Arc-shaped operating instrument for animal deep brain surgery

By combining a rectangular coordinate system with a polar coordinate system, the arc-shaped manipulator solves the problems of inaccurate positioning and complex calculations in existing instruments during deep brain surgery in animals. It achieves high-precision, multi-scenario adaptable three-dimensional positioning, which is suitable for electrophysiological recording and virus injection operations in large animals such as macaques.

CN120814926AActive Publication Date: 2025-10-21LIANGZHU LAB +1
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Patent Information

Application Number
CN202511012374.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-22
Publication Date
2025-10-21
Estimated Expiration
2045-07-22

AI Technical Summary

Technical Problem

Existing instruments are difficult to use for precise positioning in deep brain surgery in animals, especially when performing electrophysiological recordings or viral injections in the brains of large animals such as macaques. The positioning is inaccurate and the calculations are complex. Polar coordinates cannot be directly applied, and existing curved manipulators are not compatible with animal atlases.

Method used

An arc manipulation device that combines rectangular coordinate system and polar coordinate system is designed, including an arc arm assembly and a calibration platform. Through the combination of X-axis, Y-axis, and Z-axis calibration blocks and an arc ruler, direct zero point calibration of the equipment is achieved. It supports rapid replacement and electric control of various experimental equipment to meet three-dimensional positioning requirements.

Benefits of technology

It achieves precise positioning without subsequent coordinate conversion, improves the versatility and adaptability of the equipment, enables high-precision positioning in complex three-dimensional anatomical paths, simplifies the operation process, and is suitable for brain surgery in non-human primates.

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Abstract

The invention belongs to the technical field of animal intracranial surgery positioning tools, and particularly relates to an arc-shaped operation instrument for animal deep brain surgery, which comprises an arc arm assembly and a calibration table, and is compatible with a rectangular coordinate system and a polar coordinate system, and in actual use, through simple coordinate conversion, an animal standard brain map based on the rectangular coordinate system can be converted into an animal standard brain map based on the polar coordinate system. The method is applied to a polar coordinate system of more complex space positioning; the device can be directly installed on a mature stereotaxic instrument in the market, and the use cost is relatively low. Through mutual cooperation of a large number of adjustable joints, the equipment can easily carry out zero calibration operation on a commercial standard stereotaxic instrument, so that a rectangular coordinate zero point in the standard stereotaxic instrument and a coordinate zero point in a polar coordinate system of the equipment are registered together, and conversion between a two-dimensional coordinate and a three-dimensional coordinate is realized; the method has the advantages of more convenient and accurate positioning of the complex brain region, high experiment efficiency, strong flexibility, diversified use scenes and the like.
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Description

Technical Field

[0001] The invention belongs to the technical field of positioning tools for animal intracranial surgery, and in particular relates to an arc-shaped operating instrument for deep brain surgery of animals. Background Art

[0002] In recent years, there has been a growing demand for research on deep nuclei (such as the thalamus and basal ganglia) in basic brain science. Because these nuclei are located deep within the brain, precise positioning is required to facilitate subsequent manipulations of the target nuclei, such as electrophysiological recording, electrical stimulation, or viral injection.

[0003] Most of the devices currently on the market use a rectangular coordinate system for positioning, and brain maps of different species are constructed within the framework of the rectangular coordinate system. However, the brain is approximately spherical, and when performing electrical stimulation on certain deep nuclei, the vertical positioning method makes it difficult for the electrodes to effectively avoid blood vessels in the brain. Although some devices on the market also provide a rotation function, on the one hand, this device requires subsequent coordinate conversion, converting rectangular coordinates into polar coordinates to obtain usable data. The calculation is relatively complex and time-consuming, making it difficult to respond to emergencies, and long-term anesthesia will also have a negative impact on the animal's condition; on the other hand, this device has a low degree of adjustment freedom, making it difficult to cover the entire brain, and the positioning is not accurate.

[0004] Existing arc-shaped manipulators are designed based on the polar coordinate system for the human brain and are only used in clinical brain surgery. They cannot be adapted to the brains of large animals (such as macaques). In addition, this arc-shaped manipulator cannot directly convert the rectangular coordinates of animal atlases into polar coordinates and cannot be used directly in basic scientific research. The usage scenarios are relatively simple and it cannot provide supporting clamping equipment for operations such as electrophysiological recording or virus injection in basic scientific research.

[0005] Therefore, it is necessary to design an instrument that combines the rectangular coordinate system and the polar coordinate system and is suitable for deep brain surgery on animals (excluding humans). Summary of the Invention

[0006] In order to solve the above problems existing in the prior art, the present invention provides an arc-shaped operating instrument for deep brain surgery in animals.

[0007] The technical solution adopted in the present invention is:

[0008] An arc-shaped operating instrument for deep brain surgery on animals, comprising an arc arm assembly and a calibration platform;

[0009] The calibration platform includes an X-direction calibration block, a Y-direction calibration block, a Z-direction calibration block, and a calibration shaft seat; the X-direction calibration block is connected to the X-direction slide of the stereo positioner and can be adjusted in the X direction; the Y-direction calibration block is connected to the X-direction calibration block and can be adjusted in the Y direction; the Z-direction calibration block is connected to the Y-direction calibration block and can be adjusted in the Z direction, and the calibration shaft seat is fixed on the Z-direction calibration block; after the calibration platform is installed, the axis of the calibration shaft is parallel to the Y direction and passes through the zero point of the stereo positioner; the X, Y, and Z directions are perpendicular to each other;

[0010] The arc arm assembly includes an arc ruler, a clamp assembly and a radial adjuster; one end of the arc ruler is connected to the calibration shaft seat and can rotate around the axis of the calibration shaft, and the arc center of the arc ruler coincides with the zero point of the stereotaxic instrument; the arc ruler is provided with a slidable arc track slider; the radial adjuster is installed on the arc track slider and slides along the arc ruler with it; the clamp assembly is installed on the radial adjuster and is adjusted by it in the radial direction of the arc ruler; surgical tools or adjustment pointers can be installed on the clamp assembly, and the axes of the surgical tools and the adjustment pointer coincide with the radial direction of the arc ruler.

[0011] As an alternative or supplement to the above structure: the X-direction calibration block is L-shaped, and an X-direction adjustment knob is provided on the X-direction calibration block. The screw connected to the X-direction adjustment knob is threadedly connected to the X-direction slide.

[0012] As an alternative or supplement to the above structure: one end of the Y-direction calibration block connected to the X-direction calibration block has a connection hole parallel to the Y direction, and one end of the Z-direction calibration block connected to the Y-direction calibration block has a connection hole parallel to the Z direction.

[0013] As an alternative or supplement to the above structure: the stereotaxic instrument is provided with a movable positioning ear rod, the positioning ear rod is parallel to the Y direction, the moving trajectory of the positioning ear rod is parallel to the Y direction, and the axis of the positioning ear rod passes through the zero point of the stereotaxic instrument; the Z-direction calibration block is provided with a calibration hole, the calibration hole is coaxial with the calibration shaft seat, and when the positioning ear rod is inserted into the calibration hole, the calibration shaft seat is coaxial with it.

[0014] As an alternative or supplement to the above structure: the radial adjuster includes an adjustment platform, a radial adjustment knob, a threaded rod, a radial slide and a guide rod; the threaded rod and the guide rod are parallel to the radial direction of the arc ruler; the threaded rod is connected to the radial adjustment knob and is rotatably connected to the adjustment platform; the radial slide is slidably matched with the guide rod and threadedly matched with the threaded rod; the adjustment platform is detachably connected and fixed to the arc track slider.

[0015] As an alternative or supplement to the above structure: the clamp assembly includes an upper clamp arm, a radial seat rod, a lower clamp arm and a chuck; the upper end of the radial seat rod is connected to the radial slide through the upper clamp arm, one end of the lower clamp arm straightens the middle part of the radial seat rod, and the other end is connected to the adjustment platform; the chuck is connected to the lower end of the radial seat rod, and the clamping mouth of the chuck is used to install surgical tools or adjust pointers.

[0016] As an alternative or supplement to the above structure: an elongated hole is provided on the upper clamping arm and the lower clamping arm, and a clamping hoop is connected to the elongated hole, and the clamping hoop is used to connect the radial seat rod.

[0017] As an alternative or supplement to the above structure: an adjusting chuck is fixedly connected to the end of the arc ruler, the adjusting chuck is sleeved on the calibration shaft seat, and a clamping screw for adjusting the clamping force is provided on the adjusting chuck.

[0018] As an alternative or supplement to the above structure: a limiter is installed at the other end of the arc ruler, and the limiter is used to limit the sliding range of the surgical tool and the adjustment pointer.

[0019] The beneficial effects of the present invention are:

[0020] 1. The structure of this solution is designed with a large number of adjustable joints, combining the rectangular coordinate system with the polar coordinate system. Through adjustment, the zero point of this device can be directly calibrated to a position that coincides with the zero point of the stereotaxic instrument, eliminating the need for subsequent conversion and reducing subsequent calculation work. This enables real-time response during surgery and flexible interchange between vertical coordinates and polar coordinates.

[0021] 2. The structure of this solution adopts a modular design, which supports rapid replacement and is compatible with the installation of various experimental equipment (such as electrophysiological electrodes, injection needles, etc.), improving the versatility and adaptability of the equipment and increasing application scenarios. When the adjustment knobs are replaced with stepper motors, electric control can also be achieved to meet different experimental needs.

[0022] 3. The structure of this solution breaks through the limitations of traditional two-dimensional positioning and can meet the needs of complex three-dimensional anatomical paths; it provides fine-tuning capabilities in horizontal, vertical and rotational directions, and can accurately locate multiple deep areas within the entire brain at complex angles; through precise adjustment of structures such as dials, screws and sliders, high-precision positioning can be achieved, ensuring the stability of the equipment during complex operations.

[0023] 4. The structure of this solution can meet the needs of brain surgery on non-human primates (such as macaques), optimize the size and structure of the equipment, and fill the gap in existing technologies in the field of basic brain science research. The equipment simplifies the operation process through the visual design of the dial, slider and screw rod, allowing experimenters to quickly and intuitively complete positioning and adjustment tasks. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of this solution or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art.

[0025] Figure 1 It is a schematic diagram of the structure of the arc-shaped operating device in this scheme;

[0026] Figure 2 This is a structural diagram of the arc-shaped operating device in this scheme from another perspective;

[0027] Figure 3 It is a schematic diagram of the structure of a stereotaxic apparatus;

[0028] Figure 4 It is a structural diagram of the calibration station;

[0029] Figure 5 This is the structural diagram of the arc ruler and the calibration table;

[0030] Figure 6 This is a diagram of the coordination structure of the radial adjuster and the clamp assembly.

[0031] In the figure: 1-stereostatin; 11-X-axis rail rod; 12-positioning ear rod; 13-fixed seat; 14-X-axis slide; 2-arc ruler; 3-arc rail slider; 4-radial adjuster; 41-adjustment table; 42-radial adjustment knob; 43-threaded rod; 44-radial slide; 45-guide rod; 5-adjustment pointer; 6-calibration table; 61-X-axis calibration block; 62-X-axis adjustment knob; 63-Y-axis calibration block; 64-Z-axis calibration block; 641-calibration hole; 65-calibration shaft seat; 7-adjustment chuck; 71-clamping screw; 8-clamp assembly; 81-upper clamp arm; 82-radial seat rod; 83-lower clamp arm; 84-chuck. DETAILED DESCRIPTION

[0032] The technical solution in this embodiment will be clearly and completely described below in conjunction with the accompanying drawings. The described embodiments are only a part of the embodiments, not all of them. Based on the embodiments in this solution, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this solution.

[0033] like Figures 1 to 6 As shown, this solution designs an arc-shaped operating instrument for deep brain surgery on animals, including an arc arm assembly and a calibration platform 6. The calibration platform 6 is installed on the stereotaxic instrument 1, and the arc arm assembly is installed on the calibration platform 6.

[0034] The stereotactic instrument 1 includes components such as an X-axis rail rod 11, a positioning ear rod 12, a fixed seat 13, and an X-axis slide 14. The X-axis rail rod 11 includes two parallel to each other, the length direction of the X-axis rail rod 11 is parallel to the X-direction, and one end of the two X-axis rail rods 11 is fixedly connected by the fixed seat 13. When in use, the fixed seat 13 is fixed to an operating table or a laboratory table. A positioning ear rod 12 is provided on the lower side of the middle part of each X-axis rail rod 11. The two positioning ear rods 12 are located on the same straight line, and the midpoint between the two positioning ear rods 12 coincides with the zero point of the stereotactic instrument 1. The positioning ear rod 12 is parallel to the Y-direction, and the moving trajectory of the positioning ear rod 12 is parallel to the Y-direction. The axis of the positioning ear rod 12 passes through the zero point of the stereotactic instrument 1. The X-axis slide 14 is slidably arranged on the X-axis rail rod 11. When the X-axis slide 14 slides back and forth along the X-direction, it can drive the arc arm assembly and the calibration table 6 to adjust the position in the front and back directions.

[0035] The calibration platform 6 includes components such as an X-direction calibration block 61, a Y-direction calibration block 63, a Z-direction calibration block 64, and a calibration shaft seat 65. The X-direction, Y-direction, and Z-direction are perpendicular to each other.

[0036] The X-axis calibration block 61 is connected to the X-axis slide 14 of the stereotaxic apparatus 1 and can be adjusted in the X-axis direction. The X-axis calibration block 61 is L-shaped and equipped with an X-axis adjustment knob 62. The screw connected to the X-axis adjustment knob 62 is threadedly connected to the X-axis slide 14. After the X-axis slide 14 has slid back and forth to its maximum position and is secured with a pin, the X-axis adjustment knob 62 can be rotated to fine-tune the X-axis calibration block 61's forward and backward position.

[0037] The Y-direction calibration block 63 is connected to the X-direction calibration block 61 and can be adjusted in the Y-direction position; one end of the Y-direction calibration block 63 has a connecting hole (a long strip-shaped hole) parallel to the Y-direction. By adjusting the connection position of the screw in the connecting hole, the Y-direction calibration block 63 can be accurately adjusted in the Y-direction. A Y-direction scale area can be set on the side surface of the Y-direction calibration block 63, which is convenient for viewing and recording the adjusted position of the Y-direction calibration block 63 in the Y-direction.

[0038] The Z-direction calibration block 64 is connected to the Y-direction calibration block 63 and can be adjusted in the Z direction. The upper end of the Z-direction calibration block 64 has a connection hole (an elongated hole) parallel to the Z direction. By adjusting the connection position of the screw in the connection hole, the Z-direction calibration block 64 can be accurately adjusted in the Z direction. A calibration hole 641 is provided on the side surface of the Z-direction calibration block 64. The calibration hole 641 is coaxial with the calibration shaft seat 65. When the positioning ear rod 12 is inserted into the calibration hole 641, it can quickly ensure that the calibration shaft seat 65 and the positioning ear rod 12 are coaxial.

[0039] The calibration shaft seat 65 is fixed on the Z-direction calibration block 64. After the calibration platform 6 is installed, the axis of the calibration shaft is parallel to the Y-direction and passes through the zero point of the stereotaxic instrument 1. The end of the calibration shaft seat 65 is cylindrical.

[0040] The arc arm assembly includes an arc ruler 2 , a clamp assembly 8 and a radial adjuster 4 .

[0041] One end of the arc ruler 2 is connected to the calibration shaft seat 65 through an adjusting chuck 7, so that the arc ruler 2 can rotate around the axis of the calibration shaft. The end of the arc ruler 2 is fixedly connected to the adjusting chuck 7, which is sleeved on the calibration shaft seat 65. The adjusting chuck 7 is provided with a clamping screw 71 for adjusting the clamping force. A circular scale is provided at one end of the adjusting chuck 7, and the scale on the scale can display the distance value of the rotation of the arc ruler 2. The arc center of the arc ruler 2 coincides with the zero point of the stereotaxic instrument 1; the arc ruler 2 is provided with a slidable arc track slider 3, and when the arc track slider 3 slides to different positions, the scale data of the position of the arc track slider 3 can be read. In addition, a limiter is installed at the other end of the arc ruler 2, and the limiter is used to limit the sliding range of the surgical tool and the adjustment pointer 5.

[0042] The radial adjuster 4 is mounted on the arc track slider 3 and slides along the arc ruler 2 with the arc track slider 3. The arc ruler 2 has a scale. The radial adjuster 4 comprises an adjustment platform 41, a radial adjustment knob 42, a threaded rod 43, a radial slide 44, and a guide rod 45. The threaded rod 43 and guide rod 45 are parallel to the radial direction of the arc ruler 2. The threaded rod 43 is connected to the radial adjustment knob 42 and is rotatably connected to the adjustment platform 41. The radial slide 44 is slidably engaged with the guide rod 45 and threadedly engaged with the threaded rod 43. The adjustment platform 41 is detachably connected to and fixed to the arc track slider 3.

[0043] The clamp assembly 8 is mounted on the radial adjuster 4 and is thereby adjusted in the radial direction of the arc ruler 2. The clamp assembly 8 can be mounted with a surgical tool or an adjustment pointer 5, with the axes of the surgical tool and the adjustment pointer 5 aligning with the radial direction of the arc ruler 2. The clamp assembly 8 comprises an upper clamp arm 81, a radial seat rod 82, a lower clamp arm 83, and a clamp head 84. The upper end of the radial seat rod 82 is connected to the radial slide 44 via the upper clamp arm 81. One end of the lower clamp arm 83 straightens the middle of the radial seat rod 82 and the other end is connected to the adjustment platform 41. The clamp head 84 is connected to the lower end of the radial seat rod 82, and the clamping opening of the clamp head 84 is used to mount a surgical tool or the adjustment pointer 5.

[0044] The upper clamping arm 81 and the lower clamping arm 83 are provided with long strip holes, and a clamping hoop is connected to the long strip holes. The clamping hoop is used to connect the radial seat rod 82. When the clamping hoop is connected to different positions of the upper clamping arm 81 and the lower clamping arm 83, the axis deviation of the radial seat rod 82 can be adjusted, thereby ensuring that the axis of the radial seat rod 82 is parallel to the radial direction of the arc ruler 2.

[0045] The working process of the arc operating device in this scheme:

[0046] (1) Equipment zero point calibration: First, fix the stereotaxic instrument 1, assemble the arc operating instrument, and install it on the X-axis slide 14 of the stereotaxic instrument 1 with the zero point, and install the adjustment pointer 5 on the clamp assembly 8. Slide the X-axis slide 14 back and forth until the calibration pointer 5 is roughly aligned with the zero position on the stereotaxic apparatus 1. Rotate the radial adjustment knob 42 to lower the height of the calibration pointer 5, bringing it as close to the zero position as possible. Loosen the X-axis calibration block 61, the Y-axis calibration block 63, and the Z-axis calibration block 64 to fine-tune the calibration pointer 5 horizontally, forward and backward, and vertically. At the same time, fine-tune the rotation angle of the arc ruler 2 as needed to align the 0° line of the scale with the directional line on its right side, ensuring that the calibration pointer 5 is completely perpendicular to the zero position on the stereotaxic apparatus 1. At this point, the entire arc ruler 2 is considered to have completed zero-point calibration. Record the scale readings of each component at this point, which are the "zero position" of all scales of the manipulator arm. Based on this, the calibration pointer 5 is considered to be completely at the "zero position" in the animal brain atlas coordinate system. After zeroing is complete, raise the calibration pointer 5 to a safe height and tighten all screws to prevent any accidents for subsequent use.

[0047] (2) After induction of anesthesia, the macaque's head was fixed on the stereotaxic apparatus 1, and two ear bars were inserted into the left and right ear canals of the macaque respectively. The positions of the ear bars on both sides were adjusted so that the macaque's head was fixed as much as possible in the middle position of the stereotaxic apparatus 1;

[0048] (3) After the skin of the macaque's head is disinfected, the skin is cut open with a scalpel, and the muscles, periosteum and other tissues are removed to fully expose the skull. The position of the animal's head is fine-tuned left and right again according to the suture on the skull surface, so that the suture of the animal's skull is as completely as possible on the central axis of the stereotaxic instrument 1. The suture of the skull and the ear bar lines on the left and right sides are drawn on the surface of the animal's skull with a marker. The intersection of the two lines on the skull can be considered as the projection of the coordinate zero point in the brain atlas on the skull;

[0049] (4) Remove the entire operating arm together with the X-axis slide 14 on the stereotaxic instrument 1 from the zero-calibrated stereotaxic instrument 1, install it on the animal's stereotaxic instrument 1, and move the slider of the stereotaxic instrument 1 to the "zero position" after zero calibration. First, observe the height position of the calibration shaft seat 65 at this time to see if it is flush with the ear bar. If it is not on the same horizontal line, the arc ruler 2 will not completely point to the "zero position" in the brain map coordinates. Then lower the height of the adjustment pointer 5 so that it is as close to the surface of the animal's skull as possible, and observe whether the adjustment pointer 5 is vertically pointing to the intersection on the skull. If not, give priority to fine-tuning the position of the animal's head on the stereotaxic instrument 1. If it is impossible to completely adjust the animal's head to match the adjustment pointer 5 due to factors such as large differences in the animal's head, consider fine-tuning the position on the operating arm so that the adjustment pointer 5 is completely vertically pointing to the intersection on the skull, and record the scale at this time and mark it as the new "zero position." Subsequent movement and other operations are calculated based on this "zero position."

[0050] (5) According to the three-dimensional spatial coordinates of the target brain area in the brain map, a route to the target brain area is planned to meet special requirements such as avoiding dangerous areas or taking into account other target areas at the same time. This route is converted into a polar coordinate system and the coordinates are adjusted according to the new "zero point position". By rotating the arc ruler 2, the positioning requirements of the special position are achieved.

[0051] (6) After the positioning work is completed, the adjustment pointer 5 is removed and replaced. According to the experimental requirements, surgical tools such as metal electrodes or glass electrodes are installed on the clamp assembly 8. By rotating the screw, the metal electrode or glass electrode and other tools are slowly penetrated to the target depth. After waiting for several minutes for stability, the corresponding pin screw is tightened to assist in fixing the clamp assembly 8.

[0052] The above embodiments are merely examples for the purpose of illustrating the present invention clearly and are not intended to limit the embodiments. It is not necessary and impossible to enumerate all embodiments here. Obvious changes or modifications derived therefrom are still within the scope of protection of this technology.

Claims

1. An arc-shaped operating instrument for deep brain surgery in animals, characterized by: It includes an arc arm assembly and a calibration platform (6); The calibration platform (6) comprises an X-direction calibration block (61), a Y-direction calibration block (63), a Z-direction calibration block (64) and a calibration shaft seat (65); the X-direction calibration block (61) is connected to the X-direction slide (14) of the stereo positioning instrument (1) and can be adjusted in the X-direction position; the Y-direction calibration block (63) is connected to the X-direction calibration block (61) and can be adjusted in the Y-direction position; the Z-direction calibration block (64) is connected to the Y-direction calibration block (63) and can be adjusted in the Z-direction position, and the calibration shaft seat (65) is fixed on the Z-direction calibration block (64); after the calibration platform (6) is installed, the axis of the calibration shaft is parallel to the Y-direction and passes through the zero point of the stereo positioning instrument (1); the X-direction, Y-direction and Z-direction are perpendicular to each other; The arc arm assembly comprises an arc ruler (2), a clamp assembly (8) and a radial adjuster (4); one end of the arc ruler (2) is connected to the calibration shaft seat (65) and can rotate around the axis of the calibration shaft, and the arc center of the arc ruler (2) coincides with the zero point of the stereoscopic positioning instrument (1); a slidable arc track slider (3) is provided on the arc ruler (2); the radial adjuster (4) is installed on the arc track slider (3) and slides along the arc ruler (2); the clamp assembly (8) is installed on the radial adjuster (4) and is adjusted by the clamp assembly (8) in the radial direction of the arc ruler (2); a surgical tool or an adjustment pointer (5) can be installed on the clamp assembly (8), and the axes of the surgical tool and the adjustment pointer (5) coincide with the radial direction of the arc ruler (2).

2. The arc-shaped operating instrument for deep brain surgery on animals according to claim 1, characterized in that: The X-direction calibration block (61) is L-shaped, and an X-direction adjustment knob (62) is provided on the X-direction calibration block (61). The screw connected to the X-direction adjustment knob (62) is threadedly connected to the X-direction slide (14).

3. The arc-shaped operating instrument for deep brain surgery on animals according to claim 1, characterized in that: One end of the Y-direction calibration block (63) connected to the X-direction calibration block (61) has a connection hole parallel to the Y-direction, and one end of the Z-direction calibration block (64) connected to the Y-direction calibration block (63) has a connection hole parallel to the Z-direction.

4. The arc-shaped operating instrument for deep brain surgery on animals according to claim 1, characterized in that: The stereoscopic positioner (1) is provided with a movable positioning ear rod (12), the positioning ear rod (12) is parallel to the Y direction, the moving track of the positioning ear rod (12) is parallel to the Y direction, and the axis of the positioning ear rod (12) passes through the zero point of the stereoscopic positioner (1); the Z-direction calibration block (64) is provided with a calibration hole (641), the calibration hole (641) is coaxial with the calibration shaft seat (65), and when the positioning ear rod (12) is inserted into the calibration hole (641), the calibration shaft seat (65) is coaxial with it.

5. The arc-shaped operating instrument for deep brain surgery on animals according to claim 1, characterized in that: The radial adjuster (4) comprises an adjusting platform (41), a radial adjusting knob (42), a threaded rod (43), a radial slide (44) and a guide rod (45); the threaded rod (43) and the guide rod (45) are parallel to the radial direction of the arc ruler (2); the threaded rod (43) is connected to the radial adjusting knob (42) and is rotatably connected to the adjusting platform (41); the radial slide (44) is slidably matched with the guide rod (45) and threadedly matched with the threaded rod (43); the adjusting platform (41) is detachably connected to and fixed on the arc track slider (3).

6. The arc-shaped operating instrument for deep brain surgery on animals according to claim 5, characterized in that: The clamp assembly (8) includes an upper clamp arm (81), a radial seat rod (82), a lower clamp arm (83) and a clamp head (84); the upper end of the radial seat rod (82) is connected to the radial slide (44) through the upper clamp arm (81), one end of the lower clamp arm (83) straightens the middle part of the radial seat rod (82), and the other end is connected to the adjustment platform (41); the clamp head (84) is connected to the lower end of the radial seat rod (82), and the clamping mouth of the clamp head (84) is used to install surgical tools or adjust the pointer (5).

7. The arc-shaped operating instrument for deep brain surgery on animals according to claim 6, characterized in that: The upper clamping arm (81) and the lower clamping arm (83) are provided with long strip holes, and the long strip holes are connected with a clamping hoop, and the clamping hoop is used to connect the radial seat rod (82).

8. The arc-shaped operating instrument for deep brain surgery on animals according to claim 1, characterized in that: An adjusting chuck (7) is fixedly connected to the end of the arc ruler (2), and the adjusting chuck (7) is sleeved on the calibration shaft seat (65). A clamping screw (71) for adjusting the clamping force is provided on the adjusting chuck (7).

9. The arc-shaped operating instrument for deep brain surgery on animals according to claim 8, characterized in that: A limiter is installed at the other end of the arc ruler (2), and the limiter is used to limit the sliding range of the surgical tool and the adjustment pointer (5).

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