Food medicine for reducing blood uric acid and treating gout

Abstract

A food medicine for reducing blood uric acid and treating gout is characterized in that celery seeds, celery, mulberry fruits, mulberry leaves, sea buckthorn fruit powder, dandelions, rhizoma polygonati, poria cocos and beach kidney grass serve as a basic formula; the auxiliary materials comprise one, several or all of a plurality of formula combinations of ramulus mori, lycium ruthenicum, radix puerariae, Chinese yam, clerodendranthus spicatus, lysimachia christinae hance, acanthopanax, anserine, astragalus membranaceus, purslane, herba cepbalanoplosis segeti, galangal, hovenia dulcis thunb, astragalus membranaceus, luteolin, uric acid-reducing edible probiotics and the like, and are used for treating hyperuricemia and gout.

Description

Technical Field

[0001] The present invention relates to a food medicine for lowering blood uric acid and treating gout, which belongs to the scope of medical food, and most of the raw materials are medicine and food homologous foods. Background Art

[0003] Gout falls under the categories of "arthralgia" and "limb paralysis" in Traditional Chinese Medicine. Gouty arthritis is caused by disorders in purine metabolism or uric acid excretion, characterized by elevated blood uric acid levels and the accumulation of sodium urate crystals in connective tissue. Acute attacks are characterized by intense, stabbing pain, limited mobility, and considerable suffering. It is more common in middle-aged and elderly men and postmenopausal women, with a certain genetic predisposition and increased susceptibility in those with a favorable diet. The prevalence of gout in my country is between 1% and 3%.

[0004] Hyperuricemia can result from excessive uric acid production, decreased uric acid excretion, or both. Furthermore, hyperuricemia can trigger a series of inflammatory responses, leading to damage to the body. The treatment principle for gout is to primarily address pain relief during acute phases, such as inflammatory reactions, and to primarily inhibit uric acid production and promote uric acid excretion during chronic phases, such as hyperuricemia. Currently, the main medications for gout include allopurinol, colchicine, and glucocorticoids. However, long-term use of these drugs can cause side effects such as exfoliative dermatitis, fever, vasculitis, gastrointestinal symptoms, bone marrow suppression, and damage to kidney, liver, and central nervous system cells. Therefore, the search for highly effective and low-toxic anti-gout and uric acid-lowering agents is of great significance. Using traditional Chinese medicine (TCM) with low toxicity or a combination of TCM and Western medicine to treat gout offers significant advantages. Therefore, the search for new TCM-derived drugs for the treatment of gout and hyperuricemia is a new direction in anti-gout drug development and a hot topic in pharmaceutical research. Chinese medicine has accumulated considerable experience in the clinical treatment of hyperuricemia and gout. In recent years, natural medicine has attracted increasing attention for its proven efficacy, diverse approaches, and minimal side effects in treating gout. Studies have shown that plant-derived compounds such as alkaloids, flavonoids, glycosides, organic acids, triterpenes, and polyphenols have significant uric acid-lowering effects. The active ingredients of natural products have two primary mechanisms of action against hyperuricemia: one is by inhibiting uric acid production by affecting key enzymes in purine metabolism; the other is by regulating urate transporters, promoting renal uric acid excretion.

[0005] In 2010, a brewery manager first discovered that drinking Spartina alterniflora extract could treat gout and lower high uric acid levels in the urine. Professor Qin Pei of Nanjing University and his team conducted continuous experimentation and exploration in the cultivation and functional development of Spartina alterniflora. Through experiments and use, they confirmed that Spartina alterniflora extract can lower uric acid levels and treat gout while also boosting human immunity. This discovery was published in the journal "Spartina alterniflora Ecological Engineering." However, the Chinese pharmacopoeia lacks in-depth research on the medicinal properties of Spartina alterniflora, an introduced species. The inventors found in clinical practice that consuming Spartina alterniflora extract caused diarrhea in people with spleen and stomach deficiency, but there is no documentation regarding its cooling properties.

[0006] CN201710649881.3 background technology discloses: According to the measurement of Nanjing University, the extract of Spartina alterniflora, Spartina powder, is rich in three major categories of active ingredients: the active polysaccharide content is as high as 32%, the total saponin content is 20.8%, and the total flavonoids are about 2.15%, which are generally higher than those of general terrestrial plants; Spartina powder has many functions such as enhancing the body's immunity, resisting fatigue, dilating blood vessels, lowering blood uric acid and resisting gout.

[0007] Recently, patent application CN202210250238.4 was found to record "Beneficial effects: The seabuckthorn fruit extract with gout prevention and treatment effects provided by the present invention has been shown through animal experimental studies to significantly reduce uric acid and blood urea nitrogen levels in acute hyperuricemia model mice. During the experiment, it was found that although the positive drug high-dose allopurine had a significant effect on lowering uric acid, it also had a significant renal damage effect. Compared with the model group, it significantly increased blood creatinine and blood uric acid nitrogen levels. Seabuckthorn fruit extract, especially the water extract and ethanol extract of seabuckthorn fruit, can not only reduce blood uric acid levels, but also reduce blood urea nitrogen levels, without a significant effect on blood creatinine levels. No obvious adverse reactions were observed, making it safer for clinical application."

[0008] 201611132388.6 Topical medications for pityriasis rosea include extracts from Spartina alterniflora and seabuckthorn fruit. These extracts, applied to the affected area, have anti-inflammatory and anti-allergic properties while also helping to stabilize the skin's protective acidic layer. Combined with oral and internal medications, these medications are highly effective in treating pityriasis rosea.

[0009] 201911057802.5, a uric acid-lowering and anti-gout composition and its preparation method and application, comprising the following raw materials in parts by weight: 6-20 parts of marine fish oligopeptides, 12-24 parts of Hovenia dulcis seeds, 10-20 parts of chicory, 15-30 parts of dandelion, 5-15 parts of mango powder, 2-10 parts of acerola cherry powder, 2-10 parts of monk fruit, and 0.2-2 parts of sweetener. The beneficial effect of the present invention is that the marine fish oligopeptides are compounded with the medicinal and edible raw materials Hovenia dulcis seeds, chicory, and dandelion, and the fruit raw materials mango powder and acerola cherry powder, which can not only inhibit uric acid production, but also promote uric acid excretion and alleviate complications such as hyperuricemia. It also has a synergistic effect, can better lower blood uric acid levels, and achieve anti-gout effects. Long-term use is safe and has no side effects.

[0010] Gout treatment primarily requires rapid and effective symptom relief during acute attacks, and secondly, prevention of acute arthritis. While some gout-preventing and treatment medications are available, they are often ineffective and often slow to respond to traditional Chinese medicine. Further clinical data demonstrate that the limitations of existing medications, adverse reactions, and the limited availability of treatment options have limited the prevention and treatment of gout. Therefore, there is an urgent need to develop new, safe, and side-effect-free medications that can effectively alleviate gout symptoms. Summary of the Invention

[0012] Currently, there are more than 100 million people with hyperuricemia in China. It can be seen that the development of uric acid-lowering medical foods for the treatment of gout is very consistent with national policies and the needs of the times.

[0013] There are more than 100 varieties of traditional Chinese medicine that are both medicinal and edible, which have low toxicity and side effects, can cure diseases and are edible. The present invention mainly uses varieties that are both medicinal and edible, which are non-toxic and have no side effects, and the raw material cost is not too high.

[0014] Research and testing by multiple university hospitals, including Guangzhou University of Chinese Medicine, and experiments by the inventor over the years have shown that mulberries, mulberry leaves, celery seeds, celery, sea buckthorn, dandelion, polygonatum, black wolfberry, kudzu root, purslane, etc. contain large amounts of vitamins, trace elements, flavonoids, saponins, phenolic acid compounds and other active substances that can inhibit the activity of xanthine oxidase, thereby reducing the amount of uric acid synthesis in the body. They can prevent and treat high uric acid and gout, hyperlipidemia, hyperglycemia, and hypertension, and prevent and fight cancer. Mulberries are rich in anthocyanins, which can nourish the retina and protect eyesight, reduce damage to the eyes from watching mobile phones, computers, and televisions, repair liver and kidney damage, and have a diuretic function.

[0015] Description of the properties of Chinese herbal medicine for lowering uric acid:

[0016] Celery seeds contain 50 times the blood pressure-lowering and lipid-lowering properties of celery. Short-term use can lower blood pressure and blood lipids, and long-term use is far superior to other Chinese and Western medicines, without any toxic side effects. Celery seeds are particularly effective for treating hypertension. They can lower blood pressure and blood lipids. They also have a soothing effect on rheumatism, rheumatoid arthritis, gout, and hyperuricemia.

[0017] Seabuckthorn fruit has the effects of strengthening the spleen and digestion, relieving cough and expectoration, and promoting blood circulation and removing blood stasis. It is mainly used to treat spleen deficiency, poor appetite, cough and sputum, and blood stasis.

[0018] Seabuckthorn fruit is used as medicine to relieve cough and phlegm, strengthen the stomach and aid digestion, and promote blood circulation and dissipate blood stasis. Modern medical research shows that seabuckthorn fruit can lower cholesterol, relieve angina attacks, and prevent and treat coronary artery atherosclerosis.

[0019] Acanthopanax is warm in nature and has the effects of dispelling rheumatism, nourishing the liver and kidneys, strengthening tendons and bones, promoting diuresis and reducing swelling. It contains ginsenosides.

[0020] Mulberries taste sweet and sour, are slightly cold in nature, and enter the heart, liver, and kidney meridians. They have the effects of nourishing blood and yin, promoting fluid production and quenching thirst, clearing the intestines and moistening dryness. They are mainly used to treat symptoms such as dizziness, tinnitus, palpitations, insomnia, weakness in the waist and knees, premature graying of hair, and dry stools caused by insufficient yin and blood.

[0021] Mulberries are rich in protein, essential amino acids, total sugars, free acids, crude fiber, vitamins, minerals, and other functional ingredients, possessing high nutritional value. They contain vitamins such as VA, VC, VB, VE, and carotene, as well as a variety of free amino acids, including seven essential amino acids and 12 non-essential amino acids. Mulberries are also rich in minerals, with calcium, phosphorus, iron, copper, and zinc contributing to their high concentrations. Selenium is particularly abundant, reaching 4.6 μg / 100g, ten times that of kiwifruit and eight times that of apples, making it the highest content among fruits. Mulberries are also found to contain the anti-aging trace elements molybdenum and strontium.

[0022] Mulberries contain a variety of functional ingredients, such as rutin, anthocyanins, resveratrol, etc., which have good anti-cancer, anti-aging, anti-ulcer, and antiviral effects.

[0023] Immunomodulatory effect. Studies have shown that mulberry polysaccharide is a good immunomodulator with good application prospects. Its immunomodulatory mechanism needs further study.

[0024] Mulberry's antioxidant effect. Research in recent years has shown that mulberry has a certain ability to scavenge various free radicals and has a strong antioxidant effect.

[0025] Mulberries have the effect of lowering blood lipids. Research results show that mulberries can effectively regulate blood lipids, thereby protecting the cardiovascular and cerebrovascular systems.

[0026] Mulberry has a hypoglycemic effect. Continuous high blood sugar levels can cause lesions in various tissues and organs throughout the body, leading to the occurrence of acute and chronic complications. Wang Qiang et al. studied the effects of different doses of mulberry polysaccharides (MBPs) on physiological and biochemical indicators (including blood sugar levels, blood lipid indicators, lipid peroxidation levels, and serum antioxidant status) of diabetic rats induced by streptozotocin (STZ). The experimental results showed that mulberry polysaccharides can inhibit or reduce the increase in blood sugar in rats, with a significant hypoglycemic effect, and have a significant regulatory effect on the blood lipid indicators of rats, and have a significant regulatory effect on the lipid peroxidation level and serum antioxidant status of rats. The experiment confirmed that mulberry polysaccharides have a good effect in preventing and treating diabetes. Hu Haimei

[11] found that mulberry polysaccharides can reduce the blood sugar of hyperglycemic mice, but have no significant effect on the blood sugar of normal mice.

[0027] Mulberries have anti-cancer effects. Studies have shown that mulberry anthocyanins can effectively prevent the metastasis of cancer cells and avoid the sudden onset of cancer. As a metastasis inhibitor of cancer cells, mulberries are a potential anti-cancer drug.

[0028] Research by Wang Ruipo and others from the School of Life Sciences at East China Normal University showed that mulberry flavonoids can reduce the uric acid level in rats with hyperuricemia and have a positive preventive and therapeutic effect on renal injury in rats with hyperuricemia induced by adenine.

[0029] Mulberry leaves have the effects of dispersing wind-heat, clearing the lungs and moistening dryness, calming the liver and improving eyesight, cooling blood and stopping bleeding.

[0030] Research by Wang Ke and others from the School of Life Sciences at East China Normal University showed that total flavonoids from mulberry leaves can significantly lower serum uric acid levels, which is comparable to the uric acid-lowering effect of allopurinol; and can significantly lower uric acid nitrogen, creatinine, malondialdehyde, triglycerides, free fatty acid levels, and liver and kidney coefficients. The results showed that total flavonoids from mulberry leaves have the effect of intervening in adenine-induced hyperuricemia and renal damage.

[0031] Mulberry twigs can treat wind-cold-dampness arthritis, limb cramps, beriberi edema, and itchy muscles. Wang Caiping and colleagues from Nanjing University found that mulberry twig extract inhibited xanthine oxidase activity and protein expression in the liver of hyperuricemic mice and reduced renal-specific uric acid transporter protein expression. This suggests that mulberry twig extract can reduce serum uric acid levels in hyperuricemic mice by inhibiting hepatic uric acid production and promoting renal uric acid excretion.

[0032] Dandelion is a perennial herb in the Asteraceae family. Its flower heads are crowned with seeds adorned with a pompom of white hairs. After blooming, the flowers are carried by the wind to new locations, nurturing new life. The dandelion plant contains a variety of healthy nutrients, including taraxol, taraxein, choline, organic acids, and inulin, which have diuretic, laxative, jaundice-relieving, and muscle-strengthening properties. Dandelion also contains protein, fat, carbohydrates, trace elements, and vitamins, making it a rich source of nutritional value. It can be eaten raw, stir-fried, or used in soups, making it a useful both medicinal and edible plant. Research by Zou Chuanzong and others from Gansu Medical College has shown that dandelion ethyl acetate extract has a significant uric acid-lowering effect in rats with acute hyperuricemia.

[0033] Purslane has a sour and cold taste and is known to clear heat and detoxify, cool blood and stop bleeding, and relieve dysentery. It is primarily used to treat heat-induced bloody dysentery, heat-induced sores, metrorrhagia, and bloody stools. It is mentioned in the Compendium of Materia Medica and the Newly Revised Compendium of Materia Medica. Purslane can be eaten as a vegetable. The Compendium of Materia Medica classifies it as a vegetable and states, "Many people harvest the seedlings, boil them, and dry them in the sun as a vegetable." Traditionally, people dried them in the sun and salted them for consumption as pickles. Purslane contains a large amount of potassium, which has a beneficial diuretic and detumescent effect. It also contains carotene, which promotes ulcer healing. It is rich in fatty acids, which may help prevent heart disease. However, individuals with spleen and stomach deficiency, loose stools, and pregnant women should avoid consuming purslane. Portulaca oleracea is mainly used to clear away heat and detoxify, cool blood and stop dysentery, and stop bleeding. It is commonly used for pain, diabetes, hyperlipidemia, atherosclerosis, hypertension, bronchial asthma, midwifery, Alzheimer's disease, Parkinson's syndrome, fatty liver, acute liver injury, liver fibrosis, dysentery, flat warts, colitis, and cancer. Lv Youwei et al. administered a high-dose (1.48 g / kg / d) or low-dose (0.74 g / kg / d) Portulaca oleracea extract to a hyperuricemia mouse model for 21 days. The extract significantly reduced serum uric acid, malondialdehyde, and xanthine oxidase levels, and increased superoxide dismutase, glutathione, glutathione peroxidase, and urine creatinine levels in the mice. This suggests that Portulaca oleracea extract can improve early renal damage. The mechanism is related to inhibiting uric acid production, reducing the production of lipid oxidation metabolites, and enhancing the body's antioxidant capacity.

[0034] Beach Kidney Grass refers to Spartina alterniflora and Spartina rice (a salt-tolerant, agriculturally promoted high-yield rice variety, developed through sexual hybridization, bioengineering, and cultivation on saline-alkali lands along the coast), as well as hybrid varieties derived from these plants. They grow on beaches, and their roots, with a taste similar to reeds, have hollow stalks. Due to their high-salt environment, their stems and leaves secrete salt, similar to the function of the human kidney. The inventor and those around them who had high uric acid levels took Beach Kidney Grass extract. Some individuals with spleen and stomach deficiency experienced diarrhea two hours after taking it, while others experienced gastrointestinal discomfort. The inventor believes that Beach Kidney Grass grows on beaches and is waterlogged and has a cold medicinal property. Based on the Traditional Chinese Medicine principle of treating the condition by its appearance, the inventor theorizes that it may be helpful in treating kidney disease.

[0035] Black goji berries are the dried fruit of Lycium ruthenicum Murr., a wild plant of the Solanaceae family. The berries are spherical and turn purple-black when ripe. They are non-toxic, sweet, and neutral in nature, and have been shown to improve eyesight, benefit the liver, and nourish the kidneys and improve essence. Studies have shown that long-term consumption of anthocyanin extract from black goji berries can effectively inhibit elevated serum uric acid levels and exhibit preventive and therapeutic effects against acute gouty arthritis. Studies have also shown that a mixture of freeze-dried black goji berry powder and celery seed extract has a more potent xanthine oxidase inhibitory effect than either black goji berries or celery seeds alone.

[0036] Pueraria root is the dried root of Pueraria montana (Lour.) Merr., a plant of the genus Pueraria in the legume family. It is harvested in autumn and winter, cut into thick slices or small pieces while fresh, and dried. It is sweet, pungent, and cool, and has the functions of raising yang and stopping diarrhea, promoting blood circulation and activating collaterals, and detoxifying alcohol. As a pungent and cool antipyretic drug, Pueraria root has the effects of clearing heat, promoting the production of body fluids, and quenching thirst. Pharmacological studies have shown that it has the effects of resisting oxidative stress, reducing the accumulation of inflammatory factors, enhancing insulin sensitivity, and reducing insulin resistance. It is commonly used for exogenous fever and headache, stiff neck and back pain, thirst, diabetes, measles that does not break out, dysentery, diarrhea, dizziness and headache, hemiplegia caused by stroke, chest pain and heart pain, and alcohol poisoning. It is a food that can be used as medicine and food, and is also the main or auxiliary medicine in traditional Chinese medicine prescriptions for the treatment of hyperuricemia. Puerarin, as the main active ingredient in Pueraria root, has a certain XO inhibitory ability and can alleviate pathological characteristics such as inflammatory response and kidney damage caused by hyperuricemia. Therefore, puerarin has good potential for the prevention and treatment of hyperuricemia.

[0037] Thistle is the dried aerial part of the Asteraceae plant, Echinops serrata. It has a sweet and bitter taste and cool properties. It has the effects of cooling blood, stopping bleeding, dispersing blood stasis, detoxifying, and eliminating carbuncles. It can be used to treat epistaxis, hematemesis, hematuria, hematuria, hematuria, hematochezia, metrorrhagia, traumatic bleeding, carbuncles, and sores.

[0038] Luteolin is a natural flavonoid found in a variety of plants. It exhibits a variety of pharmacological activities, including anti-inflammatory, anti-allergic, uric acid-lowering, anti-tumor, antibacterial, and antiviral. It is primarily used clinically for cough relief, expectoration, anti-inflammatory, uric acid-lowering, and treatment of cardiovascular disease, amyotrophic lateral sclerosis, SARS, and hepatitis.

[0039] Anserine is a type of histidine dipeptide naturally present in vertebrates. It is water-soluble and has strong antioxidant and anti-aging properties. It has been used as a natural antioxidant in the food industry.

[0040] The seeds of Hovenia dulcis have the functions of detoxifying alcohol, quenching thirst, relieving restlessness, stopping vomiting, and promoting urination and defecation. Hovenia dulcis contains a large amount of glucose and calcium malate, which has a strong diuretic effect. It can promote the decomposition and excretion of ethanol, significantly reduce the concentration of ethanol in the blood, eliminate the free radicals produced by ethanol in the body, and prevent the formation of peroxide esters, thereby reducing the damage of ethanol to liver tissue, avoiding various metabolic abnormalities caused by alcohol poisoning, and inducing various diseases. The seeds can be diuretic, and soaking them in wine can also relax the meridians and activate the collaterals, treat left paralysis and right paralysis, rheumatism and numbness; and the fruit can be eaten fresh to treat tracheitis, asthma, etc. The latest research has also found that Hovenia dulcis has important functions such as protecting the liver, resisting early liver fibrosis, delaying and preventing the formation of fatty liver caused by ethanol, resisting mutations, preventing and treating cancer, anti-tumor, and anti-aging

[11] . According to Traditional Chinese Medicine, Citrus aurantium is sweet and neutral in nature, entering the spleen and stomach meridians, and possessing the ability to quench thirst and alleviate alcohol consumption. Doctors throughout history have used it as a key remedy for alcoholism, thirst, and diabetes, including excessive drinking, drunkenness, dry mouth, and thirst. The Compendium of Materia Medica states that it is "sweet, mild, and non-toxic, primarily used to treat headaches and lower abdominal cramps." The Tang Materia Medica states that it "quenches thirst and relieves restlessness, nourishes the five internal organs, promotes urination and defecation, and removes heat from the diaphragm, with properties similar to honey." The Southern Yunnan Materia Medica states that it "treats all forms of left-sided paralysis, right-sided paralysis, rheumatic numbness, and can detoxify alcohol." Consuming it as porridge is particularly effective for relieving excessive drinking, dry mouth, and thirst, as described in the Lao Lao Heng Yan book: "Citrus aurantium porridge relieves restlessness and clears heat, especially detoxifying alcohol. It is particularly suitable for consumption on an empty stomach the morning after intoxication."

[0041] Research by Zhang Feng et al. from Tianjin University of Science and Technology showed that the water extract and polysaccharide of Hovenia dulcis reduced serum uric acid in mice from 136.21 μM to 50.40 μM and 56.09 μM, respectively, and inhibited the activity of hepatic xanthine oxidase. Serum biochemistry analysis, liver and kidney indices, and histopathological analysis showed that Hovenia dulcis and polysaccharide can improve liver and kidney damage caused by hyperuricemia. It is used for damp-heat jaundice, gallbladder distension and hypochondriac pain, stranguria with stones, stranguria with heat, painful and astringent urination, carbuncles, furuncles, and snake and insect bites.

[0042] The present invention provides a food and medicine for lowering blood uric acid and treating gout. The food and medicine are characterized by: the herb of the beach sedge has a cooling property and, together with seabuckthorn fruit, has a good therapeutic effect on lowering blood uric acid and treating gout, and enhances human immunity. The beach sedge extract and the seabuckthorn fruit extract are mixed in a ratio of 1:0.3-2. Alternatively, the aboveground stems and leaves of the beach sedge and the seabuckthorn fruit can be boiled in water in a traditional Chinese medicine boiling method in a ratio of 1:0.3-2.

[0043] Taking the human body weight of 60 kg as the standard, 2 grams of beach nephrodisiac extract and 0.5-3 grams of sea buckthorn fruit extract are mixed and taken once a day without adverse reactions. Those with higher uric acid values ​​(over 580μmol / L, the following uric acid units are all μmol / L) can take it twice a day. Those who weigh more than 60 kg can increase the dosage proportionally.

[0044] The invention discloses a food medicine for lowering blood uric acid and treating gout. The food medicine is characterized by comprising: celery seeds, celery, mulberry fruits, mulberry leaves, sea buckthorn fruit powder, dandelion, polygonatum, poria, and beach kidney grass as a basic formula; and containing one, several, or a combination of all of the auxiliary materials, such as mulberry branches, black wolfberry, kudzu root, yam, cat's whiskers, desmodium, acanthopanax, anserine, astragalus, purslane, thistle, galangal, prunus aurantium, astragalus, luteolin, and edible probiotics capable of lowering uric acid, for treating hyperuricemia and gout.

[0045] The invention discloses a food medicine for lowering blood uric acid and treating gout. The food medicine is characterized by comprising 10-30 parts of celery seeds, 10-30 parts of mulberries, 5-25 parts of mulberry leaves, 10-30 parts of seabuckthorn fruit powder, 10-30 parts of dandelions, 5-20 parts of polygonatum, 5-20 parts of poria cocos and 2-30 parts of scutellaria baicalensis as a basic formula. The celery seeds, mulberries, seabuckthorn fruit powder, polygonatum and poria cocos can be used in their original powder or extracts, while the mulberry leaves, dandelions and scutellaria baicalensis can be used in their extracts.

[0046] The invention discloses a food medicine for lowering blood uric acid and treating gout. The food medicine is characterized by comprising 10-30 parts of celery seeds, 10-30 parts of mulberry fruits, 5-25 parts of mulberry leaves, 5-25 parts of mulberry branches, 10-30 parts of seabuckthorn fruit powder, 10-30 parts of dandelions, 5-20 parts of polygonatum, 5-20 parts of poria cocos and 2-30 parts of scutellaria baicalensis as a basic formula. The celery seeds, mulberry fruits, seabuckthorn fruit powder, polygonatum and poria cocos can be used in their original powder or extracts, while the mulberry leaves, mulberry branches, dandelions and scutellaria baicalensis can be used in their extracts.

[0047] A food medicine for lowering blood uric acid and treating gout is characterized by: celery seeds, mulberry fruits, polygonatum, poria, black wolfberry, kudzu root, and sea buckthorn fruit powder are ground into powder or their extracts are used; celery, dandelion, mulberry leaves, mulberry branches, beach kidney grass, yam, cat's whiskers, desmodium, acanthopanax, anserine, astragalus, purslane, thistle, galangal, hovenia dulcis, astragalus, luteolin, chicken's gizzard lining, and wild smilax are used as extracts.

[0048] The invention discloses a food medicine for lowering blood uric acid and treating gout, which is characterized by the following raw materials: celery seeds, mulberries, mulberry leaves, sea buckthorn, dandelion, polygonatum, black wolfberry, poria, beach nephrodisiac, purslane, kudzu root, mulberry branches and maltodextrin.

[0049] The invention discloses a food medicine for lowering blood uric acid and treating gout, which is characterized in that the raw materials are celery seeds, mulberries, mulberry leaves, sea buckthorn, dandelion, seagrass, purslane and maltodextrin.

[0050] The invention discloses a food medicine for lowering blood uric acid and treating gout. The food medicine is characterized by comprising the following raw materials: celery seeds, celery, mulberries, mulberry leaves, mulberry branches, sea buckthorn, dandelion, maltodextrin, beach nephritis, poria, polygonatum, black wolfberry, kudzu root, yam, cat's whiskers, desmodium, acanthopanax, anserine, astragalus, purslane, smilax glabra, thistle, and uric acid-lowering probiotics.

[0051] Uric acid-lowering probiotics include two types: those that inhibit xanthine oxidase and those that decompose uric acid, including Lactobacillus gasseri LG08, Lactobacillus reuteri FPH2951, Bifidobacterium breve FPHC4024, Pediococcus pentosaceus, etc.

[0052] The invention discloses a food medicine for lowering blood uric acid and treating gout, which is characterized in that its components include celery seeds and seabuckthorn fruit powder, or acanthopanax senticosus extract.

[0053] The invention discloses a food medicine for lowering blood uric acid and treating gout, which is characterized in that its components include beach spathiphyllum, seabuckthorn fruit, acanthopanax senticosus, luteolin and anserine.

[0054] A food medicine for lowering blood uric acid and treating gout, characterized by: a basic formula of celery seeds, mulberry fruits, mulberry leaves, sea buckthorn fruit powder, dandelion, and beach kidney grass, containing one, several, or all of the following auxiliary materials: polygonatum, tuckahoe, black wolfberry, kudzu root, yam, cat's whiskers, desmodium, acanthopanax, anserine, astragalus, purslane, thistle, galangal, hovenia dulcis, astragalus, luteolin, baking soda, edible probiotics for lowering uric acid, etc. When the uric acid level is higher than 530 μmol / L, the food medicine can be taken at staggered times with the Western medicine Febuxostat tablets, thereby combining traditional Chinese and Western medicine to enhance the uric acid-lowering effect and complement each other.

[0055] The inventors used celery seeds, mulberries, mulberry leaves, sea buckthorn, dandelion, and seaweed as ingredients in a uric acid-lowering formula, along with their rich flavonoids, saponins, enzymes, and other trace active substances and vitamins. They formulated this solid beverage into a drink called Celery, Mulberry, and Berry Vitamin Solid Beverage. Clinical trials have shown this drink to be significantly effective in lowering uric acid (87-year-old Ms. Lin saw her uric acid level drop by 370 μmol / L per day). It also boasts blood sugar-lowering and antioxidant benefits, achieving unexpected results.

[0056] Traditional Chinese medicine believes that gout is caused by insufficient internal qi and liver and kidney deficiency, followed by external pathogens of wind, cold, dampness and heat, which cause qi and blood to stagnate, and pain to form when qi and blood do not circulate smoothly. If treatment is not timely, the condition will continue to worsen, resulting in the deposition of tophi. The present invention treats gout and reduces high uric acid. It uses celery seeds, celery, mulberries, mulberry leaves, mulberry branches, sea buckthorn, dandelion, polygonatum, black wolfberry, poria, seaweed, purslane, Acanthopanax senticosus, kudzu root and other plants’ various flavonoids, saponins, and biological enzymes to inhibit xanthine oxidase in the human body, thereby controlling uric acid production. It also uses uric acid-lowering edible probiotics to decompose uric acid, and plant diuretic substances to promote human metabolism, continuously dissolve and eliminate excess uric acid in the body, and repair damaged tissues, thereby achieving the purpose of rehabilitation. Clinical experiments have shown that the present invention also has the effect of lowering blood sugar, lowering uric acid, and can also lower creatinine, urea nitrogen, and blood lipids, enhance immunity, and has no side effects, achieving unexpected results.

[0057] The present invention is a drug for lowering blood uric acid and treating gout. The drug is developed based on research and clinical trials to address issues with the use of a herbaceous sedge extract in treating gout. Combining traditional Chinese medicine with modern scientific research, the drug has achieved promising results through clinical validation. The inventors have demonstrated a uric acid-lowering efficacy of over 93% in clinical practice (some individuals interrupted the drug during the acid-dissolving phase, making it impossible to assess efficacy). The drug also has the added benefit of boosting human immunity.

[0058] The above ingredients, celery seeds, mulberries, mulberry leaves, mulberry branches, sea buckthorn, dandelion, maltodextrin, beach kidney grass, Poria cocos, Polygonatum sibiricum, black wolfberry, Pueraria root, yam pair, cat's whiskers, Centella asiatica, Acanthopanax senticosus, anserine, astragalus, purslane, chicory, and uric acid-lowering probiotics, have been clinically shown to be effective in reducing high blood sugar in the human body and can be used to lower blood sugar in the human body.

[0059] The inventors believe that beach kidney grass, which grows on the beach and is resistant to waterlogging, is similar to reeds and should be classified as a cold herb. To prevent side effects such as gastrointestinal discomfort, warming foods or traditional Chinese medicines should be added to combined foods or medicines to achieve a neutral overall balance of yin and yang in the human body.

[0060] The invention provides a food medicine for lowering blood uric acid and treating gout, which is characterized by: 1 gram to 2 grams of anserine is used to lower blood uric acid.

[0061] Ms. Lin * Xiang, 84, suffered from a weak spleen and stomach. Two hours after taking 2 grams of sea buckthorn extract, she developed diarrhea. She later combined the sea buckthorn extract with ginger powder, which relieved her stomach discomfort and lowered her blood uric acid level. However, she noticed blurry vision a few days later, which the inventors attributed to excessive ginger powder consumption. Her husband, Yang * Fa, 86, had just been discharged from the hospital after nearly a month of hospitalization. He suffered from lung problems caused by long-term smoking, frail health, and difficulty controlling his bladder and bowel movements. He also had high cholesterol, high blood sugar, and high blood pressure, as well as chronic prostatitis, frequent urination, and uncontrollable urination. He had purchased sea buckthorn fruit powder but had not yet used it. Sea buckthorn fruit, with its warming properties, relieves cough and expectoration, aids digestion, and promotes blood circulation and blood stasis. It is used for cough with excessive sputum, indigestion, abdominal pain from food stagnation, bruises from falls, and amenorrhea. It is not a conventional treatment for gout. According to the inventors, promoting blood circulation and dispersing blood stasis is helpful in treating gout; digestion and stagnation can help with gastrointestinal discomfort after taking haitan senna; and sea buckthorn fruit has a warming nature, which is helpful in removing the coldness of haitan senna. Therefore, with a try-it attitude, they mixed haitan senna extract with sea buckthorn fruit powder. Ms. Lin felt very well, her blood uric acid level dropped smoothly, and she experienced no side effects such as blurred vision. Her husband, Yang *Fa, also took haitan senna extract and sea buckthorn fruit powder and recovered quickly. Five days after being discharged from the hospital, he was able to get out of bed and urinate on his own, and his previous frequent and urgent urination was much less severe. Based on the Traditional Chinese Medicine theory that hollow plants promote diuresis, the inventors inferred that haitan senna (a waterlogged plant with hollow roots and stems that facilitate oxygenation) also has diuretic and urinary benefits, effectively eliminating urinary tract inflammation.

[0062] The beach kidney grass extract and sea buckthorn fruit extract, one warm and one cool, work together in harmony, complementing each other and bringing out the best in each other. They are rich in pure natural vitamins, polysaccharides, saponins, flavonoids and bioactive ingredients. They control uric acid production and regulate body functions by inhibiting xanthine oxidase in the human body.

[0063] The food of the invention extracts the essence of beach kidney grass (growing in the harsh environment of high salt and ebb and flow on the beach) and sea buckthorn fruit (growing in saline-alkali land in the desert), and is a combination of mountain and sea delicacies and the complementation of yin and yang.

[0064] In the present invention, the beach nephrodisiac is added with sea buckthorn fruit, and part of Acanthopanax senticosus can be added, or the beach nephrodisiac is added with Acanthopanax senticosus.

[0065] The beach grass referred to in the present invention is a plant of the genus Poaceae, including Spartina alterniflora, Spartina rice, sterile Spartina alterniflora and its closely related variants and hybrid plants. The chemical substances contained in the plant are similar to those of Spartina alterniflora and have similar functions. The plant is characterized by the ability to secrete salt on the surface of its leaves and stems when growing on beaches with high salt concentrations, which is similar to the function of the human kidney. According to the traditional Chinese medicine principle of treating the body by its type, and based on many years of clinical trials, the plant has a significant effect on lowering uric acid, and can also enhance human immunity and lower blood lipids. According to the principle that hollowness can promote diuresis, the plant has a diuretic effect. The inventor believes that the plant has a cold medicinal property (beach grass is an alien species and is not recorded in the Chinese medicine pharmacopoeia and no related reports have been found).

[0066] Those with spleen and stomach deficiency should take warming foods to achieve a balance between yin and yang. Combining sea buckthorn fruit with acanthopanax bark to make a food or medicine is effective in treating gout and lowering uric acid levels while avoiding its adverse effects.

[0067] For patients with severe gout, it is recommended to take Western medicine or traditional Chinese medicine to eliminate gout pain, and take 2 grams of beach kidney grass extract and 0.5-3 grams of sea buckthorn fruit extract at the same time. If the uric acid level is too high (such as more than 600μmol / L), it can be staggered with traditional Chinese medicine to take 1-2 40-80mg of Febuxostat tablets with fewer side effects. After the uric acid level drops to less than 420μmol / L, take 3-4 grams of Celery, Mulberry and Vitamin solid drink alone. For patients without gout symptoms or uric acid levels not higher than 530, 3-4 grams of Celery, Mulberry and Vitamin solid drink can be taken alone. Generally, it is taken once a day, and there is no discomfort after taking it. If the symptoms are severe, it can be taken twice a day.

[0068] Food and medicine formula 1 for lowering uric acid and treating gout: Celery seeds, mulberry fruits, mulberry leaves, sea buckthorn fruit powder, dandelion, and beach kidney grass are the basic formula, and it contains one, several, or all of the following auxiliary ingredients: polygonatum, poria, mulberry branches, black wolfberry, kudzu root, yam, cat's whiskers, money grass, Acanthopanax senticosus, anserine, astragalus, purslane, chicory, galangal, tangerine peel, astragalus, celery, luteolin, edible probiotics for lowering uric acid, etc., to treat hyperuricemia and gout.

[0069] Food and medicine formula 2 for lowering uric acid and treating gout: Celery seeds, mulberry fruits, mulberry leaves, sea buckthorn fruit powder, dandelion, polygonatum, poria, and beach kidney grass are the basic formula, and it contains one, several, or all of the auxiliary ingredients such as black wolfberry, mulberry branches, kudzu root, yam, cat's whiskers, money grass, Acanthopanax senticosus, anserine, astragalus, purslane, chicory, galangal, tangerine peel, astragalus, celery, luteolin, edible probiotics that lower uric acid, etc., to treat hyperuricemia and gout.

[0070] Food and medicine formula 3 for lowering uric acid and treating gout: 10-30 parts of celery seeds, 10-30 parts of mulberry fruits, 5-25 parts of mulberry leaves, 10-30 parts of sea buckthorn fruit powder, 10-30 parts of dandelion, 5-20 parts of polygonatum, 5-20 parts of poria cocos, and 2-30 parts of beach kidney grass as the basic formula.

[0071] Food and medicine formula 4 for lowering uric acid and treating gout: beach kidney grass, sea buckthorn fruit, celery seed, luteolin, anserine, and uric acid-lowering probiotics.

[0072] Introduction to the production process of beach nephrodisiac and sea buckthorn fruit:

[0073] [Production process] 1: Mix the selected beach kidney grass and sea buckthorn fruit raw materials, clean the raw materials, extract them three times, concentrate them, spray dry them into powder, sieve and sterilize them, and pack them in the packaging machine.

[0074] [Production process] 2: The raw materials of beach kidney grass and sea buckthorn fruit are selected, cleaned, extracted three times, concentrated, spray-dried into powder, sieved and sterilized, and the two extracts are mixed in a ratio of 1:0.3-2 and packaged by a packaging machine.

[0075] [Production process] 3: From July to October, take the above-ground part of mature beach kidney grass (generally beach kidney grass), clean it, and squeeze the juice, soak it in water to squeeze the juice, and soak it in water to squeeze the juice. The soaking water is generally used for juicing 3-5 times. The latter low-concentration juice is circulated to the previous higher-concentration juice for soaking before juicing. This can save energy and water. After filtration and concentration (using multi-effect evaporation), spray drying into powder, sieving and sterilizing, it is mixed with celery seed extract, mulberry fruit, mulberry leaf extract, sea buckthorn fruit powder, dandelion extract, polygonatum, and poria in proportion, and packaged by packaging machine. DETAILED DESCRIPTION

[0076] The present invention provides a food and medicine for lowering blood uric acid and treating gout. The food and medicine are characterized by: the herb of the beach sedge has a cooling property and, together with seabuckthorn fruit, has a good therapeutic effect on lowering blood uric acid and treating gout, and enhances human immunity. The beach sedge extract and the seabuckthorn fruit extract are mixed in a ratio of 1:0.3-2. Alternatively, the aboveground stems and leaves of the beach sedge and the seabuckthorn fruit can be boiled in water in a traditional Chinese medicine boiling method in a ratio of 1:0.3-2.

[0077] Taking the human body weight of 60 kg as the standard, 2 grams of beach nephrodisiac extract and 0.5-3 grams of sea buckthorn fruit extract are mixed and taken once a day without adverse reactions. Those with higher uric acid values ​​(over 580μmol / L, the following uric acid units are all μmol / L) can take it twice a day. Those who weigh more than 60 kg can increase the dosage proportionally.

[0078] The invention discloses a food medicine for lowering blood uric acid and treating gout. The food medicine is characterized by comprising: celery seeds, celery, mulberry fruits, mulberry leaves, sea buckthorn fruit powder, dandelion, polygonatum, poria, and beach kidney grass as a basic formula; and containing one, several, or a combination of all of the auxiliary materials, such as mulberry branches, black wolfberry, kudzu root, yam, cat's whiskers, desmodium, acanthopanax, anserine, astragalus, purslane, thistle, galangal, prunus aurantium, astragalus, luteolin, and edible probiotics capable of lowering uric acid, for treating hyperuricemia and gout.

[0079] The invention discloses a food medicine for lowering blood uric acid and treating gout. The food medicine is characterized by comprising 10-30 parts of celery seeds, 10-30 parts of mulberries, 5-25 parts of mulberry leaves, 10-30 parts of seabuckthorn fruit powder, 10-30 parts of dandelions, 5-20 parts of polygonatum, 5-20 parts of poria cocos and 2-30 parts of scutellaria baicalensis as a basic formula. The celery seeds, mulberries, seabuckthorn fruit powder, polygonatum and poria cocos can be used in their original powder or extracts, while the mulberry leaves, dandelions and scutellaria baicalensis can be used in their extracts.

[0080] A food medicine for lowering blood uric acid and treating gout is characterized by: celery seeds, mulberry fruits, polygonatum, poria, black wolfberry, kudzu root, and sea buckthorn fruit powder are ground into powder or their extracts are used; celery, dandelion, mulberry leaves, mulberry branches, beach kidney grass, yam, cat's whiskers, desmodium, acanthopanax, anserine, astragalus, purslane, thistle, galangal, hovenia dulcis, astragalus, luteolin, chicken's gizzard lining, and wild smilax are used as extracts.

[0081] The invention discloses a food medicine for lowering blood uric acid and treating gout, which is characterized by the following raw materials: celery seeds, mulberries, mulberry leaves, sea buckthorn, dandelion, polygonatum, black wolfberry, poria, beach nephrodisiac, purslane, kudzu root, mulberry branches and maltodextrin.

[0082] The invention discloses a food medicine for lowering blood uric acid and treating gout, which is characterized in that the raw materials are celery seeds, mulberries, mulberry leaves, sea buckthorn, dandelion, seagrass, purslane and maltodextrin.

[0083] The invention discloses a food medicine for lowering blood uric acid and treating gout. The food medicine is characterized by comprising the following raw materials: celery seeds, celery, mulberries, mulberry leaves, mulberry branches, sea buckthorn, dandelion, maltodextrin, beach nephritis, poria, polygonatum, black wolfberry, kudzu root, yam, cat's whiskers, desmodium, acanthopanax, anserine, astragalus, purslane, smilax glabra, thistle, and uric acid-lowering probiotics.

[0084] Uric acid-lowering probiotics include two types: those that inhibit xanthine oxidase and those that decompose uric acid, including Lactobacillus gasseri LG08, Lactobacillus reuteri FPH2951, Bifidobacterium breve FPHC4024, Pediococcus pentosaceus, etc.

[0085] The invention discloses a food medicine for lowering blood uric acid and treating gout, which is characterized in that its components include celery seeds and seabuckthorn fruit powder, or acanthopanax senticosus extract.

[0086] The invention discloses a food medicine for lowering blood uric acid and treating gout, which is characterized in that its components include beach spathiphyllum, seabuckthorn fruit, acanthopanax senticosus, luteolin and anserine.

[0087] The invention discloses a food medicine for lowering blood uric acid and treating gout. The food medicine is characterized in that its components include sea buckthorn, seabuckthorn fruit, acanthopanax senticosus, luteolin and anserine. When the uric acid level is higher than 530 μmol / L, the food medicine can be taken at different times from the western medicine Febuxostat tablets to avoid mutual interference of the medicinal properties, and the combination of traditional Chinese medicine and Western medicine can bring out the best in each other.

[0088] The inventors used celery seeds, mulberries, mulberry leaves, sea buckthorn, dandelion, and seaweed as ingredients in a uric acid-lowering formula, along with their rich flavonoids, saponins, enzymes, and other trace active substances and vitamins. They formulated this solid beverage into a drink called Celery, Mulberry, and Berry Vitamin Solid Beverage. Clinical trials have shown this drink to be significantly effective in lowering uric acid (87-year-old Ms. Lin saw her uric acid level drop by 370 μmol / L per day). It also boasts blood sugar-lowering and antioxidant benefits, achieving unexpected results.

[0089] Traditional Chinese medicine believes that gout is caused by insufficient internal qi and liver and kidney deficiency, followed by external pathogens of wind, cold, dampness and heat, which cause qi and blood to stagnate, and pain to occur if the qi and blood do not circulate smoothly. If treatment is not timely, the condition will continue to worsen, resulting in the deposition of tophi. The present invention treats gout and reduces high uric acid. It uses various flavonoids, saponins, and biological enzymes from plants such as celery seeds, celery, mulberries, mulberry leaves, mulberry branches, sea buckthorn, dandelion, polygonatum, black wolfberry, Poria, seaweed, purslane, and kudzu root to inhibit xanthine oxidase in the human body, thereby controlling uric acid production, and the decomposition of uric acid by edible probiotics that reduce uric acid. It also contains plant diuretic substances to promote human metabolism, continuously dissolve and eliminate excess uric acid in the body, and repair damaged tissues, thereby achieving the purpose of rehabilitation. Clinical experiments have shown that the present invention also has the effect of lowering blood sugar, lowering uric acid, and can also lower creatinine, urea nitrogen, and blood lipids, enhance immunity, and has no side effects, achieving unexpected results.

[0090] The present invention is a drug for lowering blood uric acid and treating gout. The drug is developed based on research and clinical trials to address issues with the use of a herbaceous sedge extract in treating gout. Combining traditional Chinese medicine with modern scientific research, the drug has achieved promising results through clinical validation. The inventors have demonstrated a uric acid-lowering efficacy of over 93% in clinical practice (some individuals interrupted the drug during the acid-dissolving phase, making it impossible to assess efficacy). The drug also has the added benefit of boosting human immunity.

[0091] The above ingredients, celery seeds, mulberries, mulberry leaves, mulberry branches, sea buckthorn, dandelion, maltodextrin, beach kidney grass, Poria cocos, Polygonatum sibiricum, black wolfberry, Pueraria root, yam pair, cat's whiskers, Centella asiatica, Acanthopanax senticosus, anserine, astragalus, purslane, chicory, and uric acid-lowering probiotics, have been clinically shown to be effective in reducing high blood sugar in the human body and can be used to lower blood sugar in the human body.

[0092] The inventors believe that beach kidney grass, which grows on the beach and is resistant to waterlogging, is similar to reeds and should be classified as a cold herb. To prevent side effects such as gastrointestinal discomfort, warming foods or traditional Chinese medicines should be added to combined foods or medicines to achieve a neutral overall balance of yin and yang in the human body.

[0093] The invention provides a food medicine for lowering blood uric acid and treating gout, which is characterized by: 1 gram to 2 grams of anserine is used to lower blood uric acid.

[0094] Ms. Lin * Xiang, 84, suffered from a weak spleen and stomach. Two hours after taking 2 grams of sea buckthorn extract, she developed diarrhea. She later combined the sea buckthorn extract with ginger powder, which relieved her stomach discomfort and lowered her blood uric acid level. However, she noticed blurry vision a few days later, which the inventors attributed to excessive ginger powder consumption. Her husband, Yang * Fa, 86, had just been discharged from the hospital after nearly a month of hospitalization. He suffered from lung problems caused by long-term smoking, frail health, and difficulty controlling his bladder and bowel movements. He also had high cholesterol, high blood sugar, and high blood pressure, as well as chronic prostatitis, frequent urination, and uncontrollable urination. He had purchased sea buckthorn fruit powder but had not yet used it. Sea buckthorn fruit, with its warming properties, relieves cough and expectoration, aids digestion, and promotes blood circulation and blood stasis. It is used for cough with excessive sputum, indigestion, abdominal pain from food stagnation, bruises from falls, and amenorrhea. It is not a conventional treatment for gout. According to the inventors, promoting blood circulation and dispersing blood stasis is helpful in treating gout; promoting digestion and relieving stagnation can help with gastrointestinal discomfort after taking haitan senna. The warm nature of sea buckthorn fruit can help remove the coldness of haitan senna. Therefore, with a try-it attitude, Ms. Lin mixed haitan senna extract with sea buckthorn fruit powder. As a result, she felt much better, her blood uric acid level dropped smoothly, and she experienced no side effects like blurred vision. Her husband, Yang *Fa, also took haitan senna extract and sea buckthorn fruit powder and recovered quickly. Five days after being discharged from the hospital, he was able to urinate and defecate on his own, and his previous frequent and urgent urination was significantly improved. Based on the Traditional Chinese Medicine theory that hollow plants promote diuresis, the inventors inferred that haitan senna (a waterlogged plant with hollow roots and stems that facilitate oxygenation) also has diuretic and urinary benefits, effectively eliminating urinary tract inflammation.

[0095] The beach kidney grass extract and sea buckthorn fruit extract, one warm and one cool, work together in harmony, complementing each other and bringing out the best in each other. They are rich in pure natural vitamins, polysaccharides, saponins, flavonoids and bioactive ingredients. They control uric acid production and regulate body functions by inhibiting xanthine oxidase in the human body.

[0096] The food of the invention extracts the essence of beach kidney grass (growing in the harsh environment of high salt and ebb and flow on the beach) and sea buckthorn fruit (growing in saline-alkali land in the desert), and is a combination of mountain and sea delicacies and the complementation of yin and yang.

[0097] In the present invention, the beach nephrodisiac is added with sea buckthorn fruit, and part of Acanthopanax senticosus can be added, or the beach nephrodisiac is added with Acanthopanax senticosus.

[0098] The beach grass referred to in the present invention is a plant of the genus Poaceae, including Spartina alterniflora, Spartina rice, sterile Spartina alterniflora and its closely related variants and hybrid plants. The chemical substances contained in the plant are similar to those of Spartina alterniflora and have similar functions. The plant is characterized by the ability to secrete salt on the surface of its leaves and stems when growing on beaches with high salt concentrations, which is similar to the function of the human kidney. According to the traditional Chinese medicine principle of treating the body by its type, and based on many years of clinical trials, the plant has a significant effect on lowering uric acid, and can also enhance human immunity and lower blood lipids. According to the principle that hollowness can promote diuresis, the plant has a diuretic effect. The inventor believes that the plant has a cold medicinal property (beach grass is an alien species and is not recorded in the Chinese medicine pharmacopoeia and no related reports have been found).

[0099] Those with spleen and stomach deficiency should take warming foods to achieve a balance between yin and yang. Combining sea buckthorn fruit with acanthopanax bark to make a food or medicine is effective in treating gout and lowering uric acid levels while avoiding its adverse effects.

[0100] For patients with severe gout, it is recommended to take Western medicine or traditional Chinese medicine to eliminate gout pain, and take 2 grams of beach kidney grass extract and 0.5-3 grams of sea buckthorn fruit extract at the same time. If the uric acid level is too high (such as more than 600μmol / L), it can be staggered with traditional Chinese medicine to take 1-2 40-80mg of Febuxostat tablets with fewer side effects. After the uric acid level drops to less than 420μmol / L, take 3-4 grams of Celery, Mulberry and Vitamin solid drink alone. For patients without gout symptoms or uric acid levels not higher than 530, 3-4 grams of Celery, Mulberry and Vitamin solid drink can be taken alone. Generally, it is taken once a day, and there is no discomfort after taking it. If the symptoms are severe, it can be taken twice a day.

[0101] Food and medicine formula 1 for lowering uric acid and treating gout: Celery seeds, mulberry fruits, mulberry leaves, sea buckthorn fruit powder, dandelion, and beach kidney grass are the basic formula, and it contains one, several, or all of the auxiliary ingredients such as polygonatum, poria, mulberry branches, black wolfberry, kudzu root, yam, cat's whiskers, money grass, Acanthopanax senticosus, anserine, astragalus, purslane, chicory, galangal, hovenia dulcis, astragalus, celery, luteolin, uric acid-lowering edible probiotics, etc., to treat hyperuricemia and gout.

[0102] Food and medicine formula 2 for lowering uric acid and treating gout: Celery seeds, mulberry fruits, mulberry leaves, sea buckthorn fruit powder, dandelion, polygonatum, poria, and beach kidney grass are the basic formula, and it contains one, several, or all of the auxiliary ingredients such as black wolfberry, mulberry branches, kudzu root, yam, cat's whiskers, money grass, Acanthopanax senticosus, anserine, astragalus, purslane, chicory, galangal, hovenia dulcis, astragalus, celery, luteolin, edible probiotics that lower uric acid, etc., to treat hyperuricemia and gout.

[0103] Food and medicine formula 3 for lowering uric acid and treating gout: 10-30 parts of celery seeds, 10-30 parts of mulberry fruits, 5-25 parts of mulberry leaves, 10-30 parts of sea buckthorn fruit powder, 10-30 parts of dandelion, 5-20 parts of polygonatum, 5-20 parts of poria cocos, and 2-30 parts of beach kidney grass as the basic formula.

[0104] Food and medicine formula 4 for lowering uric acid and treating gout: beach kidney grass, sea buckthorn fruit, celery seed, luteolin, anserine, and uric acid-lowering probiotics.

[0105] Introduction to the production process of beach nephrodisiac and sea buckthorn fruit:

[0106] [Production process] 1: Mix the selected beach kidney grass and sea buckthorn fruit raw materials, clean the raw materials, extract them three times, concentrate them, spray dry them into powder, sieve and sterilize them, and pack them in the packaging machine.

[0107] [Production process] 2: The raw materials of beach kidney grass and sea buckthorn fruit are selected, cleaned, extracted three times, concentrated, spray-dried into powder, sieved and sterilized, and the two extracts are mixed in a ratio of 1:0.3-2 and packaged by a packaging machine.

[0108] [Production process] 3: From July to October, take the above-ground part of mature beach kidney grass (generally beach kidney grass), clean it, and squeeze the juice, soak it in water to squeeze the juice, and soak it in water to squeeze the juice. The soaking water is generally used for juicing 3-5 times. The latter low-concentration juice is circulated to the previous higher-concentration juice for soaking before juicing. This can save energy and water. After filtration and concentration (using multi-effect evaporation), spray drying into powder, sieving and sterilizing, it is mixed with celery seed extract, mulberry fruit, mulberry leaf extract, sea buckthorn fruit powder, dandelion extract, polygonatum, and poria in proportion, and packaged by packaging machine.

[0109] You can harvest 150-200 grams of beach kidney grass from July to October, raw or dried, cut into sections, add water to cover the beach kidney grass, and cook it with sea buckthorn fruit for about 30 minutes, or add 1-3 grams of sea buckthorn fruit extract after cooking, and take them together, the effect of treating gout remains unchanged.

[0110] The following is a record of the clinical application of the medicine of the present invention.

[0111] Case 1

[0112] Lin * Xiang, an 84-year-old female, developed gout three years ago and subsequently experienced several flare-ups. She took a combination of Chinese and Western medicine, and when the pain subsided, she ignored the condition. She developed gout after the 2024 Spring Festival, but the pain has subsided recently. Her blood uric acid level was 610, and she had a weak spleen and stomach. Two hours after taking 2 grams of dandelion extract, she developed diarrhea. She later combined dandelion extract with ginger powder, which relieved her stomach discomfort and lowered her blood uric acid level. However, she noticed blurry vision a few days later, which the inventors attributed to excessive ginger consumption affecting her vision. She switched to sea buckthorn fruit powder, 2 grams each time, for two days, along with 2 grams of dandelion extract. Her blood uric acid level remained at 540. After July 2nd, she continued taking it for three more days, and on July 5th, it dropped to 476. She then ate oyster bone porridge for several days. On the morning of the 10th, her blood uric acid level reached 525, but rebounded to 493 on July 13th and 150 on July 16th. Since then, she has taken 2 grams each of dandelion extract and sea buckthorn fruit powder daily, and her uric acid level has returned to normal. She has not taken any other gout medications for over a month.

[0113] Case 2

[0114] Yang * Fa, male, 86 years old, with three highs, poor lung function due to long-term smoking. Two months ago, when he caught a cold, his lungs were easily infected and developed pneumonia. He went to a hospital in Shantou for emergency treatment. He was in a coma for 5 days, suffered from uremia, and had a mild cerebral infarction. He was discharged from the hospital 26 days later and was recuperating at home. He could not take care of himself and could not get up. He had frequent and urgent urination and could not control his urination. His chronic prostatitis was not cured. He took Qianlikang, three highs medicine, and traditional Chinese medicine from Shantou Hospital of Traditional Chinese Medicine, including 5g of scutellaria baicalensis, 15g of mulberry leaves, 10g of honeysuckle, 10g of northern bupleurum, 10g of coptis root slices, and 10g of French pinellia. g, dried tangerine peel 10g, 25g desmodium dendrum, 10g umbellatum, 10g plantain seed, 5g ephedra, 5g cicada slough, 15g kudzu root, 5g codonopsis pilosula, and 3g licorice slices. After a few days, they added 2g of beach kidney grass extract and 2g of sea buckthorn fruit powder daily. The patient recovered quickly, and after 5 days, he was able to urinate and defecate on his own. His frequent and urgent urination was also much less severe. Based on the traditional Chinese medicine theory that hollow roots can promote diuresis, the inventors hypothesized that beach kidney grass (a waterlogged plant with hollow roots and stems, which facilitates oxygen supply to the roots) could also promote diuresis and eliminate urinary tract inflammation. Later, mulberries were added, and the loss of voice caused by prolonged intubation was cured.

[0115] Case 3

[0116] Huang Ming, 58, developed gout six years ago and has intermittent flare-ups. He uses the following traditional Chinese medicine: 12g cinnamon twig, 6g processed aconite root, 6g roasted licorice root, and 6g stir-fried white atractylodes macrocephala for pain flare-ups. Other friends who experience gout pain have also had good results using the above formula. He underwent surgery at the Central Hospital for Brain Tumors two years ago. On July 21, 2023, he began taking traditional Chinese medicine at Shantou Traditional Chinese Medicine Hospital to treat fluid accumulation in his brain. At the end of May 2024, he began taking 2g of dandelion extract daily. After three days, his uric acid level dropped from 580 to 540. After one month, it dropped to 430. On the morning of July 8, 2024, his uric acid level was 410, normal. He stopped taking the medication for two days and continued to eat shrimp, leg bones, and other foods. On the morning of July 10, his uric acid level was 380. He then took 2g of dandelion extract daily plus 2g of sea buckthorn fruit powder. On July 23, his uric acid level was 380. Since then, his uric acid level has been normal, and he has not had any gout flare-ups.

[0117] Case 4

[0118] Yang**, male, 58, has suffered from gout for 15 years. Starting from July 7, 2024, he took 2 grams of beach nephrodisiac extract every day. After taking it for 3 days, the test result on July 10 was 582, 600 on the 13th, and 600 on the 14th. After that, he took 2 grams of beach nephrodisiac extract every day plus 2 grams of sea buckthorn fruit powder. He started to take 2 febuxostat tablets. The uric acid value was 540, 476 on the 16th, 412 on the 18th, and 326 on the 20th. The uric acid value was changed to 1 tablet of febuxostat. There were some increases and decreases in the middle. He has not had gout so far and feels much more comfortable.

[0119] Case 5

[0120] Yang * Xiong, male, 56 years old, took beach kidney grass extract for three days at the end of May 2024, 2 grams per day, uric acid 480→430, and took some beach kidney grass extract from time to time within a month. On the evening of June 30, 2024, after dinner, the blood uric acid level dropped from 430 to 290, and the level on July 18 was 320, which is normal. Now he often takes beach kidney grass extract plus sea buckthorn fruit powder, and often eats high-purine foods such as chicken gizzards, and his uric acid will not exceed 380.

[0121] Case 6

[0122] Chen Dong, 76, of Fengshun, had suffered from gout for over 20 years. On July 16, 2024, his gout became severe and he was unable to leave the house. On the 17th, he began taking a combination of sea buckthorn, sea buckthorn, dandelion, mulberry leaf, and celery seed powder. Three days later, the pain subsided and gradually improved. He has continued to take this combination of sea buckthorn, dandelion, mulberry leaf, and celery seed powder, and has remained gout-free for over six months. He has also noticed that the uric acid stones in his toes have softened and shrunk. His previously high blood lipids and high blood pressure have also improved. He is deeply grateful to the inventor.

[0123] Case 7

[0124] Mr. Zhou, 50 years old, weighs 67 kg, and is 1.69 meters tall. He started drinking beach kidney grass and sea buckthorn on July 8, 2024. His uric acid level was 598. On August 1, his uric acid level was 526.6, his creatinine was 135.3mmol / L, and his urea nitrogen was 7.53mmol / L. On August 29, his uric acid level was 559.2, and his creatinine was 124.2mmol / L. It is estimated that during the period of dissolving uric acid stones, his uric acid level did not decrease but increased. Mr. Zhou suspected that the medicine was ineffective and asked him to add one Febuxostat 40mg / tablet every day. On September 6, his uric acid level was 294.2, his creatinine was 126.0mmol / L, and his urea nitrogen was 7.15mmol / L. He stopped taking Febuxostat and only ate beach kidney grass, sea buckthorn, and dandelion. His uric acid level did not exceed 380 until January 2025 and returned to normal.

[0125] Case 8

[0126] Li * Long, born in 1980, has had gout for more than 18 years. He has tophi in the joints of both toes and other places. On September 24, 2024, the gout was severe. He took several times the dosage of Western medicine, but the pain was still there. He started to take beach kidney grass, sea buckthorn, dandelion, mulberry leaves, and acanthopanax bark. It started to get better, but the pain came back after a while, but the pain was significantly lighter. He added a 40mg febuxostat tablet a day, but sometimes he forgot to take the medicine when he was on a business trip. After 2 months, the pain stopped. He added celery seeds, and it has been pain-free for more than 3 months. The uric acid stones are also gradually getting smaller.

[0127] Case 9

[0128] Mr. Zheng from Shantou, 50 years old, suffered from gout attack 8 years ago. On December 12, 2024, he drank the inventor's Celery, Mulberry, and Thorn Berry Drink (rapeseed, mulberry, mulberry leaf, sea buckthorn, dandelion, and beach kidney grass). The gout pain gradually subsided, and later the pain could be relieved without taking analgesics and anti-inflammatory drugs. He has been pain-free for 2 months and continues to drink the Celery, Mulberry, and Thorn Berry Drink.

[0129] Case 10

[0130] Ms. Lin is 87 years old. On the morning of March 30, 2025, her uric acid level was 721 and her blood sugar level was 7.3. She took 3 grams of celery and mulberry thorn plus uric acid-lowering probiotic food in the morning and evening, plus 40 mg of Febuxostat, one tablet. At 7:24 am on the 31st, her uric acid level was 351 and her blood sugar level was 6.5. Her uric acid level dropped by 370 and her blood sugar level dropped by 0.8 in one day. She took 3 grams of celery and mulberry thorn plus uric acid-lowering probiotic food in the morning and evening on the 31st. On April 1st, her uric acid level was 310 and her blood sugar level was 7.7 (perhaps she ate sugar last night). On April 1st, she only ate celery and mulberry thorn vitamin drink. On April 2nd, her uric acid level was measured at 350, which was a normal level. By April 7th, her uric acid level was below 380. This proves that the uric acid-lowering product of the present invention has unexpected therapeutic effects when combined with a small amount of Febuxostat.

Claims

1. A food medicine for lowering blood uric acid and treating gout, characterized by: The basic formula is composed of celery seeds, celery, mulberry fruits, mulberry leaves, sea buckthorn fruit powder, dandelion, polygonatum, poria cocos, and beach kidney grass, and contains auxiliary materials such as mulberry branches, black wolfberry, kudzu root, yam, cat's whiskers, money grass, Acanthopanax senticosus, anserine, astragalus, purslane, chicory, galangal, hovenia dulcis, astragalus, luteolin, uric acid-lowering edible probiotics, etc., one, several, or all of the above formula combinations, for the treatment of hyperuricemia and gout.

2. A food and medicine for lowering blood uric acid and treating gout according to claim 1, characterized in that: Celery seeds, mulberry fruit, polygonatum, poria, black wolfberry, kudzu root, and sea buckthorn fruit powder are ground into powder with the original medicine or used as extracts; celery, dandelion, mulberry leaf, mulberry branch, beach kidney grass, yam, cat's whisker grass, money grass, Acanthopanax senticosus, anserine, astragalus, purslane, chicory, galangal, hovenia dulcis, astragalus, luteolin, chicken gizzard lining, and wild smilax are used as extracts.

3. A food and medicine for lowering blood uric acid and treating gout according to claim 1, characterized by: Preferably, the basic formula is 10-30 parts of celery seeds, 10-30 parts of mulberries, 5-25 parts of mulberry leaves, 10-30 parts of sea buckthorn fruit powder, 10-30 parts of dandelions, 5-20 parts of polygonatum, 5-20 parts of poria, and 2-30 parts of beach kidney grass. Celery seeds, mulberries, sea buckthorn fruit powder, polygonatum, and poria can be used as raw powder or extracts, and mulberry leaves, dandelions, and beach kidney grass can be used as extracts.

4. A food and medicine for lowering blood uric acid and treating gout according to claim 1, characterized by: Preferably, the basic formula is 10-30 parts of celery seeds, 10-30 parts of mulberry fruits, 5-25 parts of mulberry leaves, 5-25 parts of mulberry branches, 10-30 parts of sea buckthorn fruit powder, 10-30 parts of dandelions, 5-20 parts of polygonatum, 5-20 parts of poria, and 2-30 parts of beach kidney grass. Celery seeds, mulberry fruits, sea buckthorn fruit powder, polygonatum, and poria can be used in their original powder or extracts, while mulberry leaves, mulberry branches, dandelions, and beach kidney grass can be used in their extracts.

5. A food and medicine for lowering blood uric acid and treating gout according to claim 1, characterized by: Celery seeds, mulberry fruit, polygonatum, poria, black wolfberry, kudzu root, and sea buckthorn fruit powder are ground into powder or their extracts are used; dandelion, mulberry leaf, beach kidney grass, yam, cat's whisker grass, money grass, Acanthopanax senticosus, anserine, astragalus, purslane, thistle, galangal, hovenia dulcis, astragalus, and luteolin are used as extracts.

6. A food and medicine for lowering blood uric acid and treating gout according to claim 1, characterized by: The basic formula is composed of celery seeds, mulberries, mulberry leaves, sea buckthorn fruit powder, dandelion, and beach kidney grass, and contains auxiliary materials such as polygonatum, poria, black wolfberry, kudzu root, yam, cat's whiskers, desmodium, acanthopanax, anserine, astragalus, purslane, chicory, galangal, hovenia dulcis, astragalus, luteolin, baking soda, edible probiotics for lowering uric acid, etc. When uric acid level is higher than 530μmol / L, it can be taken at different times with the western medicine Febuxostat tablets, combining Chinese and Western medicine to enhance the uric acid-lowering effect.

7. The present invention provides a food and medicine for lowering blood uric acid and treating gout, which is characterized by: Edible probiotics for lowering uric acid include two types: those that inhibit xanthine oxidase and those that decompose uric acid, including Lactobacillus gasseri LG08, Lactobacillus reuteri FPH2951, Bifidobacterium breve FPHC4024, and Pediococcus pentosaceus.

8. A food and medicine for lowering blood uric acid and treating gout according to claim 1, characterized by: For patients with severe gout, take the traditional Chinese medicine 12g of cinnamon twig, 6g of processed aconite, 6g of roasted licorice, and 6g of stir-fried white atractylodes to eliminate gout pain, and simultaneously take celery seeds, mulberry fruits, mulberry leaves, sea buckthorn fruit powder, dandelion, and beach kidney grass as the basic formula, which contains one, several, or all of the following auxiliary materials: polygonatum, poria, black wolfberry, kudzu root, yam, cat's whiskers, money grass, Acanthopanax senticosus, anserine, astragalus, purslane, chicory, galangal, hovenia dulcis, astragalus, luteolin, edible probiotics for lowering uric acid, etc.

9. A food and medicine for lowering blood uric acid and treating gout according to claims 1-8, characterized in that: It has the effect of lowering blood sugar, lowering uric acid, creatinine, urea nitrogen, and blood lipids, enhancing immunity, and has no side effects.

10. The processing technology of a food medicine for lowering blood uric acid and treating gout according to claim 1, characterized by: The above formula raw powder or extract is added together in proportion and mixed, and then packed in a packaging machine.