate of tyrosinase inhibitors μg / cm² 0 (not added) 15.2 18.5 Tensile strength (MD) MPa 18 25 23 Elongation at break (MD) % 350 480 450 Surface microstructure fidelity (Qualitative Assessment) No microstructure good excellent As shown in Table 1, Examples 1 and 2 exhibit higher peel strength than Comparative Example 1, demonstrating that the substrates of the present invention possess superior adhesion properties. This is attributed to the uniformity of the material blend and the potential mechanical engagement effect of the microstructured surface. Furthermore, the WVTR of Examples 1 and 2 is higher than that of Comparative Example 1. This is primarily due to the introduction of the porous material and the microstructured surface increasing the specific surface area, thereby improving the substrate's breathability and helping to maintain dryness and comfort on the skin. Furthermore, Examples 1 and 2 outperform Comparative Example 1 in both tensile strength and elongation at break, demonstrating that the preparation method of the present invention improves the mechanical properties of the material, making it tougher and less prone to breakage.

Claims

1. A cosmetic medical tape substrate, characterized in that: The cosmetic medical tape substrate comprises the following components in parts by weight: 60-90 parts of polyethylene plastic, 10-40 parts of ethylene-vinyl acetate copolymer, 0.5-5 parts of chitosan derivative, 1-10 parts of porous material, and 0.1-3 parts of tyrosinase inhibitor.

2. The cosmetic medical tape substrate according to claim 1, characterized in that: The chitosan derivative is carboxymethyl chitosan or chitosan oligosaccharide.

3. The cosmetic medical tape substrate according to claim 1, characterized in that: The porous material is zeolite molecular sieve or activated carbon fiber.

4. The cosmetic medical tape substrate according to claim 1, characterized in that: The tyrosinase inhibitor is arbutin, kojic acid dipalmitate or glabridin.

5. A method for preparing a cosmetic medical tape substrate according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1, melt blending, adding polyethylene plastic and ethylene-vinyl acetate copolymer into a twin-screw extruder to melt the materials; the molten materials are extruded through a die to obtain a uniform melt blend; S2, introducing functional additives: transferring the homogeneous melt blend to a mixer, and sequentially adding the chitosan derivative, porous material, and tyrosinase inhibitor while maintaining the material temperature at 120-180° C.; adjusting the mixer speed to 500-1000 RPM and mixing for 15-45 minutes to obtain a melt in which the functional additives are uniformly dispersed; S3, adding a microwave absorbent, adding a microwave absorbent to the melt in which the functional additives are uniformly dispersed according to the microwave heating requirements; switching the mixing equipment to a static mixer, and controlling the mixing time to 5-15 minutes to obtain a microwave-responsive melt; S4, microwave-assisted blending treatment, introducing the microwave-responsive melt into a microwave generator, setting the microwave generator frequency to 2.45-5.8 GHz and the power density to 10-50 W / cm³; the material is heated in the microwave field, and the interface temperature between the chitosan derivative and the porous material rises to 180-220° C., triggering a thermal activation reaction of the tyrosinase inhibitor, thereby obtaining a microwave-activated melt; S5, preliminary forming, the microwave activated melt is formed by a calender, and an air knife is used to assist cooling during the forming process to reduce the surface temperature of the material to 80-120° C., thereby obtaining a plastic substrate film.

6. The method for preparing a cosmetic medical tape substrate according to claim 5, characterized in that: The method further comprises: S6, hot pressing micro-embossing, performing online hot pressing treatment on the plastic substrate film, setting the temperature of the embossing mold to 90-150° C.; the mold surface structure is an array of protrusions with a line width of 10-100 μm, a depth of 5-50 μm, and a spacing of 20-200 μm, to obtain a microstructured embossed substrate; S7, pressure-maintaining cooling and shaping, transferring the microstructure imprinted substrate together with the mold to a circulating water-cooled press, setting the cooling rate to 5-20°C / min, and maintaining the pressure at 5-15 MPa until the substrate temperature drops to 40-80°C; obtaining a shaped microstructured substrate; S8, demoulding and post-processing, peeling the shaped microstructured substrate from the mold, and cutting the substrate into strip products with a width of 10-100 mm by a slitting machine after demoulding. The slitting knife temperature is maintained at 50-80° C. to obtain a finished cosmetic medical tape substrate.

7. The method for preparing a cosmetic medical tape substrate according to claim 5, wherein: In step S1, the heating temperature of the twin-screw extruder is 150-200° C., and the screw speed is 200-500 RPM.

8. The method for preparing a cosmetic medical tape substrate according to claim 5, wherein: In step S3, the microwave absorber is formed by mixing silicon carbide and ferrite in a mass ratio of 1:1-3:1.

Images