Bioengineering apoptotic body based on apoptotic body membrane protein and liposome as well as preparation method and application of bioengineering apoptotic body

By preparing bioengineered apoptotic bodies (ALPs) and using apoptotic body membrane proteins to chimera with liposomes to load gastrodin and Cy5, the problems of neuroinflammation and brain function recovery in TBI were solved, and the effects of reducing neuroinflammation and neuronal repair were achieved.

CN120733064AActive Publication Date: 2025-10-03GUANGDONG YUNZHAO MEDICAL TECH CO LTD
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Patent Information

Application Number
CN202510972164.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-15
Publication Date
2025-10-03
Estimated Expiration
2045-07-15

AI Technical Summary

Technical Problem

Existing treatments for traumatic brain injury (TBI) mainly focus on relieving symptoms and lack strategies to effectively control neuroinflammation and promote brain function recovery, especially by regulating microglial phenotype to alleviate neuroinflammation and promote neural repair.

Method used

A bioengineered apoptotic body (ALP) based on apoptotic body membrane protein and liposomes was developed. By chimerizing the apoptotic body membrane protein with liposomes loaded with gastrodin and Cy5, it was prepared to be able to responsively release gastrodin and ApoM in a highly reactive oxygen microenvironment, regulate microglial polarization, reduce neuroinflammation and promote neuronal proliferation.

Benefits of technology

ALP can effectively activate M2 microglial polarization, reduce neuroinflammation in TBI model mice, improve motor function, promote neuronal proliferation and repair, reduce ROS levels in brain tissue, reduce neuronal apoptosis and necrosis, and relieve brain edema.

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Abstract

The invention discloses a bioengineering apoptotic body based on apoptotic body membrane protein and lipidosome as well as a preparation method and application of the bioengineering apoptotic body. The bioengineered apoptotic body is formed by chimeric combination of apoptotic body membrane protein and liposome loaded with gastrodin and Cy5. The bioengineered apoptotic body for simulating the natural apoptosis process of the mesenchymal stem cells is constructed, microglial cells can be promoted to be polarized to an M2 type, anti-inflammatory factors and neurotrophic factors are released, neuronal proliferation is promoted, the cell oxidation resistance is improved, the neuromotor function is improved, and encephaledema is relieved, so that traumatic brain injury is effectively treated.
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