Magnetic stimulation coil nerve function detection and regulation method and system

Abstract

The present application relates to a kind of magnetic stimulation coil nerve function detection and regulation method and system, wherein, method includes by control circuit driving capacitor discharges to double-path stimulation coil, generate millisecond-level pulse magnetic field;Utilize the pulse magnetic field and act on nerve tissue, produce including nerve regulation effect of suprathreshold stimulation and subthreshold stimulation;Real-time acquisition is induced by pulse magnetic field stimulation and is produced evoked potential signal;Analysis the evoked potential signal, calculate nerve conduction time and excitation inhibition ratio;According to nerve conduction time and excitation inhibition ratio adjustment double-path stimulation timing and / or capacitor discharge parameter, carry out the detection and coordination regulation of nerve function, to realize the purpose of real-time detection, quantitative evaluation and adaptive accurate regulation to nerve function.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical equipment, in particular to a magnetic stimulation coil nerve function detection and regulation method and system. BACKGROUND

[0002] Transcranial magnetic stimulation technology as a non-invasive nerve regulation means, in recent years, has shown important value in brain science research and treatment of nervous system diseases. The technology generates induced current in neural tissue through pulsed magnetic field, thereby regulating neuronal activity, and has been widely used in the treatment of depression, stroke rehabilitation and other diseases. However, the traditional magnetic stimulation technology mostly adopts single path stimulation mode, lacks real-time detection and feedback regulation ability of nerve function, and is difficult to realize individualized, adaptive and precise intervention. The existing system still has obvious limitations in the integration of stimulation parameter optimization, multi-target point cooperation and function evaluation, which restricts the further improvement of its clinical effect. SUMMARY

[0003] The main purpose of the present application is to provide a magnetic stimulation coil nerve function detection and regulation method and system, which realizes real-time detection, quantitative evaluation and adaptive precise regulation of nerve function through nerve electrophysiological detection and magnetic stimulation regulation.

[0004] To achieve the above purpose, the present application provides a magnetic stimulation coil nerve function detection and regulation method, comprising the following steps:

[0005] Discharge the capacitor to the double-path stimulation coil through the control circuit to generate a millisecond-level pulsed magnetic field;

[0006] Use the pulsed magnetic field to act on neural tissue to produce nerve regulation effects including suprathreshold stimulation and subthreshold stimulation;

[0007] Real-time acquisition of evoked potential signals induced by pulsed magnetic field stimulation;

[0008] Analysis of the evoked potential signal, calculation of nerve conduction time and excitation inhibition ratio;

[0009] Adjust the double-path stimulation timing and / or capacitor discharge parameters according to the nerve conduction time and excitation inhibition ratio to detect and cooperatively regulate the nerve function.

[0010] Further, before the step of discharging the capacitor to the double-path stimulation coil through the control circuit, it further comprises:

[0011] Receiving a stimulation parameter configuration instruction for the double-path stimulation coil;

[0012] Setting the stimulation intensity, stimulation frequency and stimulation mode according to the instruction;

[0013] Initialize the capacitor discharge parameter.

[0014] Further, the step of generating a millisecond-level pulsed magnetic field by controlling the circuit to drive the capacitor to discharge to the double-channel stimulation coil, comprises:

[0015] The trigger circuit turns on the charge-discharge circuit;

[0016] The capacitor discharges to the double-channel stimulation coil to generate a millisecond-level pulsed magnetic field in the double-channel stimulation coil.

[0017] Further, the step of using the pulsed magnetic field to act on the neural tissue to produce a neural regulation effect including suprathreshold stimulation and subthreshold stimulation, comprises:

[0018] Apply a pulsed stimulation of a first magnetic field strength, which is higher than a preset motor threshold, to induce an action potential in the target neural tissue;

[0019] Apply a pulsed stimulation of a second magnetic field strength, which is lower than the preset motor threshold and sufficient to modulate the membrane potential of neurons, to modulate the excitability of the target neural tissue;

[0020] The determination of the preset motor threshold comprises:

[0021] Apply an initial stimulation intensity to the target neural tissue;

[0022] Adjust the stimulation intensity step by step and monitor the electromyographic response in real time;

[0023] Determine the stimulation intensity corresponding to the compound muscle action potential capable of inducing the minimum preset wave amplitude as the preset motor threshold of the target individual.

[0024] Further, the step of collecting the evoked potential signal induced by the pulsed magnetic field stimulation in real time comprises:

[0025] Collect the electromyographic signal or electroencephalographic signal through electrodes;

[0026] Amplify and filter the electromyographic signal or electroencephalographic signal;

[0027] Obtain the evoked potential signal.

[0028] Further, the step of analyzing the evoked potential signal to calculate the nerve conduction time and the excitation-inhibition ratio comprises:

[0029] Measure the latency and amplitude of the evoked potential signal;

[0030] Calculate the nerve conduction time based on the latency;

[0031] calculate an excitation-inhibition ratio based on the amplitude changes of the multiple evoked potential signals obtained under different stimulation parameter conditions;

[0032] The different stimulation parameter conditions include different stimulation intervals or different stimulation intensities.

[0033] Further, the step of detecting and co-regulating the nerve function according to the nerve conduction time and the excitation-inhibition ratio includes:

[0034] judging the nerve function state according to the nerve conduction time and the excitation-inhibition ratio;

[0035] generating new dual-channel stimulation parameter instructions based on the nerve function state;

[0036] independently or cooperatively adjusting at least one of the stimulation intensity, frequency and pulse interval timing of the dual-channel stimulation coils according to the new dual-channel stimulation parameter instructions.

[0037] Further, the step of judging the nerve function state according to the nerve conduction time and the excitation-inhibition ratio includes:

[0038] comparing the nerve conduction time with a preset standard reference value to evaluate the integrity of the nerve conduction pathway;

[0039] comparing the excitation-inhibition ratio with a preset standard reference value to evaluate the balance of the cortical inhibition or facilitation function.

[0040] Further, adjusting the dual-channel stimulation timing includes at least one of the following modes:

[0041] synchronous mode, controlling the two stimulation coils to output pulse magnetic fields at the same time;

[0042] sequence mode, controlling the two stimulation coils to output pulse magnetic fields at preset millisecond-level time intervals, wherein the first output pulse magnetic field is a subthreshold stimulation for modulating nerve excitability, and the second output pulse magnetic field is a suprathreshold stimulation for triggering an action potential;

[0043] different frequency mode, controlling the two stimulation coils to independently output pulse magnetic fields at different stimulation frequencies.

[0044] The present application also provides a magnetic stimulation coil nerve function detection and regulation system, comprising:

[0045] a magnetic field generation unit for discharging a capacitor to a dual-channel stimulation coil through a control circuit to generate a millisecond-level pulse magnetic field;

[0046] a coil stimulation unit for acting on nerve tissue with the pulse magnetic field to produce nerve regulation effects including suprathreshold stimulation and subthreshold stimulation.

[0047] a signal acquisition unit, configured to acquire an evoked potential signal generated by the pulsed magnetic field stimulation in real time;

[0048] a calculation unit, configured to analyze the evoked potential signal, and calculate a nerve conduction time and an excitation-inhibition ratio;

[0049] a parameter adjustment unit, configured to adjust a double-channel stimulation timing and / or a capacitance discharge parameter according to the nerve conduction time and the excitation-inhibition ratio, and perform detection and synergistic regulation of neural function.

[0050] The magnetic stimulation coil neural function detection and regulation method and system provided by the application have the following beneficial effects: the application integrates neural function detection and regulation functions, and realizes closed-loop adaptive precise magnetic stimulation intervention. Firstly, through the synergistic working timing control of the double-channel stimulation coil, the application realizes millisecond-level precision synchronous or sequence stimulation of multiple target points, enhances the regulation ability of neural network interaction, and automatically calculates neural conduction characteristic parameters based on the real-time acquired evoked potential signal, establishes an objective and quantitative neural function evaluation system, and dynamically adjusts the stimulation parameters according to the detection results, forms a complete closed loop of "detection-evaluation-regulation", and effectively improves the individualized treatment precision and neural rehabilitation effect. BRIEF DESCRIPTION OF DRAWINGS

[0051] Figure 1 is a flowchart of the magnetic stimulation coil neural function detection and regulation method in an embodiment of the application;

[0052] Figure 2 is a structural block diagram of the magnetic stimulation coil neural function detection and regulation system in an embodiment of the application.

[0053] The implementation of the object, functional characteristics and advantages of the application will be further described with reference to the embodiments and the accompanying drawings. DETAILED DESCRIPTION

[0054] In order to make the object, technical scheme and advantages of the application more clear, the application will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the application and not to limit the application.

[0055] Referring to Figure 1 is a flowchart of the magnetic stimulation coil neural function detection and regulation method provided by the application, including the following steps:

[0056] S1, discharging the capacitance to the double-channel stimulation coil through the control circuit to generate a millisecond-level pulsed magnetic field;

[0057] S2, using the pulsed magnetic field to act on the neural tissue to produce a neuromodulation effect including suprathreshold stimulation and subthreshold stimulation;

[0058] S3, collecting an evoked potential signal induced by the pulsed magnetic field stimulation in real time;

[0059] S4, analyzing the evoked potential signal to calculate the nerve conduction time and the excitation inhibition ratio;

[0060] S5, adjusting the double-channel stimulation timing and / or the capacitor discharge parameters according to the nerve conduction time and the excitation inhibition ratio to detect and synergistically regulate the neural function.

[0061] In one embodiment, before the step of driving the capacitor to discharge to the double-channel stimulation coil by the control circuit, further comprising:

[0062] Receiving a stimulation parameter configuration instruction for the double-channel stimulation coil;

[0063] Setting the stimulation intensity, stimulation frequency and stimulation mode according to the instruction;

[0064] Initializing the capacitor discharge parameters.

[0065] In a specific implementation, before performing the capacitor discharge and magnetic field generation, the individualized configuration and initialization of the stimulation parameters need to be completed first. Through the human-computer interaction interface, the user's stimulation parameter configuration instruction for the double-channel stimulation coil is received, which includes the stimulation intensity B, the stimulation frequency f and the stimulation mode M (such as single pulse stimulation, repetitive stimulation, sequence stimulation, TBS stimulation, PAS, ERPs, etc.). According to the instruction, a preset algorithm model is called, for example, the required capacitor charging voltage V is calculated through the formula V=k*B, where k is a proportional coefficient related to the characteristics of the coil, so as to convert the magnetic field intensity parameter B into specific electrical parameters. At the same time, the corresponding trigger pulse sequence timing control word is generated according to the stimulation frequency f and the stimulation mode M, and the control parameters of the capacitor charging and discharging circuit are initialized, including the charging voltage threshold V max , the maximum allowed discharge current I max and the pulse width t pulse (usually 0.1-1.0 ms), so as to ensure the accuracy and safety of the subsequent pulsed magnetic field generation.

[0066] In one embodiment, for step S1,

[0067] The step of generating a millisecond-level pulsed magnetic field by driving the capacitor to discharge to the double-channel stimulation coil through the control circuit includes:

[0068] Triggering the circuit to turn on the charging and discharging circuit;

[0069] The electric energy is released to the double-channel stimulating coil through the capacitor, and a millisecond pulse magnetic field is generated in the double-channel stimulating coil.

[0070] In a specific implementation, when receiving the trigger signal, the high-voltage charging and discharging circuit is precisely turned on through a control circuit (such as a thyristor trigger circuit), so that the capacitor pre-charged to high voltage instantaneously releases the stored electric energy to the double-channel stimulating coil. This discharging process follows the Faraday's law of electromagnetic induction, generates a rapidly changing current in the coil, and further generates a high-intensity, short-time pulse magnetic field (the magnetic field strength can reach 8T at most). The duration of the pulse magnetic field is in the millisecond level, which can effectively penetrate the skull and act on the central nervous system. In the embodiment, the double-channel stimulating coil can work independently, and by controlling the time sequence of discharging of the two capacitors, the synchronous, alternating or sequential stimulation mode is realized, which provides a key physical field basis for subsequent precise detection and coordinated regulation of neural function.

[0071] In one embodiment, for step S2,

[0072] The step of using the pulse magnetic field to act on the neural tissue to produce neural regulation effects including suprathreshold stimulation and subthreshold stimulation, comprises:

[0073] applying a pulse stimulation of a first magnetic field strength, the first magnetic field strength being higher than a preset motor threshold, for inducing an action potential in the target neural tissue;

[0074] applying a pulse stimulation of a second magnetic field strength, the second magnetic field strength being lower than the preset motor threshold and being sufficient to modulate the membrane potential of neurons, for modulating the excitability of the target neural tissue;

[0075] The determination of the preset motor threshold comprises:

[0076] applying an initial stimulation intensity to the target neural tissue;

[0077] adjusting the stimulation intensity step by step and monitoring the electromyographic response in real time;

[0078] The stimulation intensity corresponding to the compound muscle action potential capable of inducing the minimum preset wave amplitude is determined as the preset motor threshold of the target individual.

[0079] In a specific implementation, a first magnetic field intensity pulse stimulation higher than the preset motor threshold (MT) of the target individual is applied, which is sufficient to depolarize the target nerve cell membrane potential and trigger an action potential, thereby producing an immediate nerve excitation effect; then a second magnetic field intensity pulse stimulation lower than the preset motor threshold (MT) but precisely calibrated is applied, which is not sufficient to trigger an action potential, but can effectively change the excitability state of the neural network by modulating the membrane potential level of the neuron (such as slight depolarization or hyperpolarization), thereby realizing the long-term regulation effect of inducing cortical inhibition and facilitation. The determination of the preset motor threshold completely follows the clinical electrophysiological standard process: starting from the initial stimulation intensity, the intensity is gradually adjusted by automatic calculation function and the electromyographic response of the target muscle is monitored in real time, and finally the precise stimulation intensity corresponding to the composite muscle action potential (CMAP) capable of stably inducing the minimum preset amplitude (usually 50 μV) is determined as the individualized motor threshold of the subject. The standardized process of the present embodiment ensures the accuracy and safety of neural regulation, and provides an objective physiological benchmark for the setting of all subsequent stimulation parameters.

[0080] In one embodiment, for step S3,

[0081] The step of collecting the evoked potential signal induced by the pulsed magnetic field stimulation in real time comprises:

[0082] Collecting the electromyographic signal or electroencephalographic signal through electrodes;

[0083] Amplifying and filtering the electromyographic signal or electroencephalographic signal;

[0084] Obtaining the evoked potential signal.

[0085] In a specific implementation, the electromyographic signal generated by the target muscle or the electroencephalographic signal recorded by the scalp is collected through high-precision surface electrodes or needle electrodes, which are specific neuroelectrophysiological responses induced by the preceding pulsed magnetic field stimulation. The raw bioelectric signal collected first enters a high-performance differential amplifier for preliminary amplification, which has an input impedance greater than 5 MΩ and a common-mode rejection ratio exceeding 100 dB, which can effectively extract microvolt-level effective signals and suppress environmental interference. Subsequently, the signal is shaped in the frequency domain by an analog bandpass filter with a passband of 20 Hz to 500 Hz, and the power frequency interference is eliminated by a 50 Hz notch filter, and finally the evoked potential signal with good signal-to-noise ratio and clear characteristics is obtained. The system noise of the entire signal chain is controlled within 1 μV, ensuring the accuracy of subsequent analysis to meet the requirements of clinical diagnosis, and providing a reliable data basis for the calculation of nerve conduction time and excitability indicators.

[0086] In one embodiment, for step S4,

[0087] The step of analyzing the evoked potential signal, calculating the nerve conduction time and the excitation-inhibition ratio, comprises:

[0088] Measuring the latency and amplitude of the evoked potential signal;

[0089] Calculating the nerve conduction time based on the latency;

[0090] Calculating the excitation-inhibition ratio based on the amplitude changes of multiple evoked potential signals obtained under different stimulation parameter conditions;

[0091] Wherein, the different stimulation parameter conditions include different stimulation intervals or different stimulation intensities.

[0092] In a specific implementation, a digital signal processing algorithm is used to identify the features of the pre-processed evoked potential signal, measure the latency (i.e. the time interval from the application of the stimulus to the appearance of a specific waveform peak) and peak amplitude (the maximum amplitude value of the signal) of each response waveform. Based on the latency data, the conduction efficiency of the neural pathway is evaluated by calculating parameters such as central motor conduction time (CMCT), which can be obtained by subtracting the peripheral nerve segment conduction time from the total conduction time from the cortex to the target muscle. To further evaluate the excitatory-inhibitory balance characteristics of the neural circuit, the excitation-inhibition ratio is calculated by comparing the amplitude changes of multiple evoked potential signals obtained under different stimulation parameter conditions: in the short-interval intracortical inhibition mode, the degree of inhibition is quantified by calculating the ratio of the MEP amplitude produced by the combination of the conditioning stimulus and the test stimulus to the MEP amplitude produced by the test stimulus alone; in the intracortical facilitation mode, the same ratio calculation method is used to evaluate the facilitation effect. These different stimulation conditions include varying stimulation intervals (such as 2 ms interval for short-interval inhibition and 15 ms interval for facilitation) or adjusting stimulation intensity (such as subthreshold intensity for conditioning stimulus and suprathreshold intensity for test stimulus), and through this multi-parameter combination test method, the excitatory and inhibitory functional status of the neural network is comprehensively evaluated.

[0093] In one embodiment, for step S5,

[0094] The step of adjusting the dual-channel stimulation timing and / or capacitance discharge parameters according to the nerve conduction time and the excitation-inhibition ratio, and detecting and co-regulating the neural function, comprises:

[0095] Judging the neural function status according to the nerve conduction time and the excitation-inhibition ratio;

[0096] Generating new dual-channel stimulation parameter instructions based on the neural function status;

[0097] Adjusting at least one of the stimulation intensity, frequency and pulse interval timing of the dual-channel stimulation coils independently or cooperatively according to the new dual-channel stimulation parameter instructions.

[0098] In a specific implementation, the quantitative indicators of nerve conduction time and excitation-inhibition ratio calculated according to step S4 are used to objectively judge the current nerve function state through an embedded evaluation algorithm: the nerve conduction efficiency of the nerve pathway can be evaluated by comparing the nerve conduction time with the preset standard reference value, and the balance state of the cortical inhibition and facilitation function can be judged by comparing the excitation-inhibition ratio with the normal range. Based on the evaluation results, new dual-channel stimulation parameter instructions are generated, which contain targeted parameter adjustment strategies, such as higher frequency facilitation stimulation for pathways with conduction delay, and low frequency inhibitory stimulation for neural networks with insufficient inhibition function. Finally, according to the generated parameter instructions, the working parameters of the dual-channel stimulation coils are adjusted independently or cooperatively, including precisely adjusting the stimulation intensity of each channel (by changing the capacitance charging voltage), the stimulation frequency (by adjusting the pulse emission interval), and the timing relationship between the two pulses (synchronous, sequential, or delayed mode), so as to achieve precise intervention and functional remodeling of different neural network loops. This real-time physiological feedback-based parameter dynamic optimization mechanism ensures individualization, precision, and adaptability of nerve function regulation.

[0099] In one embodiment, the step of judging the nerve function state according to the nerve conduction time and the excitation-inhibition ratio comprises:

[0100] comparing the nerve conduction time with the preset standard reference value to evaluate the integrity of the nerve conduction pathway;

[0101] comparing the excitation-inhibition ratio with the preset standard reference value to evaluate the balance of the cortical inhibition or facilitation function.

[0102] In a specific implementation, the real-time detected nerve conduction time is compared with the standardized reference value range in the built-in database for different ages, genders, and physiological states. When the conduction time significantly exceeds the upper limit of the reference range, it indicates that there may be demyelination or axon damage in the nerve pathway from the cortex to the target muscle, suggesting that the integrity of the conduction pathway is impaired. At the same time, the calculated excitation-inhibition ratio (such as the short-interval intracortical inhibition ratio or the intracortical facilitation ratio) is compared with the statistical reference range of normal population. If the inhibition ratio is abnormally high, it reflects insufficient cortical inhibition function, and if the facilitation ratio is abnormally low, it indicates a disorder in the regulation of neural network excitability. Through comprehensive analysis of these quantitative indicators, the balance of cortical inhibition and facilitation function is accurately evaluated, providing an objective basis for subsequent individualized nerve regulation.

[0103] In one embodiment, adjusting the dual-channel stimulation timing comprises at least one of the following modes:

[0104] synchronous mode, controlling the two stimulation coils to output pulse magnetic fields simultaneously;

[0105] The sequence mode controls the two stimulation coils to output pulse magnetic fields at preset millisecond-level time intervals, wherein the first output pulse magnetic field is subthreshold stimulation for modulating neural excitability, and the second output pulse magnetic field is suprathreshold stimulation for triggering an action potential;

[0106] The different frequency mode controls the two stimulation coils to independently output pulse magnetic fields at different stimulation frequencies.

[0107] Specifically, precise coordinated control of the two stimulation coils is achieved through the three timing modes. In the synchronous mode, the two stimulation coils are controlled to simultaneously output pulse magnetic fields. This mode can implement symmetric intervention on bilateral cerebral hemispheres or different neural networks in the same brain region, and is suitable for treatment scenarios requiring bilateral collaborative activation. The sequence mode adopts millisecond-level timing control, so that the two coils output pulses at preset time intervals (usually 1-30 milliseconds). The first pilot pulse adopts subthreshold stimulation strength to pre-modulate the excitability level of the target neurons, and the subsequent pulse adopts suprathreshold stimulation strength to trigger an action potential on the basis of the modulated nerves. This timing combination can significantly enhance neural plasticity effects. The different frequency mode allows the two coils to work independently at different frequencies, for example, one coil uses low-frequency stimulation (1 Hz) to suppress overactive neural networks, while the other coil uses high-frequency stimulation (10 Hz) to promote under-functioning neural circuits, thereby realizing differentiated regulation strategies for complex neurological disorders. Programmable combinations of the three modes provide flexible and diverse neural regulation schemes for clinical treatment, enabling precise adaptation to the specific physiological states and treatment needs of different patients.

[0108] Reference Figure 2 The structure block diagram of the magnetic stimulation coil neural function detection and regulation system in an embodiment of the present application comprises:

[0109] The magnetic field generation unit is configured to generate millisecond-level pulse magnetic fields by controlling the discharge of the capacitor to the two stimulation coils through the control circuit;

[0110] The coil stimulation unit is configured to use the pulse magnetic fields to act on neural tissues to produce neural regulation effects including suprathreshold stimulation and subthreshold stimulation;

[0111] The signal acquisition unit is configured to acquire evoked potential signals induced by the pulse magnetic field stimulation in real time;

[0112] The calculation unit is configured to analyze the evoked potential signals and calculate neural conduction time and excitation inhibition ratio;

[0113] The parameter adjustment unit is configured to adjust the two stimulation timing and / or capacitor discharge parameters according to the neural conduction time and excitation inhibition ratio to detect and cooperatively regulate neural function.

[0114] The specific implementation of each unit in the above device example can refer to the description in the above method embodiments, which will not be repeated here.

[0115] In summary, the application generates a millisecond-level pulse magnetic field by controlling the circuit to drive the capacitor to discharge to the double-path stimulation coil; utilizes the pulse magnetic field to act on the nerve tissue to produce a nerve regulation effect including suprathreshold stimulation and subthreshold stimulation; collects an evoked potential signal generated by the pulse magnetic field stimulation in real time; analyzes the evoked potential signal to calculate the nerve conduction time and the excitation inhibition ratio; adjusts the double-path stimulation timing and / or the capacitor discharge parameters according to the nerve conduction time and the excitation inhibition ratio to detect and synergistically regulate the nerve function, so as to achieve the purpose of real-time detection, quantitative evaluation and self-adaptive precise regulation of the nerve function.

[0116] Those skilled in the art can understand that all or part of the processes in the above-mentioned embodiments can be completed by a computer program instructing related hardware. The computer program can be stored in a non-volatile computer readable storage medium. When the computer program is executed, the processes of the above-mentioned embodiments can be included. Any reference to memory, storage, database or other medium provided by the application and used in the embodiments can include non-volatile and / or volatile memory. Non-volatile memory can include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM) or flash memory. Volatile memory can include random access memory (RAM) or external cache memory. As an illustration but not limitation, RAM is available in various forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (SSRSDRAM), enhanced SDRAM (ESDRAM), synchronous link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM) and memory bus dynamic RAM, etc.

[0117] It should be noted that in this document, the terms "comprise", "comprise", or any other variant thereof are intended to cover non-exclusive inclusion, so that processes, devices, articles or methods comprising a series of elements not only include those elements, but also include other elements not explicitly listed, or include elements inherent to such processes, devices, articles or methods. Without more limitations, the element defined by the statement "comprises a" does not exclude the presence of another identical element in the process, device, article or method comprising the element.

[0118] The above merely describes preferred embodiments of the present application, and is not intended to limit the patent scope of the present application, and any equivalent structure or equivalent process conversion, or direct or indirect application in other related technical fields, which are made by using the content of the present application specification and drawings, are also included in the patent protection scope of the present application.

Claims

1. A magnetic stimulation coil nerve function detection and regulation system, characterized in that, The method comprises the following steps: a magnetic field generating unit for generating a millisecond-level pulse magnetic field by discharging a capacitor to a double-channel stimulation coil through a control circuit; a coil stimulation unit for acting on neural tissue with the pulse magnetic field to produce a neural regulation effect including suprathreshold stimulation and subthreshold stimulation, comprising: applying pulse stimulation of a first magnetic field intensity higher than a preset motor threshold to induce an action potential in the target neural tissue; applying pulse stimulation of a second magnetic field intensity lower than the preset motor threshold and sufficient to modulate the membrane potential of neurons to modulate the excitability of the target neural tissue; wherein the determination of the preset motor threshold comprises: applying an initial stimulation intensity to the target neural tissue; adjusting the stimulation intensity step by step and monitoring the electromyographic response in real time; determining the stimulation intensity corresponding to the compound muscle action potential capable of inducing the minimum preset wave amplitude as the preset motor threshold of the target individual; a signal acquisition unit for acquiring an evoked potential signal induced by the pulse magnetic field stimulation in real time; a calculation unit for analyzing the evoked potential signal and calculating the nerve conduction time and the excitation inhibition ratio; a parameter adjustment unit for adjusting the double-channel stimulation timing and / or capacitor discharge parameters according to the nerve conduction time and the excitation inhibition ratio to detect and synergistically regulate the neural function, comprising: judging the neural function state according to the nerve conduction time and the excitation inhibition ratio; generating new double-channel stimulation parameter instructions based on the neural function state; independently or synergistically adjusting at least one of the stimulation intensity, frequency and pulse interval timing of the double-channel stimulation coil according to the new double-channel stimulation parameter instructions; wherein the adjustment of the double-channel stimulation timing comprises at least one of the following modes: a synchronous mode for controlling the two stimulation coils to output pulse magnetic fields simultaneously; a sequence mode for controlling the two stimulation coils to output pulse magnetic fields at preset millisecond-level time intervals, wherein the first output pulse magnetic field is a subthreshold stimulation for modulating neural excitability, and the second output pulse magnetic field is a suprathreshold stimulation for inducing an action potential; a different frequency mode for controlling the two stimulation coils to independently output pulse magnetic fields at different stimulation frequencies.

2. The magnetic stimulation coil neural function detection and regulation system according to claim 1, characterized in that, Before the step of discharging the capacitor to the double-channel stimulation coil through the control circuit, the method further comprises: receiving stimulation parameter configuration instructions for the double-channel stimulation coil; setting the stimulation intensity, stimulation frequency and stimulation mode according to the instructions; initializing the capacitor discharge parameters.

3. The magnetic stimulation coil neural function detection and regulation system according to claim 1, characterized in that, The step of discharging the capacitor to the double-channel stimulation coil through the control circuit to generate a millisecond-level pulse magnetic field comprises: turning on the charging and discharging circuit; releasing electrical energy from the capacitor to the double-channel stimulation coil to generate a millisecond-level pulse magnetic field in the double-channel stimulation coil.

4. The magnetic stimulation coil neural function detection and regulation system according to claim 1, characterized in that, The step of acquiring an evoked potential signal induced by the pulse magnetic field stimulation in real time comprises: acquiring electromyographic signals or electroencephalographic signals through electrodes; amplifying and filtering the electromyographic signals or electroencephalographic signals; obtaining the evoked potential signal.

5. The magnetic stimulation coil neural function detection and regulation system according to claim 1, characterized in that, The step of analyzing the evoked potential signal and calculating the nerve conduction time and the excitation inhibition ratio comprises: measuring the latency and amplitude of the evoked potential signal; calculating the nerve conduction time based on the latency; An excitation-inhibition ratio is calculated based on amplitude changes of a plurality of evoked potential signals acquired under different stimulation parameter conditions; The different stimulation parameter conditions include different stimulation intervals or different stimulation intensities.

6. The magnetic stimulation coil neurofunction detection and regulation system according to claim 1, characterized in that, The step of judging the nerve function state according to the nerve conduction time and the excitation-inhibition ratio comprises: The nerve conduction time is compared with a preset standard reference value to evaluate the integrity of the nerve conduction pathway; The excitation-inhibition ratio is compared with a preset standard reference value to evaluate the balance of the cortical inhibition or facilitation function.

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